Publikationen zur Methodik und Evaluation des DQS

Schwarzkopf D, Rüddel H, Brinkmann A, Fleischmann-Struzek C, Friedrich ME, Glas M, Gogoll C, Gründling M, Meybohm P, Pletz MW et al: The German Quality Network Sepsis: Evaluation of a Quality Collaborative on Decreasing Sepsis-Related Mortality in a Controlled Interrupted Time Series Analysis . Frontiers in Medicine 2022, 9:882340.

Schwarzkopf D, Rüddel H, Gründling M, Putensen C, Reinhart K: The German Quality Network Sepsis: study protocol for the evaluation of a quality collaborative on decreasing sepsis-related mortality in a quasi-experimental difference-in-differences design. Implement Sci 2018, 13(1):15.

Schwarzkopf D, Fleischmann-Struzek C, Rüddel H, Reinhart K, Thomas-Rüddel DO: A risk-model for hospital mortality among patients with severe sepsis or septic shock based on German national administrative claims data. PLOS ONE 2018, 13(3):e0194371.

Publikationen aus dem Vorläuferprojekt des DQS: Medical EDUcation for sepsis Source control and Antibiotics (MEDUSA)

Rüddel H, Thomas-Rüddel DO, Reinhart K, Bach F, Gerlach H, Lindner M, Marshall JC, Simon P, Weiss M, Bloos F et al: Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled trial. Crit Care 2022, 26(1):51.

Schwarzkopf D, Matthaeus-Kraemer CT, Thomas-Rüddel DO, Rüddel H, Poidinger B, Bach F, Gerlach H, Gründling M, Lindner M, Scheer C et al: A multifaceted educational intervention improved anti-infectious measures but had no effect on mortality in patients with severe sepsis. Scientific Reports 2022, 12(1):3925.

Thomas-Rüddel DO, Hoffmann P, Schwarzkopf D, Scheer C, Bach F, Komann M, Gerlach H, Weiss M, Lindner M, Rüddel H et al: Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature. Crit Care 2021, 25(1):368.

Bloos F, Rüddel H, Thomas-Rüddel D, Schwarzkopf D, Pausch C, Harbarth S, Schreiber T, Gründling M, Marshall J, Simon P et al: Effect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomized trial. Intensive Care Med 2017, 43(11):1602 - 1612.

Matthaeus-Kraemer CT, Thomas-Rueddel DO, Schwarzkopf D, Rueddel H, Poidinger B, Reinhart K, Bloos F: Crossing the handover chasm: Clinicians' perceptions of barriers to the early detection and timely management of severe sepsis and septic shock. J Crit Care 2016, 36:85-91.

Matthaeus-Kraemer CT, Thomas-Rueddel DO, Schwarzkopf D, Rueddel H, Poidinger B, Reinhart K, Bloos F: Barriers and supportive conditions to improve quality of care for critically ill patients: A team approach to quality improvement. J Crit Care 2015, 30(4):685-691.

Thomas-Rueddel DO, Poidinger B, Weiss M, Bach F, Dey K, Häberle H, Kaisers U, Rüddel H, Schädler D, Scheer C et al: Hyperlactatemia is an independent predictor of mortality and denotes distinct subtypes of severe sepsis and septic shock. J Crit Care 2015, 30(2):439.e431-436.

Bloos F, Thomas-Ruddel D, Ruddel H, Engel C, Schwarzkopf D, Marshall JC, Harbarth S, Simon P, Riessen R, Keh D et al: Impact of compliance with infection management guidelines on outcome in patients with severe sepsis: a prospective observational multi-center study. Crit Care 2014, 18(2):R42.

Publikationen zur Sepsisepidemiologie

Fleischmann-Struzek C, Schwarzkopf D, Reinhart K: Inzidenz der Sepsis in Deutschland und weltweit: Aktueller Wissensstand und Limitationen der Erhebung in Abrechnungsdaten. Med Klin Intensivmed Notfmed 2022, 117(4):264–268.

Born S, Dame C, Matthäus-Krämer C, Schlapbach LJ, Reichert F, Schettler A, Schwarzkopf D, Thomas-Rüddel D, Proquitté H, Reinhart K et al: Epidemiology of Sepsis Among Children and Neonates in Germany: Results From an Observational Study Based on Nationwide Diagnosis-Related Groups Data Between 2010 and 2016. Crit Care Med 2021, 49(7):1049-1057.

Fleischmann-Struzek C, Mikolajetz A, Schwarzkopf D, Cohen J, Hartog CS, Pletz M, Gastmeier P, Reinhart K: Challenges in assessing the burden of sepsis and understanding the inequalities of sepsis outcomes between National Health Systems: secular trends in sepsis and infection incidence and mortality in Germany. Intensive Care Med 2018, 44(11):1826-1835.

Fleischmann C, Thomas–Rueddel DO, Hartmann M, Hartog CS, Welte T, Heublein S, Dennler U, Reinhart K: Fallzahlen und Sterblichkeitsraten von Sepsis-Patienten im Krankenhaus. Dtsch Arztebl International 2016, 113(10):159-166.

Publikationen zur Nutzbarkeit von Routinedaten für epidemiologische Surveillance und Qualitätsmanagement der Sepsis

Thomas‑Rüddel D, Rose N, Fleischmann‑Struzek C, Reinhart K, Boden B, Dorow H, Edel A, Gonnert FA, Götz J, Gründling M, Heim M, Holbeck K, Jaschinski U, Koch C, Künzer C, Le Ngoc K, Lindau S, Mehlmann NB, Meybohm P, Neb H, Ouart D, Putensen C, Sander M, Schewe JC, Schlattmann P, Schmidt G, Schneider G, Spies C, Steinsberger F, Tam C, Zacharowski K, Zinn S, Schwarzkopf D: Think sepsis, write sepsis, code sepsis – patient characteristics associated with sepsis (under-)coding in administrative health data. Infection 2026, 54:421–432. https://doi.org/10.1007/s15010-025-02685-8

Schwarzkopf D, Rose N, Fleischmann-Struzek C, Boden B, Dorow H, Edel A, Friedrich M, Gonnert F A, Götz J, Gründling M, Heim M, Holbeck K, Jaschinski U, Koch C, Künzer C, Ngoc K L, Lindau S, Mehlmann N B, Meschede J, Meybohm P, Ouart D, Putensen C, Sander M, Schewe J C, Schlattmann P, Schmidt G, Schneider G, Spies C, Steinsberger F, Zacharowski K, Zinn S, Reinhart K: Understanding the biases to sepsis surveillance and quality assurance caused by inaccurate coding in administrative health data. Infection. 2023 Sep 9. doi: 10.1007/s15010-023-02091-y.

Schwarzkopf D, Rose N, Fleischmann-Struzek C, Reinhart K: Ergebnisbericht: Validierung und Optimierung der Nutzbarkeit von Routinedaten zur Qualitätsverbesserung des Sepsis-Managements im Krankenhaus. 2022.

Schwarzkopf D, Fleischmann-Struzek C, Schlattmann P, Dorow H, Ouart D, Edel A, Gonnert FA, Götz J, Gründling M, Heim M et al: Validation study of German inpatient administrative health data for epidemiological surveillance and measurement of quality of care for sepsis: the OPTIMISE study protocol. BMJ Open 2020, 10(10):e035763.

Fleischmann-Struzek C, Thomas-Rüddel DO, Schettler A, Schwarzkopf D, Stacke A, Seymour CW, Haas C, Dennler U, Reinhart K: Comparing the validity of different ICD coding abstraction strategies for sepsis case identification in German claims data. PLOS ONE 2018, 13(7):e0198847.

Wedekind L, Fleischmann-Struzek C, Rose N, Spoden M, Günster C, Schlattmann P, Scherag A, Reinhart K, Schwarzkopf D: Development and validation of risk-adjusted indicators for the long-term outcome of acute sepsis care in German hospitals based on health claims data. Front. Med. 2022, 9:1069042