Publications

2020

Deinhardt-Emmer S, Rennert K, Schicke E, Cseresnyes Z, Windolph M, Nietzsche S, Heller R, Swiczak F, Haupt KF, Carlstedt S, Schacke M, Figge MT, Ehrhardt C, Löffler B, Mosig AS; Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model., Biofabrication, 2020, accepted

2019

Schubert M, Becher S, Wallert M, Maeβ MB, Abhari M, Rennert K, Mosig AS, Groβe S, Heller R, Grün M, Lorkowski S; The PPARγ antagonist 2-chloro-5-nitro-N-phenylbenzamide (GW9662) triggers PLIN2 expression via PPARδ and induces lipogenesis and triglyceride accumulation in human THP-1 macrophages, Mol Pharmacol. 2019, Dec 23.

Graf K, Last A, Gratz R, Allert S, Linde S, Westermann M, Gröger M, Mosig AS, Gresnigt MS, Hube B; Keeping Candida commensal - How lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model. Disease Models & Mechanisms, 2019, Sep 12, 12(9)

Maurer M., Gresnigt M.S., Last A., Wollny T., Berlinghof F., Pospich R., Cseresnyes Z., Medyukhina A., Graf K., Gröger M., Raasch M., Siwczak F., Nietzsche S., Jacobsen I.D., Figge M.T., Hube B., Huber O., Mosig A.S.; A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. Biomaterials, 2019, 220, November 2019, 119396

Blaurock N., GrögerM., Siwczak F., Dinger J., Schmerler D., Mosig AS.* and Kiehntopf M.* CAAP48, a new sepsis biomarker, induces hepatic dysfunction in an in vitro liver-on-chip model. Frontiers in Immunology, 2019, Feb 25;10:273. doi: 10.3389/fimmu.2019.00273. (* contributed equally)

2018

Leonhardt J., Große S., Marx C., Siwczak F., Stengel S., Bruns T., Bauer R., Kiehntopf M., Williams DL., Wang ZQ., Mosig AS., Weis S., Bauer M., Heller R. Candida albicans βglucan differentiateshuman monocytes into a specific subsetof macrophages. Frontiers in Immunology, 2018, Nov 30;9:2818. doi: 10.3389/fimmu.2018.02818

Pein H., Ville A., Pace S., Temml V., Garscha U., Raasch M., Alsabil K., Viault G., Dinh CH., Guilet D., Troisi F., Neukirch K., König S., Bilancia R., Waltenberger B., Stuppner H., Wallert M., Lorkowski S., Weinigel C., Rummler S., Birringer M., Roviezzo F., Sautebin L., Helesbeux JJ., Séraphin D., Mosig AS., Schuster D., Rossi A., Richomme P., Werz O., Koeberle A.; Endogenous metabolites of vitamin E limit inflammation by targeting 5lipoxygenase. Nature Communications, 2018, e-pub ahead DOI: 10.1038/s41467-018-06158-5

Raasch M, Fritsche E, Kurtz A, Bauer M, Mosig AS. Microphysiological systems meet hiPSC technology New tools for disease modeling of liver infections in basic research and drug development, Adcanced Drug Delivery Reviews, DOI: 10.1016/j.addr.2018.06.008

Heinze K, Kritsch D, Mosig AS., Dürst M, Häfner N, Runnebaum IB. Functional analyses of RUNX3 and CaMKIINα in ovarian cancer cell lines reveal tumor-suppressive functions for CaMKIINα and dichotomous roles for RUNX3 transcript variants. International Journal of Molecular Sciences, 2018, Jan 15;19(1), DOI: 10.3390/ijms19010253.

Ryabchykov O., Bräutigam K., Galler K., Neugebauer U., Mosig AS.,Bocklitz T., Popp J. Characterization of the unique human liver cell line HepaRG by Raman microspectroscopy. Journal of Raman Spectroscopy, 2018, June; 49(6): 935-942, DOI: 10.1002/jrs.5392

2017

Gröger M, Dinger J, Kiehntopf M, Peters FT, Rauen U, Mosig AS Preservation of Cell Structure, Metabolism and Biotransformation Activity of Liver-on-chip Organ Models by Hypothermic Storage. Advanced Healthcare Materials, 2017, September 17, doi:10.1002./adhm.201700616

Fahrner R, Möller A, Press AT, Kortgen A, Kiehntopf MD, Rauchfuss F, Settmacher U, Mosig AS Short-term treatment with taurolidine is associated with liver injury. BMC Pharmacology and Toxicology, 2017, 18(1) doi: 10.1186/s40360-017-0168-z

Rennert K, Nitschke M, Wallert M, Keune N, Raasch M., Lorkowski S, Mosig AS Thermo-responsive cell culture carrier effects on macrophage functionality and detachment efficiency. Journal auf Tissue Engineering, 2017, Aug 25;8:2041731417726428. doi: 10.1177/2041731417726428

Kritsch D, Hoffmann F, Steinbach D, Jansen L, Mary S, Mosig A, Sonnemann J, Peters S, Thomale J, Dürst M, Runnebaum I, Häfner, N Tribbles 2 mediates cisplatin sensitivity and DNA damage response in epithelial ovarian cancer. International Journal of Cancer, 2017 Oct 15;141(8):1600-1614. doi: 10.1002/ijc.30860

Mann A, Pelz T, Rennert K, Mosig A, Decker M, Lupp A. Evaluation of HepaRG cells for the assessment of indirect drug-induced hepatotoxicity using INH as a model substance. Human Cell, 2017 May 19. Oct;30(4):267-278. doi: 10.1007/s13577-017-0175-9

Thomas L, Rao Z, Gerstmeier J, Raasch M, Weinigel C, Rummler S, Menche D, Müller R, Pergola C, Mosig A, Werz O. Selective upregulation of TNFα expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with V-ATPase. Biochemical Pharmacology, 2017, 130:71-82, doi: 10.1016/j.bcp.2017.02.004.

Mosig AS, Nawroth J, Loskill P. Organs-on-a-chip: Neue Perspektiven in der Medikamentenentwicklung und Personalisierten Medizin. Deutsche Zeitschrift für Klinische Forschung, 1/2017

Pergola C, Schubert K, Pace S, Ziereisen J, Nikels F, Scherer O, Hüttel S, Zahler S, Vollmar A, Weinigel C, Rummler S, Muller R, Raasch M, Mosig AS, Koeberle A, Werz O. Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy. Scientific Reports, 2017, 7:41434, doi: 10.1038/srep41434

Schüler R, Osterhoff MA, Frahnow T, Seltmann AC, Busjahn A, Kabisch S, Xu L, Mosig AS, Spranger J, Möhlig M, Hornemann S, Kruse M, Pfeiffer AFH. High saturated fat diet increases circulating angiotensin converting enzyme which is enhanced by the rs4343 polymorphism defining persons at risk of nutrient dependent increases of blood pressure. Journal of American Heart Association (JAHA), 2017, 6(1): e004465

Gröger M, Lange M, Rennert K, Kaschowitz T, Plettenberg H, Hoffmann M, Mosig AS. Novel approach for the prediction of cell densities and viability in standardized translucent cell culture biochips with near infrared spectroscopy. Engineering in Life Sciences, 2017, doi:10.1002/elsc.201600162

2016

Mosig AS Organ-on-chip models: new opportunities for biomedical research, Future Science OA, 2016, FSO130, doi: 10.4155/fsoa-2016-0038, Editorial

Englert C, Trützschler AK, Raasch M, Bus T, Borchers P, Mosig AS*, Träger A*, Schubert US*. Crossing the blood-brain barrier: Glutathione-conjugated poly(ethylene imine) for gene delivery. Journal of Controlled Release 2016, 30 (241):1-14. (* shared senior authorship)

Raasch M, Rennert K, Jahn T, Gärtner C, Schönfelder G, Huber O, Seiler AEM, Mosig AS. An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex development. Biomicrofluidics, 2016, 10(4): 44102 - 441016

Rennert K, Heisig K, Groeger M, Wallert M, Funke H, Lorkowski S, Huber O, Mosig AS. Recruitment of CD16+ monocytes to endothelial cells in response to LPS-treatment and concomitant TNF release is regulated by CX3CR1 and interfered by soluble fractalkine. Cytokine, 2016, 83: 4152

Gröger M, Rennert K, Giszas B, Weiß E, Dinger J, Funke H, Kiehntopf M, Peters FT, Lupp A, Bauer M, Claus RA, Huber O, Mosig AS. Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model. Scientific Reports, 2016, 6: 21868

Rennert K, Otto P, Funke H, Huber O, Tomaso H, Mosig AS. A human macrophage - hepatocyte co-culture model for comparative studies of infection and replication of Francisella tularensis LVS strain and subspecies holarctica and mediasiatica. BMC Microbiology 2016,16(1):2

Press AT, Ungelenk L, Rinkenauer AC, Gröger M, Lehmann FD, Mosig AS, Schubert US., Clemens, MG, Bauer M. A new fluorescent dye for cell tracing and mitochondrial imaging in vitro and in vivo. Journal of Biophotonics, 2016, 9(9):888-900

2015

Rennert K, Steinborn S, Gröger M, Ungerböck B, Jank AM, Ehgartner J, Nietzsche S, Dinger J, Kiehntopf M, Funke H, Peters FT, Lupp A, Gärtner C, Mayr T, Bauer M, Huber O, Mosig AS. A microfluidically perfused three dimensional human liver model. Biomaterials, 2015, 71:119-31.

Gögebakan Ö, Osterhoff MA, Schüler R, Pivovarova O, Kruse M, Seltmann AC, Mosig AS, Rudovich N, Nauck M, Pfeiffer AF. GIP increases adipose tissue expression and blood levels of MCP-1 in humans and links high energy diets to inflammation: a randomised trial. Diabetologia, 2015, 58(8):1759-68

Rinkenauer AC, Press AT, Raasch M, Pietsch C, Schweizer S, Schwörer S, Rudolph KL, Mosig AS, Bauer M, Traeger A, Schubert US. Comparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo. Journal of Controlled Release, 2015, 216:158-68

Maeß M, Keller AA, Rennert K, Mosig AS, Lorkowski S. Optimization of the transfection of human THP-1 macrophages by application of Nunc UpCell technology. Analytical Biochemistry, 2015, 479:40-2

Raasch M, Rennert K, Jahn T, Peters S, Henkel T, Huber O, Schulz I, Becker H, Lorkowski S, Funke H, Mosig AS. Microfluidically supported biochip design for culture of endothelial cell layers with improved perfusion conditions. Biofabrication, 2014, 7(1):015013.

Press AT, Traeger A, Pietsch C, Mosig AS, Wagner M, Clemens MG, Jbeily N, Koch N, Gottschaldt M, Bézière N, Ermolayev V, Ntziachristos V, Popp J, Kessels M, Qualmann B, Schubert US, Bauer M. Cell type-specific delivery of short interfering RNAs by dye-functionalized "theranostic“ nanoparticles, Nature Communications, 2014, 5:5565

Wallert M, Mosig AS, Rennert K, Funke H, Ristow M, Pellegrino RM, Cruciani G, Galli F, Lorkowski S, Birringer M. Long-chain metabolites of α-tocopherol occur in human serum and inhibit macrophage foam cell formation in vitro, Free Radical Biology & Medicine, 2013, 68:43-51

Liesenfeld M, Mosig S, Funke H, Jansen L, Runnebaum IB, Durst M, Backsch C. SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes. BMC Cancer, 2013, 13(1): 507

Lange M, Engelhardt S, Liebold S, Plettenberg H, Mosig AS, Hoffmann M. Analysis of glucose and fetal calf serum in aqueous solution for Multi Organ Tissue Flow (MOTiF) bioreactors using NIR Spectroscopy. Biomedical Engineering, 2013

Pottgiesser T, Schumacher YO, Funke H, Rennert K, Baumstark MW, Neunuebel K, Mosig S. Gene expression in the detection of autologous blood transfusion in sports - a pilot study Vox Sanguinis, 2009, 96(4):333

Mosig S, Rennert K, Krause S, Kzhyshkowska J, Neunubel K, Heller R, Funke H. Different functions of monocyte subsets in familial hypercholesterolemia: potential function of CD14+ CD16+ monocytes in detoxification of oxidized LDL. FASEB Journal, 2009, 23(3): 866-874

Mosig S, Rennert K, Buttner P, Krause S, Lutjohann D, Soufi M, Heller R, Funke H. Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism. BMC Medical Genomics, 2008, 1: 60

Büttner P, Mosig S, Funke H. Gene expression profiles of T lymphocytes are sensitive to the influence of heavy smoking: A pilot study. Immunogenetics, 2007, 59(1):37-43

Büttner P, Mosig S, Lechtermann A, Funke H, Mooren FC. Exercise affects the gene expression profiles of human white blood cells. Journal of Applied Physiology, 2007, 102(1):26-36