Publications

Aromolaran O, Beder T, Oswald M, Oyelade J, Adebiyi E, Koenig R (2020) Essential gene prediction in Drosophila melanogaster using machine learning approaches based on sequence and functional features. Computational and Structural Biotechnology Journal 18: 612-621

Bauer M, Wetzker R (2020) The cellular basis of organ failure in sepsis-signaling during damage and repair processes. Medizinische Klinik-Intensivmedizin Und Notfallmedizin 115: 4-9

Chung HY, Wickel J, Brunkhorst FM, Geis C (2020) Sepsis-Associated Encephalopathy: From Delirium to Dementia? Journal of Clinical Medicine 9: 14

Deinhardt-Emmer S, Rennert K, Schicke E, Cseresnyes Z, Windolph M, Nietzsche S, Heller R, Siwczak F, Haupt KF, Carlstedt S, Schacke M, Figge MT, Ehrhardt C, Loffler B, Mosig AS (2020) Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model. Biofabrication 12: 025012

Diab M, Platzer S, Guenther A, Sponholz C, Scherag A, Lehmann T, Velichkov I, Hagel S, Bauer M, Brunkhorst FM, Doenst T (2020) Assessing efficacy of CytoSorb haemoadsorber for prevention of organ dysfunction in cardiac surgery patients with infective endocarditis: REMOVE-protocol for randomised controlled trial. Bmj Open 10: 8

Diab M, Tasar R, Sponholz C, Lehmann T, Pletz MW, Bauer M, Brunkhorst FM, Doenst T (2020) Changes in inflammatory and vasoactive mediator profiles during valvular surgery with or without infective endocarditis: A case control pilot study. PLoS One 15: 23

Dickmann P, Bauer M (2020) Sepsis 2019 - New Trends and Their Implications for Multiple Trauma Patients. Z Orthop Unfall 158: 81-89

Ehrlich C, Hohenstein C, Winning J, Ruddel H (2020) Effect of positive end-expiratory pressure and positioning on jugular vein expansion in emergency department patients. European Journal of Emergency Medicine 27: 110-113

Engelmann C, Riemann M, Carlstedt S, Grimlowski R, Andreas N, Koliesnik I, Meier E, Austerfield P, Haenold R (2020) Identification of undescribed Relb expression domains in the murine brain by new Relb:cre-katushka reporter mice. Developmental Dynamics 249: 983-997

Forstner C, Kolditz M, Kesselmeier M, Ewig S, Rohde G, Barten-Neiner G, Rupp J, Witzenrath M, Welte T, Pletz MW, Dreher M, Cornelissen C, Knuppel W, Stolz D, Suttorp N, Witzenrath M, Creutz P, Mikolajewska A, Bauer T, Krieger D, Pankow W, Thiemig D, Hauptmeier B, Ewig S, Wehde D, Prediger M, Schmager S, Kolditz M, Schulte-Hubbert B, Langner S, Albrich W, Welte T, Freise J, Barten G, Toro OA, Nawrocki M, Nairn J, Witte M, Kroner W, Illig T, Klopp N, Kreuter M, Herth F, Hummler S, Ravn P, Vestergaard-Jensen A, Baunbaek-Knudsen G, Pletz M, Kroegel C, Forstner C, Winning J, Schleenvoigt B, Dalhoff K, Rupp J, Horster R, Dromann D, Rohde G, Drijkoningen J, Braeken D, Buschmann H, Schaberg T, Hering I, Panning M, Wallner M, Grp CS (2020) Pneumococcal conjugate serotype distribution and predominating role of serotype 3 in German adults with community-acquired pneumonia. Vaccine 38: 1129-1136

Gawlytta R, Brunkhorst F, Niemeyer H, Boettche M, Knaevelsrud C, Rosendahl J (2020) Dyadic post-traumatic stress after intensive care: Case report of a sepsis patient and his wife. Intensive and Critical Care Nursing 58: 5

Glaser A, Hammerl F, Graler MH, Coldewey SM, Volkner C, Frech MJ, Yang F, Luo JK, Tonnies E, Halbach OVU, Brandt N, Heimes D, Nesslauer AM, Korenke GC, Owczarek-Lipska M, Neidhardt J, Rolfs A, Wree A, Witt M, Brauer AU (2020) Identification of Brain-Specific Treatment Effects in NPC1 Disease by Focusing on Cellular and Molecular Changes of Sphingosine-1-Phosphate Metabolism. Int J Mol Sci 21: 31

Graber K, Khan F, Gluck B, Weigel C, Marzo S, Doshi H, Ehrhardt C, Heller R, Graler M, Henke A (2020) The role of sphingosine-1-phosphate signaling in HSV-1-infected human umbilical vein endothelial cells. Virus Research 276: 12

Guillen-Guio B, Lorenzo-Salazar JM, Ma SF, Hou PC, Hernandez-Beeftink T, Corrales A, Garcia-Laorden MI, Jou J, Espinosa E, Muriel A, Dominguez D, Lorente L, Martin MM, Rodriguez-Gallego C, Sole-Violan J, Ambros A, Carriedo D, Blanco J, Anon JM, Reilly JP, Jones TK, Ittner CAG, Feng R, Schoneweck F, Kiehntopf M, Noth I, Scholz M, Brunkhorst FM, Scherag A, Meyer NJ, Villar J, Flores C (2020) Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study. Lancet Respiratory Medicine 8: 258-266

Hoflmayer D, Steinhoff A, Hube-Magg C, Kluth M, Simon R, Burandt E, Tsourlakis MC, Minner S, Sauter G, Buscheck F, Wilczak W, Steurer S, Huland H, Graefen M, Haese A, Heinzer H, Schlomm T, Jacobsen F, Hinsch A, Poos AM, Oswald M, Rippe K, Konig R, Schroeder C (2020) Expression of CCCTC-binding factor (CTCF) is linked to poor prognosis in prostate cancer. Molecular Oncology 14: 129-138

Horhold F, Eisel D, Oswald M, Kolte A, Roll D, Osen W, Eichmuller SB, Konig R (2020) Reprogramming of macrophages employing gene regulatory and metabolic network models. PLoS Comput Biol 16: e1007657

Huang J, Ramoji A, Guo SX, Bocklitz T, Boivin-Jahns V, Moller J, Kiehntopf M, Noutsias M, Popp J, Neugebauer U (2020) Vibrational spectroscopy as a powerful tool for follow-up immunoadsorption therapy treatment of dilated cardiomyopathy - a case report. Analyst 145: 486-496

Ibidapo-obe O, Stengel S, Kose-Vogel N, Quickert S, Reuken PA, Busch M, Bauer M, Stallmach A, Bruns T (2020) Mucosal-Associated Invariant T Cells Redistribute to the Peritoneal Cavity During Spontaneous Bacterial Peritonitis and Contribute to Peritoneal Inflammation. Cellular and Molecular Gastroenterology and Hepatology 9: 661-677

Jagtap P, Prasad P, Pateria A, Deshmukh SD, Gupta S (2020) A Single Step in vitro Bioassay Mimicking TLR4-LPS Pathway and the Role of MD2 and CD14 Coreceptors. Front Immunol 11: 9

Kleiber A, Ramoji A, Mayer G, Neugebauer U, Popp J, Henkel T (2020) 3-Step flow focusing enables multidirectional imaging of bioparticles for imaging flow cytometry. Lab Chip 20: 1676-1686

Kose-Vogel N, Stengel S, Gardey E, Kirchberger-Tolstik T, Reuken PA, Stallmach A, Bruns T (2020) Transcriptional Suppression of the NLRP3 Inflammasome and Cytokine Release in Primary Macrophages by Low-Dose Anthracyclines. Cells 9: 17

Leikeim RSM, Kesselmeier M, Löffler B, Rödel J, Höring S (2020) Diagnostic accuracy and clinical impact of loop-mediated isothermal amplification for rapid detection of Staphylococcus aureus bacteremia: a retrospective observational study. European Journal of Clinical Microbiology & Infectious Diseases 39: 679-688

Liu XY, Guo SX, Ramoji A, Bocklitz T, Rosch P, Popp J, Yu HQ (2020) Spatiotemporal Organization of Biofilm Matrix Revealed by Confocal Raman Mapping Integrated with Non-negative Matrix Factorization Analysis. Anal Chem 92: 707-715

Mayer K, Hahn-Ast C, Schwab K, Schmidt-Wolf IGH, Brossart P, Glasmacher A, von Lilienfeld-Toal M (2020) Long-term follow-up of Cladribine, high-dose Cytarabine, and Idarubicin as salvage treatment for relapsed acute myeloid leukemia and literature review. European Journal of Haematology 104: 538-545

Neu C, Baumbach P, Plooij AK, Skitek K, Gotze J, von Loeffelholz C, Schmidt-Winter C, Coldewey SM (2020) Non-invasive Assessment of Mitochondrial Oxygen Metabolism in the Critically Ill Patient Using the Protoporphyrin IX-Triplet State Lifetime Technique-A Feasibility Study. Front Immunol 11: 9

Paul JJ, Weigel C, Muller T, Heller R, Spiegel S, Graler MH (2020) Inflammatory Conditions Disrupt Constitutive Endothelial Cell Barrier Stabilization by Alleviating Autonomous Secretion of Sphingosine 1-Phosphate. Cells 9: 16

Poos AM, Kordass T, Kolte A, Ast V, Oswald M, Rippe K, Konig R (2019) Modelling TERT regulation across 19 different cancer types based on the MIPRIP 2.0 gene regulatory network approach. BMC Bioinformatics 20: 12

Przybilla J, Ahnert P, Bogatsch H, Bloos F, Brunkhorst FM, Bauer M, Loeffler M, Witzenrath M, Suttorp N, Scholz M, SepNet Critical Care Trials G, SepNet Critical Care Trials G, Grp PS (2020) Markov State Modelling of Disease Courses and Mortality Risks of Patients with Community-Acquired Pneumonia. Journal of Clinical Medicine 9: 14

Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, Colombara DV, Ikuta KS, Kissoon N, Finfer S, Fleischmann-Struzek C, Machado FR, Reinhart KK, Rowan K, Seymour CW, Watson RS, West TE, Marinho F, Hay SI, Lozano R, Lopez AD, Angus DC, Murray CJL, Naghavi M (2020) Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet 395: 200-211

Santos I, Colaco HG, Neves-Costaa A, Seixas E, Velho TR, Pedroso D, Barros A, Martins R, Carvalho N, Payen D, Weis S, Yi HS, Shong M, Moita LF (2020) CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15-deficient mice protects against abdominal sepsis. Proc Natl Acad Sci U S A 117: 12281-12287

Schmidt KF, Schwarzkopf D, Baldwin LM, Brunkhorst FM, Freytag A, Heintze C, Reinhart K, Schneider N, von Korff M, Worrack S, Wensing M, Gensichen J, Baenfer M, Berhold C, Bindara-Klippel A, Corea M, Davydov D, Eckholdt L, Eissler F, Ch E, Fleischmann-Struzek C, Freitag A, Gehrke-Beck S, Geist A, Gerlach H, Goldmann A, Graf J, Hamzei F, Hartmann M, Hartog C, Heintze C, Huelle K, Jakobi U, Kerth S, Keh D, Klefisch F, Kuehnemund R, Kuhnsch H, Lehmann T, Lehmke J, Lehmkuhl P, Meier-Hellmann A, Muehlberg J, Mueller F, Oehmichen F, Ollenschlaeger G, Oppert M, Pohl M, Rademacher S, Reil L, Sablotzki A, Schelle M, Schelling G, Scherag A, Schreiber T, Spies C, Thiel P, Tiedemann G, Toepfer L, Toussaint S, Grp SS (2020) Long-Term Courses of Sepsis Survivors: Effects of a Primary Care Management Intervention. American Journal of Medicine 133: 381

Sieg M, Hartmann M, Settmacher U, Arefian H (2020) Comparative cost-effectiveness of cabozantinib as second-line therapy for patients with advanced hepatocellular carcinoma in Germany and the United States. BMC Gastroenterol 20: 12

Spengler K, Kryeziu N, Grosse S, Mosig AS, Heller R (2020) VEGF Triggers Transient Induction of Autophagy in Endothelial Cells via AMPK alpha 1. Cells 9: 18

Stengel S, Quickert S, Lutz P, Ibidapo-Obe O, Steube A, Kose-Vogel N, Yarbakht M, Reuken PA, Busch M, Brandt A, Bergheim I, Deshmukh SD, Stallmach A, Bruns T (2020) Peritoneal Level of CD206 Associates With Mortality and an In flammatory Macrophage Phenotype in Patients With Decompensated Cirrhosis and Spontaneous Bacterial Peritonitis. Gastroenterology 158: 1745-1761

Stepanovska B, Lange AI, Schwalm S, Pfeilschifter J, Coldewey SM, Huwiler A (2020) Downregulation of S1P Lyase Improves Barrier Function in Human Cerebral Microvascular Endothelial Cells Following an Inflammatory Challenge. Int J Mol Sci 21: 19

Syllwasschy BF, Beck MS, Druzeta I, Hopp MT, Ramoji A, Neugebauer U, Nozinovic S, Menche D, Willbold D, Ohlenschlager O, Kuhl T, Imhof D (2020) High-affinity binding and catalytic activity of His/Tyr-based sequences: Extending heme-regulatory motifs beyond CP. Biochimica Et Biophysica Acta-General Subjects 1864: 10

Thomas-Ruddel D, Winning J, Dickmann P, Ouart D, Kortgen A, Janssens U, Bauer M (2020) Coronavirus disease 2019 (COVID-19): update for anesthesiologists and intensivists March 2020. Anaesthesist 10.1007/s00101-020-00760-3: 10

Thomas-Rüddel D, Winning J, Dickmann P, Ouart D, Kortgen A, Janssens U, Bauer M (2020) [Coronavirus disease 2019 (COVID-19): update for anesthesiologists and intensivists March 2020]. Anaesthesist 69: 225-235 (German)

Tuchscherr L, Loffler B, Proctor RA (2020) Persistence of Staphylococcus aureus: Multiple Metabolic Pathways Impact the Expression of Virulence Factors in Small-Colony Variants (SCVs). Frontiers in Microbiology 11: 1028

Zipprich HM, Arends MC, Schumacher U, Bahr V, Scherag A, Kwetkat A, Wedding U, Brunkhorst FM, Witte OW, Prell T, Redecker C (2020) Outcome of Older Patients with Acute Neuropsychological Symptoms Not Fulfilling Criteria of Delirium. Journal of the American Geriatrics Society 68: 1469-1475

Al-Zaben N, Medyukhina A, Dietrich S, Marolda A, Hunniger K, Kurzai O, Figge MT (2019) Automated tracking of label-free cells with enhanced recognition of whole tracks. Sci Rep 9: 10

Ammer-Herrmenau C, Kulkarni U, Andreas N, Ungelenk M, Ravens S, Hubner C, Kather A, Kurth I, Bauer M, Kamradt T (2019) Sepsis induces long-lasting impairments in CD4(+) T-cell responses despite rapid numerical recovery of T-lymphocyte populations. PLoS One 14: 16

Arefian H, Hagel S, Fischer D, Scherag A, Brunkhorst FM, Maschmann J, Hartmann M (2019) Estimating extra length of stay due to healthcare-associated infections before and after implementation of a hospital-wide infection control program. PLoS One 14: 11

Baumbach P, Neu C, Derlien S, Bauer M, Nisser M, Buder A, Coldewey SM (2019) A pilot study of exercise-induced changes in mitochondrial oxygen metabolism measured by a cellular oxygen metabolism monitor (PICOMET). BBA-Molecular Basis of Disease 1865: 749-758

Blankenhaus B, Braza F, Martins R, Bastos-Amador P, Gonzalez-Garcia I, Carlos AR, Mahu I, Faisca P, Nunes JM, Ventura P, Hoerr V, Weis S, Guerra J, Cardoso S, Domingos A, Lopez M, Soares MP (2019) Ferritin regulates organismal energy balance and thermogenesis. Molecular Metabolism 24: 64-79

Blaurock-Moller N, Groger M, Siwczak F, Dinger J, Schmerler D, Mosig AS, Kiehntopf M (2019) CAAP48, a New Sepsis Biomarker, Induces Hepatic Dysfunction in an in vitro Liver-on-Chip Model. Front Immunol 10: 12

Bramer D, Gunther A, Rupprecht S, Nowack S, Adam J, Meyer F, Schwab M, Surber R, Witte OW, Hoyer H, Hoyer D (2019) Very Low Frequency Heart Rate Variability Predicts the Development of Post-Stroke Infections. Translational Stroke Research 10: 607-619

Burghold CM, Hohenstein C, Rueddel H (2019) Trendelenburg position in the ED: many critically ill patients in the emergency department do not tolerate the Trendelenburg position. European Journal of Emergency Medicine 26: 212-216

Ceanga M, Keiner S, Grunewald B, Haselmann H, Frahm C, Couillard-Despres S, Witte OW, Redecker C, Geis C, Kunze A (2019) Stroke Accelerates and Uncouples Intrinsic and Synaptic Excitability Maturation of Mouse Hippocampal DCX+ Adult-Born Granule Cells. Journal of Neuroscience 39: 1755-1766

Demontis D, Walters RK, Martin J, et al. (2019) Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nat Genet 51: 63-75

Dennhardt S, Finke KR, Huwiler A, Coldewey SM (2019) Sphingosine-1-phosphate promotes barrier-stabilizing effects in human microvascular endothelial cells via AMPK-dependent mechanisms. BBA-Molecular Basis of Disease 1865: 774-781

Eisel D, Das K, Dickes E, Konig R, Osen W, Eichmuller SB (2019) Cognate Interaction With CD4(+) T Cells Instructs Tumor-Associated Macrophages to Acquire M1-Like Phenotype. Front Immunol 10: 12

Englert FA, Seidel RA, Galler K, Gouveia Z, Soares MP, Neugebauer U, Clemens MG, Sponholz C, Heinemann SH, Pohnert G, Bauer M, Weis S (2019) Labile heme impairs hepatic microcirculation and promotes hepatic injury. Arch Biochem Biophys 672: 108075

Findeisen A, Arefian H, Doenst T, Hagel S, Pletz MW, Hartmann M, Maschmann J (2019) Economic burden of surgical site infections in patients undergoing cardiac surgery. European Journal of Cardio-Thoracic Surgery 55: 494-500

Fleischmann-Struzek C, Mikolajetz A, Reinhart K, Curtis JR, Haase U, Thomas-Ruddel D, Dennler U, Hartog CS (2019) Hospitalization and intensive Therapy at the End of Life. Dtsch Arztebl Int 116: 653

Friesecke S, Traeger K, Schittek GA, Molnar Z, Bach F, Kogelmann K, Bogdanski R, Weyland A, Nierhaus A, Nestler F, Olboeter D, Tomescu D, Jacob D, Haake H, Grigoryev E, Nitsch M, Baumann A, Quintel M, Schott M, Kielstein JT, Meier-Hellmann A, Born F, Schumacher U, Singer M, Kellum J, Brunkhorst FM (2019) International registry on the use of the CytoSorb (R) adsorber in ICU patients: Study protocol and preliminary results. Medizinische Klinik-Intensivmedizin und Notfallmedizin 114: 699-707

Fuchs A, Pletz MW, Kaasch AJ (2019) Diagnosis of sepsis and empirical treatment in the emergency department. Notfall & Rettungsmedizin 22: 198-204

Gawlytta R, Wintermann GB, Bottche M, Niemeyer H, Knaevelsrud C, Rosendahl J (2019) [Posttraumatic stress disorder after intensive care : Prevalence, risk factors, and treatment]. Med Klin Intensivmed Notfmed 114: 9-14

Graf K, Last A, Gratz R, Allert S, Linde S, Westermann M, Groger M, Mosig AS, Gresnigt MS, Hube B (2019) Keeping Candida commensal: how lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model. Dis Model Mech 12: 16

Hagel S, Fiedler S, Hohn A, Brinkmann A, Frey OR, Hoyer H, Schlattmann P, Kiehntopf M, Roberts JA, Pletz MW, Bloos F, Angermair S, Bracht H, Barth E, Kluge S, Nierhaus A, Motsch J, Brenner T, Annecke T, Bach F, Weigand M, Schappacher M, von Ameln-Mayerhofer A, Michels G, Roehr A, Fuchs T, Eichner S, Barth E, Kong C, Pinder N, Muller C, Petersen M, Schlattmann P, Steinbach G, Jarczak D, Weisman D, Kurlbaum M, Braune A, Grp TS (2019) Therapeutic drug monitoring-based dose optimisation of piperacillin/tazobactam to improve outcome in patients with sepsis (TARGET): a prospective, multi-centre, randomised controlled trial. Trials 20: 330

Hagel S, Ludewig K, Pletz MW, Frosinski J, Moeser A, Wolkewitz M, Gastmeier P, Harbarth S, Brunkhorst FM, Kesselmeier M, Scherag A (2019) Effectiveness of a hospital-wide infection control programme on the incidence of healthcare-associated infections and associated severe sepsis and septic shock: a prospective interventional study. Clinical Microbiology and Infection 25: 462-468

Hagel S, Schmitt S, Kesselmeier M, Baier M, Welte T, Ewig S, Pletz MW (2019) M. pneumoniae and C. pneumoniae are no relevant pathogens in critically ill patients with hospital-acquired respiratory tract infections. Infection 47: 471-474

Hartung S, Rauh C, Hoang TNM, Jahreis S, Wagner K, Macheleidt J, Brakhage AA, Rummler S, Hochhaus A, von Lilienfeld-Toal M (2019) Fast and Quantitative Evaluation of Human Leukocyte Interaction with Aspergillus fumigatus Conidia by Flow Cytometry. Cytometry Part A 95A: 332-338

Heun Y, Pircher J, Czermak T, Bluem P, Hupel G, Bohmer M, Kraemer BF, Pogoda K, Pfeifer A, Woernle M, Ribeiro A, Hubner M, Kreth S, Claus RA, Weis S, Ungelenk L, Krotz F, Pohl U, Mannell H (2019) Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis. EBioMedicine 42: 120-132

Hirschberger S, Hubner M, Strauss G, Effinger D, Bauer M, Weis S, Giamarellos-Bourboulis EJ, Kreth S (2019) Identification of suitable controls for miRNA quantification in T-cells and whole blood cells in sepsis. Sci Rep 9: 13

Huang CY, Daniels R, Lembo A, Hartog C, O'Brien J, Heymann T, Reinhart K, Nguyen HB, Ssep (2019) Life after sepsis: an international survey of survivors to understand the post-sepsis syndrome. International Journal for Quality in Health Care 31: 191-198

Hufsky F, Ibrahim B, Modha S, Clokie MRJ, Deinhardt-Emmer S, Dutilh BE, Lycett S, Simmonds P, Thiel V, Abroi A, Adriaenssens EM, Escalera-Zamudio M, Kelly JN, Lamkiewicz K, Lu L, Susat J, Sicheritz T, Robertson DL, Marz M (2019) The Third Annual Meeting of the European Virus Bioinformatics Center. Viruses-Basel 11: 19

Joerk A, Ritter M, Langguth N, Seidel RA, Freitag D, Herrmann KH, Schaefgen A, Ritter M, Gunther M, Sommer C, Braemer D, Walter J, Ewald C, Kalff R, Reichenbach JR, Westerhausen M, Pohnert G, Witt OW, Holthoff K (2019) Propentdyopents as Heme Degradation Intermediates Constrict Mouse Cerebral Arterioles and Are Present in the Cerebrospinal Fluid of Patients With Subarachnoid Hemorrhage. Circ Res 124: E101-E114

Kapitan M, Niemiec MJ, Steimle A, Frick JS, Jacobsen ID (2019) Fungi as Part of the Microbiota and Interactions with Intestinal Bacteria. In Fungal Physiology and Immunopathogenesis, Rodrigues ML (ed), Vol. 422, pp 265-301. Cham: Springer International Publishing Ag.

Karakike E, Adami ME, Lada M, Gkavogianni T, Koutelidakis IM, Bauer M, Giamarellos-Bourboulis EJ, Tsangaris I (2019) Late Peaks of HMGB1 and Sepsis Outcome: Evidence For Synergy With Chronic Inflammatory Disorders. Shock 52: 334-339

Karunakaran I, Aiam S, Jayagopi S, Frohberger SJ, Hansen JN, Kuehlwein J, Holbling BV, Schumak B, Hubner MP, Graler MH, HaIie A, van Echten-Deckert G (2019) Neural sphingosine 1-phosphate accumulation activates microglia and links impaired autophagy and inflammation. Glia 67: 1859-1872

Keul P, Polzin A, Kaiser K, Gräler M, Dannenberg L, Daum G, Heusch G, Levkau B (2019) Potent anti-inflammatory properties of HDL in vascular smooth muscle cells mediated by HDL-S1P and their impairment in coronary artery disease due to lower HDL-S1P: a new aspect of HDL dysfunction and its therapy. FASEB Journal 33: 1482-1495

Klaile E, Muller MM, Zubiria-Barrera C, Brehme S, Klassert TE, Stock M, Durotin A, Nguyen TD, Feer S, Singer BB, Zipfel PF, Rudolphi S, Jacobsen ID, Slevogt H (2019) Unaltered Fungal Burden and Lethality in Human CEACAM1-Transgenic Mice During Candida albicans Dissemination and Systemic Infection. Frontiers in Microbiology 10: 23

Koliesnik IO, Andreas N, Thuy A, Sreekantapuram S, Haenold R, Weilh F (2019) Alternative NF-kappa B signaling controls peripheral homeostasis and function of regulatory T cells. Immunobiology 224: 687-696

Kolte A, Konig R (2019) Temporal progression of gene regulation of peripheral white blood cells explains gender dimorphism of critically ill patients after trauma. Mol Med 25: 14

König C, Matt B, Kortgen A, Turnbull AE, Hartog CS (2019) What matters most to sepsis survivors: a qualitative analysis to identify specific health-related quality of life domains. Quality of Life Research 28: 637-647

König R, Cao XQ, Oswald M, Forstner C, Rohde G, Rupp J, Witzenrath M, Welte T, Kolditz M, Pletz M, Dreher M, Cornelissen C, Knuppel W, Stolz D, Suttorp N, Witzenrath M, Creutz P, Mikolajewska A, Bauer T, Krieger D, Pankow W, Thiemig D, Hauptmeier B, Ewig S, Wehde D, Prediger M, Schmager S, Kolditz M, Schulte-Hubbert B, Langner S, Albrich W, Welte T, Freise J, Barten G, Toro OA, Nawrocki M, Naim J, Witte M, Kroner W, Illig T, Klopp N, Kreuter M, Herth F, Hummler S, Ravn P, Vestergaard-Jensen A, Baunbaek-Knudsen G, Pletz M, Kroegel C, Frosinski J, Winning J, Schleenvoigt B, Dalhoff K, Rupp J, Horster R, Dromann D, Rohde G, Drijkoningen J, Braeken D, Buschmann H, Schaberg T, Hering I, Panning M, Wallner M, Grp CS (2019) Macrolide combination therapy for patients hospitalised with community-acquired pneumonia? An individualised approach supported by machine learning. European Respiratory Journal 54: 11

Kosilek RP, Baumeister SE, Ittermann T, Grundling M, Brunkhorst FM, Felix SB, Abel P, Friesecke S, Apfelbacher C, Brandl M, Schmidt K, Hoffmann W, Schmidt CO, Chenot JF, Volzke H, Gensichen JS (2019) The association of intensive care with utilization and costs of outpatient healthcare services and quality of life. PLoS One 14: 15

Kresinsky A, Schnoder TM, Jacobsen ID, Rauner M, Hofbauer LC, Ast V, Konig R, Hoffmann B, Svensson CM, Figge MT, Hilger I, Heidel FH, Bohmer FD, Muller JP (2019) Lack of CD45 in FLT3-ITD mice results in a myeloproliferative phenotype, cortical porosity, and ectopic bone formation. Oncogene 38: 4773-4787

Kruger W, Vielreicher S, Kapitan M, Jacobsen ID, Niemiec MJ (2019) Fungal-Bacterial Interactions in Health and Disease. Pathogens 8: 41

Liu JJ, Hoffmann P, Steinmetzer J, Askes SHC, Kupfer S, Gorls H, Grafe S, Neugebauer U, Gandra UR, Schiller A (2019) Visible light-activated biocompatible photo-CORM for CO-release with colorimetric and fluorometric dual turn-on response. Polyhedron 172: 175-181

Mallm JP, Iskar M, Ishaque N, Klett LC, Kugler SJ, Muino JM, Teif VB, Poos AM, Grossmann S, Erdel F, Tavernari D, Koser SD, Schumacher S, Brors B, Konig R, Remondini D, Vingron M, Stilgenbauer S, Lichter P, Zapatka M, Mertens D, Rippe K (2019) Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks. Molecular Systems Biology 15: 20

Maurer M, Gresnigt MS, Last A, Wollny T, Berlinghof F, Pospich R, Cseresnyes Z, Medyukhina A, Graf K, Groger M, Raasch M, Siwczak F, Nietzsche S, Jacobsen ID, Figge MT, Hube B, Huber O, Mosig AS (2019) A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. Biomaterials 220: 119396

Minner S, Lutz J, Hube-Magg C, Kluth M, Simon R, Hoflmayer D, Burandt E, Tsourlakis MC, Sauter G, Buscheck F, Wilczak W, Steurer S, Schlomm T, Huland H, Graefen M, Haese A, Heinzer H, Jacobsen F, Hinsch A, Poos A, Oswald M, Rippe K, Konig R, Schroeder C (2019) Loss of CCAAT-enhancer-binding protein alpha (CEBPA) is linked to poor prognosis in PTEN deleted and TMPRSS2:ERG fusion type prostate cancers. Prostate 79: 302-311

Mondol AS, Topfer N, Ruger J, Neugebauer U, Popp J, Schie IW (2019) New perspectives for viability studies with high-content analysis Raman spectroscopy (HCA-RS). Sci Rep 9: 12

Ndongson-Dongmo B, Lang GP, Mece O, Hechaichi N, Lajqi T, Hoyer D, Brodhun M, Heller R, Wetzker R, Franz M, Levy FO, Bauer R (2019) Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in mice. Basic Res Cardiol 114: 20

Nesslauer AM, Glaser A, Graler M, Engelmann R, Muller-Hilke B, Frank M, Burstein C, Rolfs A, Neidhardt J, Wree A, Witt M, Brauer AU (2019) A therapy with miglustat, 2-hydroxypropyl-beta-cyclodextrin and allopregnanolone restores splenic cholesterol homeostasis in Niemann-pick disease type C1. Lipids in Health and Disease 18: 18

Neugebauer S, Wichmann C, Bremer-Streck S, Hagel S, Kiehntopf M (2019) Simultaneous Quantification of Nine Antimicrobials by LC-MS/MS for Therapeutic Drug Monitoring in Critically Ill Patients. Therapeutic Drug Monitoring 41: 29-37

Persyn A, Rogiers O, Brock M, Vande Velde G, Lamkanfi M, Jacobsen ID, Himmelreich U, Lagrou K, Van Dijck P, Kuchadkova S (2019) Monitoring of Fluconazole and Caspofungin Activity against In Vivo Candida glabrata Biofilms by Bioluminescence Imaging. Antimicrob Agents Chemother 63: 10

Pletz MW, Bauer M, Brakhage AA (2019) One step closer to precision medicine for infectious diseases. Lancet Infectious Diseases 19: 564-565

Raasch M, Fritsche E, Kurtz A, Bauer M, Mosig AS (2019) Microphysiological systems meet hiPSC technology - New tools for disease modeling of liver infections in basic research and drug development. Adv Drug Deliv Rev 140: 51-67

Ramu V, Reddy GU, Liu JJ, Hoffmann P, Sollapur R, Wyrwa R, Kupfer S, Spielmann C, Bonnet S, Neugebauer U, Schiller A (2019) Two-Photon-Induced CO-Releasing Molecules as Molecular Logic Systems in Solution, Polymers, and Cells. Chemistry-a European Journal 25: 8453-8458

Roell D, Rosler TW, Hessenkemper W, Kraft F, Hauschild M, Bartsch S, Abraham TE, Houtsmuller AB, Matusch R, van Royen ME, Baniahmad A (2019) Halogen-substituted anthranilic acid derivatives provide a novel chemical platform for androgen receptor antagonists. Journal of Steroid Biochemistry and Molecular Biology 188: 59-70

Rosendahl J, Kisyova H, Gawlytta R, Scherag A (2019) Comparative validation of three screening instruments for posttraumatic stress disorder after intensive care. Journal of Critical Care 53: 149-154

Rubio I, Osuchowski MF, Shankar-Hari M, Skirecki T, Winkler MS, Lachmann G, La Rosee P, Monneret G, Venet F, Bauer M, Brunkhorst FM, Kox M, Cavaillon JM, Uhle F, Weigand MA, Flohe SB, Wiersinga WJ, Martin-Fernandez M, Almansa R, Martin-Loeches I, Torres A, Giamarellos-Bourboulis EJ, Girardis M, Cossarizza A, Netea MG, van der Poll T, Scherag A, Meisel C, Schefold JC, Bermejo-Martin JF (2019) Current gaps in sepsis immunology: new opportunities for translational research. Lancet Infect Dis 19: e422-e436

Saeed K, Wilson DC, Bloos F, Schuetz P, van der Does Y, Melander O, Hausfater P, Legramante JM, Claessens YE, Amin D, Rosenqvist M, White G, Mueller B, Limper M, Callejo CC, Brandi A, Macchi MA, Cortes N, Kutz A, Patka P, Yanez MC, Bernardini S, Beau N, Dryden M, van Gorp ECM, Minieri M, Chan L, Rood PPM, del Castillo JG (2019) The early identification of disease progression in patients with suspected infection presenting to the emergency department: a multi-centre derivation and validation study. Critical Care 23: 15

Scheer CS, Kuhn SO, Fuchs C, Vollmer M, Modler A, Brunkhorst F, Shankar-Hari M, Hahnenkamp K, Gundling M, Rehberg S (2019) DO SEPSIS-3 CRITERIA FACILITATE EARLIER RECOGNITION OF SEPSIS AND SEPTIC SHOCK? A RETROSPECTIVE COHORT STUDY. Shock 51: 306-311

Schmidl L, Schmidl G, Gawlik A, Dellith J, Hubner U, Tympel V, Schmidl F, Plentz J, Geis C, Haselmann H (2019) Combining super-resolution microscopy with neuronal network recording using magnesium fluoride thin films as cover layer for multi-electrode array technology. Sci Rep 9: 9

Schubert J, Bramer D, Huttner HB, Gerner ST, Fuhrer H, Melzer N, Dik A, Pruss H, Ly LT, Fuchs K, Leypoldt F, Nissen G, Schirotzek I, Dohmen C, Bosel J, Lewerenz J, Thaler F, Kraft A, Juranek A, Ringelstein M, Suhs KW, Urbanek C, Scherag A, Geis C, Witte OW, Gunther A, Network GI (2019) Management and prognostic markers in patients with autoimmune encephalitis requiring ICU treatment. Neurology-Neuroimmunology & Neuroinflammation 6: e514

Schwarz N, Knutti N, Rose M, Neugebauer S, Geiger J, Jahns R, Klopp N, Illig T, Mathay C, Betsou F, Scherag A, Kiehntopf M (2019) Quality Assessment of the Preanalytical Workflow in Liquid Biobanking: Taurine as a Serum-Specific Quality Indicator for Preanalytical Process Variations. Biopreservation and Biobanking 17: 458-467

Schwarzkopf D (2019) Nonbeneficial care-a burden for clinicians and relatives. Medizinische Klinik-Intensivmedizin Und Notfallmedizin 114: 222-228

Tannert A, Grohs R, Popp J, Neugebauer U (2019) Phenotypic antibiotic susceptibility testing of pathogenic bacteria using photonic readout methods: recent achievements and impact. Applied Microbiology and Biotechnology 103: 549-566

Töpfer N, Muller MM, Dahms M, Ramoji A, Popp J, Slevogt H, Neugebauer U (2019) Raman spectroscopy reveals LPS-induced changes of biomolecular composition in monocytic THP-1 cells in a label-free manner. Integrative Biology 11: 87-98

Tuchscherr L, Pollath C, Siegmund A, Deinhardt-Emmer S, Hoerr V, Svensson CM, Figge MT, Monecke S, Loffler B (2019) Clinical S. aureus Isolates Vary in Their Virulence to Promote Adaptation to the Host. Toxins 11: 15

Vaidya M, Jentsch JA, Peters S, Keul P, Weske S, Graler MH, Mladenov E, Iliakis G, Heusch G, Levkau B (2019) Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages. J Lipid Res 60: 506-515

Vivas W, Leonhardt I, Hunniger K, Hader A, Marolda A, Kurzai O (2019) Multiple Signaling Pathways Involved in Human Dendritic Cell Maturation Are Affected by the Fungal Quorum-Sensing Molecule Farnesol. Journal of Immunology 203: 2959-2969

Weis S, Kesselmeier M, Davis JS, Morris AM, Lee S, Scherag A, Hagel S, Pletz MW (2019) Cefazolin versus anti-staphylococcal penicillins for the treatment of patients with Staphylococcus aureus bacteraemia. Clinical Microbiology and Infection 25: 818-827

Westphal S, Stoppe C, Gruenewald M, et al. (2019) Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study. Bmc Cardiovascular Disorders 19: 12

Winkler MS, Martz KB, Nierhaus A, Daum G, Schwedhelm E, Kluge S, Graler MH (2019) Loss of sphingosine 1-phosphate (S1P) in septic shock is predominantly caused by decreased levels of high-density lipoproteins (HDL). Journal of Intensive Care 7: 9

Wintermann GB, Petrowski K, Weidner K, Strauss B, Rosendahl J (2019) Impact of post-traumatic stress symptoms on the health-related quality of life in a cohort study with chronically critically ill patients and their partners: age matters. Critical Care 23: 10

Wissbrock A, Goradia NB, Kumar A, George AAP, Kuhl T, Bellstedt P, Ramachandran R, Hoffmann P, Galler K, Popp J, Neugebauer U, Hampel K, Zimmermann B, Adam S, Wiendl M, Kronke G, Hamza I, Heinemann SH, Frey S, Hueber AJ, Ohlenschlaeger O, Imhof D (2019) Structural insights into heme binding to IL-36 alpha proinflammatory cytokine. Sci Rep 9: 14
Yarbakht M, Pradhan P, Kose-Vogel N, Bae H, Stengel S, Meyer T, Schmitt M, Stallmach A, Popp J, Bocklitz TW, Bruns T (2019) Nonlinear Multimodal Imaging Characteristics of Early Septic Liver Injury in a Mouse Model of Peritonitis. Anal Chem 91: 11116-11121

Zhao B, Dewald C, Hennig M, Bossert J, Bauer M, Pletz MW, Jandt KD (2019) Microorganisms @ materials surfaces in aircraft: Potential risks for public health? - A systematic review. Travel Medicine and Infectious Disease 28: 6-14

Zimmermann S, Klinger-Strobel M, Bohnert JA, Wendler S, Rodel J, Pletz MW, Loffler B, Tuchscherr L (2019) Clinically Approved Drugs Inhibit the Staphylococcus aureus Multidrug NorA Efflux Pump and Reduce Biofilm Formation. Frontiers in Microbiology 10: 13

Ali N, Girnus S, Rosch P, Popp J, Bocklitz T (2018) Sample-Size Planning for Multivariate Data: A Raman-Spectroscopy-Based Example. Anal Chem 90: 12485-12492

Ansari SS, Sharma AK, Soni H, Ali DM, Tews B, Koenig R, Eibl H, Berger MR (2018) Induction of ER and mitochondrial stress by the alkylphosphocholine erufosine in oral squamous cell carcinoma cells. Cell Death Dis 9: 296

Bauer M, Coldewey SM, Leitner M, Loffler B, Weis S, Wetzker R (2018) Deterioration of Organ Function As a Hallmark in Sepsis: The Cellular Perspective. Front Immunol 9: 1460

Bauer M, Weis S, Netea MG, Wetzker R (2018) Remembering Pathogen Dose: Long-Term Adaptation in Innate Immunity. Trends Immunol 39: 438-445

Baumbach P, Gotz T, Gunther A, Weiss T, Meissner W (2018) Chronic intensive care-related pain: Exploratory analysis on predictors and influence on health-related quality of life. Eur J Pain 10.1002/ejp.1129

Beder T, Saluz HP (2018) Virulence-related comparative transcriptomics of infectious and non-infectious chlamydial particles. BMC Genomics 19: 575

Betsch C, Rossmann C, Pletz MW, Vollmar HC, Freytag A, Wichmann O, Hanke R, Hanke W, Heinemeier D, Schmid P, Eitze S, Weber W, Reinhardt A, Kupke NK, Forstner C, Fleischmann-Struzek C, Mikolajetz A, Romhild J, Neufeind J, Rieck T, Suchecka K, Reinhart K (2018) Increasing influenza and pneumococcal vaccine uptake in the elderly: study protocol for the multi-methods prospective intervention study Vaccination60. BMC Public Health 18: 885

Blaess M, Bibak N, Claus RA, Kohl M, Bonaterra GA, Kinscherf R, Laufer S, Deigner HP (2018) NB 06: From a simple lysosomotropic aSMase inhibitor to tools for elucidating the role of lysosomes in signaling apoptosis and LPS-induced inflammation. Eur J Med Chem 153: 73-104

Bloos F, Held J, Schlattmann P, Brillinger N, Kurzai O, Cornely OA, Thomas-Ruddel D (2018) (1,3)-beta-D-glucan-based diagnosis of invasive Candida infection versus culture-based diagnosis in patients with sepsis and with an increased risk of invasive Candida infection (CandiSep): study protocol for a randomized controlled trial. Trials 19: 472

Bondeva T, Schindler C, Schindler K, Wolf G (2018) MORG1(+/-) mice are protected from histological renal damage and inflammation in a murine model of endotoxemia. BMC Nephrol 19: 29

Brunzel M, Majdanski TC, Vitz J, Nischang I, Schubert US (2018) Fast Screening of Diol Impurities in Methoxy Poly(Ethylene Glycol)s (mPEG)s by Liquid Chromatography on Monolithic Silica Rods. Polymers 10: 1395

Carlos AR, Weis S, Moita MR, Singh S, Blankenhaus B, Cardoso S, Larsen R, Rebelo S, Schaeuble S, Del Barrio L, Mithieux G, Rajas F, Lindig S, Bauer M, Soares MP (2018) Iron-mediated control of glucose metabolism is central to promote disease tolerance to polymicrobial infections. Free Radical Bio Med 120: S112-S112

Carlos AR, Weis S, Soares MP (2018) Cross-Talk Between Iron and Glucose Metabolism in the Establishment of Disease Tolerance. Front Immunol 9: 2498

Chung HY, Witt CJ, Hurtado-Oliveros J, Wickel J, Graler MH, Lupp A, Claus RA (2018) Acid Sphingomyelinase Inhibition Stabilizes Hepatic Ceramide Content and Improves Hepatic Biotransformation Capacity in a Murine Model of Polymicrobial Sepsis. Int J Mol Sci 19

Dennhardt S, Pirschel W, Wissuwa B, Daniel C, Gunzer F, Lindig S, Medyukhina A, Kiehntopf M, Rudolph WW, Zipfel PF, Gunzer M, Figge MT, Amann K, Coldewey SM (2018) Modeling Hemolytic-Uremic Syndrome: In-Depth Characterization of Distinct Murine Models Reflecting Different Features of Human Disease. Front Immunol 9: 1459

Doulias T, Quickert S, Weis S, Claus RA, Kontopoulou K, Giamarellos-Bourboulis EJ, Bauer M, Koutelidakis IM (2018) Low-dose hydrocortisone prolongs survival in a lethal sepsis model in adrenalectomized rats. J Surg Res 227: 72-80

Eitze S, Fleischmann-Struzek C, Betsch C, Reinhart K, vaccination60+ study g (2018) Determinants of sepsis knowledge: a representative survey of the elderly population in Germany. Crit Care 22: 273

Elke G, Bloos F, Wilson DC, Brunkhorst FM, Briegel J, Reinhart K, Loeffler M, Kluge S, Nierhaus A, Jaschinski U, Moerer O, Weyland A, Meybohm P, SepNet Critical Care Trials G (2018) The use of mid-regional proadrenomedullin to identify disease severity and treatment response to sepsis - a secondary analysis of a large randomised controlled trial. Crit Care 22

Elke G, Bloos F, Wilson DC, Meybohm P, SepNet Critical Care Trials G (2018) Identification of developing multiple organ failure in sepsis patients with low or moderate SOFA scores. Crit Care 22: 147

Fahrner R, Groeger M, Settmacher U, Mosig AS (2018) Influence of extracellular nucleotides on hepatic inflammation in a microfluidically perfused liver-on-chip model. Brit J Surg 105: 22-23

Fang H, Hua C, Weiss S, Liu A, Cheng W, Claus R, Rödel J, Dirsch O, Dahmen U (2018) Modulation of Innate Immunity by G-CSF and Inflammatory Response by LBPK95A Improves the Outcome of Sepsis in a Rat Model. J Immunol Res 2018: 12

Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N (2018) The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med 6: 223-230

Fleischmann-Struzek C, Mikolajetz A, Schwarzkopf D, Cohen J, Hartog CS, Pletz M, Gastmeier P, Reinhart K (2018) Challenges in assessing the burden of sepsis and understanding the inequalities of sepsis outcomes between National Health Systems: secular trends in sepsis and infection incidence and mortality in Germany. Intensive Care Med 44: 1826-1835

Fleischmann-Struzek C, Thomas-Ruddel DO, Schettler A, Schwarzkopf D, Stacke A, Seymour CW, Haas C, Dennler U, Reinhart K (2018) Comparing the validity of different ICD coding abstraction strategies for sepsis case identification in German claims data. PLoS One 13: e0198847

Geraci J, Neubauer S, Poellath C, Hansen U, Rizzo F, Krafft C, Westermann M, Hussain M, Peters G, Pletz MW, Loeffler B, Makarewicz O, Tuchscherr L (2018) The Staphylococcus aureus extracellular matrix protein (Emp) has a fibrous structure and binds to different extracellular matrices (vol 7, 13665, 2017). Sci Rep 8

Groeger M, Dinger J, Kiehntopf M, Peters FT, Rauen U, Mosig AS (2018) Preservation of Cell Structure, Metabolism, and Biotransformation Activity of Liver-On-Chip Organ Models by Hypothermic Storage. Adv Healthc Mater 7

Hartog CS, Reinhart K (2018) Staff and family response to end-of-life care in the ICU. Curr Opin Anesthesiol 31: 195-200

Haselmann H, Mannara F, Werner C, Planaguma J, Miguez-Cabello F, Schmidl L, Grunewald B, Petit-Pedrol M, Kirmse K, Classen J, Demir F, Klocker N, Soto D, Doose S, Dalmau J, Hallermann S, Geis C (2018) Human Autoantibodies against the AMPA Receptor Subunit GluA2 Induce Receptor Reorganization and Memory Dysfunction. Neuron 100: 91-105 e109

Helbing DL, Bohm L, Witte OW (2018) Sepsis-associated encephalopathy. CMAJ 190: E1083

Hilbert-Carius P, Schwarzkopf D, Reinhart K, Hartog CS, Lefering R, Bernhard M, Struck MF (2018) Synthetic colloid resuscitation in severely injured patients: analysis of a nationwide trauma registry (TraumaRegister DGU). Sci Rep 8: 11567

Horing S, Loffler B, Pletz MW, Rossler S, Weis S, Schleenvoigt BT (2018) Dual antiretroviral therapy with tenofovir (TDF) and darunavir/ritonavir (DRV/RTV) in an HIV-1 positive patient: a case report, review, and meta-analysis of the literature on dual treatment strategies using protease inhibitors in combination with an NRTI. Infection 46: 599-605

Horn P, von Loeffelholz C, Forkert F, Stengel S, Reuken P, Aschenbach R, Stallmach A, Bruns T (2018) Low circulating chemerin levels correlate with hepatic dysfunction and increased mortality in decompensated liver cirrhosis. Sci Rep 8: 9242

Irizar PA, Schaeuble S, Esser D, Groth M, Frahm C, Priebe S, Baumgart M, Hartmann N, Marthandan S, Menzel U, Mueller J, Schmidt S, Ast V, Caliebe A, Koenig R, Krawczak M, Ristow M, Schuster S, Cellerino A, Diekmann S, Englert C, Hemmerich P, Suehnel J, Guthke R, Witte OW, Platzer M, Ruppin E, Kaleta C (2018) Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly. Nat Commun 9

Karrasch M, Geraci J, Sachse S, Rodel J, Loffler B, Bauer M, Thomas-Ruddel D, Hagel S, Aschenbach R, Bloos F (2018) Early adjustment of antimicrobial therapy after PCR/electrospray ionization mass spectrometry-based pathogen detection in critically ill patients with suspected sepsis. Clin Chem Lab Med 56: e207-e209

Kesselmeier M, Putter C, Volckmar AL, Baurecht H, Grallert H, Illig T, Ismail K, Ollikainen M, Silen Y, Keski-Rahkonen A, Bulik CM, Collier DA, Zeggini E, Hebebrand J, Scherag A, Hinney A, Gcan, Wtccc (2018) High-throughput DNA methylation analysis in anorexia nervosa confirms TNXB hypermethylation. World J Biol Psychiatry 19: 187-199

Kesselmeier M, Scherag A (2018) Commentary: Arguing for Adaptive Clinical Trials in Sepsis. Front Immunol 9

Kirchhoff J, Glaser U, Bohnert JA, Pletz MW, Popp J, Neugebauer U (2018) Simple Ciprofloxacin Resistance Test and Determination of Minimal Inhibitory Concentration within 2 h Using Raman Spectroscopy. Anal Chem 90: 1811-1818

Kulkarni U, Herrmenau C, Win SJ, Bauer M, Kamradt T (2018) IL-7 treatment augments and prolongs sepsis-induced expansion of IL-10-producing B lymphocytes and myeloid-derived suppressor cells. PLoS One 13

Lehmann R, Muller MM, Klassert TE, Driesch D, Stock M, Heinrich A, Conrad T, Moore C, Schier UK, Guthke R, Slevogt H (2018) Differential regulation of the transcriptomic and secretomic landscape of sensor and effector functions of human airway epithelial cells. Mucosal Immunol 11: 627-642

Leonhardt J, Grosse S, Marx C, Siwczak F, Stengel S, Bruns T, Bauer R, Kiehntopf M, Williams DL, Wang ZQ, Mosig AS, Weis S, Bauer M, Heller R (2018) Candida albicans beta-Glucan Differentiates Human Monocytes Into a Specific Subset of Macrophages. Front Immunol 9: 13

Luo S, Dasari P, Reiher N, Hartmann A, Jacksch S, Wende E, Barz D, Niemiec MJ, Jacobsen I, Beyersdorf N, Huenig T, Klos A, Skerka C, Zipfel PF (2018) The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments. Mol Immunol 93: 266-277

Majdanski TC, Vitz J, Meier A, Brunzel M, Schubert S, Nischang I, Schubert US (2018) “Green” ethers as solvent alternatives for anionic ring-opening polymerizations of ethylene oxide (EO): In-situ kinetic and advanced characterization studies. Polymer 159: 86-94

Mede R, Hoffmann P, Neumann C, Goerls H, Schmitt M, Popp J, Neugebauer U, Westerhausen M (2018) Acetoxymethyl Concept for Intracellular Administration of Carbon Monoxide with Mn(CO)(3)-Based PhotoCORMs. Chem-Eur J 24: 3321-3329

Meinel C, Sparta G, Dahse H-M, Hoerhold F, Koenig R, Westermann M, Coldewey SM, Cseresnyes Z, Figge MT, Hammerschmidt S, Skerka C, Zipfel PF (2018) Streptococcus pneumoniae From Patients With Hemolytic Uremic Syndrome Binds Human Plasminogen via the Surface Protein PspC and Uses Plasmin to Damage Human Endothelial Cells. J Infect Dis 217: 358-370

Mohnle P, Hirschberger S, Hinske LC, Briegel J, Hubner M, Weis S, Dimopoulos G, Bauer M, Giamarellos-Bourboulis EJ, Kreth S (2018) MicroRNAs 143 and 150 in whole blood enable detection of T-cell immunoparalysis in sepsis. Mol Med 24: 54

Neubert F, Beliu G, Terpitz U, Werner C, Geis C, Sauer M, Doose S (2018) Bioorthogonal Click Chemistry Enables Site-specific Fluorescence Labeling of Functional NMDA Receptors for Super-Resolution Imaging. Angewandte Chemie-International Edition 57: 16364-16369

Nierhaus A, Bloos F, Wilson DC, Elke G, Meybohm P, SepNet Critical Care Trials G (2018) Predicting the requirement for renal replacement therapy in intensive care patients with sepsis. Crit Care 22: 201

Pein H, Ville A, Pace S, Temml V, Garscha U, Raasch M, Alsabil K, Viault G, Dinh CP, Guilet D, Troisi F, Neukirch K, Konig S, Bilancia R, Waltenberger B, Stuppner H, Wallert M, Lorkowski S, Weinigel C, Rummler S, Birringer M, Roviezzo F, Sautebin L, Helesbeux JJ, Seraphin D, Mosig AS, Schuster D, Rossi A, Richomme P, Werz O, Koeberle A (2018) Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase. Nat Commun 9: 3834

Petit-Pedrol M, Sell J, Planaguma J, Mannara F, Radosevic M, Haselmann H, Ceanga M, Sabater L, Spatola M, Soto D, Gasull X, Dalmau J, Geis C (2018) LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory. Brain 141: 3144-3159

Pilat Z, Bernatova S, Jezek J, Kirchhoff J, Tannert A, Neugebauer U, Samek O, Zemanek P (2018) Microfluidic Cultivation and Laser Tweezers Raman Spectroscopy of E. coli under Antibiotic Stress. Sensors (Basel) 18

Pletz MW, Weis S, Forstner C, Wagenlehner F (2018) Urosepsis. Urologe 57: 79-92

Pletz MW, Weis S, Forstner C, Wagenlehner F (2018) Urosepsis. Med Klin Intensivmed Notfmed 113: 143-156

Polke M, Leonhardt I, Kurzai O, Jacobsen ID (2018) Farnesol signalling in Candida albicans - more than just communication. Crit Rev Microbiol 44: 230-243

Prausse MTE, Lehnert T, Timme S, Hunniger K, Leonhardt I, Kurzai O, Figge MT (2018) Predictive Virtual Infection Modeling of Fungal Immune Evasion in Human Whole Blood. Front Immunol 9: 560

Retsas T, Huse K, Lazaridis LD, Karampela N, Bauer M, Platzer M, Kolonia V, Papageorgiou E, Giamarellos-Bourboulis EJ, Dimopoulos G (2018) Haplotypes composed of minor frequency single nucleotide polymorphisms of the TNF gene protect from progression into sepsis: A study using the new sepsis classification. Int J Infect Dis 67: 102-106

Reuken PA, Albig H, Roedel J, Hocke M, Will U, Stallmach A, Bruns T (2018) Fungal Infections in Patients With Infected Pancreatic Necrosis and Pseudocysts: Risk Factors and Outcome. Pancreas 47: 92-98

Ritter M, Neupane S, Seidel RA, Steinbeck C, Pohnert G (2018) In vivo and in vitro identification of Z-BOX C - a new bilirubin oxidation end product. Org Biomol Chem 16: 3553-3555

Ryabchykov O, Brautigam K, Galler K, Neugebauer U, Mosig A, Bocklitz T, Popp J (2018) Raman spectroscopic investigation of the human liver stem cell line HepaRG J Raman Spectrosc 49: 935-942

Salm F, Schwab F, Behnke M, Brunkhorst FM, Scherag A, Geffers C, Gastmeier P (2018) Nudge to better care - blood cultures and catheter-related bloodstream infections in Germany at two points in time (2006, 2015). Antimicrob Resist Infect Control 7: 141

Schaarschmidt B, Vlaic S, Medyukhina A, Neugebauer S, Nietzsche S, Gonnert FA, Rodel J, Singer M, Kiehntopf M, Figge MT, Jacobsen ID, Bauer M, Press AT (2018) Molecular signatures of liver dysfunction are distinct in fungal and bacterial infections in mice. Theranostics 8: 3766-3780

Schie IW, Rueger J, Mondol AS, Ramoji A, Neugebauer U, Krafft C, Popp J (2018) High-Throughput Screening Raman Spectroscopy Platform for Label-Free Cellomics. Anal Chem 90: 2023-2030

Schmidt JJ, Lueck C, Ziesing S, Stoll M, Haller H, Gottlieb J, Eder M, Welte T, Hoeper MM, Scherag A, David S (2018) Clinical course, treatment and outcome of Pneumocystis pneumonia in immunocompromised adults: a retrospective analysis over 17 years. Crit Care 22: 307

Schwarzkopf D, Fleischmann-Struzek C, Rueddel H, Reinhart K, Thomas-Rueddel DO (2018) A risk-model for hospital mortality among patients with severe sepsis or septic shock based on German national administrative claims data. PLoS One 13

Schwarzkopf D, Ruddel H, Grundling M, Putensen C, Reinhart K (2018) The German Quality Network Sepsis: study protocol for the evaluation of a quality collaborative on decreasing sepsis-related mortality in a quasi-experimental difference-in-differences design. Implement Sci 13: 15

Seeley JJ, Baker RG, Mohamed G, Bruns T, Hayden MS, Deshmukh SD, Freedberg DE, Ghosh S (2018) Induction of innate immune memory via microRNA targeting of chromatin remodelling factors. Nature 10.1038/s41586-018-0253-5

Sprenger M, Kasper L, Hensel M, Hube B (2018) Metabolic adaptation of intracellular bacteria and fungi to macrophages. Int J Med Microbiol 308: 215-227

Stein C, Tittelbach J, Monecke S, Weis S, Makarewicz O, Ehricht R, Pletz M (2018) Rethinking the Molecular Diagnostics for Methicillin-Resistant Staphylococcus aureus. Infect Cont Hosp Ep 39: 495-496

Tannert A, Ramoji A, Neugebauer U, Popp J (2018) Photonic monitoring of treatment during infection and sepsis: development of new detection strategies and potential clinical applications. Anal Bioanal Chem 410: 773-790

Thomas-Rueddel DO, Poidinger B, Kott M, Weiss M, Reinhart K, Bloos F, Grp MS (2018) Influence of pathogen and focus of infection on procalcitonin values in sepsis patients with bacteremia or candidemia. Crit Care 22

Thunstrom Salzer A, Niemiec MJ, Hosseinzadeh A, Stylianou M, Astrom F, Rohm M, Ahlm C, Wahlin A, Ermert D, Urban CF (2018) Assessment of Neutrophil Chemotaxis Upon G-CSF Treatment of Healthy Stem Cell Donors and in Allogeneic Transplant Recipients. Front Immunol 9: 1968

Timme S, Lehnert T, Prausse MTE, Hunniger K, Leonhardt I, Kurzai O, Figge MT (2018) Quantitative Simulations Predict Treatment Strategies Against Fungal Infections in Virtual Neutropenic Patients. Front Immunol 9: 667

Titulaer J, Arefian H, Hartmann M, Younis MZ, Guntinas-Lichius O (2018) Cost-effectiveness of allergic rhinitis treatment: An exploratory study. SAGE Open Med 6: 2050312118794588

Trivedi PJ, Tickle J, Vesterhus MN, Eddowes PJ, Bruns T, Vainio J, Parker R, Smith D, Liaskou E, Thorbjornsen LW, Hirschfield GM, Auvinen K, Hubscher SG, Salmi M, Adams DH, Weston CJ (2018) Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner. Gut 67: 1135-1145

Verma AH, Zafar H, Ponde NO, Hepworth OW, Sihra D, Aggor FEY, Ainscough JS, Ho J, Richardson JP, Coleman BM, Hube B, Stacey M, McGeachy MJ, Naglik JR, Gaffen SL, Moyes DL (2018) IL-36 and IL-1/IL-17 Drive Immunity to Oral Candidiasis via Parallel Mechanisms. J Immunol 201: 627-634

Vogt K, Mahajan-Thakur S, Wolf R, Broderdorf S, Vogel C, Boehm A, Ritter CA, Graeler M, Oswald S, Greinacher A, Kroemer HK, Jedlitschky G, Rauch BH (2018) Release of Platelet-Derived Sphingosine-1-Phosphate Involves Multidrug Resistance Protein 4 (MRP4/ABCC4) and Is Inhibited by Statins. Thromb Haemostasis 118: 132-142

von Loeffelholz C, Birkenfeld AL (2018) Is mIndy a Mediator of Energy Metabolism Reprogramming in Hepatocellular Carcinoma Induced by Interleukin-6/Signal Transducer and Activator of Transcription 3 Signaling? Reply. Hepatology 67: 452-453

von Loeffelholz C, Gissey LC, Schumann T, Henke C, Kurzbach A, Struck J, Bergmann A, Hanefeld M, Schatz U, Bornstein SR, Casella G, Mingrone G, Birkenfeld AL (2018) The anorexigenic peptide neurotensin relates to insulin sensitivity in obese patients after BPD or RYGB metabolic surgery. Int J Obesity 10.1038/s41366-018-0084-3

Waschke A, Arefian H, Walter J, Hartmann M, Maschmann J, Kalff R (2018) Cost-effectiveness of the long-term use of temozolomide for treating newly diagnosed glioblastoma in Germany. J Neuro-Oncol 138: 359-367

Weber M, Schaer J, Walther G, Kaerger K, Steinmann J, Rath P-M, Spiess B, Buchheidt D, Hamprecht A, Kurzai O (2018) FunResDB-A web resource for genotypic susceptibility testing of Aspergillus fumigatus. Med Mycol 56: 117-120

Weickert MO, Hattersley JG, Kyrou I, Arafat AM, Rudovich N, Roden M, Nowotny P, von Loeffelholz C, Matysik S, Schmitz G, Pfeiffer AFH (2018) Effects of supplemented isoenergetic diets varying in cereal fiber and protein content on the bile acid metabolic signature and relation to insulin resistance. Nutr Diabetes 8

Weske S, Vaidya M, Reese A, Lipinski KvW, Keul P, Bayer JK, Fischer JW, Floegel U, Nelsen J, Epple M, Scatena M, Schwedhelm E, Doerr M, Voelzke H, Moritz E, Hannemann A, Rauch BH, Graeler MH, Heusch G, Levkau B (2018) Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss. Nat Med 24: 667-+

Winter A, Staubert S, Ammon D, Aiche S, Beyan O, Bischoff V, Daumke P, Decker S, Funkat G, Gewehr JE, de Greiff A, Haferkamp S, Hahn U, Henkel A, Kirsten T, Kloss T, Lippert J, Lobe M, Lowitsch V, Maassen O, Maschmann J, Meister S, Mikolajczyk R, Nuchter M, Pletz MW, Rahm E, Riedel M, Saleh K, Schuppert A, Smers S, Stollenwerk A, Uhlig S, Wendt T, Zenker S, Fleig W, Marx G, Scherag A, Loffler M (2018) Smart Medical Information Technology for Healthcare (SMITH). Methods Inf Med 57: e92-e105

Wintermann GB, Rosendahl J, Weidner K, Strauss B, Petrowski K (2018) Predictors of Major Depressive Disorder following Intensive Care of Chronically Critically Ill Patients. Crit Care Res Pract 2018: 1586736

Wintermann G-B, Rosendahl J, Weidner K, Strauss B, Hinz A, Petrowski K (2018) Fatigue in chronically critically ill patients following intensive care - reliability and validity of the multidimensional fatigue inventory (MFI-20). Health Qual Life Out 16

Wintermann G-B, Rosendahl J, Weidner K, Strauss B, Hinz A, Petrowski K (2018) Self-reported fatigue following intensive care of chronically critically ill patients: a prospective cohort study. J Intensive Care 6

Wissuwa B, Heinemann SH, Bauer M, Coldewey SM (2018) Studies into Slo1 K+ channels and their ligand docosahexaenoic acid in murine sepsis to delineate off-target effects of immunonutrition. Life Sci 203: 112-120

Zilch A, Rien C, Weigel C, Huskobla S, Gluck B, Spengler K, Sauerbrei A, Heller R, Graler M, Henke A (2018) Influence of sphingosine-1-phosphate signaling on HCMV replication in human embryonal lung fibroblasts. Med Microbiol Immunol 207: 227-242

Zipfel PF, Luo S, Dasari P, Reiher N, Jacobsen I, Beyersdorf N, Klos A, Serka C (2018) Reply to Kang and Brooks: Comment on the interpretation of binding of Pra1, the fungal immune evasion protein from Candida albicans to the human C3 and on the conformational changes of C3 upon activation: Kang and Brooks Optimization of biolayer-interferometry-based binding assay of he interaction between the Candida albicans protein Pra1 and complement protein C3. Mol Immunol 101: 638-639

Alonso-Pernas P, Arias-Cordero E, Novoselov A, Ebert C, Rybak J, Kaltenpoth M, Westermann M, Neugebauer U, Boland W (2017) Bacterial Community and PHB-Accumulating Bacteria Associated with the Wall and Specialized Niches of the Hindgut of the Forest Cockchafer (Melolontha hippocastani). Front Microbiol 8: 291

Antonakos N, Tsaganos T, Oberle V, Tsangaris I, Lada M, Pistiki A, Machairas N, Souli M, Bauer M, Giamarellos-Bourboulis EJ (2017) Decreased cytokine production by mononuclear cells after severe gram-negative infections: early clinical signs and association with final outcome. Crit Care 21: 48

Arefian H, Heublein S, Scherag A, Brunkhorst FM, Younis MZ, Moerer O, Fischer D, Hartmann M (2017) Hospital-related cost of sepsis: A systematic review. J Infection 10.1016/j.jinf.2016.11.006

Baumbach P, Gotz T, Gunther A, Weiss T, Meissner W (2017) Somatosensory Functions in Survivors of Critical Illness. Crit Care Med 45: e567-e574

Bloos F, Ruddel H, Thomas-Ruddel D, Schwarzkopf D, Pausch C, Harbarth S, Schreiber T, Grundling M, Marshall J, Simon P, Levy MM, Weiss M, Weyland A, Gerlach H, Schurholz T, Engel C, Matthaus-Kramer C, Scheer C, Bach F, Riessen R, Poidinger B, Dey K, Weiler N, Meier-Hellmann A, Haberle HH, Wobker G, Kaisers UX, Reinhart K, group Ms (2017) Effect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomized trial. Intensive Care Med 10.1007/s00134-017-4782-4

Blurton SP, Kesselmeier M, Gondan M (2017) The first-passage time distribution for the diffusion model with variable drift. J Math Psychol 76: 7-12

Borisow N, Kleiter I, Gahlen A, Fischer K, Wernecke K-D, Pache F, Ruprecht K, Havla J, Krumbholz M, Kuempfel T, Aktas O, Ringelstein M, Geis C, Kleinschnitz C, Berthele A, Hemmer B, Angstwurm K, Weissert R, Stellmann J-P, Schuster S, Stangel M, Lauda F, Tumani H, Mayer C, Zeltner L, Ziemann U, Linker RA, Schwab M, Marziniak M, Bergh FT, Hofstadt-van Oy U, Neuhaus O, Winkelmann A, Marouf W, Rueckriem L, Faiss J, Wildemann B, Paul F, Jarius S, Trebst C, Hellwig K, Study NNO (2017) Influence of female sex and fertile age on neuromyelitis optica spectrum disorders. Multiple Sclerosis J 23: 1092-1103

Borken F, Markwart R, Requardt RP, Schubert K, Spacek M, Verner M, Ruckriem S, Scherag A, Oehmichen F, Brunkhorst FM, Rubio I (2017) Chronic Critical Illness from Sepsis Is Associated with an Enhanced TCR Response. J Immunol 10.4049/jimmunol.1700142

Brandes S, Dietrich S, Huenniger K, Kurzai O, Figge MT (2017) Migration and interaction tracking for quantitative analysis of phagocyte-pathogen confrontation assays. Med Image Anal 36: 172-183

Bruns T, Nuraldeen R, Mai M, Stengel S, Zimmermann HW, Yagmur E, Trautwein C, Stallmach A, Strnad P (2017) Low serum transferrin correlates with acute-on-chronic organ failure and indicates short-term mortality in decompensated cirrhosis. Liver Int 10.1111/liv.13211

Chung H-Y, Kollmey AS, Schrepper A, Kohl M, Blaess MF, Stehr SN, Lupp A, Graeler MH, Claus RA (2017) Adjustment of Dysregulated Ceramide Metabolism in a Murine Model of Sepsis-Induced Cardiac Dysfunction. Int J Mol Sci 18

Chung H-Y, Witt CJ, Jbeily N, Hurtado-Oliveros J, Giszas B, Lupp A, Graeler MH, Bruns T, Stallmach A, Gonnert FA, Claus RA (2017) Acid Sphingomyelinase Inhibition Prevents Development of Sepsis Sequelae in the Murine Liver. Sci Rep 7

Davidson JE, Aslakson RA, Long AC, Puntillo KA, Kross EK, Hart J, Cox CE, Wunsch H, Wickline MA, Nunnally ME, Netzer G, Kentish-Barnes N, Sprung CL, Hartog C, Coombs M, Gerritsen RT, Hopkins RO, Franck LS, Skrobik Y, Kon AA, Scruth EA, Harvey MA, Lewis-Newby M, White DB, Swoboda SM, Cooke CR, Levy MM, Azoulay E, Curtis JR (2017) Guidelines for Family-Centered Care in the Neonatal, Pediatric, and Adult ICU. Crit Care Med 45: 103-128

Diab M, Sponholz C, von Loeffelholz C, Scheffel P, Bauer M, Kortgen A, Lehmann T, Faerber G, Pletz MW, Doenst T (2017) Impact of perioperative liver dysfunction on in-hospital mortality and long-term survival in infective endocarditis patients. Infection 45: 857-866

Dickmann P, Scherag A, Coldewey SM, Sponholz C, Brunkhorst FM, Bauer M (2017) [Epistemology in the intensive care unit-what is the purpose of a definition? : Paradigm shift in sepsis research]. Anaesthesist 66: 622-625

Dix A, Czakai K, Leonhardt I, Schaeferhoff K, Bonin M, Guthke R, Einsele H, Kurzai O, Loeffler J, Linde J (2017) Specific and Novel microRNAs Are Regulated as Response to Fungal Infection in Human Dendritic Cells. Front Microbiol 8

Fahrner R, Moller A, Press AT, Kortgen A, Kiehntopf M, Rauchfuss F, Settmacher U, Mosig AS (2017) Short-term treatment with taurolidine is associated with liver injury. BMC Pharmacol Toxicol 18: 61

Gawlytta R, Niemeyer H, Boettche M, Scherag A, Knaevelsrud C, Rosendahl J (2017) Internet-based cognitive-behavioural writing therapy for reducing post-traumatic stress after intensive care for sepsis in patients and their spouses (REPAIR): study protocol for a randomised-controlled trial. Bmj Open 7

Gawlytta R, Wintermann G, Jaenichen D, Knaevelsrud C, Niemeyer H, Böttche C, Rosendahl J (2017) Posttraumatische Belastungsstörung nach intensivmedizinischer Behandlung einer Sepsis: Patienten und Partner als Betroffene. Trauma und Gewalt 11: 308-318

Gawlytta R, Wintermann GB, Bottche M, Niemeyer H, Knaevelsrud C, Rosendahl J (2017) [Posttraumatic stress disorder after intensive care : Prevalence, risk factors, and treatment]. Med Klin Intensivmed Notfmed 10.1007/s00063-017-0266-0

Geis C, Geuss E, Sommer C, Schmidt HH, Kleinschnitz C (2017) NOX4 is an early initiator of neuropathic pain. Exp Neurol 288: 94-103

Geisel MH, Bauer M, Hennig F, Hoffmann B, Lehmann N, Mohlenkamp S, Kroger K, Kara K, Muller T, Moebus S, Erbel R, Scherag A, Jockel KH, Mahabadi AA, investigative group of the Heinz Nixdorf Recall s (2017) Comparison of coronary artery calcification, carotid intima-media thickness and ankle-brachial index for predicting 10-year incident cardiovascular events in the general population. Eur Heart J 10.1093/eurheartj/ehx120

Geissler K, Markwart R, Requardt RP, Weigel C, Schubert K, Scherag A, Rubio I, Guntinas-Lichius O (2017) Functional characterization of T-cells from palatine tonsils in patients with chronic tonsillitis. PLoS One 12

Gerritsen RT, Hartog CS, Curtis JR (2017) New developments in the provision of family-centered care in the intensive care unit. Intensive Care Med 43: 550-553

Gerwien F, Abu S, Wisgott S, Brunke S, Kasper L, Hube B (2017) The Fungal Pathogen Candida glabrata Does Not Depend on Surface Ferric Reductases for Iron Acquisition. Front Microbiol 8

Groeger M, Lange M, Rennert K, Kaschowitz T, Plettenberg H, Hoffmann M, Mosig AS (2017) Novel approach for the prediction of cell densities and viability in standardized translucent cell culture biochips with near infrared spectroscopy. Eng Life Sci 17: 585-593

Grunewald B, Lange MD, Werner C, O'Leary A, Weishaupt A, Popp S, Pearce DA, Wiendl H, Reif A, Pape HC, Toyka KV, Sommer C, Geis C (2017) Defective synaptic transmission causes disease signs in a mouse model of juvenile neuronal ceroid lipofuscinosis. Elife 6

Guo S, Bocklitz T, Neugebauer U, Popp J (2017) Common mistakes in cross-validating classification models. Anal Method 9: 4410-4417

Heidenreich S, Witte N, Weber P, Goehring I, Tolkachov A, von Loeffelholz C, Doecke S, Bauer M, Stockmann M, Pfeiffer AFH, Birkenfeld AL, Pietzke M, Kempa S, Muenzner M, Schupp M (2017) Retinol saturase coordinates liver metabolism by regulating ChREBP activity. Nat Commun 8

Hinney A, Kesselmeier M, Jall S, Volckmar AL, Foecker M, Antel J, Heid IM, Winkler TW, Grant SFA, Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H, Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM, Adan R, Brandys M, van Elburg A, Perica VB, Franklin CS, Tschoep MH, Zeggini E, Bulik CM, Collier D, Scherag A, Mueller TD, Hebebrand J, Gcan, Wtccc, Giant, Egg, Price Fdn Collaborative G, Children's Hosp P (2017) Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Mol Psychiatry 22: 192-201

Jacobsen ID, Hube B (2017) Candida albicans morphology: still in focus. Expert Rev Anti Infect Ther 15: 327-330

Kesselmeier M, Lorenzo Bermejo J (2017) Robust logistic regression to narrow down the winner's curse for rare and recessive susceptibility variants. Brief Bioinform 10.1093/bib/bbw074

Kirov H, Schwarzer M, Neugebauer S, Faerber G, Diab M, Doenst T (2017) Metabolomic profiling in patients undergoing Off-Pump or On-Pump coronary artery bypass surgery. Bmc Cardiovascular Disorders 17: 1-8

Kissoon N, Reinhart K, Daniels R, Machado MFR, Schachter RD, Finfer S (2017) Sepsis in Children: Global Implications of the World Health Assembly Resolution on Sepsis. Pediatric Crit Care Med 18: E625-E627

Klaile E, Mueller MM, Schaefer MR, Clauder A-K, Feer S, Heyl KA, Stock M, Klassert TE, Zipfel PF, Singer BB, Slevogt H (2017) Binding of Candida albicans to Human CEACAM1 and CEACAM6 Modulates the Inflammatory Response of Intestinal Epithelial Cells. MBio 8

Klassert TE, Braeuer J, Hoelzer M, Stock M, Riege K, Zubiria-Barrera C, Muller MM, Rummler S, Skerka C, Marz M, Slevogt H (2017) Differential Effects of Vitamins A and D on the Transcriptional Landscape of Human Monocytes during Infection. Sci Rep 7

Koese N, Stengel S, Stallmach A, Bruns T (2017) Regulation of the NLRP3 inflammasome in monocytes and macrophages from patients with decompensated cirrhosis by low-dose genotoxic stress. J Hepatol 66: S585-S585

Lehnert T, Figge MT (2017) Dimensionality of Motion and Binding Valency Govern Receptor-Ligand Kinetics As Revealed by Agent-Based Modeling. Front Immunol 8

Leiske MN, Truetzschler A-K, Armoneit S, Sungur P, Hoeppener S, Lehmann M, Traeger A, Schubert US (2017) Mission ImPOxable - or the unknown utilization of non-toxic poly(2-oxazoline)s as cryoprotectants and surfactants at the same time. Journal of Materials Chemistry B 5: 9102-9113

Leonhardt J, Villela DC, Teichmann A, Munter L-M, Mayer MC, Mardahl M, Kirsch S, Namsolleck P, Lucht K, Benz V, Alenina N, Daniell N, Horiuchi M, Iwai M, Multhaup G, Schuelein R, Bader M, Santos RA, Unger T, Steckelings UM (2017) Evidence for Heterodimerization and Functional Interaction of the Angiotensin Type 2 Receptor and the Receptor MAS. Hypertension 69: 1128-+

Mai M, Stengel S, Al-Herwi E, Peter J, Schmidt C, Rubio I, Stallmach A, Bruns T (2017) Genetic variants of TRAF6 modulate peritoneal immunity and the risk of spontaneous bacterial peritonitis in cirrhosis: A combined prospective-retrospective study. Sci Rep 7

Mailaender-Sanchez D, Braunsdorf C, Grumaz C, Mueller C, Lorenz S, Stevens P, Wagener J, Hebecker B, Hube B, Bracher F, Sohn K, Schaller M (2017) Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. PLoS One 12

Malavia D, Lehtovirta-Morley LE, Alamir O, Weiss E, Gow NAR, Hube B, Wilson D (2017) Zinc Limitation Induces a Hyper-Adherent Goliath Phenotype in Candida albicans. Front Microbiol 8

Martin R, Pohlers S, Muhlschlegel FA, Kurzai O (2017) CO2 sensing in fungi: at the heart of metabolic signaling. Curr Genetics 63: 965-972

Matt B, Schwarzkopf D, Reinhart K, Konig C, Hartog CS (2017) Relatives' perception of stressors and psychological outcomes - Results from a survey study. J Crit Care 39: 172-177

Mede R, Hoffmann P, Klein M, Goerls H, Schmitt M, Neugebauer U, Gessner G, Heinemann SH, Popp J, Westerhausen M (2017) A Water-Soluble Mn(CO)(3)-Based and Non-Toxic PhotoCORM for Administration of Carbon Monoxide Inside of Cells. Z Anorg Allg Chem 643: 2057-2062

Mede R, Traber J, Klein M, Goerls H, Gessner G, Hoffmann P, Schmitt M, Popp J, Heinemann SH, Neugebauer U, Westerhausen M (2017) Synthesis and solution stability of water-soluble kappa N-2,kappa O-bis(3,5-dimethylpyrazolyl)ethanol manganese(I) tricarbonyl bromide (CORM-ONN1). Dalton Transactions 46: 1684-1693

Mehta S, Burns KEA, Machado FR, Fox-Robichaud AE, Cook DJ, Calfee CS, Ware LB, Burnham EL, Kissoon i, Marshall JC, Mancebo J, Finfer S, Hartog C, Reinhart K, Maitland K, Stapleton RD, Kwizera A, Amin P, Abroug F, Smith O, Laake JH, Shrestha GS, Herridge MS (2017) Gender Parity in Critical Care Medicine. Am J Respir Crit Care Med 196: 425-429

Meissner W, Komann M, Erlenwein J, Stamer U, Scherag A (2017) The Quality of Postoperative Pain Therapy in German Hospitals. Dtsch Arztebl Int 114: 161-+

Mitroi DN, Karunakaran I, Graeler M, Saba JD, Ehninger D, Dolores Ledesma M, van Echten-Deckert G (2017) SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. Autophagy 13: 885-899

Morel J, Hargreaves I, Brealey D, Neergheen V, Backman JT, Lindig S, Blass M, Bauer M, McAuley DF, Singer M (2017) Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis. Clin Sci (Lond) 131: 747-758

Muehlig Y, Scherag A, Bickenbach A, Giesen U, Holl R, Holle R, Kiess W, Lennerz B, Brintrup DL, Moss A, Neef M, Ose C, Reinehr T, Teuner CM, Wiegand S, Wolters B, Wabitsch M, Hebebrand J (2017) A Structured, Manual-Based Low-Level Intervention vs. Treatment as Usual Evaluated in a Randomized Controlled Trial for Adolescents with Extreme Obesity - the STEREO Trial. Obesity Facts 10: 341-352

Mueller MM, Lehmann R, Klassert TE, Reifenstein S, Conrad T, Moore C, Kuhn A, Behnert A, Guthke R, Driesch D, Slevogt H (2017) Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNF alpha expression. Sci Rep 7

Naglik JR, Koenig A, Hube B, Gaffen SL (2017) Candida albicans-epithelial interactions and induction of mucosal innate immunity. Curr Opin Microbiol 40: 104-112

Niecke A, Schneider G, Hartog CS, Michels G (2017) Traumatized relatives of intensive care patients. Med Klin Intensivmed Notfmed 112: 612-617

Noack K, Kramer OH (2017) Analyzing the Impact of Pan- and Class-Specific HDACi on Differentiation-Associated Factors. Method Mol Biol 1510: 375-385

Pohlers S, Martin R, Krueger T, Hellwig D, Haenel F, Kniemeyer O, Saluz HP, Van Dijck P, Ernst JF, Brakhage A, Muhlschlegel FA, Kurzai O (2017) Lipid Signaling via Pkh 1/2 Regulates Fungal CO2 Sensing through the Kinase Sch9. MBio 8

Polzin A, Piayda K, Keul P, Dannenberg L, Mohring A, Graeler M, Zeus T, Kelm M, Levkau B (2017) Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease. J Mol Cell Cardiol 110: 35-37

Prechter F, Katzer K, Bauer M, Stallmach A (2017) Sleeping with the enemy: Clostridium difficile infection in the intensive care unit. Crit Care 21

Press AT, Butans MJ, Haider TP, Weber C, Neugebauer S, Kiehntopf M, Schubert US, Clemens MG, Bauer M, Kortgen A (2017) Fast simultaneous assessment of renal and liver function using polymethine dyes in animal models of chronic and acute organ injury. Sci Rep 7

Press AT, Ramoji A, Luehe MV, Rinkenauer AC, Hoff J, Butans M, Roessel C, Pietsch C, Neugebauer U, Schacher FH, Bauer M (2017) Cargo-carrier interactions significantly contribute to micellar conformation and biodistribution. Npg Asia Materials 9

Rademann P, Weidinger A, Drechsler S, Meszaros A, Zipperle J, Jafarmadar M, Dumitrescu S, Hacobian A, Ungelenk L, Roestel F, Kaszaki J, Szabo A, Skulachev VP, Bauer M, Bahrami S, Weis S, Kozlov AV, Osuchowski MF (2017) Mitochondria-Targeted Antioxidants SkQ1 and MitoTEMPO Failed to Exert a Long-Term Beneficial Effect in Murine Polymicrobial Sepsis. Oxidat Med Cell Longevity6412682 10.1155/2017/6412682

Rathinasamy A, Domschke C, Ge Y, Boehm H-H, Dettling S, Jansen D, Lasitschka F, Umansky L, Graeler MH, Hartmann J, Herold-Mende C, Schuetz F, Beckhove P (2017) Tumor specific regulatory T cells in the bone marrow of breast cancer patients selectively upregulate the emigration receptor S1P1. Cancer Immunol Immunother 66: 593-603

Reddy UG, Axthelm J, Hoffmann P, Taye N, Glaeser S, Goerls H, Hopkins SL, Plass W, Neugebauer U, Bonnet S, Schiller A (2017) Co-Registered Molecular Logic Gate with a CO-Releasing Molecule Triggered by Light and Peroxide. J Am Chem Soc 139: 4991-4994

Reddy UG, Liu J, Hoffmann P, Steinmetzer J, Goerls H, Kupfer S, Askes SHC, Neugebauer U, Graefe S, Schiller A (2017) Light-responsive paper strips as CO-releasing material with a colourimetric response. Chem Sci 8: 6555-6560

Reiher N, Reza MJ, Zipfel PF (2017) Candida albicans battles the Dectin-1 and Dectin-2 mediated host-immune response. Mol Immunol 89: 157-157

Reiser M, Scherag A, Forstner C, Brunkhorst FM, Harbarth S, Doenst T, Pletz MW, Hagel S (2017) Effect of pre-operative octenidine nasal ointment and showering on surgical site infections in patients undergoing cardiac surgery. J Hosp Infect 95: 137-143

Rekowski J, Kollmann C, Bornkamp B, Ickstadt K, Scherag A (2017) Phase II dose-response trials: A simulation study to compare analysis method performance under design considerations. J Biopharm Stat 10.1080/10543406.2017.1293078: 1-17

Rennert K, Nitschke M, Wallert M, Keune N, Raasch M, Lorkowski S, Mosig AS (2017) Thermo-responsive cell culture carrier: Effects on macrophage functionality and detachment efficiency. J Tissue Eng 8

Reuken PA, Torres D, Baier M, Loeffler B, Luebbert C, Lippmann N, Stallmach A, Bruns T (2017) Risk Factors for Multi-Drug Resistant Pathogens and Failure of Empiric First-Line Therapy in Acute Cholangitis. PLoS One 12

Rieck M, Kremser C, Jobin K, Mettke E, Kurts C, Graeler M, Willecke K, Kolanus W (2017) Ceramide synthase 2 facilitates S1P-dependent egress of thymocytes into the circulation in mice. Eur J Immunol 47: 677-684

Rupprecht S, Schultze T, Nachtmann A, Rastan AJ, Doenst T, Schwab M, Witte OW, Rohe S, Zwacka I, Hoyer H (2017) Impact of sleep disordered breathing on short-term post-operative outcome after elective coronary artery bypass graft surgery: a prospective observational study. Eur Respir J 49

Saraiva JP, Oswald M, Biering A, Roell D, Assmann C, Klassert T, Blaess M, Czakai K, Claus R, Loeffler J, Slevogt H, Koenig R (2017) Fungal biomarker discovery by integration of classifiers. BMC Genomics 18

Saraiva JPLF, Zubiria-Barrera C, Klassert TE, Lautenbach MJ, Blaess M, Claus RA, Slevogt H, Koenig R (2017) Combination of Classifiers Identifies Fungal-Specific Activation of Lysosome Genes in Human Monocytes. Front Microbiol 8

Scherag A, Hartog CS, Fleischmann C, Ouart D, Hoffmann F, Koenig C, Kesselmeier M, Fiedler S, Philipp M, Braune A, Eichhorn C, Gampe C, Romeike H, Reinhart K, Mid-German Sepsis C (2017) A patient cohort on long-term sequelae of sepsis survivors: study protocol of the Mid-German Sepsis Cohort. Bmj Open 7

Schroeder U-C, Kirchhoff J, Huebner U, Mayer G, Glaser U, Henkel T, Pfister W, Fritzsche W, Popp J, Neugebauer U (2017) On-chip spectroscopic assessment of microbial susceptibility to antibiotics within 3.5 hours. J Biophotonics 10: 1547-1557

Schwarzkopf D, Ruddel H, Thomas-Ruddel DO, Felfe J, Poidinger B, Matthaus-Kramer CT, Hartog CS, Bloos F (2017) Perceived Nonbeneficial Treatment of Patients, Burnout, and Intention to Leave the Job Among ICU Nurses and Junior and Senior Physicians. Crit Care Med 10.1097/CCM.0000000000002081

Seidel RA, Claudel T, Schleser FA, Ojha NK, Westerhausen M, Nietzsche S, Sponholz C, Cuperus F, Coldewey SM, Heinemann SH, Pohnert G, Trauner M, Bauer M (2017) Impact of higher-order heme degradation products on hepatic function and hemodynamics. J Hepatol 67: 272-281

Sheychenko SN, Burkhardt M, Sheval EV, Natashina UA, Grosse C, Nikolaev AL, Gopin AV, Neugebauer U, Kudryavtsev AA, Sivakov V, Osminkina LA (2017) Antimicrobial Effect of Biocompatible Silicon Nanoparticles Activated Using Therapeutic Ultrasound. Langmuir 33: 2603-2609

Simon T-P, Mueckenheim H, Wagner T, Sponholz C, Claus RA, Saenger J, Marx G, Schuerholz T (2017) Organ-specific effects on inflammation and apoptosis of recombinant human activated protein C in a murine model of sepsis. Eur J Inflamm 15: 66-77

Skrahina V, Brock M, Hube B, Brunke S (2017) Candida albicans Hap43 Domains Are Required under Iron Starvation but Not Excess. Front Microbiol 8

Stengel S, Stallmach A, Richter K, Landrock A, Hampe J, Bruns T (2017) Serum metabolic signatures in patients with overt hepatic encephalopathy. J Hepatol 67: 1114-1115

Thomas L, Rao Z, Gerstmeier J, Raasch M, Weinigel C, Rummler S, Menche D, Mueller R, Pergola C, Mosig A, Werz O (2017) Selective upregulation of TNF alpha, expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with V-ATPase. Biochem Pharmacol 130: 71-82

Thomas-Rueddel DO, Bauer M (2017) Limited evidence to recommend lactate kinetics-guided therapy. Crit Care 21

Trauer J, Muhi S, McBryde ES, Al Harbi SA, Arabi YM, Boyle AJ, Cartin-Ceba R, Chen W, Chen Y-T, Falcone M, Gajic O, Godsell J, Gong MN, Kor D, Loesche W, McAuley DF, O'Neal HR, Jr., Osthoff M, Otto GP, Sossdorf M, Tsai M-J, Valerio-Rojas JC, van der Poll T, Violi F, Ware L, Widmer AF, Wiewel MA, Winning J, Eisen DP (2017) Quantifying the Effects of Prior Acetyl-Salicylic Acid on Sepsis-Related Deaths: An Individual Patient Data Meta-Analysis Using Propensity Matching. Crit Care Med 45: 1871-1879

Turnbull AE, Hartog CS (2017) Goal-concordant care in the ICU: a conceptual framework for future research. Intensive Care Med 43: 1847-1849

Van de Vyver H, Bovenkamp PR, Hoerr V, Schwegmann K, Tuchscherr L, Niemann S, Kursawe L, Grosse C, Moter A, Hansen U, Neugebauer U, Kuhlmann MT, Peters G, Hermann S, Loeffler B (2017) A Novel Mouse Model of Staphylococcus aureus Vascular Graft Infection Noninvasive Imaging of Biofilm Development in Vivo. Am J Pathol 187: 268-279

Verma AH, Richardson JP, Zhou C, Coleman BM, Moyes DL, Ho J, Huppler AR, Ramani K, McGeachy MJ, Mufazalov IA, Waisman A, Kane LP, Biswas PS, Hube B, Naglik JR, Gaffen SL (2017) Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin. Sci Immunol 2

von Loeffelholz C, Docke S, Lock JF, Lieske S, Horn P, Kriebel J, Wahl S, Singmann P, de Las Heras Gala T, Grallert H, Raschzok N, Sauer IM, Heller R, Jahreis G, Claus RA, Bauer M, Stockmann M, Birkenfeld AL, Pfeiffer AF (2017) Increased lipogenesis in spite of upregulated hepatic 5'AMP-activated protein kinase in human non-alcoholic fatty liver. Hepatol Res 10.1111/hepr.12825

von Loeffelholz C, Lieske S, Neuschafer-Rube F, Willmes DM, Raschzok N, Sauer IM, Konig J, Fromm M, Horn P, Chatzigeorgiou A, Pathe-Neuschafer-Rube A, Jordan J, Pfeiffer AFH, Mingrone G, Bornstein SR, Stroehle P, Harms C, Wunderlich FT, Helfand SL, Bernier M, de Cabo R, Shulman GI, Chavakis T, Puschel GP, Birkenfeld AL (2017) The Human Longevity Gene Homolog INDY and Interleukin-6 Interact in Hepatic Lipid Metabolism. Hepatology 10.1002/hep.29089

von Loeffelholz C, Pfeiffer AFH, Lock JF, Lieske S, Doecke S, Murahovschi V, Kriebel J, Gala TdlH, Grallert H, Rudovich N, Stockmann M, Spranger J, Jahreis G, Bornstein SR, Lau G, Xu A, Schulz-Menger J, Exner L, Haufe S, Jordan J, Engeli S, Birkenfeld AL (2017) ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives. Hormone Metab Res 49: 343-349

von Wnuck Lipinski K, Weske S, Keul P, Peters S, Baba HA, Heusch G, Graler MH, Levkau B (2017) Hepatocyte nuclear factor 1A deficiency causes hemolytic anemia in mice by altering erythrocyte sphingolipid homeostasis. Blood 130: 2786-2798

Weis S, Carlos AR, Moita MR, Singh S, Blankenhaus B, Cardoso S, Larsen R, Rebelo S, Schaeuble S, Del Barrio L, Mithieux G, Rajas F, Lindig S, Bauer M, Soares MP (2017) Metabolic Adaptation Establishes Disease Tolerance to Sepsis. Cell 169: 1263-+

Weis S, Hagel S, Schmitz RP, Scherag A, Brunkhorst FM, Forstner C, Loffler B, Pletz MW (2017) Study on the utility of a statewide counselling programme for improving mortality outcomes of patients with Staphylococcus aureus bacteraemia in Thuringia (SUPPORT): a study protocol of a cluster-randomised crossover trial. Bmj Open 7: e013976

Weis S, Kimmig A, Hagel S, Pletz MW (2017) Antibiotic stewardship and Staphylococcus aureus Bacteremia. Med Klin Intensivmed Notfmed 112: 192-198

Weis S, Rubio I, Ludwig K, Weigel C, Jentho E (2017) Hormesis and Defense of Infectious Disease. Int J Mol Sci 18

Winkler MS, Nierhaus A, Poppe A, Greiwe G, Graeler MH, Daum G (2017) Sphingosine-1-Phosphate: A Potential Biomarker and Therapeutic Target for Endothelial Dysfunction and Sepsis? Shock 47: 666-672

Wintermann G-B, Rosendahl J, Weidner K, Strauss B, Petrowski K (2017) Risk Factors of Delayed Onset Posttraumatic Stress Disorder in Chronically Critically Ill Patients. J Nerv Mental Dis 205: 780-787

Wollina U, Wetzker R, Abdel-Naser MB, Kruglikov IL (2017) Role of adipose tissue in facial aging. Clin Interv Aging 12: 2069-2076

Zimmermann S, Tuchscherr L, Roedel J, Loeffler B, Bohnert JA (2017) Optimized efflux assay for the NorA multidrug efflux pump in Staphylococcus aureus. J Microbiol Method 142: 39-40

Ali S, Akhter S, Neubauer H, Scherag A, Kesselmeier M, Melzer F, Khan I, El-Adawy H, Azam A, Qadeer S, Ali Q (2016) Brucellosis in pregnant women from Pakistan: an observational study. BMC infectious diseases 16: 468

Allert S, Brunke S, Hube B (2016) In Vivo Transcriptional Profiling of Human Pathogenic Fungi during Infection: Reflecting the Real Life? PLoS Pathog 12

Arefian H, Hagel S, Heublein S, Rissner F, Scherag A, Brunkhorst FM, Baldessarini RJ, Hartmann M (2016a) Extra length of stay and costs because of health care-associated infections at a German university hospital. American journal of infection control 44: 160-166

Arefian H, Vogel M, Kwetkat A, Hartmann M (2016b) Economic Evaluation of Interventions for Prevention of Hospital Acquired Infections: A Systematic Review. PloS one 11: e0146381

Axer H, Grimm A, Pausch C, Teschner U, Zinke J, Eisenach S, Beck S, Guntinas-Lichius O, Brunkhorst FM, Witte OW (2016) The impairment of small nerve fibers in severe sepsis and septic shock. Crit Care 20

Bauer M, Giamarellos-Bourboulis EJ, Kortgen A, Moeller E, Felsmann K, Cavaillon JM, Guntinas-Lichius O, Rutschmann O, Ruryk A, Kohl M, Wlotzka B, Russwurm S, Marshall JC, Reinhart K (2016) A Transcriptomic Biomarker to Quantify Systemic Inflammation in Sepsis - A Prospective Multicenter Phase II Diagnostic Study. E Biomedicine 6: 114-125

Baumbach P, Goetz T, Guenther A, Weiss T, Meissner W (2016a) Prevalence and Characteristics of Chronic Intensive Care-Related Pain: The Role of Severe Sepsis and Septic Shock. Crit Care Med 44: 1129-1137

Baumbach P, Meissner W, Guenther A, Witte OW, Goetz T (2016b) Perceived cognitive impairments after critical illness: a longitudinal study in survivors and family member controls. Acta Anaesth Scand 60: 1121-1130

Baumbach P, Weiss T, Giermann C, Cubillos S, Meissner W, Norgauer J (2016c) Standardized quantitative sensory testing in patients with psoriasis vulgaris: evidence for altered large and small fibre functioning. Journal of the European Academy of Dermatology and Venereology : JEADV 30: E137-E140

Bergmann L, Martini S, Kesselmeier M, Armbruster W, Notheisen T, Adamzik M, Eichholz R (2016) Phrenic nerve block caused by interscalene brachial plexus block: breathing effects of different sites of injection. BMC anesthesiology 16: 45

Blaurock N, Schmerler D, Huenniger K, Kurzai O, Ludewig K, Baier M, Brunkhorst FM, Imhof D, Kiehntopf M (2016) C-Terminal Alpha-1 Antitrypsin Peptide: A New Sepsis Biomarker with Immunomodulatory Function. Mediators of Inflammation

Bloos F, Trips E, Nierhaus A, Briegel J, Heyland DK, Jaschinski U, Moerer O, Weyland A, Marx G, Grundling M, Kluge S, Kaufmann I, Ott K, Quintel M, Jelschen F, Meybohm P, Rademacher S, Meier-Hellmann A, Utzolino S, Kaisers UX, Putensen C, Elke G, Ragaller M, Gerlach H, Ludewig K, Kiehntopf M, Bogatsch H, Engel C, Brunkhorst FM, Loeffler M, Reinhart K, for SepNet Critical Care Trials G (2016a) Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock: A Randomized Clinical Trial. JAMA internal medicine

Bloos F, Zhang Z, Boulain T (2016b) Lactate-guided resuscitation saves lives: yes. Intens Care Med 42: 466-469

Bottcher B, Pollath C, Staib P, Hube B, Brunke S (2016) Candida species Rewired Hyphae Developmental Programs for Chlamydospore Formation. Front Microbiol 7

Brewitz HH, Goradia N, Schubert E, Galler K, Kuehl T, Syllwasschy B, Popp J, Neugebauer U, Hagelueken G, Schiemann O, Ohlenschlaeger O, Imhof D (2016) Heme interacts with histidine- and tyrosine-based protein motifs and inhibits enzymatic activity of chloramphenicol acetyltransferase from Escherichia coli. Biochim Biophys Acta-General Subjects 1860: 1343-1353

Brunkhorst FM, Olgemoeller U (2016) Projects and Activities of the Department of Infectiology/Immunology. Medizinische Klinik, Intensivmedizin und Notfallmedizin 111: 360-361

Bruns T, Reuken PA, Stengel S, Gerber L, Appenrodt B, Schade JH, Lammert F, Zeuzem S, Stallmach A (2016a) NOD2 Risk Variants and Pathological Bacterial Translocation in Decompensated Cirrhosis. Digestive diseases and sciences 61: 2142-2144

Bruns T, Reuken PA, Stengel S, Gerber L, Appenrodt B, Schade JH, Lammert F, Zeuzem S, Stallmach A (2016b) The prognostic significance of bacterial DNA in patients with decompensated cirrhosis and suspected infection. Liver Int 36: 1133-1142

Chung H-Y, Hupe DC, Otto GP, Sprenger M, Bunck AC, Dorer MJ, Bockmeyer CL, Deigner H-P, Graeler MH, Claus RA (2016) Acid Sphingomyelinase Promotes Endothelial Stress Response in Systemic Inflammation and Sepsis. Molecular medicine 22: 412-423

Coldewey SM, Benetti E, Collino M, Pfeilschifter J, Sponholz C, Bauer M, Huwiler A, Thiemermann C (2016) Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis. Scientific reports 6

Cortes-Poch I, Hartog CS (2016) Change Is Not Necessarily Progress: Revision of the Sepsis Definition Should Be Based on New Scientific Insights. American journal of respiratory and critical care medicine 194: 16-18

Doppler K, Schleyer B, Geis C, Gruenewald B, Putz E, Villmann C, Sommer C (2016) LOCKJAW IN STIFF-PERSON SYNDROME WITH AUTOANTIBODIES AGAINST GLYCINE RECEPTORS. Neurology - Neuroimmunol Neuroinflamm 3

Dreiling M, Bischoff S, Schiffner R, Rupprecht S, Kiehntopf M, Schubert H, Witte OW, Nathanielsz PW, Schwab M, Rakers F (2016) Stress-induced decrease of uterine blood flow in sheep is mediated by alpha 1-adrenergic receptors. Stress 19: 547-551

Englert C, Truetzschler A-K, Raasch M, Bus T, Borchers P, Mosig AS, Traeger A, Schubert US (2016) Crossing the blood-brain barrier: Glutathione-conjugated poly(ethylene imine) for gene delivery. Journal of controlled release : official journal of the Controlled Release Society 241: 1-14

Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, Angus DC, Reinhart K, International Forum of Acute Care T (2016a) Assessment of Global Incidence and Mortality of Hospital-treated Sepsis - Current Estimates and Limitations. American journal of respiratory and critical care medicine

Fleischmann C, Thomas-Rueddel DO, Hartmann M, Hartog CS, Welte T, Heublein S, Dennler U, Reinhart K (2016b) Hospital Incidence and Mortality Rates of Sepsis An Analysis of Hospital Episode (DRG) Statistics in Germany From 2007 to 2013. Deutsches Arzteblatt international 113: 159-+

Galler K, Froehlich E, Kortgen A, Bauer M, Popp J, Neugebauer U (2016a) Hepatic cirrhosis and recovery as reflected by Raman spectroscopy: information revealed by statistical analysis might lead to a prognostic biomarker. Analytical and bioanalytical chemistry 408: 8053-8063

Galler K, Requardt RP, Glaser U, Markwart R, Bocklitz T, Bauer M, Popp J, Neugebauer U (2016b) Single cell analysis in native tissue: Quantification of the retinoid content of hepatic stellate cells. Scientific reports 6

Geisel MH, Coassin S, Hessler N, Bauer M, Eisele L, Erbel R, Haun M, Hennig F, Moskau-Hartmann S, Hoffmann B, Joeckel K-H, Kedenko L, Kiechl S, Kollerits B, Mahabadi A-A, Moebus S, Nuernberg G, Nuernberg P, Paulweber B, Vens M, Willeit J, Willeit K, Klockgether T, Ziegler A, Scherag A, Kronenberg F (2016) Update of the effect estimates for common variants associated with carotid intima media thickness within four independent samples: The Bonn IMT Family Study, the Heinz Nixdorf Recall Study, the SAPHIR Study and the Bruneck Study. Atherosclerosis 249: 83-87

Gerwien F, Safyan A, Wisgott S, Hille F, Kaemmer P, Linde J, Brunke S, Kasper L, Hube B (2016) A Novel Hybrid Iron Regulation Network Combines Features from Pathogenic and Nonpathogenic Yeasts. mBio 7

Giamarellos-Bourboulis EJ, Platzer M, Karagiannidis I, Kanni T, Nikolakis G, Ulrich J, Bellutti M, Gollnick H, Bauer M, Zouboulis CC, Huse K (2016) High Copy Numbers of beta-Defensin Cluster on 8p23.1, Confer Genetic Susceptibility, and Modulate the Physical Course of Hidradenitis Suppurativa/Acne Inversa. The Journal of investigative dermatology

Gietzelt M, Hofer T, Knaup-Gregori P, Konig R, Lopprich M, Poos A, Ganzinger M (2016) The Use of Tools, Modelling Methods, Data Types, and Endpoints in Systems Medicine: A Survey on Projects of the German e:Med-Programme. Studies Health Technol Informatics 228: 670-674

Goetz T, Baumbach P, Huonker R, Kranczioch C, Witte OW, Debener S, Klingner C, Brunkhorst FM, Guenther A (2016a) Slowed peak resting frequency and MEG overactivation in survivors of severe sepsis and septic shock. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 127: 1247-1253

Goetz T, Baumbach P, Reuken P, Huonker R, Kranczioch C, Debener S, Brunkhorst FM, Witte OW, Klingner C, Guenther A (2016b) The loss of neural synchrony in the post septic brain. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 127: 2200-2207

Groger M, Rennert K, Giszas B, Weiss E, Dinger J, Funke H, Kiehntopf M, Peters FT, Lupp A, Bauer M, Claus RA, Huber O, Mosig AS (2016) Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model. Scientific reports 6: 21868

Grunewald B, Bennett JL, Toyka KV, Sommer C, Geis C (2016) Efficacy of Polyvalent Human Immunoglobulins in an Animal Model of Neuromyelitis Optica Evoked by Intrathecal Anti-Aquaporin 4 Antibodies. International journal of molecular sciences 17

Hagel S, Ludewig K, Moeser A, Baier M, Loffler B, Schleenvoigt B, Forstner C, Pletz MW (2016) Characteristics and management of patients with influenza in a German hospital during the 2014/2015 influenza season. Infection 44: 667-672

Hahn-Ast C, Felder L, Mayer K, Mueckter S, Ruhnke M, Hein R, Hellmich M, Schwab K, Rachow T, Brossart P, von Lilienfeld-Toal M (2016) Outcome of empirical or targeted antifungal therapy after antifungal prophylaxis in febrile neutropenia. Annals of hematology 95: 1001-1009

Hamzei F, Vry M-S, Saur D, Glauche V, Hoeren M, Mader I, Weiller C, Rijntjes M (2016) The Dual-Loop Model and the Human Mirror Neuron System: an Exploratory Combined fMRI and DTI Study of the Inferior Frontal Gyrus. Cerebral Cortex 26: 2215-2224

Hanke D, Huonker R, Weiss T, Witte OW, Gotz T (2016) Modality-independent reduction mechanisms of primary sensory evoked fields in a one-back task. NeuroImage 124: 918-922

Hebecker B, Vlaic S, Conrad T, Bauer M, Brunke S, Kapitan M, Linde J, Hube B, Jacobsen ID (2016) Dual-species transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions. Scientific reports 6

Heinrich A, Heyl KA, Klaile E, Muller MM, Klassert TE, Wiessner A, Fischer K, Schumann RR, Seifert U, Riesbeck K, Moter A, Singer BB, Bachmann S, Slevogt H (2016) Moraxella catarrhalis induces CEACAM3-Syk-Card9-dependent activation of human granulocytes. Cellular microbiology

Hemdan NYA, Weigel C, Reimann C-M, Graler MH (2016) Modulating sphingosine 1-phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis. European journal of immunology 46: 2767-2777

Hennig A, Markwart R, Wolff K, Schubert K, Cui Y, Prior IA, Esparza-Franco MA, Ladds G, Rubio I (2016) Feedback activation of neurofibromin terminates growth factor-induced Ras activation. Cell communication and signaling : CCS 14

Herrtwich L, Nanda I, Evangelou K, Nikolova T, Horn V, Sagar, Erny D, Stefanowski J, Rogell L, Klein C, Gharun K, Follo M, Seidl M, Kremer B, Muenke N, Senges J, Fliegauf M, Aschman T, Pfeifer D, Sarrazin S, Sieweke MH, Wagner D, Dierks C, Haaf T, Ness T, Zaiss MM, Voll RE, Deshmukh SD, Prinz M, Goldmann T, Hoelscher C, Hauser AE, Lopez-Contreras AJ, Gruen D, Gorgoulis V, Diefenbach A, Henneke P, Triantafyllopoulou A (2016) DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas. Cell 167: 1264-+

Hessler N, Geisel MH, Coassin S, Erbel R, Heilmann S, Hennig F, Hoffmann B, Joeckel K-H, Moebus S, Moskau-Hartmann S, Nuernberg G, Nuernberg P, Vens M, Klockgether T, Kronenberg F, Scherag A, Ziegler A (2016) Linkage and Association Analysis Identifies TRAF1 Influencing Common Carotid Intima-Media Thickness. Stroke; a journal of cerebral circulation 47: 2904-2909

Hilgenstock R, Weiss T, Huonker R, Witte OW (2016) Behavioural and neurofunctional impact of transcranial direct current stimulation on somatosensory learning. Human Brain Mapping 37: 1277-1295

Hoefs S, Mogavero S, Hube B (2016) Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota. J Microbiol 54: 149-169

Hoerr V, Duggan GE, Zbytnuik L, Poon KK, Grosse C, Neugebauer U, Methling K, Loffler B, Vogel HJ (2016) Characterization and prediction of the mechanism of action of antibiotics through NMR metabolomics. BMC Microbiol 16: 82

Horn P, Metzing UB, Steidl R, Romeike B, Rauchfuss F, Sponholz C, Thomas-Ruddel D, Ludewig K, Birkenfeld AL, Settmacher U, Bauer M, Claus RA, von Loeffelholz C (2016) Chemerin in peritoneal sepsis and its associations with glucose metabolism and prognosis: a translational cross-sectional study. Crit Care 20: 39

Jakab A, Mogavero S, Foerster TM, Pekmezovic M, Jablonowski N, Dombradi V, Pocsi I, Hube B (2016) Effects of the glucocorticoid betamethasone on the interaction of Candida albicans with human epithelial cells. Microbiol Sgm 162: 2116-2125 

Keh D, Trips E, Marx G, Wirtz SP, Abduljawwad E, Bercker S, Bogatsch H, Briegel J, Engel C, Gerlach H, Goldmann A, Kuhn S-O, Huter L, Meier-Hellmann A, Nierhaus A, Kluge S, Lehmke J, Loeffler M, Oppert M, Resener K, Schadler D, Schuerholz T, Simon P, Weiler N, Weyland A, Reinhart K, Brunkhorst FM, SepNet-Critical Care Trials G (2016) Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis The HYPRESS Randomized Clinical Trial. JAMA internal medicine 316: 1775-1785

Kesselmeier M, Lorenzo Bermejo J (2016) Robust logistic regression to narrow down the winner's curse for rare and recessive susceptibility variants. Briefings in bioinformatics 

Kesselmeier M, Putter C, Volckmar AL, Baurecht H, Grallert H, Illig T, Ismail K, Ollikainen M, Silen Y, Keski-Rahkonen A, Bulik CM, Collier DA, Zeggini E, Hebebrand J, Scherag A, Hinney A, Gcan, Wtccc (2016) High-throughput DNA methylation analysis in anorexia nervosa confirms TNXB hypermethylation. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry: 1-13

Klein M, Neugebauer U, Schmitt M, Popp J (2016) Elucidation of the CO-Release Kinetics of CORM-A1 by Means of Vibrational Spectroscopy. Chem Phys Chem 17: 985-993 

Kleiter I, Gahlen A, Borisow N, Fischer K, Wernecke KD, Wegner B, Hellwig K, Pache F, Ruprecht K, Havla J, Krumbholz M, Kumpfel T, Aktas O, Hartung HP, Ringelstein M, Geis C, Kleinschnitz C, Berthele A, Hemmer B, Angstwurm K, Stellmann JP, Schuster S, Stangel M, Lauda F, Tumani H, Mayer C, Zeltner L, Ziemann U, Linker R, Schwab M, Marziniak M, Then Bergh F, Hofstadt-van Oy U, Neuhaus O, Winkelmann A, Marouf W, Faiss J, Wildemann B, Paul F, Jarius S, Trebst C, Neuromyelitis Optica Study G (2016) Neuromyelitis optica: Evaluation of 871 attacks and 1,153 treatment courses. Ann Neurol 79: 206-216 

Klinger-Strobel M, Ernst J, Lautenschlager C, Pletz MW, Fischer D, Makarewicz O (2016a) A blue fluorescent labeling technique utilizing micro- and nanoparticles for tracking in LIVE/DEAD((R)) stained pathogenic biofilms of Staphylococcus aureus and Burkholderia cepacia. International journal of nanomedicine 11: 575-583 

Klinger-Strobel M, Glaeser S, Makarewicz O, Wyrwa R, Weisser J, Pletz MW, Schiller A (2016b) Bactericidal Effect of a Photoresponsive Carbon Monoxide-Releasing Nonwoven against Staphylococcus aureus Biofilms. Antimicrobial agents and chemotherapy 60: 4037-4046 

Klinger-Strobel M, Makarewicz O, Pletz MW, Stallmach A, Lautenschlaeger C (2016c) TiO2-containing and ZnO-containing borosilicate glass-a novel thin glass with exceptional antibiofilm performances to prevent microfouling. J Mater Sci-Mater M 27

Kolditz M, Scherag A, Rohde G, Ewig S, Welte T, Pletz M, Group CS (2016) Comparison of the qSOFA and CRB-65 for risk prediction in patients with community-acquired pneumonia. Intens Care Med 

Kolter J, Feuerstein R, Spoeri E, Gharun K, Elling R, Trieu-Cuot P, Goldmann T, Waskow C, Chen ZJ, Kirschning CJ, Deshmukh SD, Henneke P (2016) Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion. J Immunol 196: 2733-2741 

Kordass T, Weber CE, Oswald M, Ast V, Bernhardt M, Novak D, Utikal J, Eichmuller SB, Konig R (2016) SOX5 is involved in balanced MITF regulation in human melanoma cells. BMC medical genomics 9: 10

Ksionda O, Melton AA, Bache J, Tenhagen M, Bakker J, Harvey R, Winter SS, Rubio I, Roose JP (2016) RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines. Oncogene 

Kusic D, Ramoji A, Neugebauer U, Rosch P, Popp J (2016) Raman Spectroscopic Characterization of Packaged L. pneumophila Strains Expelled by T. thermophila. Analytical chemistry 88: 2533-2537

Lange K, Buerger M, Stallmach A, Bruns T (2016) Effects of Antibiotics on Gut Microbiota. Digestive Diseases 34: 260-268

Luo T, Krueger T, Knuepfer U, Kasper L, Wielsch N, Hube B, Kortgen A, Bauer M, Giamarellos-Bourboulis EJ, Dimopoulos G, Brakhage AA, Kniemeyer O (2016) Immunoproteomic Analysis of Antibody Responses to Extracellular Proteins of Candida albicans Revealing the Importance of Glycosylation for Antigen Recognition. Journal of proteome research 15: 2394-2406 

Manchanda H, Seidel N, Blaess MF, Claus RA, Linde J, Slevogt H, Sauerbrei A, Guthke R, Schmidtke M (2016) Differential Biphasic Transcriptional Host Response Associated with Coevolution of Hemagglutinin Quasispecies of Influenza A Virus. Front Microbiol 7 

Matthaeus-Kraemer CT, Thomas-Rueddel DO, Schwarzkopf D, Rueddel H, Poidinger B, Reinhart K, Bloos F (2016) Crossing the handover chasm: Clinicians' perceptions of barriers to the early detection and timely management of severe sepsis and septic shock. J Crit Care 36: 85-91

Mitroi DN, Deutschmann AU, Raucamp M, Karunakaran I, Glebov K, Hans M, Walter J, Saba J, Graeler M, Ehninger D, Sopova E, Shupliakov O, Swandulla D, van Echten-Deckert G (2016) Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin-proteasome mediated mechanism. Scientific reports 6

Moeller C, Fleischmann C, Thomas-Rueddel D, Vlasakov V, Rochwerg B, Theurer P, Gattinoni L, Reinhart K, Hartog CS (2016) How safe is gelatin? A systematic review and meta-analysis of gelatin-containing plasma expanders vs crystalloids and albumin. J Crit Care 35: 75-83

Mothes H, Koeppen J, Bayer O, Richter M, Kabisch B, Schwarzkopf D, Hein HA, Zanow J, Doenst T, Settmacher U (2016) Acute mesenteric ischemia following cardiovascular surgery - A nested case-control study. International journal of surgery 26: 79-85

Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Hofs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Forster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Hader A, Kurzai O, Luo T, Kruger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR (2016) Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature 532: 64-68

Naranjo-Ortiz MA, Brock M, Brunke S, Hube B, Marcet-Houben M, Gabaldon T (2016) Widespread Inter- and Intra-Domain Horizontal Gene Transfer of D-Amino Acid Metabolism Enzymes in Eukaryotes. Front Microbiol 7

Neugebauer S, Giamarellos-Bourboulis EJ, Pelekanou A, Marioli A, Baziaka F, Tsangaris I, Bauer M, Kiehntopf M (2016) Metabolite Profiles in Sepsis: Developing Prognostic Tools Based on the Type of Infection. Crit Care Med 44: 1649-1662

Noack K, Mahendrarajah N, Hennig D, Schmidt L, Grebien F, Hildebrand D, Christmann M, Kaina B, Sellmer A, Mahboobi S, Kubatzky K, Heinzel T, Kramer OH (2016) Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells. Arch Toxicol

Otto GP, Rathkolb B, Oestereicher MA, Lengger CJ, Moerth C, Micklich K, Fuchs H, Gailus-Durner V, Wolf E, Hrabe de Angelis M (2016) Clinical Chemistry Reference Intervals for C57BL/6J, C57BL/6N, and C3HeB/FeJ Mice (Mus musculus). Journal of the American Association for Laboratory Animal Science : JAALAS 55: 375-386

Planaguma J, Haselmann H, Mannara F, Petit-Pedrol M, Grunewald B, Aguilar E, Ropke L, Martin-Garcia E, Titulaer MJ, Jercog P, Graus F, Maldonado R, Geis C, Dalmau J (2016) Ephrin-B2 prevents N-methyl-D-aspartate receptor antibody effects on memory and neuroplasticity. Ann Neurol 80: 388-400

Poos AM, Maicher A, Dieckmann AK, Oswald M, Eils R, Kupiec M, Luke B, Konig R (2016) Mixed Integer Linear Programming based machine learning approach identifies regulators of telomerase in yeast. Nucl Acid Res 44: e93-e93

Press AT, Ungelenk L, Rinkenauer AC, Groeger M, Lehmann F, Mosig A, Schubert US, Clemens MG, Bauer M (2016) A new fluorescent dye for cell tracing and mitochondrial imaging in vitro and in vivo. J Biophotonics 9: 888-900

Raasch M, Rennert K, Jahn T, Gaertner C, Schoenfelder G, Huber O, Seiler AEM, Mosig AS (2016) An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex development. Biomicrofluidics 10

Rachow T, Dornaus S, Sayer HG, Hermann B, Hochhaus A, von Lilienfeld-Toal M (2016) Case report: false positive elevated serum-galactomannan levels after autologous hematopoietic stem cell transplantation caused by oral nutritional supplements. Clin Case Rep 4: 505-508

Ramoji A, Galler K, Glaser U, Henkel T, Mayer G, Dellith J, Bauer M, Popp J, Neugebauer U (2016) Characterization of different substrates for Raman spectroscopic imaging of eukaryotic cells. J Raman Spectrosc 47: 773-786

Rennert K, Heisig K, Groeger M, Wallert M, Funke H, Lorkowski S, Huber O, Mosig AS (2016a) Recruitment of CD16(+) monocytes to endothelial cells in response to LPS-treatment and concomitant TNF release is regulated by CX3CR1 and interfered by soluble fractalkine. Cytokine 83: 41-52

Rennert K, Otto P, Funke H, Huber O, Tomaso H, Mosig AS (2016b) A human macrophage - hepatocyte co-culture model for comparative studies of infection and replication of Francisella tularensis LVS strain and subspecies holarctica and mediasiatica. BMC Microbiol 16

Richter ME, Neugebauer S, Engelmann F, Hagel S, Ludewig K, La Rosee P, Sayer HG, Hochhaus A, von Lilienfeld-Toal M, Bretschneider T, Pausch C, Engel C, Brunkhorst FM, Kiehntopf M (2016) Biomarker candidates for the detection of an infectious etiology of febrile neutropenia. Infection

Ritter M, Seidel RA, Bellstedt P, Schneider B, Bauer M, Goerls H, Pohnert G (2016) Isolation and Identification of Intermediates of the Oxidative Bilirubin Degradation. Organic letters 18: 4432-4435

Rittirsch D, Schoenborn V, Lindig S, Wanner E, Sprengel K, Gunkel S, Blaess M, Schaarschmidt B, Sailer P, Marsmann S, Simmen H-P, Cinelli P, Bauer M, Claus RA, Wanner GA (2016) An Integrated Clinico-transcriptomic Approach Identifies a Central Role of the Heme Degradation Pathway for Septic Complications After Trauma. Ann Surg 264: 1125-1134

Rueddel J, Schleenvoigt BT, Schueler E, Schmidt C, Pletz MW, Stallmach A (2016) Yellow fever vaccination during treatment with infliximab in a patient with ulcerative colitis: A case report. Zeitschrift fur Gastroenterologie 54: 1081-1084

Ruffo E, Malacarne V, Larsen SE, Das R, Patrussi L, Wulfing C, Biskup C, Kapnick SM, Verbist K, Tedrick P, Schwartzberg PL, Baldari CT, Rubio I, Nichols KE, Snow AL, Baldanzi G, Graziani A (2016) Inhibition of diacylglycerol kinase alpha restores restimulation-induced cell death and reduces immunopathology in XLP-1. Science translational medicine 8: 321ra327

Rump K, Unterberg M, Bergmann L, Bankfalvi A, Menon A, Schaefer S, Scherag A, Bazzi Z, Siffert W, Peters J, Adamzik M (2016) AQP5-1364A/C polymorphism and the AQP5 expression influence sepsis survival and immune cell migration: a prospective laboratory and patient study. J Transl Med 14

Ryabchykov O, Bocklitz T, Ramoji A, Neugebauer U, Foerster M, Kroegel C, Bauer M, Kiehntopf M, Popp J (2016) Automatization of spike correction in Raman spectra of biological samples. Chemometrics and Intelligent Laboratory Systems 155: 1-6

Salah FS, Ebbinghaus M, Muley VY, Zhou Z, Al-Saadi KRD, Pacyna-Gengelbach M, O'Sullivan GA, Betz H, Koenig R, Wang ZQ, Braeuer R, Petersen I (2016) Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death. Cell Death Disease 7

Schafer ST, Franken L, Adamzik M, Schumak B, Scherag A, Engler A, Schonborn N, Walden J, Koch S, Baba HA, Steinmann J, Westendorf AM, Fandrey J, Bieber T, Kurts C, Frede S, Peters J, Limmer A (2016) Mitochondrial DNA: An Endogenous Trigger for Immune Paralysis. Anesthesiology

Scherag A, Schoneweck F, Kesselmeier M, Taudien S, Platzer M, Felder M, Sponholz C, Rautanen A, Hill AV, Hinds CJ, Hossain H, Suttorp N, Kurzai O, Slevogt H, Giamarellos-Bourboulis EJ, Armaganidis A, Trips E, Scholz M, Brunkhorst FM (2016) Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality. E BioMedicine

Schindler K, Bondeva T, Schindler C, Claus RA, Franke S, Wolf G (2016) Preconditioned suppression of prolyl-hydroxylases attenuates renal injury but increases mortality in septic murine models. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Schmidt K, Worrack S, Von Korff M, Davydow D, Brunkhorst F, Ehlert U, Pausch C, Mehlhorn J, Schneider N, Scherag A, Freytag A, Reinhart K, Wensing M, Gensichen J, Group SS (2016) Effect of a Primary Care Management Intervention on Mental Health-Related Quality of Life Among Survivors of Sepsis: A Randomized Clinical Trial. JAMA : the journal of the American Medical Association 315: 2703-2711

Schulz A, Buettner R, Toledo A, Baader SL, von Maltzahn J, Irintchev A, Bauer R, Morrison H (2016) Neuron-Specific Deletion of the Nf2 Tumor Suppressor Impairs Functional Nerve Regeneration. PloS one 11

Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A, Rubenfeld G, Kahn JM, Shankar-Hari M, Singer M, Deutschman CS, Escobar GJ, Angus DC (2016) Assessment of clinical criteria for sepsis: For the third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA : the journal of the American Medical Association 315: 762-774

Sharma AK, Eils R, Koenig R (2016) Copy Number Alterations in Enzyme-Coding and Cancer-Causing Genes Reprogram Tumor Metabolism. Cancer research 76: 4058-4067

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Djillali A, Bauer M, Bellomo R, Bernard GR, Chiche J-D, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld G, van der Poll T, Vincent J-L, Angus DC (2016) The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA : the journal of the American Medical Association 315: 801-810

Sponholz C, Kramer M, Schoneweck F, Menzel U, Inanloo Rahatloo K, Giamarellos-Bourboulis EJ, Papavassileiou V, Lymberopoulou K, Pavlaki M, Koutelidakis I, Perdios I, Scherag A, Bauer M, Platzer M, Huse K (2016a) Polymorphisms of cystathionine beta-synthase gene are associated with susceptibility to sepsis. European journal of human genetics : EJHG

Sponholz C, Matthes K, Rupp D, Backaus W, Klammt S, Karailieva D, Bauschke A, Settmacher U, Kohl M, Clemens MG, Mitzner S, Bauer M, Kortgen A (2016b) Molecular adsorbent recirculating system and single-pass albumin dialysis in liver failure - a prospective, randomised crossover study. Crit Care 20: 2

Stoeckel S, Kirchhoff J, Neugebauer U, Roesch P, Popp J (2016) The application of Raman spectroscopy for the detection and identification of microorganisms. J Raman Spectrosc 47: 89-109

Taudien S, Lausser L, Giamarellos-Bourboulis EJ, Sponholz C, Schoneweck F, Felder M, Schirra LR, Schmid F, Gogos C, Groth S, Petersen BS, Franke A, Lieb W, Huse K, Zipfel PF, Kurzai O, Moepps B, Gierschik P, Bauer M, Scherag A, Kestler HA, Platzer M (2016) Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive. E BioMedicine

Teutschbein J, Simon S, Lother J, Springer J, Hortschansky P, Morton CO, Loeffler J, Einsele H, Conneally E, Rogers TR, Guthke R, Brakhage AA, Kniemeyer O (2016) Proteomic Profiling of Serological Responses to Aspergillus fumigatus Antigens in Patients with Invasive Aspergillosis. Journal of proteome research 15: 1580-1591

Theilacker C, Ludewig K, Serr A, Schimpf J, Held J, Boegelein M, Bahr V, Rusch S, Pohl A, Kogelmann K, Frieseke S, Bogdanski R, Brunkhorst FM, Kern WV, Splenectomy Pneumococcus F (2016) Overwhelming Postsplenectomy Infection: A Prospective Multicenter Cohort Study. Clin Infect Diseases 62: 871-878

Trivedi PJ, Bruns T, Ward S, Mai M, Schmidt C, Hirschfield GM, Weston CJ, Adams DH (2016) Intestinal CCL25 expression is increased in colitis and correlates with inflammatory activity. J Autoimmun 68: 98-104

Tuchscherr L, Kreis CA, Hoerr V, Flint L, Hachmeister M, Geraci J, Bremer-Streck S, Kiehntopf M, Medina E, Kribus M, Raschke M, Pletz M, Peters G, Loeffler B (2016) Staphylococcus aureus develops increased resistance to antibiotics by forming dynamic small colony variants during chronic osteomyelitis. The Journal of antimicrobial chemotherapy 71: 438-448

Vanaja SK, Russo AJ, Behl B, Banerjee I, Yankova M, Deshmukh SD, Rathinam VA (2016) Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation. Cell 165: 1106-1119

Vogel M, Schmitz RP, Hagel S, Pletz MW, Gagelmann N, Scherag A, Schlattmann P, Brunkhorst FM (2016) Infectious disease consultation for Staphylococcus aureus bacteremia - A systematic review and meta-analysis. The Journal of infection 72: 19-28

Vogt A, Reuken PA, Stengel S, Stallmach A, Bruns T (2016) Dual-sugar tests of small intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: a prospective study. World journal of gastroenterology : WJG 22: 3275-3284

von Lilienfeld-Toal M, Berger A, Christopeit M, Hentrich M, Heussel CP, Kalkreuth J, Klein M, Kochanek M, Penack O, Hauf E, Rieger C, Silling G, Vehreschild M, Weber T, Wolf H-H, Lehners N, Schalk E, Mayer K (2016) Community acquired respiratory virus infections in cancer patients-Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology. Eur J Cancer 67: 200-212

von Loeffelholz C, Horn P, Birkenfeld AL, Claus RA, Metzing BU, Doecke S, Jahreis G, Heller R, Hoppe S, Stockmann M, Lock JF, Rieger A, Weickert MO, Settmacher U, Rauchfuss F, Pfeiffer AFH, Bauer M, Sponholz C (2016) Fetuin A is a Predictor of Liver Fat in Preoperative Patients with Nonalcoholic Fatty Liver Disease. Journal of investigative surgery : the official journal of the Academy of Surgical Research 29: 266-274

Wang HJ, Hinney A, Song JY, Scherag A, Meng XR, Grallert H, Illig T, Hebebrand J, Wang Y, Ma J (2016) Association of common variants identified by recent genome-wide association studies with obesity in Chinese children: a case-control study. BMC medical genetics 17: 7

Weis S, Kaasch AJ, Rieg S, Loeffler B, Hagel S, Forstner C, Brunkhorst FM, Pletz MW (2016) Which antibiotic to choose? - In Reply. Dtsch Med Wochenschr 141: 675-676

Werner C, Pauli M, Doose S, Weishaupt A, Haselmann H, Grunewald B, Sauer M, Heckmann M, Toyka KV, Asan E, Sommer C, Geis C (2016) Human autoantibodies to amphiphysin induce defective presynaptic vesicle dynamics and composition. Brain : a journal of neurology 139: 365-379

Wintermann G-B, Weidner K, Strauss B, Rosendahl J, Petrowski K (2016) Predictors of posttraumatic stress and quality of life in family members of chronically critically ill patients after intensive care. Ann Intensive Care 6

Zimmermann HW, Bruns T, Weston CJ, Curbishley SM, Liaskou E, Li K-K, Resheq YJ, Badenhorst PW, Adams DH (2016) Bidirectional transendothelial migration of monocytes across hepatic sinusoidal endothelium shapes monocyte differentiation and regulates the balance between immunity and tolerance in liver. Hepatology 63: 233-246

Boettcher B, Palige K, Jacobsen ID, Hube B, Brunke S (2015) Csr1/Zap1 Maintains Zinc Homeostasis and Influences Virulence in Candida dubliniensis but Is Not Coupled to Morphogenesis. Eukaryot Cell 14: 661-670

Brandes S, Mokhtari Z, Essig F, Hunniger K, Kurzai O, Figge MT (2015) Automated segmentation and tracking of non-rigid objects in time-lapse microscopy videos of polymorphonuclear neutrophils. Med Image Anal 10.1016/j.media.2014.10.002

Brunke S, Quintin J, Kasper L, Jacobsen ID, Richter ME, Hiller E, Schwarzmuller T, d'Enfert C, Kuchler K, Rupp S, Hube B, Ferrandon D (2015) Of mice, flies - and men? Comparing fungal infection models for large-scale screening efforts. Disease Models & Mechanisms 10.1242/dmm.019901

Bruns T, Lutz P, Stallmach A, Nischalke HD (2015) Low ascitic fluid protein does not indicate an increased risk for spontaneous bacterial peritonitis in current cohorts. J Hepatol 10.1016/j.jhep.2015.03.040

Bruns T, Zimmermann HW, Pachnio A, Li KK, Trivedi PJ, Reynolds G, Hubscher S, Stamataki Z, Badenhors PW, Weston CJ, Moss PA, Adams DH (2015) CMV Infection of Human Sinusoidal Endothelium Regulates Hepatic T Cell Recruitment and Activation. J Hepatol 10.1016/j.jhep.2015.02.046

Cambau E, Bauer M (2015) Multi-pathogen real-time PCR system adds benefit for my patients: yes. Intensive Care Med 41: 528-530

Duggan S, Leonhardt I, Huenniger K, Kurzai O (2015) Host response to Candida albicans bloodstream infection and sepsis. Virulence 6: 316-326

Ekaney ML, Bockmeyer CL, Sossdorf M, Reuken PA, Conradi F, Schuerholz T, Blaess MF, Friedman SL, Losche W, Bauer M, Claus RA (2015) Preserved expression of mRNA coding von Willebrand factor-cleaving protease, ADAMTS13 by selenite and activated protein C. Molecular medicine 10.2119/molmed.2014.00202

Gabrielli E, Pericolini E, Luciano E, Sabbatini S, Roselletti E, Perito S, Kasper L, Hube B, Vecchiarelli A (2015) Induction of Caspase-11 by Aspartyl Proteinases of Candida albicans and Implication in Promoting Inflammatory Response. Infection and immunity 83: 1940-1948

Geis C, Ritter C, Ruschil C, Weishaupt A, Grunewald B, Stoll G, Holmoy T, Misu T, Fujihara K, Hemmer B, Stadelmann C, Bennett JL, Sommer C, Toyka KV (2015) The intrinsic pathogenic role of autoantibodies to aquaporin 4 mediating spinal cord disease in a rat passive-transfer model. Exp Neurol 265: 8-21

Goeb E, Reymann S, Langhauser F, Schuhmann MK, Kraft P, Thielmann I, Goebel K, Brede M, Homola G, Solymosi L, Stoll G, Geis C, Meuth SG, Nieswandt B, Kleinschnitz C (2015) Blocking of Plasma Kallikrein Ameliorates Stroke by Reducing Thromboinflammation. Ann Neurol 77: 784-803

Götz T, Milde T, Curio G, Debener S, Lehmann T, Leistritz L, Witte OW, Witte H, Haueisen J (2015) Primary somatosensory contextual modulation is encoded by oscillation frequency change. Clinical Neurophysiology 10.1016/j.clinph.2014.12.028

Grosse C, Bergner N, Dellith J, Heller R, Bauer M, Mellmann A, Popp J, Neugebauer U (2015) Label-free imaging and spectroscopic analysis of intracellular bacterial infections. Analytical Chemistry 87: 2137-2142

Hagel S, Reischke J, Kesselmeier M, Winning J, Gastmeier P, Brunkhorst FM, Scherag A, Pletz MW (2015) Quantifying the Hawthorne Effect in Hand Hygiene Compliance Through Comparing Direct Observation With Automated Hand Hygiene Monitoring. Infection Control and Hospital Epidemiology 10.1017/ice.2015.93: 1-6

Hartog CS, Benbenishty J (2015) Understanding nurse-physician conflicts in the ICU. Intensive Care Med 10.1007/s00134-014-3517-z

Hartog CS, Schwarzkopf D, Riedemann NC, Pfeifer R, Guenther A, Egerland K, Sprung CL, Hoyer H, Gensichen J, Reinhart K (2015) End-of-life care in the intensive care unit: A patient-based questionnaire of intensive care unit staff perception and relatives' psychological response. Palliat Med 29: 336-345

Haselmann H, Ropke L, Werner C, Kunze A, Geis C (2015) Interactions of Human Autoantibodies with Hippocampal GABAergic Synaptic Transmission - Analyzing Antibody-Induced Effects ex vivo. Front Neurol 6: 136-136

Heinekamp T, Schmidt H, Lapp K, Pahtz V, Shopova I, Koster-Eiserfunke N, Kruger T, Kniemeyer O, Brakhage AA (2015) Interference of Aspergillus fumigatus with the immune response. Seminars in Immunopathology 37: 141-152

Hube B, Hay R, Brasch J, Veraldi S, Schaller M (2015) Dermatomycoses and inflammation: The adaptive balance between growth, damage, and survival. J Myc Med 25: E44-E58

Huenniger K, Bieber K, Martin R, Lehnert T, Figge MT, Loeffler J, Guo R-F, Riedemann NC, Kurzai O (2015) A Second Stimulus Required for Enhanced Antifungal Activity of Human Neutrophils in Blood Is Provided by Anaphylatoxin C5a. J Immunol 194: 1199-1210

Joynt GM, Lipman J, Hartog C, Guidet B, Paruk F, Feldman C, Kissoon N, Sprung CL (2015) The Durban World Congress Ethics Round Table IV: health care professional end-of-life decision making. J Crit Care 30: 224-230

Karch A, Castell S, Schwab F, Geffers C, Bongartz H, Brunkhorst FM, Gastmeier P, Mikolajczyk RT (2015) Proposing an empirically justified reference threshold for blood culture sampling rates in intensive care units. Journal of Clinical Microbiology 53: 648-652

Klinger-Strobel M, Lautenschlager C, Fischer D, Mainz JG, Bruns T, Tuchscherr L, Pletz MW, Makarewicz O (2015) Aspects of pulmonary drug delivery strategies for infections in cystic fibrosis - where do we stand? Expert Opinion on Drug Delivery 10.1517/17425247.2015.1007949: 1-24

Knippenberg S, Ueberberg B, Maus R, Bohling J, Ding N, Tarres MT, Hoymann H-G, Jonigk D, Izykowski N, Paton JC, Ogunniyi AD, Lindig S, Bauer M, Welte T, Seeger W, Guenther A, Sisson TH, Gauldie J, Kolb M, Maus UA (2015) Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin. Thorax 70: 636-646

Kramer M, Quickert S, Sponholz C, Menzel U, Huse K, Platzer M, Bauer M, Claus RA (2015) Alternative Splicing of SMPD1 in Human Sepsis. PloS one 10

Kunze A, Achilles A, Keiner S, Witte OW, Redecker C (2015) Two distinct populations of doublecortin-positive cells in the perilesional zone of cortical infarcts. BMC Neuroscience 16

Lappchen CH, Ringer T, Blessin J, Schulz K, Seidel G, Lange R, Hamzei F (2015) Daily iTBS worsens hand motor training - A combined TMS, fMRI and mirror training study. NeuroImage 107: 257-265

Leonhardt I, Spielberg S, Weber M, Albrecht-Eckardt D, Blaess M, Claus R, Barz D, Scherlach K, Hertweck C, Loeffler J, Huenniger K, Kurzai O (2015) The Fungal Quorum-Sensing Molecule Farnesol Activates Innate Immune Cells but Suppresses Cellular Adaptive Immunity. mBio 6

Liu A, Weiss S, Fang H, Claus RA, Roedel J, Dirsch O, Dahmen U (2015) Lipopolysaccharide-binding protein (LBP) blockade augments the protective effect of granulocyte colony-stimulating factor (G-CSF) in a rat sepsis model. Shock 43: 497-503

Liu X, Hinney A, Scholz M, Scherag A, Tonjes A, Stumvoll M, Stadler PF, Hebebrand J, Bottcher Y (2015) Indications for Potential Parent-of-Origin Effects within the FTO Gene. PloS one 10: e0119206

Locke AE, Kahali B, Berndt SI, et al. (2015) Genetic studies of body mass index yield new insights for obesity biology. Nature 518: 197-206 (contributing CSCC member: Scherag A)

Matthaeus-Kraemer CT, Thomas-Rueddel DO, Schwarzkopf D, Rueddel H, Poidinger B, Reinhart K, Bloos F (2015) Barriers and supportive conditions to improve quality of care for critically ill patients: A team approach to quality improvement. J Crit Care 10.1016/j.jcrc.2015.03.022

Mayer K, Hahn-Ast C, Muckter S, Schmitz A, Krause S, Felder L, Bekeredjian-Ding I, Molitor E, Brossart P, von Lilienfeld-Toal M (2015) Comparison of antibiotic prophylaxis with cotrimoxazole/colistin (COT/COL) versus ciprofloxacin (CIP) in patients with acute myeloid leukemia. Supportive Care in Cancer 23: 1321-1329

Murahovschi V, Pivovarova O, Ilkavets I, Dmitrieva RM, Docke S, Keyhani-Nejad F, Gogebakan O, Osterhoff M, Kemper M, Hornemann S, Markova M, Kloting N, Stockmann M, Weickert MO, Lamounier-Zepter V, Neuhaus P, Konradi A, Dooley S, von Loeffelholz C, Bluher M, Pfeiffer AF, Rudovich N (2015) WISP1 is a novel adipokine linked to inflammation in obesity. Diabetes 10.2337/db14-0444

Nead KT, Li A, Wehner MR, Neupane B, Gustafsson S, Butterworth A, Engert JC, Davis AD, Hegele RA, Miller R, den Hoed M, Khaw KT, Kilpelainen TO, Wareham N, Edwards TL, Hallmans G, Varga TV, Kardia SL, Smith JA, Zhao W, Faul JD, Weir D, Mi J, Xi B, Quinteros SC, Cooper C, Sayer AA, Jameson K, Grontved A, Fornage M, Sidney S, Hanis CL, Highland HM, Haring HU, Heni M, Lasky-Su J, Weiss ST, Gerhard GS, Still C, Melka MM, Pausova Z, Paus T, Grant SF, Hakonarson H, Price RA, Wang K, Scherag A, Hebebrand J, Hinney A, BioBank Japan A-BMIGC, Franks PW, Frayling TM, McCarthy MI, Hirschhorn JN, Loos RJ, Ingelsson E, Gerstein HC, Yusuf S, Beyene J, Anand SS, Meyre D (2015) Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals. Human molecular genetics 10.1093/hmg/ddv097

Nussbaum C, Bannenberg S, Keul P, Graler MH, Goncalves-de-Albuquerque CF, Korhonen H, von Wnuck Lipinski K, Heusch G, de Castro Faria Neto HC, Rohwedder I, Gothert JR, Prasad VP, Haufe G, Lange-Sperandio B, Offermanns S, Sperandio M, Levkau B (2015) Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. Nature Communications 6: 6416

Otto GP, Grunwald B, Geis C, Kothe S, Hurtado-Oliveros J, Chung HY, Ekaney M, Bockmeyer CL, Sossdorf M, Busch M, Claus RA (2015) Impact of antibiotic treatment intensity on long-term sepsis-associated kidney injury in a polymicrobial peritoneal contamination and infection model. Nephron 129: 137-142

Otto GP, Hurtado-Oliveros J, Chung H-Y, Knoll K, Neumann T, Mueller HJ, Herbsleb M, Kohl M, Busch M, Sossdorf M, Claus RA (2015) Plasma Neutrophil Gelatinase-Associated Lipocalin Is Primarily Related to Inflammation during Sepsis: A Translational Approach. PloS one 10

Pers TH, Karjalainen JM, Chan Y, Westra HJ, Wood AR, Yang J, Lui JC, Vedantam S, Gustafsson S, Esko T, Frayling T, Speliotes EK, Genetic Investigation of ATC, Boehnke M, Raychaudhuri S, Fehrmann RS, Hirschhorn JN, Franke L (2015) Biological interpretation of genome-wide association studies using predicted gene functions. Nature Communications 6: 5890

Pivovarova O, von Loeffelholz C, Ilkavets I, Sticht C, Zhuk S, Murahovschi V, Lukowski S, Docke S, Kriebel J, de Las Heras Gala T, Malashicheva A, Kostareva A, Lock JF, Stockmann M, Grallert H, Gretz N, Dooley S, Pfeiffer AF, Rudovich N (2015) Modulation of insulin degrading enzyme activity and liver cell proliferation. Cell Cycle 10.1080/15384101.2015.1046647: 1-8

Raasch M, Rennert K, Jahn T, Peters S, Henkel T, Huber O, Schulz I, Becker H, Lorkowski S, Funke H, Mosig A (2015) Microfluidically supported biochip design for culture of endothelial cell layers with improved perfusion conditions. Biofabrication 7

Rautanen A, Mills TC, Gordon AC, Hutton P, Steffens M, Nuamah R, Chiche JD, Parks T, Chapman SJ, Davenport EE, Elliott KS, Bion J, Lichtner P, Meitinger T, Wienker TF, Caulfield MJ, Mein C, Bloos F, Bobek I, Cotogni P, Sramek V, Sarapuu S, Kobilay M, Ranieri VM, Rello J, Sirgo G, Weiss YG, Russwurm S, Schneider EM, Reinhart K, Holloway PA, Knight JC, Garrard CS, Russell JA, Walley KR, Stuber F, Hill AV, Hinds CJ, Investigators EEG (2015) Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. The Lancet Respiratory Medicine 3: 53-60

Reis H, Putter C, Megger DA, Bracht T, Weber F, Hoffmann AC, Bertram S, Wohlschlager J, Hagemann S, Eisenacher M, Scherag A, Schlaak JF, Canbay A, Meyer HE, Sitek B, Baba HA (2015) A structured proteomic approach identifies 14-3-3Sigma as a novel and reliable protein biomarker in panel based differential diagnostics of liver tumors. Biochimica et Biophysica Acta 10.1016/j.bbapap.2014.10.024

Schoeneweck F, Kuhnt E, Scholz M, Brunkhorst FM, Scherag A (2015) Common genomic variation in the FER gene: useful to stratify patients with sepsis due to pneumonia? Intensive Care Med 41: 1379-1381

Schroder UC, Beleites C, Assmann C, Glaser U, Hubner U, Pfister W, Fritzsche W, Popp J, Neugebauer U (2015) Detection of vancomycin resistances in enterococci within 3 (1/2) hours. Scientific Reports 5: 8217

Schwarzkopf D, Westermann I, Skupin H, Riedemann NC, Reinhart K, Pfeifer R, Fritzenwanger M, Guenther A, Witte OW, Hartog CS (2015) A novel questionnaire to measure staff perception of end-of-life decision making in the intensive care unit-Development and psychometric testing. J Crit Care 30: 187-195

Seidel RA, Kahnes M, Bauer M, Pohnert G (2015) Simultaneous determination of the bilirubin oxidation end products Z-BOX A and Z-BOX B in human serum using liquid chromatography coupled to tandem mass spectrometry. Journal of Chromatography B 974: 83-89

Shungin D, Winkler TW, Croteau-Chonka DC, et al. (2015) New genetic loci link adipose and insulin biology to body fat distribution. Nature 518: 187-196 (contributing CSCC member: Scherag A)

Silge A, Abdou E, Schneider K, Meisel S, Bocklitz T, Lu-Walther H-W, Heintzmann R, Roesch P, Popp J (2015) Shedding light on host niches: label-free in situ detection of Mycobacterium gordonae via carotenoids in macrophages by Raman microspectroscopy. Cellular microbiology 17: 832-842

Stein C, Makarewicz O, Bohnert JA, Pfeifer Y, Kesselmeier M, Hagel S, Pletz MW (2015) Three Dimensional Checkerboard Synergy Analysis of Colistin, Meropenem, Tigecycline against Multidrug-Resistant Clinical Klebsiella pneumonia Isolates. PloS one 10

Szafranski K, Kramer M (2015) It's a bit over, is that ok? The subtle surplus from tandem alternative splicing. RNA Biology 12: 115-122

Thiele M, Rabe S, Hessenkemper W, Roell D, Bartsch S, Kraft F, Abraham TE, Houtsmuller AB, van Royen ME, Giannis A, Baniahmad A (2015) Novel Nor-Homo- and Spiro-Oxetan- Steroids Target the Human Androgen Receptor and Act as Antiandrogens. Current Medicinal Chemistry 22: 1156-1167

Thomas-Rueddel DO, Poidinger B, Weiss M, Bach F, Dey K, Haberle H, Kaisers U, Ruddel H, Schadler D, Scheer C, Schreiber T, Schurholz T, Simon P, Sommerer A, Schwarzkopf D, Weyland A, Wobker G, Reinhart K, Bloos F, for the Medical Education for Sepsis Source C, Antibiotics study g (2015) Hyperlactatemia is an independent predictor of mortality and denotes distinct subtypes of severe sepsis and septic shock. J Crit Care 10.1016/j.jcrc.2014.10.027

Ullrich N, Heinemann A, Nilewski E, Scheffrahn I, Klode J, Scherag A, Schadendorf D, Singer BB, Helfrich I (2015) CEACAM1-3S Drives Melanoma Cells into NK Cell-Mediated Cytolysis and Enhances Patient Survival. Canc Res 75: 1897-1907

Urbach A, Brueckner J, Witte OW (2015) Cortical spreading depolarization stimulates gliogenesis in the rat entorhinal cortex. J Cereb Blood Flow Metab 35: 576-582

Vettorazzi S, Bode C, Dejager L, Frappart L, Shelest E, Klassen C, Tasdogan A, Reichardt HM, Libert C, Schneider M, Weih F, Henriette Uhlenhaut N, David JP, Graler M, Kleiman A, Tuckermann JP (2015) Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1. Nature Communications 6: 7796

Vry MS, Tritschler LC, Hamzei F, Rijntjes M, Kaller CP, Hoeren M, Umarova R, Glauche V, Hermsdoerfer J, Goldenberg G, Hennig J, Weiller C (2015) The ventral fiber pathway for pantomime of object use. NeuroImage 106: 252-263

Weis S, Bielow T, Sommerer I, Iovanna J, Malicet C, Moessner J, Hoffmeister A (2015) P8 deficiency increases cellular ROS and induces HO-1. Arch Biochem Biophys 565: 89-94

Weis S, Franke A, Berg T, Moessner J, Fleig WE, Schoppmeyer K (2015) Percutaneous ethanol injection or percutaneous acetic acid injection for early hepatocellular carcinoma. Cochrane Database of Systematic Reviews 10.1002/14651858.CD006745.pub3

Wintermann GB, Brunkhorst FM, Petrowski K, Strauss B, Oehmichen F, Pohl M, Rosendahl J (2015) Stress Disorders Following Prolonged Critical Illness in Survivors of Severe Sepsis. Crit Care Med 10.1097/CCM.0000000000000936

Augsten M, Bottcher A, Spanbroek R, Rubio I, Friedrich K (2014) Graded inhibition of oncogenic Ras-signaling by multivalent Ras-binding domains. Cell Communication and Signaling 12: 1

Axer H, Rosendahl J, Brunkhorst FM (2014) [Neurological and psychological long-term effects of sepsis]. Medizinische Klinik, Intensivmedizin und Notfallmedizin 109: 596-603

Bacher P, Kniemeyer O, Teutschbein J, Thon M, Vodisch M, Wartenberg D, Scharf DH, Koester-Eiserfunke N, Schutte M, Dubel S, Assenmacher M, Brakhage AA, Scheffold A (2014) Identification of immunogenic antigens from Aspergillus fumigatus by direct multiparameter characterization of specific conventional and regulatory CD4+ T cells. J Immunol 193: 3332-3343

Bauer M, Kiehntopf M (2014) Shades of yellow - monitoring nutritional needs and hepatobiliary function in the critically ill. Hepatology 10.1002/hep.27076

Bayry J, Beaussart A, Dufrene YF, Sharma M, Bansal K, Kniemeyer O, Aimanianda V, Brakhage AA, Kaveri SV, Kwon-Chung KJ, Latge JP, Beauvais A (2014) Surface structure characterization of Aspergillus fumigatus conidia mutated in the melanin synthesis pathway and their human cellular immune response. Infection and Immunity 82: 3141-3153

Biskup C, Rubio I (2014) Real-time visualization and quantification of native Ras activation in single living cells. Methods Mol Biol 1120: 285-305

Blessin J, Hamzei F (2014) A New Approach in Neurorehabilitation – The Role of the Mirror Neuron System. Eur Neurol Rev 9: 60-63

Bloos F, Senderrek M, Bauer M (2014) Sensitivity of Blood Culture vs Polymerase Chain Reaction for Skin Contaminants in Specimen Retrieved via the Distal Lumen of Seldinger-Guided Central Venous Catheters. Chest 145: 430-431

Bloos F, Thomas-Ruddel D, Ruddel H, Engel C, Schwarzkopf D, Marshall JC, Harbarth S, Simon P, Riessen R, Keh D, Dey K, Weiss M, Toussaint S, Schadler D, Weyland A, Ragaller M, Schwarzkopf K, Eiche J, Kuhnle G, Hoyer H, Hartog C, Kaisers U, Reinhart K (2014) Impact of compliance with infection management guidelines on outcome in patients with severe sepsis: a prospective observational multi-center study. Crit Care 18: R42

Blume KR, Dietrich C, Huonker R, Gotz T, Sens E, Friedel R, Hofmann GO, Miltner WH, Weiss T (2014) Cortical reorganization after macroreplantation at the upper extremity: a magnetoencephalographic study. Brain : a journal of neurology 137: 757-769

Bode C, Berlin M, Röstel F, Teichmann B, Gräler MH (2014) Evaluating Sphingosine and its Analogues as Potential Alternatives for Aggressive Lymphoma Treatment. Cellular Physiology and Biochemistry 34: 1686-1700

Bohlender C, Glaser S, Klein M, Weisser J, Thein S, Neugebauer U, Popp J, Wyrwa R, Schiller A (2014) Light-triggered CO release from nanoporous non-wovens. J Materials Chem B 2: 1454-1463

Brämer D, Hoyer D (2014) Herzfrequenzvariabilität als Marker Schlaganfall-assoziierter Infektionen. Neurophysiol Lab 36: 23-32

Bramer D, Hoyer H, Gunther A, Nowack S, Brunkhorst FM, Witte OW, Hoyer D (2014) Study protocol: prediction of stroke associated infections by markers of autonomic control. BMC neurology 14: 9

Braun SD, Monecke S, Thurmer A, Ruppelt A, Makarewicz O, Pletz M, Reibetaig A, Slickers P, Ehricht R (2014) Rapid identification of carbapenemase genes in gram-negative bacteria with an oligonucleotide microarray-based assay. PloS one 9: e102232

Brunke S, Hube B (2014) Adaptive prediction as a strategy in microbial infections. PLoS Pathog 10: e1004356

Brunke S, Seider K, Fischer D, Jacobsen ID, Kasper L, Jablonowski N, Wartenberg A, Bader O, Enache-Angoulvant A, Schaller M, d'Enfert C, Hube B (2014) One Small Step for a Yeast - Microevolution within Macrophages Renders Candida glabrata Hypervirulent Due to a Single Point Mutation. PLoS Pathog 10: e1004478

Brunke S, Seider K, Richter ME, Bremer-Streck S, Ramachandra S, Kiehntopf M, Brock M, Hube B (2014) Histidine degradation via an aminotransferase increases the nutritional flexibility of Candida glabrata. Eukaryot Cell EC.00072-14 [pii] 10.1128/EC.00072-14

Brunkhorst FM (2014) Antibiotikatherapie bei Sepsis--immer maximal "breit" behandeln? Drug Res 64: 9-10

Brunkhorst FM, Patchev V (2014) [Sepsis-associated Purpura Fulminans International Registry-Europe (SAPFIRE).]. Medizinische Klinik, Intensivmedizin und Notfallmedizin 10.1007/s00063-014-0402-z

Bruns T, Zimmermann HW, Stallmach A (2014) Risk factors and outcome of bacterial infections in cirrhosis. World journal of gastroenterology : WJG 20: 2542-2554

Donat CK, Fischer F, Walter B, Deuther-Conrad W, Brodhun M, Bauer R, Brust P (2014) Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet. Acta neurobiologiae experimentalis 74: 197-210

Donat CK, Fischer F, Walter B, Kayser T, Deuther-Conrad W, Brodhun M, Bauer R, Brust P (2014) Early increase of cannbinoid receptor density after experimental traumatic brain injury in the newborn piglet. Acta neurobiologiae experimentalis 74: 1-15

Dorner L, Schwarzkopf D, Skupin H, Philipp S, Gugel K, Meissner W, Schuler S, Hartog CS (2014) Teaching medical students to talk about death and dying in the ICU: feasibility of a peer-tutored workshop. Intensive Care Med 10.1007/s00134-014-3541-z

Ekaney M, Otto GP, Sossdorf M, Sponholz C, Boehringer M, Loesche W, Rittirsch D, Wilharm A, Kurzai O, Bauer M, Claus RA (2014) Impact of plasma histones in human sepsis and their contribution to cellular injury and inflammation. Crit Care 18: 543

Ene IV, Brunke S, Brown AJ, Hube B (2014) Metabolism in Fungal Pathogenesis. Cold Spring Harbor perspectives in medicine 10.1101/cshperspect.a019695

Ewald C, Duenisch P, Walter J, Gotz T, Witte OW, Kalff R, Gunther A (2014) Bone flap necrosis after decompressive hemicraniectomy for malignant middle cerebral artery infarction. Neurocritical care 20: 91-97

Fischer D, Hube B, Brunke S (2014) Fine-Scale Chromosomal Changes in Fungal Fitness. Current Fungal Infection Reports 8: 171-178

Frister A, Schmidt C, Schneble N, Brodhun M, Gonnert FA, Bauer M, Hirsch E, Muller JP, Wetzker R, Bauer R (2014) Phosphoinositide 3-Kinase gamma Affects LPS-Induced Disturbance of Blood-Brain Barrier Via Lipid Kinase-Independent Control of cAMP in Microglial Cells. Neuromolecular medicine 10.1007/s12017-014-8320-z

Galler K, Brautigam K, Grosse C, Popp J, Neugebauer U (2014) Making a big thing of a small cell--recent advances in single cell analysis. The Analyst 139: 1237-1273

Galler K, Schleser F, Frohlich E, Requardt RP, Kortgen A, Bauer M, Popp J, Neugebauer U (2014) Exploitation of the hepatic stellate cell Raman signature for their detection in native tissue samples. Integrative biology : quantitative biosciences from nano to macro 6: 946-956

Geis C (2014) Effects of pooled human immunoglobulins in an animal model of neuromyelitis optica with chronic application of autoantibodies to aquaporin 4. Clinical and experimental immunology 178 Suppl 1: 130-131

Geissler K, Bohne S, Siggel R, Sachse S, Kiehntopf M, Bauer M, Straube E, Guntinas-Lichius O (2014) Preoperative serum pattern analysis to predict the outcome of tonsillectomy in adults with chronic tonsillitis. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies 10.1007/s00405-014-3084-5

Giamarellos-Bourboulis EJ (2014) Should we be moving from suppression to stimulation to deal with immunoparalysis in sepsis patients? Immunotherapy 6: 113-115

Gondan M, Blurton SP, Kesselmeier M (2014) Even faster and even more accurate first-passage time densities and distributions for the Wiener diffusion model. J Math Psychol 60: 20-22

Götz T, Günther A, Witte OW, Brunkhorst FM, Seidel G, Hamzei F (2014) Long-term sequelae of severe sepsis: cognitive impairment and structural brain alterations - an MRI study (LossCog MRI). BMC neurology 14: 145

Götz T, Huonker R, Witte OW, Haueisen J (2014) Thalamocortical Impulse Propagation and Information Transfer in EEG and MEG. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 31: 253-260

Griewank KG, Murali R, Puig-Butille JA, Schilling B, Livingstone E, Potrony M, Carrera C, Schimming T, Moller I, Schwamborn M, Sucker A, Hillen U, Badenas C, Malvehy J, Zimmer L, Scherag A, Puig S, Schadendorf D (2014) TERT promoter mutation status as an independent prognostic factor in cutaneous melanoma. Journal of the National Cancer Institute 106

Grimm A, Axer H (2014) Hochauflösender Ultraschall in der Darstellung des Plexus brachialis und der zervikalen Nervenwurzeln. Neurophysiol Lab 36: 135-146

Grimm A, Decard BF, Bischof A, Axer H (2014) Ultrasound of the peripheral nerves in systemic vasculitic neuropathies. Journal of the neurological sciences 347: 44-49

Grimm A, Heiling B, Schumacher U, Witte OW, Axer H (2014) Ultrasound differentiation of axonal and demyelinating neuropathies. Muscle & nerve 50: 976-983

Grimm A, Heiling B, Witte OW, Axer H (2014) Nervenultraschall bei Polyneuropathie - sinnvoll oder nicht? Neurophysiol Lab

Grunewald B, Geis C (2014) Measuring spinal presynaptic inhibition in mice by dorsal root potential recording in vivo. Journal of visualized experiments : JoVE 10.3791/51473

Hagel S, Bruns T, Pletz MW, Engel C, Kalff R, Ewald C (2014) External ventricular drain infections: risk factors and outcome. Interdisciplinary perspectives on infectious diseases 2014: 708531

Hartog C, Bloos F (2014) Venous oxygen saturation. Best practice & research Clinical anaesthesiology 28: 419-428

Hartog CS, Natanson C, Sun J, Klein HG, Reinhart K (2014) Concerns over use of hydroxyethyl starch solutions. Brit Med J 349

Hartog CS, Peschel I, Schwarzkopf D, Curtis JR, Westermann I, Kabisch B, Pfeifer R, Guenther A, Michalsen A, Reinhart K (2014) Are written advance directives helpful to guide end-of-life therapy in the intensive care unit? A retrospective matched-cohort study. J Crit Care 29: 128-133

Hattersley JG, Pfeiffer AF, Roden M, Petzke KJ, Hoffmann D, Rudovich NN, Randeva HS, Vatish M, Osterhoff M, Goegebakan O, Hornemann S, Nowotny P, Machann J, Hierholzer J, von Loeffelholz C, Mohlig M, Arafat AM, Weickert MO (2014) Modulation of amino acid metabolic signatures by supplemented isoenergetic diets differing in protein and cereal fiber content. The Journal of clinical endocrinology and metabolism 10.1210/jc.2014-2302: jc20142302

Hebecker B, Naglik JR, Hube B, Jacobsen ID (2014) Pathogenicity mechanisms and host response during oral Candida albicans infections. Expert Rev Anti Infect Ther 10.1586/14787210.2014.916210

Henry BD, Neill DR, Becker KA, Gore S, Bricio-Moreno L, Ziobro R, Edwards MJ, Muhlemann K, Steinmann J, Kleuser B, Japtok L, Luginbuhl M, Wolfmeier H, Scherag A, Gulbins E, Kadioglu A, Draeger A, Babiychuk EB (2014) Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice. Nature biotechnology 10.1038/nbt.3037

Heyl KA, Klassert TE, Heinrich A, Muller MM, Klaile E, Dienemann H, Grunewald C, Bals R, Singer BB, Slevogt H (2014) Dectin-1 is expressed in human lung and mediates the proinflammatory immune response to nontypeable Haemophilus influenzae. mBio 5: e01492-01414

Hillmann F, Linde J, Beckmann N, Cyrulies M, Strassburger M, Heinekamp T, Haas H, Guthke R, Kniemeyer O, Brakhage AA (2014) The novel globin protein fungoglobin is involved in low oxygen adaptation of Aspergillus fumigatus. Molecular microbiology 93: 539-553

Hinney A, Albayrak O, Antel J, Volckmar AL, Sims R, Chapman J, Harold D, Gerrish A, Heid IM, Winkler TW, Scherag A, Wiltfang J, Williams J, Hebebrand J, Consortium G, Consortium I, Consortium G (2014) Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity. American journal of medical genetics Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 10.1002/ajmg.b.32234

Hoggart CJ, Venturini G, Mangino M, Gomez F, Ascari G, Zhao JH, Teumer A, Winkler TW, Tsernikova N, Luan J, Mihailov E, Ehret GB, Zhang W, Lamparter D, Esko T, Mace A, Rueger S, Bochud PY, Barcella M, Dauvilliers Y, Benyamin B, Evans DM, Hayward C, Lopez MF, Franke L, Russo A, Heid IM, Salvi E, Vendantam S, Arking DE, Boerwinkle E, Chambers JC, Fiorito G, Grallert H, Guarrera S, Homuth G, Huffman JE, Porteous D, Generation Scotland C, LifeLines Cohort s, Consortium G, Moradpour D, Iranzo A, Hebebrand J, Kemp JP, Lammers GJ, Aubert V, Heim MH, Martin NG, Montgomery GW, Peraita-Adrados R, Santamaria J, Negro F, Schmidt CO, Scott RA, Spector TD, Strauch K, Volzke H, Wareham NJ, Yuan W, Bell JT, Chakravarti A, Kooner JS, Peters A, Matullo G, Wallaschofski H, Whitfield JB, Paccaud F, Vollenweider P, Bergmann S, Beckmann JS, Tafti M, Hastie ND, Cusi D, Bochud M, Frayling TM, Metspalu A, Jarvelin MR, Scherag A, Smith GD, Borecki IB, Rousson V, Hirschhorn JN, Rivolta C, Loos RJ, Kutalik Z (2014) Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index. PLoS genetics 10: e1004508

Hoppe S, von Loeffelholz C, Lock JF, Doecke S, Sinn BV, Rieger A, Malinowski M, Pfeiffer AFH, Neuhaus P, Stockmann M (2014) Nonalcoholic Steatohepatits and Liver Steatosis Modify Partial Hepatectomy Recovery. Journal of investigative surgery : the official journal of the Academy of Surgical Research

InanlooRahatloo K, Parsa AF, Huse K, Rasooli P, Davaran S, Platzer M, Kramer M, Fan JB, Turk C, Amini S, Steemers F, Gunderson K, Ronaghi M, Elahi E (2014) Mutation in ST6GALNAC5 identified in family with coronary artery disease. Scientific reports 4: 3595

Jacobsen ID, Luttich A, Kurzai O, Hube B, Brock M (2014) In vivo imaging of disseminated murine Candida albicans infection reveals unexpected host sites of fungal persistence during antifungal therapy. The Journal of antimicrobial chemotherapy 69: 2785-2796

Jbeily N, Claus RA, Dahlke K, Neugebauer U, Bauer M, Gonnert FA (2014) Comparative suitability of CFDA-SE and rhodamine 6G for in vivo assessment of leukocyte-endothelium interactions. J Biophotonics 7: 369-375

Joerk A, Seidel RA, Walter SG, Wiegand A, Kahnes M, Klopfleisch M, Kirmse K, Pohnert G, Westerhausen M, Witte OW, Holthoff K (2014) Impact of heme and heme degradation products on vascular diameter in mouse visual cortex. Journal of the American Heart Association 3

Karaca I, Tamboli IY, Glebov K, Richter J, Fell LH, Grimm MO, Haupenthal VJ, Hartmann T, Graler MH, van Echten-Deckert G, Walter J (2014) Deficiency of Sphingosine-1-phosphate Lyase Impairs Lysosomal Metabolism of the Amyloid Precursor Protein. The Journal of biological chemistry 289: 16761-16772

Karner M, Kocjan A, Stein J, Schreiber S, von Boyen G, Uebel P, Schmidt C, Kupcinskas L, Dina I, Zuelch F, Keilhauer G, Stremmel W (2014) First Multicenter Study of Modified Release Phosphatidylcholine "LT-02" in Ulcerative Colitis: A Randomized, Placebo-Controlled Trial in Mesalazine-Refractory Courses. The American journal of gastroenterology 10.1038/ajg.2014.104

Kasper L, Seider K, Gerwien F, Allert S, Brunke S, Schwarzmuller T, Ames L, Zubiria-Barrera C, Mansour MK, Becken U, Barz D, Vyas JM, Reiling N, Haas A, Haynes K, Kuchler K, Hube B (2014) Identification of Candida glabrata Genes Involved in pH Modulation and Modification of the Phagosomal Environment in Macrophages. PloS one 9: e96015

Kesselmeier M, Legrand C, Peil B, Kabisch M, Fischer C, Hamann U, Bermejo JL (2014) Practical investigation of the performance of robust logistic regression to predict the genetic risk of hypertension. BMC Proceedings 8: S65

Klassert TE, Hanisch A, Brauer J, Klaile E, Heyl KA, Mansour MM, Tam JM, Vyas JM, Slevogt H (2014) Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes. Med Microbiol Immunol 10.1007/s00430-014-0351-4

Klein M, Neugebauer U, Gheisari A, Malassa A, Jazzazi TM, Froehlich F, Westerhausen M, Schmitt M, Popp J (2014) IR spectroscopic methods for the investigation of the CO release from CORMs. The journal of physical chemistry A 118: 5381-5390

Kool M, Jones DT, Jager N, Northcott PA, Pugh TJ, Hovestadt V, Piro RM, Esparza LA, Markant SL, Remke M, Milde T, Bourdeaut F, Ryzhova M, Sturm D, Pfaff E, Stark S, Hutter S, Seker-Cin H, Johann P, Bender S, Schmidt C, Rausch T, Shih D, Reimand J, Sieber L, Wittmann A, Linke L, Witt H, Weber UD, Zapatka M, Konig R, Beroukhim R, Bergthold G, van Sluis P, Volckmann R, Koster J, Versteeg R, Schmidt S, Wolf S, Lawerenz C, Bartholomae CC, von Kalle C, Unterberg A, Herold-Mende C, Hofer S, Kulozik AE, von Deimling A, Scheurlen W, Felsberg J, Reifenberger G, Hasselblatt M, Crawford JR, Grant GA, Jabado N, Perry A, Cowdrey C, Croul S, Zadeh G, Korbel JO, Doz F, Delattre O, Bader GD, McCabe MG, Collins VP, Kieran MW, Cho YJ, Pomeroy SL, Witt O, Brors B, Taylor MD, Schuller U, Korshunov A, Eils R, Wechsler-Reya RJ, Lichter P, Pfister SM, Project IPT (2014) Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. Cancer cell 25: 393-405

Kortgen A (2014) Surrogates of peripheral microcirculation to predict weaning failure, yet another piece of the puzzle. Minerva anestesiologica 80: 1156-1157

Kroll K, Pahtz V, Hillmann F, Vaknin Y, Schmidt-Heck W, Roth M, Jacobsen ID, Osherov N, Brakhage AA, Kniemeyer O (2014) Identification of hypoxia-inducible target genes of Aspergillus fumigatus by transcriptome analysis reveals cellular respiration as an important contributor to hypoxic survival. Eukaryot Cell 13: 1241-1253

Kruse M, von Loeffelholz C, Hoffmann D, Pohlmann A, Seltmann AC, Osterhoff M, Hornemann S, Pivovarova O, Rohn S, Jahreis G, Pfeiffer AF (2014) Dietary rapeseed/canola oil supplementation reduces serum lipids and liver enzymes and alters postprandial inflammatory responses in adipose tissue compared to olive oil supplementation in obese men. Molecular nutrition & food research 10.1002/mnfr.201400446

Kumar V, Cheng SC, Johnson MD, Smeekens SP, Wojtowicz A, Giamarellos-Bourboulis E, Karjalainen J, Franke L, Withoff S, Plantinga TS, van de Veerdonk FL, van der Meer JW, Joosten LA, Sokol H, Bauer H, Herrmann BG, Bochud PY, Marchetti O, Perfect JR, Xavier RJ, Kullberg BJ, Wijmenga C, Netea MG (2014) Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia. Nature communications 5: 4675

Kunze A, Drescher R, Kaiser K, Freesmeyer M, Witte OW, Axer H (2014) Serial FDG PET/CT in autoimmune encephalitis with faciobrachial dystonic seizures. Clinical nuclear medicine 39: e436-438

Lapp K, Vodisch M, Kroll K, Strassburger M, Kniemeyer O, Heinekamp T, Brakhage AA (2014) Characterization of the Aspergillus fumigatus detoxification systems for reactive nitrogen intermediates and their impact on virulence. Front Microbiol 5: 469

Liaskou E, Jeffery LE, Trivedi PJ, Reynolds GM, Suresh S, Bruns T, Adams DH, Sansom DM, Hirschfield GM (2014) Loss of CD28 Expression by Liver-infiltrating T cells Contributes to Pathogenesis of Primary Sclerosing Cholangitis. Gastroenterology 10.1053/j.gastro.2014.04.003

Licht V, Noack K, Schlott B, Forster M, Schlenker Y, Licht A, Kramer OH, Heinzel T (2014) Caspase-3 and Caspase-6 cleave STAT1 in leukemic cells. Oncotarget 5: 2305-2317

Lynen Jansen P, Stallmach A, Lohse AW, Lerch MM (2014) [Development of Gastrointestinal Infectious Diseases between 2000 and 2012]. Zeitschrift fur Gastroenterologie 52: 549-557

Malkewitz A, Makarewicz O, Kentouche K, Keller P, Karrasch M, Pletz MW (2014) Epstein-Barr Virus MicroRNAs in plasma as potential biomarkers for chronic infections: (response to: Kawano et al; The Journal of Infectious Diseases; 2013; 208:771-9). The Journal of infectious diseases 209: 1297-1298

Mancini M, Soldovieri MV, Gessner G, Wissuwa B, Barrese V, Boscia F, Secondo A, Miceli F, Franco C, Ambrosino P, Canzoniero LM, Bauer M, Hoshi T, Heinemann SH, Taglialatela M (2014) Critical role of large-conductance calcium- and voltage-activated potassium channels in leptin-induced neuroprotection of N-methyl-d-aspartate-exposed cortical neurons. Pharmacological research : the official journal of the Italian Pharmacological Society 87: 80-86

Markwart R, Condotta SA, Requardt RP, Borken F, Schubert K, Weigel C, Bauer M, Griffith TS, Forster M, Brunkhorst FM, Badovinac VP, Rubio I (2014) Immunosuppression after sepsis: systemic inflammation and sepsis induce a loss of naive T-cells but no enduring cell-autonomous defects in T-cell function. PloS one 9: e115094

Mayerl S, Muller J, Bauer R, Richert S, Kassmann CM, Darras VM, Buder K, Boelen A, Visser TJ, Heuer H (2014) Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis. The Journal of clinical investigation 124: 1987-1999

Mech F, Wilson D, Lehnert T, Hube B, Thilo Figge M (2014) Epithelial invasion outcompetes hypha development during Candida albicans infection as revealed by an image-based systems biology approach. Cytometry Part A : the journal of the International Society for Analytical Cytology 85: 126-139

Mehlhorn J, Freytag A, Schmidt K, Brunkhorst FM, Graf J, Troitzsch U, Schlattmann P, Wensing M, Gensichen J (2014) Rehabilitation Interventions for Postintensive Care Syndrome: A Systematic Review. Crit Care Med 10.1097/CCM.0000000000000148

Miramon P, Dunker C, Kasper L, Jacobsen ID, Barz D, Kurzai O, Hube B (2014) A family of glutathione peroxidases contributes to oxidative stress resistance in Candida albicans. Medical mycology : official publication of the International Society for Human and Animal Mycology 52: 223-239

Munchberg U, Rosch P, Bauer M, Popp J (2014) Raman spectroscopic identification of single bacterial cells under antibiotic influence. Analytical and bioanalytical chemistry 406: 3041-3050

Neugebauer U, Kurz C, Bocklitz T, Berger T, Velten T, Clement JH, Krafft C, Popp J (2014) Raman-Spectroscopy Based Cell Identification on a Microhole Array Chip. Micromachines 5: 204-215

Neugebauer U, Trenkmann S, Bocklitz T, Schmerler D, Kiehntopf M, Popp J (2014) Fast differentiation of SIRS and sepsis from blood plasma of ICU patients using Raman spectroscopy. J Biophotonics 7: 232-240

Otto GP, Sossdorf M, Breuel H, Schlattmann P, Bayer O, Claus RA, Riedemann NC, Busch M (2014) Renal outcome after vancomycin treatment and renal replacement therapy in patients with severe sepsis and septic shock: a retrospective study. J Crit Care 29: 656-661

Paruk F, Kissoon N, Hartog CS, Feldman C, Hodgson ER, Lipman J, Guidet B, Du B, Argent A, Sprung CL (2014) The Durban World Congress Ethics Round Table Conference Report: III. Withdrawing Mechanical ventilation-the approach should be individualized. J Crit Care 29: 902-907

Piro RM, Wiesberg S, Schramm G, Rebel N, Oswald M, Eils R, Reinelt G, Konig R (2014) Network topology-based detection of differential gene regulation and regulatory switches in cell metabolism and signaling. BMC systems biology 8: 56

Pletz MW, Terkamp C, Schumacher U, Rohde G, Schütte H, Welte T, Bals R (2014) Vitamin D deficiency in community-acquired pneumonia: low levels of 1,25(OH)2 D are associated with disease severity. Respiratory research 15: 53

Prell T, Schenk A, Witte OW, Grosskreutz J, Gunther A (2014) Transcranial brainstem sonography as a diagnostic tool for amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis & frontotemporal degeneration 15: 244-249

Press AT, Traeger A, Pietsch C, Mosig A, Wagner M, Clemens MG, Jbeily N, Koch N, Gottschaldt M, Beziere N, Ermolayev V, Ntziachristos V, Popp J, Kessels MM, Qualmann B, Schubert US, Bauer M (2014) Cell type-specific delivery of short interfering RNAs by dye-functionalised theranostic nanoparticles. Nature communications 5: 5565

Quintin J, Voigt J, Voort RV, Jacobsen ID, Verschueren I, Hube B, Giamarellos-Bourboulis EJ, Meer JW, Joosten LA, Kurzai O, Netea MG (2014) Differential role of NK cells against Candida albicans infection in immunocompetent or immunocompromised mice. European journal of immunology 10.1002/eji.201343828

Ramachandra S, Linde J, Brock M, Guthke R, Hube B, Brunke S (2014) Regulatory networks controlling nitrogen sensing and uptake in Candida albicans. PloS one 9: e92734

Reuken PA, Kussmann A, Kiehntopf M, Budde U, Stallmach A, Claus RA, Bruns T (2014) Imbalance of von Willebrand factor and its cleaving protease ADAMTS13 during systemic inflammation superimposed on advanced cirrhosis. Liver Int 10.1111/liv.12657

Rosendahl J, Axer H (2014) Langzeitfolgen der Sepsis – Posttraumatische Belastungsstörung, kognitive Dysfunktion, neuromuskuläre Schwäche [Long term-effects of sepsis – Post traumatic stress disorder, cognitive dysfunction, neuromuscular weakness]. Klinikarzt 43: 314-319

Schacht T, Oswald M, Eils R, Eichmuller SB, Konig R (2014) Estimating the activity of transcription factors by the effect on their target genes. Bioinformatics 30: i401-407

Schafer ST, Gessner S, Scherag A, Rump K, Frey UH, Siffert W, Westendorf AM, Steinmann J, Peters J, Adamzik M (2014) Hydrocortisone fails to abolish NF-kappaB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock. PloS one 9: e104953

Schleenvoigt BT, Fobiwe JP, Keller PM, Hagel S, Pletz MW (2014) HIV post exposure prophylaxis induced bicytopenia: a case report. AIDS research and therapy 11: 11

Schleenvoigt BT, Gajda M, Baier M, Groten T, Oppel-Heuchel H, Grimm MO, Pfister W, Richter J, Pletz MW (2014) Placental Schistosoma haematobium infection in a German returnee from Malawi. Infection 10.1007/s15010-014-0684-3

Schmidt B, Dragano N, Scherag A, Pechlivanis S, Hoffmann P, Nothen MM, Erbel R, Jockel KH, Moebus S (2014) Exploring genetic variants predisposing to diabetes mellitus and their association with indicators of socioeconomic status. BMC public health 14: 609

Schmidt K, Thiel P, Mueller F, Schmuecker K, Worrack S, Mehlhorn J, Engel C, Brenk-Franz K, Kausche S, Jakobi U, Bindara-Klippel A, Schneider N, Freytag A, Davydow D, Wensing M, Brunkhorst FM, Gensichen J (2014) Sepsis survivors monitoring and coordination in outpatient health care (SMOOTH): study protocol for a randomized controlled trial. Trials 15: 283

Schulz A, Walther C, Morrison H, Bauer R (2014) In vivo electrophysiological measurements on mouse sciatic nerves. Journal of visualized experiments : JoVE 10.3791/51181

Schwarzmuller T, Ma B, Hiller E, Istel F, Tscherner M, Brunke S, Ames L, Firon A, Green B, Cabral V, Marcet-Houben M, Jacobsen ID, Quintin J, Seider K, Frohner I, Glaser W, Jungwirth H, Bachellier-Bassi S, Chauvel M, Zeidler U, Ferrandon D, Gabaldon T, Hube B, d'Enfert C, Rupp S, Cormack B, Haynes K, Kuchler K (2014) Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes. PLoS Pathog 10: e1004211

Seidel RA, Schowtka B, Klopfleisch M, Küh T, Weiland A, Koch A, Görls H, Imhof D, Pohnert G, Westerhausen M (2014) Total synthesis and characterization of the bilirubin oxidation product (Z)-2-(4-ethenyl-3-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)ethanamide (Z-BOX B). Tetrahedron Letters 55: 6526-6529

Seider K, Gerwien F, Kasper L, Allert S, Brunke S, Jablonowski N, Schwarzmuller T, Barz D, Rupp S, Kuchler K, Hube B (2014) Immune evasion, stress resistance, and efficient nutrient acquisition are crucial for intracellular survival of Candida glabrata within macrophages. Eukaryot Cell 13: 170-183

Sponholz C, Bayer O, Kabisch B, Wurm K, Ebert K, Bauer M, Kortgen A (2014) Anticoagulation strategies in venovenous hemodialysis in critically ill patients: a five-year evaluation in a surgical intensive care unit. TheScientificWorldJournal 2014: 808320

Sponholz C, Gonnert FA, Kortgen A, Bauer M (2014) [Monitoring of liver function in the critically ill]. Anaesthesist 63: 603-612; quiz 613-604

Sponholz C, Schelenz C, Reinhart K, Schirmer U, Stehr SN (2014) Catecholamine and volume therapy for cardiac surgery in Germany--results from a postal survey. PloS one 9: e103996

Sponholz C, Settmacher U, Bauer M, Kortgen A (2014) Regional Citrate Anticoagulation for Continuous Renal Replacement Therapy in the Perioperative Care of Liver Transplant Recipients: A Single Center Experience. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 10.1111/1744-9987.12196

Sprung CL, Paruk F, Kissoon N, Hartog CS, Lipman J, Du B, Argent A, Hodgson RE, Guidet B, Groeneveld AB, Feldman C (2014) The Durban World Congress Ethics Round Table Conference Report: I. Differences between withholding and withdrawing life-sustaining treatments. J Crit Care 29: 890-895

Sprung CL, Truog RD, Curtis JR, Joynt GM, Baras M, Michalsen A, Briegel J, Kesecioglu J, Efferen L, De Robertis E, Bulpa P, Metnitz P, Patil N, Hawryluck L, Manthous C, Moreno R, Leonard S, Hill NS, Wennberg E, McDermid RC, Mikstacki A, Mularski RA, Hartog CS, Avidan A (2014) Seeking Worldwide Professional Consensus on the Principles of End-of-Life Care for the Critically Ill. The Consensus for Worldwide End-of-Life Practice for Patients in Intensive Care Units (WELPICUS) Study. American journal of respiratory and critical care medicine 190: 855-866

Stewardson AJ, Harbarth S, Graves N, Group TS (2014) Valuation of hospital bed-days released by infection control programs: a comparison of methods. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America 35: 1294-1297

Stubendorff B, Finke S, Walter M, Kniemeyer O, von Eggeling F, Gruschwitz T, Steiner T, Ott U, Wolf G, Wunderlich H, Junker K (2014) Urine protein profiling identified alpha-1-microglobulin and haptoglobin as biomarkers for early diagnosis of acute allograft rejection following kidney transplantation. World journal of urology 32: 1619-1624

Suratanee A, Schaefer MH, Betts MJ, Soons Z, Mannsperger H, Harder N, Oswald M, Gipp M, Ramminger E, Marcus G, Manner R, Rohr K, Wanker E, Russell RB, Andrade-Navarro MA, Eils R, Konig R (2014) Characterizing protein interactions employing a genome-wide siRNA cellular phenotyping screen. PLoS computational biology 10: e1003814

Thuy AV, Reimann CM, Hemdan NY, Graler MH (2014) Sphingosine 1-phosphate in blood: function, metabolism, and fate. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 34: 158-171

Trivedi PJ, Bruns T, Cheung A, Li KK, Kittler C, Kumagi T, Shah H, Corbett C, Al-Harthy N, Acarsu U, Coltescu C, Tripathi D, Stallmach A, Neuberger J, Janssen HL, Hirschfield GM (2014) Optimising risk stratification in primary biliary cirrhosis: AST/platelet ratio index predicts outcome independent of ursodeoxycholic acid response. J Hepatol 10.1016/j.jhep.2014.01.029

Ummanni R, Mannsperger HA, Sonntag J, Oswald M, Sharma AK, Konig R, Korf U (2014) Evaluation of reverse phase protein array (RPPA)-based pathway-activation profiling in 84 non-small cell lung cancer (NSCLC) cell lines as platform for cancer proteomics and biomarker discovery. Biochimica et biophysica acta 1844: 950-959

Voigt J, Hunniger K, Bouzani M, Jacobsen ID, Barz D, Hube B, Loffler J, Kurzai O (2014) Human natural killer cells acting as phagocytes against Candida albicans and mounting an inflammatory response that modulates neutrophil antifungal activity. The Journal of infectious diseases 209: 616-626

von Loeffelholz C (2014) The Role of Non-exercise Activity Thermogenesis in Human Obesity. In Endotext, De Groot LJ, Beck-Peccoz P, Chrousos G, Dungan K, Grossman A, Hershman JM, Koch C, McLachlan R, New M, Rebar R, Singer F, Vinik A, Weickert MO (eds). South Dartmouth (MA)

Ward A, Shukla K, Balwierz A, Soons Z, Konig R, Sahin O, Wiemann S (2014) MicroRNA-519a is a novel oncomir conferring tamoxifen resistance by targeting a network of tumour-suppressor genes in ER+ breast cancer. The Journal of pathology 10.1002/path.4363

Wartenberg A, Linde J, Martin R, Schreiner M, Horn F, Jacobsen ID, Jenull S, Wolf T, Kuchler K, Guthke R, Kurzai O, Forche A, d'Enfert C, Brunke S, Hube B (2014) Microevolution of Candida albicans in Macrophages Restores Filamentation in a Nonfilamentous Mutant. PLoS genetics 10: e1004824

Weber M, Hagel S, Stallmach A (2014) Gastrointestinale Infektionen [Gastrointestinal infections]. Dtsch Med Wochenschr 25/26: 1357-1372

Werner C, Haselmann H, Weishaupt A, Toyka KV, Sommer C, Geis C (2014) Stiff person-syndrome IgG affects presynaptic GABAergic release mechanisms. Journal of neural transmission 10.1007/s00702-014-1268-1

Wilson D, Mayer FL, Miramon P, Slesiona S, Jacobsen ID, Hube B (2014) Candida albicans specific genes: distinct roles in host-pathogen interactions. Eukaryot Cell 13: 977-989

Winkler TW, Day FR, Croteau-Chonka DC, Wood AR, Locke AE, Magi R, Ferreira T, Fall T, Graff M, Justice AE, Luan J, Gustafsson S, Randall JC, Vedantam S, Workalemahu T, Kilpelainen TO, Scherag A, Esko T, Kutalik Z, Heid IM, Loos RJ, Genetic Investigation of Anthropometric Traits C (2014) Quality control and conduct of genome-wide association meta-analyses. Nature protocols 9: 1192-1212

Wood AR, Esko T, Yang J, et al. (2014) Defining the role of common variation in the genomic and biological architecture of adult human height. Nature genetics 46: 1173-1186 (contributing CSCC member: Scherag A)

Zielske J, Bohne S, Axer H, Brunkhorst FM, Guntinas-Lichius O (2014) [Dysphagia management of acute and long-term critically ill intensive care patients]. Medizinische Klinik, Intensivmedizin und Notfallmedizin 109: 516-525

Zielske J, Bohne S, Brunkhorst FM, Axer H, Guntinas-Lichius O (2014) Acute and long-term dysphagia in critically ill patients with severe sepsis: results of a prospective controlled observational study. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies 271: 3085-3093

Aschoff M, Hotz-Wagenblatt A, Glatting KH, Fischer M, Eils R, Konig R (2013) SplicingCompass: differential splicing detection using RNA-Seq data. Bioinformatics 10.1093/bioinformatics/btt101

Axer H, Grimm A, Porzelius C, Teschner U, Schumacher U, Witte OW, Brunkhorst FM (2013) Impairment of small somatic and autonomic nerve fibres in intensive care unit patients with severe sepsis and critical illness polyneuropathy -- a single center controlled observational study. BMC neurology 13: 159

Axer H, Zinke J, Axer M, Grimm A (2013) Elektrophysiologische Diagnostik der Critical Illness Polyneuropathie und Critical Illness Myopathie. Neurophysiol Lab 35: 18-33

Bacher P, Kniemeyer O, Schonbrunn A, Sawitzki B, Assenmacher M, Rietschel E, Steinbach A, Cornely OA, Brakhage AA, Thiel A, Scheffold A (2013) Antigen-specific expansion of human regulatory T cells as a major tolerance mechanism against mucosal fungi. Mucosal immunology 10.1038/mi.2013.107

Bacher P, Schink C, Teutschbein J, Kniemeyer O, Assenmacher M, Brakhage AA, Scheffold A (2013) Antigen-Reactive T Cell Enrichment for Direct, High-Resolution Analysis of the Human Naive and Memory Th Cell Repertoire. J Immunol 10.4049/jimmunol.1202221

Bayer O, Schwarzkopf D, Doenst T, Cook D, Kabisch B, Schelenz C, Bauer M, Riedemann NC, Sakr Y, Kohl M, Reinhart K, Hartog CS (2013) Perioperative fluid therapy with tetrastarch and gelatin in cardiac surgery-a prospective sequential analysis*. Crit Care Med 41: 2532-2542

Beauvais A, Bozza S, Kniemeyer O, Formosa C, Balloy V, Henry C, Roberson RW, Dague E, Chignard M, Brakhage AA, Romani L, Latge JP (2013) Deletion of the alpha-(1,3)-Glucan Synthase Genes Induces a Restructuring of the Conidial Cell Wall Responsible for the Avirulence of Aspergillus fumigatus. PLoS Pathog 9: e1003716

Beleites C, Neugebauer U, Bocklitz T, Krafft C, Popp J (2013) Sample size planning for classification models. Analytica chimica acta 760: 25-33

Bielecki P, Komor U, Bielecka A, Musken M, Puchalka J, Pletz MW, Ballmann M, Martins Dos Santos VA, Weiss S, Haussler S (2013) Ex vivo transcriptional profiling reveals a common set of genes important for the adaptation of Pseudomonas aeruginosa to chronically infected host sites. Environmental microbiology 15: 570-587

Bloos F, Bayer O, Sachse S, Straube E, Reinhart K, Kortgen A (2013) Attributable costs of patients with candidemia and potential implications of polymerase chain reaction-based pathogen detection on antifungal therapy in patients with sepsis. J Crit Care 28: 2-8

Bohne S, Siggel R, Sachse S, Kiehntopf M, Bauer M, Straube E, Guntinas-Lichius O (2013) Clinical significance and diagnostic usefulness of serologic markers for improvement of outcome of tonsillectomy in adults with chronic tonsillitis. Journal of negative results in biomedicine 12: 11

Brunke S, Hube B (2013) Two unlike cousins: Candida albicans and C. glabrata infection strategies. Cellular microbiology 10.1111/cmi.12091

Caldarelli A, Muller JP, Paskowski-Rogacz M, Herrmann K, Bauer R, Koch S, Heninger AK, Krastev D, Ding L, Kasper S, Fischer T, Brodhun M, Bohmer FD, Buchholz F (2013) A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling. Leukemia 10.1038/leu.2013.83

Christaki E, Giamarellos-Bourboulis EJ (2013) The complex pathogenesis of bacteremia: From antimicrobial clearance mechanisms to the genetic background of the host. Virulence 5

Docke S, Lock JF, Birkenfeld AL, Hoppe S, Lieske S, Rieger A, Raschzok N, Sauer IM, Florian S, Osterhoff MA, Heller R, Herrmann K, Lindenmuller S, Horn P, Bauer M, Weickert MO, Neuhaus P, Stockmann M, Mohlig M, Pfeiffer AF, von Loeffelholz C (2013) Elevated hepatic chemerin mRNA expression in human non-alcoholic fatty liver disease. European journal of endocrinology / European Federation of Endocrine Societies 169: 547-557

Dorr JR, Yu Y, Milanovic M, Beuster G, Zasada C, Dabritz JH, Lisec J, Lenze D, Gerhardt A, Schleicher K, Kratzat S, Purfurst B, Walenta S, Mueller-Klieser W, Graler M, Hummel M, Keller U, Buck AK, Dorken B, Willmitzer L, Reimann M, Kempa S, Lee S, Schmitt CA (2013) Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. Nature 10.1038/nature12437

Fang H, Liu A, Sun J, Kitz A, Dirsch O, Dahmen U (2013) Granulocyte Colony Stimulating Factor Induces Lipopolysaccharide (LPS) Sensitization via Upregulation of LPS Binding Protein in Rat. PloS one 8: e56654

Finkensieper A, Bekhite MM, Fischer H, Nitza S, al. e (2013) Antibacterial Capacity of Differentiated Murine Embryonic Stem Cells During Defined in vitro Inflammatory Conditions. StemCellDev

Geissler KJ, Jung MJ, Riecken LB, Sperka T, Cui Y, Schacke S, Merkel U, Markwart R, Rubio I, Than ME, Breithaupt C, Peuker S, Seifert R, Kaupp UB, Herrlich P, Morrison H (2013) Regulation of Son of sevenless by the membrane-actin linker protein ezrin. Proceedings of the National Academy of Sciences of the United States of America 110: 20587-20592

Ghanem H, Hagel S, Keller P, Prochnau D, Stallmach A, Pletz MW (2013) [A 22-year-old patient from Ghana with fever and reduced CD4 T-cell count]. Internist (Berl) 54: 100-104

Giamarellos-Bourboulis EJ (2013) The failure of biologics in sepsis: where do we stand? International journal of antimicrobial agents 42 Suppl: S45-47

Giannitsioti E, Damoraki G, Rokkas C, Tsaganos T, Fragou A, Kannelaki S, Athanasia S, Giamarellos-Bourboulis EJ (2013) Impact of haplotypes of TNF in the natural course of infective endocarditis. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20: 459-464

Giatrakos S, Huse K, Kanni T, Tzanetakou V, Kramer M, Grech I, Papadavid E, Katoulis A, Stavrianeas N, Nothnagel M, Platzer M, Bauer M, Giamarellos-Bourboulis EJ (2013) Haplotypes of IL-12Rbeta1 impact on the clinical phenotype of hidradenitis suppurativa. Cytokine 10.1016/j.cyto.2013.03.008

Gonnert FA, Recknagel P, Hilger I, Claus RA, Bauer M, Kortgen A (2013) Hepatic excretory function in sepsis: implications from biophotonic analysis of transcellular xenobiotic transport in a rodent model. Crit Care 17: R67

Götz T, Huonker R, Kranczioch C, Reuken P, Witte OW, Günther A, Debener S (2013) Impaired evoked and resting-state brain oscillations in patients with liver cirrhosis as revealed by magnetoencephalography. NeuroImage: Clinical 2: 873-882

Grimm A, Brunkhorst FM, Axer H (2013) Neuromuskuläre Schwäche-Sepsis-induzierte CIP und CIM. NeuroTransmitter 24: 36-43

Grimm A, Teschner U, Porzelius C, Ludewig K, Zielske J, Witte OW, Brunkhorst FM, Axer H (2013) Muscle ultrasound for early assessment of critical illness neuromyopathy in severe sepsis. Crit Care 17: R227

Grimm A, Witte OW, Axer H (2013) Muskelultraschall in der neurologischen Diagnostik – ein Überblick. Neurophysiol Lab 35: 47-60

Hagel S, Ludewig K, Frosinski J, Hutagalung R, Porzelius C, Gastmeier P, Harbarth S, Pletz MW, Brunkhorst FM (2013) [Effectiveness of a hospital-wide educational programme for infection control to reduce the rate of health-care associated infections and related sepsis (ALERTS) - methods and interim results]. Dtsch Med Wochenschr 138: 1717-1722

Hagel S, Pletz MW, Brunkhorst FM, Seifert H, Kern WV (2013) [Bacteremia and sepsis]. Internist (Berl) 54: 399-407

Hagel S, Stallmach A, Keller P, Pletz M (2013) [Multiresistant Organisms.]. Zentralbl Chir 10.1055/s-0032-1328343

Hartog CS, Jensen HI (2013) Family-centered ICU care may be good for everyone. Intensive Care Med 10.1007/s00134-013-2996-7

Hartog CS, Welte T, Schlattmann P, Reinhart K (2013) Fluid replacement with hydroxyethyl starch in critical care--a reassessment. Deutsches Arzteblatt international 110: 443-450

Hennicke F, Grumbt M, Lermann U, Ueberschaar N, Palige K, Bottcher B, Jacobsen ID, Staib C, Morschhauser J, Monod M, Hube B, Hertweck C, Staib P (2013) Factors supporting cysteine tolerance and sulfite production in Candida albicans. Eukaryot Cell EC.00336-12 [pii] 10.1128/EC.00336-12

Heublein S, Wehner F, Hochsmann B, Hochhaus A, Hartmann M, La Rosee P (2013) Modelling cost effectiveness of horse antithymocyte globulin for treating severe aplastic anaemia in Germany. Annals of hematology 10.1007/s00277-013-1688-2

Holters S, Anacker J, Jansen L, Beer-Grondke K, Durst M, Rubio I (2013) Tetraspanin 1 promotes invasiveness of cervical cancer cells. International journal of oncology 43: 503-512

Hoshi T, Wissuwa B, Tian Y, Tajima N, Xu R, Bauer M, Heinemann SH, Hou S (2013) Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca2+-dependent K+ channels. Proceedings of the National Academy of Sciences of the United States of America 110: 4816-4821

Hoyer D, Tetschke F, Jaekel S, Nowack S, Witte OW, Schleussner E, Schneider U (2013) Fetal functional brain age assessed from universal developmental indices obtained from neuro-vegetative activity patterns. PloS one 8: e74431

Jbeily N, Suckert I, Gonnert FA, Acht B, Bockmeyer CL, Grossmann SD, Blaess MF, Lueth A, Deigner HP, Bauer M, Claus RA (2013) Hyperresponsiveness of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host response. Journal of lipid research 54: 410-424

Jun JE, Rubio I, Roose JP (2013) Regulation of Ras Exchange Factors and Cellular Localization of Ras Activation by Lipid Messengers in T Cells. Frontiers in immunology 4: 239

Klaile E, Klassert TE, Scheffrahn I, Muller MM, Heinrich A, Heyl KA, Dienemann H, Grunewald C, Bals R, Singer BB, Slevogt H (2013) Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons. Respiratory research 14: 85

Klopfleisch M, Seidel RA, Gorls H, Richter H, Beckert R, Imhof W, Reiher M, Pohnert G, Westerhausen M (2013) Total Synthesis and Detection of the Bilirubin Oxidation Product (Z)-2-(3-Ethenyl-4-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)ethanamide (Z-BOX A). Organic letters 15: 4608-4611

Kothe S, Muller JP, Bohmer SA, Tschongov T, Fricke M, Koch S, Thiede C, Requardt RP, Rubio I, Bohmer FD (2013) Features of Ras activation by a mislocalized oncogenic tyrosine kinase: FLT3 ITD signals through K-Ras at the plasma membrane of acute myeloid leukemia cells. Journal of cell science 126: 4746-4755

Kramer M, Sponholz C, Slaba M, Wissuwa B, Claus RA, Menzel U, Huse K, Platzer M, Bauer M (2013) Alternative 5' untranslated regions are involved in expression regulation of human heme oxygenase-1. PloS one 8: e77224

Kretz A, Herrmann KH, Fischer S, Engelmann C, Witte OW, Reichenbach JR, Weih F, Haenold R (2013) Dysfunctional NF-kappaB and brain myelin formation. European journal of human genetics : EJHG 10.1038/ejhg.2013.240

Kroll K, Pahtz V, Kniemeyer O (2013) Elucidating the fungal stress response by proteomics. Journal of proteomics 10.1016/j.jprot.2013.06.001

Kuhl T, Wissbrock A, Goradia N, Sahoo N, Galler K, Neugebauer U, Popp J, Heinemann SH, Ohlenschlager O, Imhof D (2013) Analysis of Fe(III) Heme Binding to Cysteine-Containing Heme-Regulatory Motifs in Proteins. ACS chemical biology 10.1021/cb400317x

Lindig S, Quickert S, Vodovotz Y, Wanner GA, Bauer M (2013) Age-independent co-expression of antimicrobial gene clusters in the blood of septic patients. International journal of antimicrobial agents 42 Suppl: S2-7

Louis K, Netea MG, Carrer DP, Kotsaki A, Mylona V, Pistiki A, Savva A, Roditis K, Alexis A, Van der Meer JW, Giamarellos-Bourboulis EJ (2013) Bacterial translocation in an experimental model of multiple organ dysfunctions. The Journal of surgical research 10.1016/j.jss.2013.01.064

Lubkemeier I, Requardt RP, Lin X, Sasse P, Andrie R, Schrickel JW, Chkourko H, Bukauskas FF, Kim JS, Frank M, Malan D, Zhang J, Wirth A, Dobrowolski R, Mohler PJ, Offermanns S, Fleischmann BK, Delmar M, Willecke K (2013) Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels. Basic research in cardiology 108: 348

Luttich A, Brunke S, Hube B, Jacobsen ID (2013) Serial passaging of Candida albicans in systemic murine infection suggests that the wild type strain SC5314 is well adapted to the murine kidney. PloS one 8: e64482

Martin R, Albrecht-Eckardt D, Brunke S, Hube B, Hunniger K, Kurzai O (2013) A Core Filamentation Response Network in Candida albicans Is Restricted to Eight Genes. PloS one 8: e58613

Mayer FL, Wilson D, Hube B (2013) Candida albicans pathogenicity mechanisms. Virulence 4: 119-128

Mayer FL, Wilson D, Hube B (2013) Hsp21 potentiates antifungal drug tolerance in Candida albicans. PloS one 8: e60417

Mihailidou I, Pelekanou A, Pistiki A, Spyridaki A, Tzepi IM, Damoraki G, Giamarellos-Bourboulis EJ (2013) Dexamethasone Down-Regulates Expression of Triggering Receptor Expressed on Myeloid Cells-1: Evidence for a TNFalpha-Related Effect. Frontiers in public health 1: 50

Miramon P, Kasper L, Hube B (2013) Thriving within the host: Candida spp. interactions with phagocytic cells. Med Microbiol Immunol 10.1007/s00430-013-0288-z

Muszkieta L, Beauvais A, Pahtz V, Gibbons JG, Anton Leberre V, Beau R, Shibuya K, Rokas A, Francois JM, Kniemeyer O, Brakhage AA, Latge JP (2013) Investigation of Aspergillus fumigatus biofilm formation by various "omics" approaches. Front Microbiol 4: 13

Neuschafer-Rube F, Lieske S, Kuna M, Henkel J, Perry RJ, Erion DM, Pesta D, Willmes DM, Brachs S, von Loeffelholz C, Tolkachov A, Schupp M, Pathe-Neuschafer-Rube A, Pfeiffer AF, Shulman GI, Puschel GP, Birkenfeld AL (2013) The Mammalian INDY Homolog is Induced by CREB in a Rat Model of Type 2 Diabetes. Diabetes 10.2337/db13-0749

Offen N, Flemming J, Kamawal H, Ahmad R, Wolber W, Geis C, Zaehres H, Scholer HR, Ehrenreich H, Muller AM, Siren AL (2013) Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells. Molecular medicine 19: 399-408

Otto GP, Busch M, Sossdorf M, Claus RA (2013) Impact of sepsis-associated cytokine storm on plasma NGAL during acute kidney injury in a model of polymicrobial sepsis. Crit Care 17: 419

Otto GP, Kropf M, Rodel J, Losche W, Ruster C, Claus RA, Sossdorf M, Busch M (2013) Novel approach for bacteremia detection in patients with end-stage renal failure undergoing hemodialysis. The International journal of artificial organs 10.5301/ijao.5000243: 0

Otto GP, Ludewig K, Jacobsen ID, Schaarschmidt B, Hube B, Bauer M (2013) Limitation of (1-->3)-beta-D-glucan monitoring in major elective surgery involving cardiopulmonary bypass. Crit Care 17: 437

Palige K, Linde J, Martin R, Bottcher B, Citiulo F, Sullivan DJ, Weber J, Staib C, Rupp S, Hube B, Morschhauser J, Staib P (2013) Global transcriptome sequencing identifies chlamydospore specific markers in Candida albicans and Candida dubliniensis. PloS one 8: e61940

Papaioannou M, Soderholm AA, Hong W, Dai Y, Roediger J, Roell D, Thiele M, Nyronen TH, Baniahmad A (2013) Computational and functional analysis of the androgen receptor antagonist atraric acid and its derivatives. Anti-cancer agents in medicinal chemistry

Peter J, Frey O, Stallmach A, Bruns T (2013) Attenuated antigen-specific T cell responses in cirrhosis are accompanied by elevated serum interleukin-10 levels and down-regulation of HLA-DR on monocytes. BMC gastroenterology 13: 37

Pietrella D, Pandey N, Gabrielli E, Pericolini E, Perito S, Kasper L, Bistoni F, Cassone A, Hube B, Vecchiarelli A (2013) Secreted aspartic proteases of Candida albicans activate the NLRP3 inflammasome. European journal of immunology 43: 679-692

Plaimas K, Wang Y, Rotimi SO, Olasehinde G, Fatumo S, Lanzer M, Adebiyi E, Konig R (2013) Computational and experimental analysis identified 6-diazo-5-oxonorleucine as a potential agent for treating infection by Plasmodium falciparum. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 10.1016/j.meegid.2013.09.019

Pletz MW (2013) [Pneumococcal vaccine]. Dtsch Med Wochenschr 138: 1734-1737

Pletz MW, Michaylov N, Schumacher U, van der Linden M, Duesberg CB, Fuehner T, Klugman KP, Welte T, Makarewicz O (2013) Antihypertensives suppress the emergence of fluoroquinolone-resistant mutants in pneumococci: An in vitro study. International journal of medical microbiology : IJMM 10.1016/j.ijmm.2013.02.014

Prell T, Peschel T, Kohler B, Bokemeyer MH, Dengler R, Gunther A, Grosskreutz J (2013) Structural brain abnormalities in cervical dystonia. BMC neuroscience 14: 123

Prkno A, Wacker C, Brunkhorst FM, Schlattmann P (2013) Procalcitonin-guided therapy in intensive care unit patients with severe sepsis and septic shock - a systematic review and meta-analysis. Crit Care 17: R291

Pye DS, Rubio I, Pusch R, Lin K, Pettitt AR, Till KJ (2013) Chemokine unresponsiveness of chronic lymphocytic leukemia cells results from impaired endosomal recycling of rap1 and is associated with a distinctive type of immunological anergy. J Immunol 191: 1496-1504

Recknagel P, Gonnert FA, Halilbasic E, Gajda M, Jbeily N, Lupp A, Rubio I, Claus RA, Kortgen A, Trauner M, Singer M, Bauer M (2013) Mechanisms and functional consequences of liver failure substantially differ between endotoxaemia and faecal peritonitis in rats. Liver Int 33: 283-293

Reuken PA, Stallmach A, Bruns T (2013) Mortality after urinary tract infections in patients with advanced cirrhosis - Relevance of acute kidney injury and comorbidities. Liver Int 33: 220-230

Rosendahl J, Brunkhorst FM, Jaenichen D, Strauss B (2013) Physical and mental health in patients and spouses after intensive care of severe sepsis: a dyadic perspective on long-term sequelae testing the Actor-Partner Interdependence Model. Crit Care Med 41: 69-75

Rudiger A, Dyson A, Felsmann K, Carre JE, Taylor V, Hughes S, Clatworthy I, Protti A, Pellerin D, Lemm J, Claus RA, Bauer M, Singer M (2013) Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis. Clin Sci (Lond) 124: 391-401

Rupprecht S, Walther B, Gudziol H, Steenbeck J, Freesmeyer M, Witte OW, Gunther A, Schwab M (2013) Clinical markers of early nigrostriatal neurodegeneration in idiopathic rapid eye movement sleep behavior disorder. Sleep medicine 14: 1064-1070

Schack M, Sachse S, Rodel J, Frangoulidis D, Pletz MW, Rohde GU, Straube E, Boden K (2013) Coxiella burnetii (Q fever) as a cause of community-acquired pneumonia during the warm season in Germany. Epidemiology and infection 10.1017/S0950268813002914: 1-6

Schleenvoigt BT, Keller PM, Lehmann M, Gras F, Hagel S, Stallmach A, Pletz MW (2013) [Cutaneous manifestation of tuberculosis causing impaired healing after minor injury]. Dtsch Med Wochenschr 138: 2297-2302

Schmidt C, Lautenschlager C, Petzold B, Sakr Y, Marx G, Stallmach A (2013) Confocal laser endomicroscopy reliably detects sepsis-related and treatment-associated changes in intestinal mucosal microcirculation. British journal of anaesthesia 10.1093/bja/aet219

Schmidt C, Schneble N, Muller JP, Bauer R, Perino A, Marone R, Rybalkin SD, Wymann MP, Hirsch E, Wetzker R (2013) Phosphoinositide 3-kinase gamma mediates microglial phagocytosis via lipid kinase-independent control of cAMP. Neuroscience 233: 44-53

Schmitz RP, Keller PM, Baier M, Hagel S, Pletz MW, Brunkhorst FM (2013) Quality of blood culture testing - a survey in intensive care units and microbiological laboratories across four European countries. Crit Care 17: R248

Schroder UC, Ramoji A, Glaser U, Sachse S, Leiterer C, Csaki A, Hubner U, Fritzsche W, Pfister W, Bauer M, Popp J, Neugebauer U (2013) Combined Dielectrophoresis-Raman Setup for the Classification of Pathogens Recovered from the Urinary Tract. Analytical chemistry 10.1021/ac4021616

Schulz A, Baader SL, Niwa-Kawakita M, Jung MJ, Bauer R, Garcia C, Zoch A, Schacke S, Hagel C, Mautner VF, Hanemann CO, Dun XP, Parkinson DB, Weis J, Schroder JM, Gutmann DH, Giovannini M, Morrison H (2013) Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy. Nature neuroscience 10.1038/nn.3348

Schwarzkopf D, Behrend S, Skupin H, Westermann I, Riedemann NC, Pfeifer R, Gunther A, Witte OW, Reinhart K, Hartog CS (2013) Family satisfaction in the intensive care unit: a quantitative and qualitative analysis. Intensive Care Med 39: 1071-1079

Sens E, Knorr C, Preul C, Meissner W, Witte OW, Miltner WH, Weiss T (2013) Differences in somatosensory and motor improvement during temporary functional deafferentation in stroke patients and healthy subjects. Behavioural brain research 252: 110-116

Shopova I, Bruns S, Thywissen A, Kniemeyer O, Brakhage AA, Hillmann F (2013) Extrinsic extracellular DNA leads to biofilm formation and colocalizes with matrix polysaccharides in the human pathogenic fungus Aspergillus fumigatus. Front Microbiol 4: 141

Song SP, Hennig A, Schubert K, Markwart R, Schmidt P, Prior IA, Bohmer FD, Rubio I (2013) Ras palmitoylation is necessary for N-Ras activation and signal propagation in growth factor signalling. The Biochemical journal 10.1042/BJ20121799

Sossdorf M, Fischer J, Meyer S, Dahlke K, Wissuwa B, Seidel C, Schrepper A, Bockmeyer CL, Lupp A, Neugebauer S, Schmerler D, Rodel J, Claus RA, Otto GP (2013) Physical Exercise Induces Specific Adaptations Resulting in Reduced Organ Injury and Mortality During Severe Polymicrobial Sepsis. Crit Care Med 41: 246-255

Sossdorf M, Otto GP, Boettel J, Winning J, Losche W (2013) Benefit of low-dose aspirin and non-steroidal anti-inflammatory drugs in septic patients. Crit Care 17: 402

Sossdorf M, Otto GP, Menge K, Claus RA, Losche W, Kabisch B, Kohl M, Smolenski UC, Schlattmann P, Reinhart K, Winning J (2013) Potential effect of physiotherapeutic treatment on mortality rate in patients with severe sepsis and septic shock: A retrospective cohort analysis. J Crit Care 10.1016/j.jcrc.2013.06.023

Stallmach A, Hagel S, Bruns T, Pletz M, Eckmann C (2013) [Empirical antibiotic therapy in intra-abdomial infections: cases and evidence-based therapeutic recommendations]. Zeitschrift fur Gastroenterologie 51: 1069-1081

Stehr SN, Woest I, Hartog CS, Reinhart K (2013) [Sepsis : Putting knowledge into practice]. Internist (Berl) 54: 63-74

Stein C, Makarewicz O, Pfeifer Y, Brandt C, Ramos JC, Klinger M, Pletz MW (2013) Direct RNA-based detection and differentiation of CTX-M-type extended-spectrum beta-lactamases (ESBL). PloS one 8: e80079

Toufekoula C, Papadakis V, Tsaganos T, Routsi C, Orfanos SE, Kotanidou A, Carrer DP, Raftogiannis M, Baziaka F, Giamarellos-Bourboulis EJ (2013) Compartmentalization of lipid peroxidation in sepsis by multidrug-resistant gram-negative bacteria: experimental and clinical evidence. Crit Care 17: R6

Wacker C, Prkno A, Brunkhorst FM, Schlattmann P (2013) Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. The Lancet infectious diseases 13: 426-435

Wagener J, Schneider JJ, Baxmann S, Kalbacher H, Borelli C, Nuding S, Kuchler R, Wehkamp J, Kaeser MD, Mailander-Sanchez D, Braunsdorf C, Hube B, Schild L, Forssmann WG, Korting HC, Liepke C, Schaller M (2013) A peptide derived from the highly conserved protein GAPDH is involved in tissue protection by different antifungal strategies and epithelial immunomodulation. The Journal of investigative dermatology 133: 144-153

Walter B, Eiselt M, Cumming P, Xiong G, Hinz R, Uthe S, Brust P, Bauer R (2013) Resistance of brain glucose metabolism to thiopental-induced CNS depression in newborn piglets. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 31: 157-164

Wilson D, Hebecker B, Moyes DL, Miramon P, Jablonowski N, Wisgott S, Allert S, Naglik JR, Hube B (2013) Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection. Antimicrobial agents and chemotherapy 57: 5178-5180

Zimmermann HW, Reuken PA, Koch A, Bartneck M, Adams DH, Trautwein C, Stallmach A, Tacke F, Bruns T (2013) Soluble urokinase plasminogen activator receptor is compartmentally regulated in decompensated cirrhosis and indicates immune activation and short-term mortality. Journal of internal medicine 274: 86-100

Bauer R, Schubert H (2012) Therapeutische Hypothermie – pathophysiologische und molekularbiologische Implikationen der Hirnprotektion. Intensiv- und Notfallbehandlung 37: 1-9

Bayer O, Reinhart K, Kohl M, Kabisch B, Marshall J, Sakr Y, Bauer M, Hartog C, Schwarzkopf D, Riedemann N (2012) Effects of fluid resuscitation with synthetic colloids or crystalloids alone on shock reversal, fluid balance, and patient outcomes in patients with severe sepsis: a prospective sequential analysis. Crit Care Med 40: 2543-2551

Bloos F, Sachse S, Kortgen A, Pletz MW, Lehmann M, Straube E, Riedemann NC, Reinhart K, Bauer M (2012) Evaluation of a polymerase chain reaction assay for pathogen detection in septic patients under routine condition: an observational study. PloS one 7: e46003

Bohne S, Schelhorn-Neise P, Brunkhorst FM, Guntinas-Lichius O (2012) [Severe organic dysphagia after long-term ventilation in a patient with sepsis and multiorgan failure]. Medizinische Klinik, Intensivmedizin und Notfallmedizin 107: 564-566

Brunkhorst FM, Oppert M, Marx G, Bloos F, Ludewig K, Putensen C, Nierhaus A, Jaschinski U, Meier-Hellmann A, Weyland A, Grundling M, Moerer O, Riessen R, Seibel A, Ragaller M, Buchler MW, John S, Bach F, Spies C, Reill L, Fritz H, Kiehntopf M, Kuhnt E, Bogatsch H, Engel C, Loeffler M, Kollef MH, Reinhart K, Welte T (2012) Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial. JAMA : the journal of the American Medical Association 307: 2390-2399

Bruns T, Peter J, Reuken PA, Grabe DH, Schuldes SR, Brenmoehl J, Scholmerich J, Wiest R, Stallmach A (2012) NOD2 gene variants are a risk factor for culture-positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis. Liver Int 32: 223-230

Bruns T, Reuken PA, Fischer J, Berg T, Stallmach A (2012) Further evidence for the relevance of TLR2 gene variants in spontaneous bacterial peritonitis. J Hepatol 56: 1207-1208; author reply 1208-1209

Citiulo F, Jacobsen ID, Miramon P, Schild L, Brunke S, Zipfel P, Brock M, Hube B, Wilson D (2012) Candida albicans scavenges host zinc via Pra1 during endothelial invasion. PLoS Pathog 8: e1002777

Godfrey R, Arora D, Bauer R, Stopp S, Muller JP, Heinrich T, Bohmer SA, Dagnell M, Schnetzke U, Scholl S, Ostman A, Bohmer FD (2012) Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ. Blood 119: 4499-4511

Gonnert FA, Kunisch E, Gajda M, Lambeck S, Weber M, Claus RA, Bauer M, Kinne RW (2012) Hepatic Fibrosis in a Long-term Murine Model of Sepsis. Shock 37: 399-407

Gow NA, Hube B (2012) Importance of the Candida albicans cell wall during commensalism and infection. Current opinion in microbiology 15: 406-412

Grimm A, Günther A, Witte OW, Axer H (2012) Critical-Illness-Polyneuropathie und Critical-Illness-Myopathie. Medizinische Klinik, Intensivmedizin und Notfallmedizin 107: 649-659

Hartog CS, Winning J, Bauer M (2012) Volume replacement after trauma: an update. Swiss medical weekly 142: w13685

Jacobsen ID, Wilson D, Wachtler B, Brunke S, Naglik JR, Hube B (2012) Candida albicans dimorphism as a therapeutic target. Expert Rev Anti Infect Ther 10: 85-93

Jaenichen D, Brunkhorst FM, Strauss B, Rosendahl J (2012) [Physical and mental long-term sequelae following intensive care of severe sepsis in patients and relatives]. Psychotherapie, Psychosomatik, medizinische Psychologie 62: 335-343

Kleiman A, Hubner S, Rodriguez Parkitna JM, Neumann A, Hofer S, Weigand MA, Bauer M, Schmid W, Schutz G, Libert C, Reichardt HM, Tuckermann JP (2012) Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages. Faseb J 26: 722-729

Kotsaki A, Giamarellos-Bourboulis EJ (2012) Emerging drugs for the treatment of sepsis. Expert opinion on emerging drugs 17: 379-391

Kotzampassi K, Giamarellos-Bourboulis EJ (2012) Probiotics for infectious diseases: more drugs, less dietary supplementation. International journal of antimicrobial agents 40: 288-296

Lambeck S, Weber M, Gonnert FA, Mrowka R, Bauer M (2012) Comparison of sepsis-induced transcriptomic changes in a murine model to clinical blood samples identifies common response patterns. Front Microbiol 3: 284

Loesche W, Boettel J, Kabisch B, Winning J, Claus RA, Bauer M (2012) Do aspirin and other antiplatelet drugs reduce the mortality in critically ill patients? Thrombosis 2012: 720254

Mariappan A, Makarewicz O, Chen XH, Borriss R (2012) Two-component response regulator DegU controls the expression of bacilysin in plant-growth-promoting bacterium Bacillus amyloliquefaciens FZB42. Journal of molecular microbiology and biotechnology 22: 114-125

Mayer FL, Wilson D, Jacobsen ID, Miramon P, Slesiona S, Bohovych IM, Brown AJ, Hube B (2012) Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans. PloS one 7: e38584

Miramon P, Dunker C, Windecker H, Bohovych IM, Brown AJ, Kurzai O, Hube B (2012) Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress. PloS one 7: e52850

Muller S, Baldin C, Groth M, Guthke R, Kniemeyer O, Brakhage AA, Valiante V (2012) Comparison of transcriptome technologies in the pathogenic fungus Aspergillus fumigatus reveals novel insights into the genome and MpkA dependent gene expression. BMC genomics 13: 519

Neugebauer U, Grosse C, Bauer M, Kemper B, Barroso-Pena A, Bauwens A, Glueder M, Woerdemann M, Dewenter L, Denz C, Kloss S, Rosch P, Sabat A, Schutze K, Friedrich A, Bally GV, Popp J, Mellmann A (2012) From Infection to Detection: Imaging S. aureus - host interactions. Biomedizinische Technik Biomedical engineering 10.1515/bmt-2012-4284

Neugebauer U, Marz A, Henkel T, Schmitt M, Popp J (2012) Spectroscopic detection and quantification of heme and heme degradation products. Analytical and bioanalytical chemistry 404: 2819-2829

Otto GP, Kropf M, Sossdorf M, Recknagel P, Losche W, Rodel J, Claus RA, Busch M (2012) Screening for bacteremia in sepsis and renal failure using hemofilters for renal replacement therapy. Infection 10.1007/s15010-012-0372-0

Otto GP, Neugebauer S, Claus RA, Sossdorf M (2012) Arginine metabolism is markedly impaired in polymicrobial infected mice. Crit Care 16: 412

Otto GP, Sossdorf M, Boettel J, Kabisch B, Breuel H, Winning J, Losche W (2012) Effects of low-dose acetylsalicylic acid and atherosclerotic vascular diseases on the outcome in patients with severe sepsis or septic shock. Platelets 10.3109/09537104.2012.724482

Otto GP, Wissuwa B, Mehnert A, Marx S, Raessler M, Losche W, Claus RA, Sossdorf M (2012) A method for detection and quantification of hydroxyethyl starch in plasma. Crit Care 16: 426

Pletz MW, Ewig S, Lange C, Welte T, Hoffken G (2012) [Update pneumonia 2012]. Dtsch Med Wochenschr 137: 2265-2280; quiz 2281-2264

Quintin J, Saeed S, Martens JH, Giamarellos-Bourboulis EJ, Ifrim DC, Logie C, Jacobs L, Jansen T, Kullberg BJ, Wijmenga C, Joosten LA, Xavier RJ, van der Meer JW, Stunnenberg HG, Netea MG (2012) Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes. Cell host & microbe 12: 223-232

Ramoji A, Neugebauer U, Bocklitz T, Foerster M, Kiehntopf M, Bauer M, Popp J (2012) Toward a spectroscopic hemogram: Raman spectroscopic differentiation of the two most abundant leukocytes from peripheral blood. Analytical chemistry 84: 5335-5342

Rauchfuss F, Lambeck S, Claus RA, Ullmann J, Schulz T, Weber M, Katenkamp K, Guthke R, Bauer M, Settmacher U (2012) Sustained liver regeneration after portal vein embolization --a human molecular pilot study. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 44: 681-688

Recknagel P, Claus RA, Neugebauer U, Bauer M, Gonnert FA (2012) In vivo imaging of hepatic excretory function in the rat by fluorescence microscopy. J Biophotonics 7: 571-581

Recknagel P, Gonnert FA, Westermann M, Lambeck S, Lupp A, Rudiger A, Dyson A, Carre JE, Kortgen A, Krafft C, Popp J, Sponholz C, Fuhrmann V, Hilger I, Claus RA, Riedemann NC, Wetzker R, Singer M, Trauner M, Bauer M (2012) Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis. PLoS medicine 9: e1001338

Reinhart K, Bauer M, Riedemann NC, Hartog CS (2012) New approaches to sepsis: molecular diagnostics and biomarkers. Clinical microbiology reviews 25: 609-634

Requardt RP, Hirrlinger PG, Wilhelm F, Winkler U, Besser S, Hirrlinger J (2012) Ca(2)(+) signals of astrocytes are modulated by the NAD(+)/NADH redox state. Journal of neurochemistry 120: 1014-1025

Reuken PA, Bruns T, Zimmer B, Michael A, Brunkhorst FM, Pletz MW, Stallmach A (2012) Recurrent fever and bacteraemia after endoscopic variceal haemostasis with cyanoacrylate: a case report. Infection 40: 351-353

Reuken PA, Pletz MW, Baier M, Pfister W, Stallmach A, Bruns T (2012) Emergence of spontaneous bacterial peritonitis due to enterococci - risk factors and outcome in a 12-year retrospective study. Aliment Pharmacol Ther 35: 1199-1208

Richter F, Bauer R, Ebersberger A, Lehmenkuhler A, Schaible HG (2012) Enhanced neuronal excitability in adult rat brainstem causes widespread repetitive brainstem depolarizations with cardiovascular consequences. J Cereb Blood Flow Metab

Schmerler D, Neugebauer S, Ludewig K, Bremer-Streck S, Brunkhorst FM, Kiehntopf M (2012) Targeted metabolomics for discrimination of systemic inflammatory disorders in critically ill patients. Journal of lipid research 53: 1369-1375

Schmidt K, Mehlhorn J, Kausche S, Schmücker K, Thiel P, Heintze C, Brunkhorst FM, Gensichen J (2012) Postintensive Nachsorge in der Hausarztpraxis. Medical special 6: 10-11

Schmidt K, Thiel P, Mehlhorn J, Mueller F, Gensichen J (2012) Residuen kritischer Erkrankungen in der Hausarztpraxis. Intensiv- und Notfallbehandlung 37: 139-145

Schmitt M, Dietzek B, Neugebauer U, Krafft C, Rösch P, Popp J (2012) Raman-Spektroskopie - der Weg zu einer labelfreien biomedizinischen Diagnostik. Endo heute 25: 262-267

Schubert H, Eiselt M, Walter B, Fritz H, Brodhun M, Bauer R (2012) Isoflurane/nitrous oxide anesthesia and stress-induced procedures enhance neuroapoptosis in intrauterine growth-restricted piglets. Intensive Care Med 38: 1205-1214

Schwarzkopf D, Meissner W, Wedding U, Riedemann NC, Pfeifer R, Fritzenwanger M, Günther A, Egerland K, Henkel M, Skupin H, Muecke M, Hartog CS (2012) Kommunikation im Team und Burnout: Eine Befragung von intensiv- und palliativmedizinischen Pflegekräften und Ärzten zu Therapiebeschränkungen am Lebensende. Z Palliativmed 13: 293-300

Sobke A, Klinger M, Hermann B, Sachse S, Nietzsche S, Makarewicz O, Keller PM, Pfister W, Straube E (2012) The urinary antibiotic 5-nitro-8-hydroxyquinoline (Nitroxoline) reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Antimicrobial agents and chemotherapy 56: 6021-6025

Sponholz C, Huse K, Kramer M, Giamarellos-Bourboulis EJ, Claus RA, Kern A, Engel C, Kuhnt E, Kiehntopf M, Routsi C, Mylona V, Tsangaris I, Heinemann SH, Reinhart K, Platzer M, Bauer M (2012) Gene polymorphisms in the heme degradation pathway and outcome of severe human sepsis. Shock 38: 459-465

Stallmach A, Hagel S, Bruns T, Bauer M (2012) Zu kurz gedacht: Aufgaben fur die Nachwuchsforderung in der klinischen Forschung. [Cut a long story too short: Challenges in clinical research]. Dtsch Med Wochenschr 137: 496-500

Tierney L, Linde J, Muller S, Brunke S, Molina JC, Hube B, Schock U, Guthke R, Kuchler K (2012) An Interspecies Regulatory Network Inferred from Simultaneous RNA-seq of Candida albicans Invading Innate Immune Cells. Front Microbiol 3: 85

Tzepi IM, Giamarellos-Bourboulis EJ, Carrer DP, Tsaganos T, Claus RA, Vaki I, Pelekanou A, Kotsaki A, Tziortzioti V, Topouzis S, Bauer M, Papapetropoulos A (2012) Angiopoietin-2 enhances survival in experimental sepsis induced by multidrug-resistant Pseudomonas aeruginosa. The Journal of pharmacology and experimental therapeutics 343: 278-287

Vassilev T, Bauer M (2012) Passive immunotherapy of sepsis with intravenous immune globulin: not all IVIg preparations are created equal. Crit Care 16: 407

Wachtler B, Citiulo F, Jablonowski N, Forster S, Dalle F, Schaller M, Wilson D, Hube B (2012) Candida albicans-epithelial interactions: dissecting the roles of active penetration, induced endocytosis and host factors on the infection process. PloS one 7: e36952

Weber M, Lambeck S, Ding N, Henken S, Kohl M, Deigner HP, Enot DP, Igwe EI, Frappart L, Kiehntopf M, Claus RA, Kamradt T, Weih D, Vodovotz Y, Briles DE, Ogunniyi AD, Paton JC, Maus UA, Bauer M (2012) Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia. Faseb J 26: 2424-2436

Weimann A, Kern BR, Loffler M, Sablotzki A, Thiele F, Brunkhorst FM (2012) [Enrolment of intensive care patients in clinical studies : Ethical, legal and organizational problems from an interdisciplinary point of view.]. Medizinische Klinik, Intensivmedizin und Notfallmedizin 10.1007/s00063-012-0153-7

Wilson D, Citiulo F, Hube B (2012) Zinc exploitation by pathogenic fungi. PLoS Pathog 8: e1003034

Axer H, Romeike BFM, Brunkhorst F, Zinke J, Ringer TM, Günther A (2011) Neurological sequelae of sepsis: II) Neuromuscular weakness. The Open Critical Care Medicine Journal 4: 8-14

Bruns T, Peter J, Hagel S, Herrmann A, Stallmach A (2011) The augmented neutrophil respiratory burst in response to Escherichia coli is reduced in liver cirrhosis during infection. Clinical and experimental immunology 164: 346-356

Bruns T, Peter J, Hagel S, Pfeifer R, Prinz P, Stallmach A (2011) Homozygous carrier of the NOD2 1007fs frame-shift mutation presenting with refractory community-acquired spontaneous bacterial peritonitis and developing fatal pulmonary mucormycosis: A case report. Hepatology research : the official journal of the Japan Society of Hepatology 41: 1009-1014

Gonnert FA, Recknagel P, Seidel M, Jbeily N, Dahlke K, Bockmeyer CL, Winning J, Losche W, Claus RA, Bauer M (2011) Characteristics of clinical sepsis reflected in a reliable and reproducible rodent sepsis model. The Journal of surgical research 170: e123-134

Hagel S, Brunkhorst F (2011) Sepsis. Intensivmed Notfmed 1: 57-73

Hagel S, Bruns T, Herrmann A, Stallmach A, Schmidt C (2011) Abnormal Glucose Tolerance: A Predictor Of 30-Day Mortality In Patients With Decompensated Liver Cirrhosis. Zeitschrift fur Gastroenterologie 49: 331-334

Kiehntopf M, Schmerler D, Brunkhorst FM, Winkler R, Ludewig K, Osterloh D, Bloos F, Reinhart K, Deufel T (2011) Mass spectometry-based protein patterns in the diagnosis of sepsis/systemic inflammatory response syndrome. Shock 36: 560-569

Ringer TM, Axer H, Romeike BFM, Zinke J, Brunkhorst F, Witte OW, Günther A (2011) Neurological sequelae of sepsis: I) Septic encephalopathy. The Open Critical Care Medicine Journal 4: 2-7

Seider K, Brunke S, Schild L, Jablonowski N, Wilson D, Majer O, Barz D, Haas A, Kuchler K, Schaller M, Hube B (2011) The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation. J Immunol 187: 3072-3086