Jena Sepsis Registry
Principal Investigator: Prof. Dr. Jochen Gensichen
Team: Dr. Konrad Schmidt, Katrin Ludewig, Susan Kerth, Florian Rißner, Viola Bahr, Frank Martin Brunkhorst
Duration: 01.10.2010 - 31.07.2015
The Problem
Establishing worldwide sepsis registries is a central demand of the Global Sepsis Alliance. The few already existing registries have been used only for surveillance of in-hospital mortality. We started a population-based registry for guiding also quality improvement in sepsis after care, based on information of primary care physicians.
Results so far
The Jena Sepsis Registry will be a prospective registry for patients with severe sepsis or septic shock. Since December 2010, all ICU patients were screened for inclusion criteria. In the following, baseline data on ICU- and hospital care have been extracted from patient records at ICU discharge. The primary outcome is all-cause mortality. Further, date and place of death, site and source of infection, APACHE-II-Score, microbiological data, diagnostic and therapeutic procedures, ICU- and hospital days are documented, using open source clinical trial software (OpenClinica). Follow up for the primary outcome will be collected from the primary care provider at 6, 12, 24, 36, 48 and 60 months after ICU discharge by abstracting patient records. Integrating further health status information into follow up data is planned. Preliminary Results / Feasibility:Up to now (May 31th 2012), we identified and enrolled 582 patients for baseline data. Through a pilot phase (January-June 2011), we completed six month follow-up with 95,6% of the 205 patients who were eligible for initial follow-up. Further follow up data collection is in progress. Pilot experience demonstrates the feasibility of enrolling and following up patients with high completion rates and high data quality.
Contact
Tel. +49 (0)3641 - 9 39 58 00
Universitätsklinikum Jena
Institut für Allgemeinmedizin
Bachstraße 18
07743 Jena