Androgen-Regulation of the Sepsis response: Beneficial role of androgen receptor antagonists?
Acronym: Aras
Principal Investigator: Daniela Röll
Scientific Advisor: Prof. Aria Baniahmad
Research Area: B Novel Diagnostic Tools and Approaches
Project Number: B3.3
Duration: 01.04.2011 - 28.02.2014
Module: PhD Fellowship
The Problem
Clinical and animal studies revealed that females tolerate trauma-hemorrhage and sepsis far better than males. It is discussed that male sexual hormones repress the immune and cardiovascular response. Here, treatment of male mice with various different androgen antagonists and estrogens will clarify the potential of a beneficial role.
Contact
Universitätsklinikum Jena
Institut für Humangenetik
AG Molekulargenetik
Kollegiengasse 10
07743 Jena