Mägdefrau, Ann-Sophie

Dr. rer. nat. Ann-Sophie Mägdefrau (in on marental leave)

Research Associate

Institute of General Practice and Family Medicine,

Jena University Hospital
Bachstr. 18
D-07743 Jena

Phone: 03641/9-395825
Email:

Dr. rer. nat. Ann-Sophie Maegdefrau holds a doctorate in biochemistry and has been working at the Institute of General Practice at the Jena University Hospital (UKJ) since February 2024. Her research interests to date have focused on infection and immunobiology. Currently, Ann-Sophie Maegdefrau is primarily working on the POCT-ambulant project, which addresses the assessment of clinical need and patient benefit of point-of-care tests (POCTs) in outpatient care.

Ann-Sophie Maegdefrau studied biochemistry/molecular biology at the Friedrich Schiller University Jena (Bachelor/Master). Subsequently, she worked as a research associate at the Chair of Biochemistry at the Friedrich Schiller University Jena (2015-2020). Following this, she worked as a shift supervisor at SYNLAB Jena Oncoscreen® in Sars-Cov-2 diagnostics (2020-2021). In 2023, Ann-Sophie Maegdefrau completed her doctorate in the field of molecular biology.

Curriculum Vitae

Professional Experience

Since February 2024: Research Associate at Jena University Hospital, Institute of General Practice, InfectoGnostics Research Campus Jena
2020-2021: Shift Supervisor at SYNLAB Jena Oncoscreen®
2016: Research stay at the IRCM in Montréal, Canada
2015-2020: Research Associate at the Institute of Biochemistry and Biophysics, Friedrich Schiller University

Education

2012 – 2014: Master of Science in Biochemistry at the Friedrich Schiller University Jena
2009 – 2012: Bachelor of Science in Biochemistry/Molecular Biology at the Friedrich Schiller University Jena

Qualifications

2023: Doctorate in Molecular Biology at the Friedrich Schiller University Jena, Institute of Biochemistry and Biophysics, Chair of Biochemistry; Title: "A critical role of the transcription factor Miz-1 in T cell activation and maturation", Degree: Dr. rer. nat.

Current focus areas

Point-of-Care-Tests ambulant (POCT ambulant), InfectoGnostics Forschungscampus Jena; Forschungs-Entwicklungs-Praxis-Dialog zur bedarfsgerechten Entwicklung von Point-of-Care-Tests für die Primärversorgung; gefördert durch das Bundesministerium für Bildung und Forschung

Publications

Journal Articles

Mägdefrau A-S, Kathner-Schaffert C, Matthes A, Bleidorn J, Markwart R. The Impact of Point-of-Care Testing for Group A Streptococcal Pharyngitis on Antibiotic Prescribing and Patient Health Outcomes in Outpatient Care: A Systematic Review and Meta-analysis of Randomized Controlled Trials, Open Forum Infectious Diseases, Volume 12, Issue 7, July 2025, ofaf407, https://doi.org/10.1093/ofid/ofaf407
Winkler, R., S. Magdefrau, E. M. Piskor, M. Kleemann, M. Beyer, K. Linke, L. Hansen, A. M. Schaffer, M. E. Hoffmann, S. Poepsel, F. Heyd, P. Beli, T. Moroy, S. Mahboobi, O. H. Kramer and C. Kosan (2022). "Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition." Oncogene 41(40): 4560-4572 PDF
Mägdefrau, A. S., K. Ludwig, C. Weigel, N. Köse, G. M. Guerra, A. Dakhovnik, C. Kosan (2019). "DNA-damage-induced hormetic responses." In: Rattan, S. and M. Kyriazi (2019). "The science of hormesis in health and longevity."
Szemes, M., A. R. Dallosso, Z. Melegh, T. Curry, Y. Li, C. Rivers, J. Uney, A. S. Magdefrau, K. Schwiderski, J. H. Park, K. W. Brown, J. Shandilya, S. G. Roberts and K. Malik (2013). "Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A." Hum Mol Genet 22(1): 74-83 PDF

conferences contributions

Matthes A, Esber A, Herrmann J, Bleidorn J, Markwart R, Mägdefrau A-S. Wie beeinflusst ein molekulargenetischer Test zur Erkennung von Zervixkarzinomen ärztliche Entscheidungen in Dysplasiesprechstunden? – Ergebnisse einer multizentrischen Beobachtungsstudie (Vortrag). 24. Deutscher Kongress für Versorgungsforschung; 22.09.-24.09.2025; Hamburg.