3R - Replace - Reduce - Refine 

In the Placenta Lab Jena, several working groups and research topics are working on replacement experiments to animal experiments:

https://www.uniklinikum-jena.de/Forschung/Tierexperimentelle+Forschung/3R+_+orientierte+Forschung+am+UKJ/3R+am+UKJ.html