Response to Homeostatic Disturbance for Individualized Risk Assessment in Sepsis
Acronym: Peiras
Principal Investigator: Dr. phil. Maik Soßdorf
Research Area: A Risk Assessment and Sepsis Control
Project Number: A1.2
Duration: 01.05.2011 - 30.04.2013
Module: Start-up Scientist
The Problem
The loss of homeostasis is a crucial event during sepsis and associated with a poor prognosis. Strenuous physical exercise is considered as an effective physiological tool to test the body’s homeostatic control systems. The project aims to identify predictive parameters for outcome in sepsis after a single bout of strenuous exercise.
Results so far
We established a rat exercise model and defined a cut-off lactate concentration value as inevitable study inclusion criteria. We showed that a single bout of strenuous physical exercise provokes a pattern of distinct systemic changes (e.g. hyperthermia, leukopenia, and cytokine release) which are comparable to the sepsis-associated host response. Metabolic profiling of plasma samples revealed distinct clusters of exercise-induced and sepsis-related metabolic changes. As a consequence of the sepsis-associated inflammatory response accompanied by cell activation, apoptosis and necrosis the concentration of plasma phospholipids significantly discriminates between sepsis and exercise. Post exercise we identified several parameters with the potential to distinguish between survival and non-survival in sepsis. These parameters include concentration of cytokines, metabolites from different compound classes and blood gas parameters.
Publications
Otto GP, Wissuwa B, Mehnert A, Marx S, Raessler M, Lösche W, Claus RA, Sossdorf M: A method for detection and quantification of hydroxyethyl starch in plasma, Critical Care 2012, 16:426
Otto GP, Neugebauer S, Claus RA, Sossdorf M. Arginine metabolism is markedly impaired in polymicrobial infected mice. Crit Care. 2012, 16(2):412.
Sossdorf M, Fischer J, Meyer S, Dahlke K, Wissuwa B, Lupp A, Kiehntopf M, Otto GP. Physical excercise influences the host response and mortality rate in polymicrobial infected mice. 5th International Congress “Sepsis and Multiorgan Dysfunction”, Weimar Sepsis Update 2011 - Bridging the Gap Weimar, 07. - 10. September 2011
Sossdorf M, Otto GP, Fischer J, Meyer S, Claus RA, Bauer M, Loesche W. Endurance training improves survival rate in an experimental model of polymicrobial sepsis. XIV Congress of the European Shock Society, Taormina, Giardini Naxos, August 31, September 2, 2011
Contact
Tel. +49 (0)3641 - 9 32 58 67
Center for Sepsis Control and Care
Universitätsklinikum Jena
Forschungszentrum Lobeda
Erlanger Allee 101
07747 Jena