22.11.2024
Veröffentlichung in eLife
Layer 6 corticocortical neurons are a major route for intra- and interhemispheric feedback.
eLife Assessment
This important study compares the cortical projections to primary motor and sensory areas originating from the ipsilateral and contralateral hemispheres. Results show that, while there is substantial symmetry between the two hemispheres regarding the areas sending projections to these primary cortical areas, contra-hemispheric projections had more inputs from layer 6 neurons than ipsi-projecting ones. The evidence is compelling and the conclusions are supported by rigorous analyses.