- Extracellular matrix reorganisation during tumour cell invasion: definition of the histological distribution and clinical importance of oncofetal isoforms and splicing variants of the extracellular adhesion molecules laminin, fibronectin and tenascin-C
- Molecular interaction of oncofetal extracellular matrix proteins
- Cross talk of tumour cells and myofibroblasts / carcinoma associated fibroblasts (CAF´s) in the invasion front and its role for the onkofetal extracellular matrix reorganization
- Tumor cell phenotype transition and drug resistance
in collaboration with PD Dr. Marcus Franz Research Group Myocardial Remodelling (KIM I)
- Extracellular matrix remodelling in cardiovascular diseases: Importance for diagnosis and therapy
Completed Projects
IZKF 3.1
Formation of migration supporting multi protein complexes including laminin-5 in the invasive front of oral squamous cell carcinoma - role in tumour cell activation and contribution to individual prognosis
IZKF 3.14
Splicing variants of Tenascin-C as markers for tumour progression an prognosis in urothelial carcinoma of bladder
EU "STROMA"
Selective targeting of angiogenesis and of tumor stroma
subcontractor of Prof. Dr. H. Kosmehl, Institut of Pathology; HELIOS-Klinikum Erfurt
IZKF 5.3
Tumour associated fibroblasts (TAF) in urothelial carcinoma of urinary bladder - origin, phenotype modulation and importance for invasion and metastasis
EU "ADAMANT"
Antibody Derivatives As Molecular Agents for Neoplastic Targeting
DFG
Tumour- Stroma interaction and phenotype transition of oral squamous cell carcinoma cells: influence on therapy relevant EGFR dependent signalling pathways
EU "PRIAT"
Profiling Responders In Antibody Therapies
Completed Doctoral Theses
MU Dr. Petra Richter 2005
Activation of EGFR dependent protein kinases and it's relation to invasion associated changes of laminin-5 synthesis and deposition in oral squamous cell carcinoma
Marcus Franz 2005
In vitro and in situ analysis of Laminin-5 and Tenascin-C colocalization in oral squamous cell carcinoma in vitro and in situ
Katharina Anger 2006
Analysis of Tenascin-C splicing domain expression in urothelial carcinoma of bladder
Susann Bock 2008
Analysis of Tenascin-C splicing domain expression in oral squamous cell carcinoma
Claudia Umbreit 2008
Growth factor induced phenotype changes in oral squamous cell carcinoma cells and Laminin-332: Generation of a cell culture model for Epithelial-Mesenchymal-Transition
Anke Wolheim 2009
Comparative analysis of laminin isoform expression in oral squamous cell carcinoma (OSCC) - implications for stroma reorganisation and tumour angioneogenesis
Markus Tost 2009
Evaluation of unspliced Tenascin-C as tumor marker in bladder carcinoma
Dr. med. univ. Anja Baldinger 2011
Reorganisation of cardial extra-cellular matrix and reexpression of fetal molecule variants of fibronectin and tenascin-C in cardiovascular disease
Thomas Gecks 2012
Validation of large unspliced tenascin-C variants as surveillance marker in urothelial carcinoma of the urinary bladder
Jana Geweiler 2014
Evaluation of the predicitive value of markers of stromal activation and Epithelial-Mesenchymal-Transition for therapy response in oral cancer
Doreen Kandraschow
Expression analysis of ADAM23, GPNMB and RGS5 in human tumours
Completed Diploma and Master Theses
Christiane Geyer 2006
Analysis of high molecular extracellular matrix proteins by means of protein chip technology
Michaela Weidig 2009
Characterisation of tissue distribution of fibroblastic and myofibroblastic markers in urothelial carcinoma of urinary bladder - influence of carcinoma cells on regulation of fibroblastic differentiation
Juliane Brandt 2009
Analysis of growth factor induced phenotype modulation and matrix reorganisation in urothelial carcinoma of urinary bladder
Robert Koellner 2009
Characterisation of laminin, fibronectin, and tenascin-C isoform expression during tumour angioneogensis
Kerstin Galler 2010
Analysis of the differential expression of tenascin-C and fibronectin splice variants in tumour vessels of human carcinomas
Julia Schulte 2011
Analysis of the distribution of EMT markers in urothelial carcinoma of the urinary bladder - influence of activated tumour associated fibroblasts
Matthias Ditze 2011
Remodeling of extracellular matrix and fibroblast/ myocardiocyt interaction
Nilay Köse 2014
Influence of ED-A+-fibronectin-antibody based targeted delivery of IL-10 on chronic rejection in a rat heart transplantation model: comparative evaluation of the immune response in a preventive and a therapeutic setting
Dominique Tuch 2018
Characterization of a cell cultur model of therapy induced phenotype transition and drug resistance in oral carcinoma
Completed Bachelor Theses
Kristin Schult 2011
Analysis of the influence of the EGFR inhibitor Gefitinib on activated fibroblasts
Philipp Balzer 2011
Characterization of aFGF/TGFß1 costimulated fibroblasts
Stefanie Gühne 2012
Analysis of fibroblast induced phenotype changes and therapy sensitivity in oral carcinoma cells
Barbara Ziffels 2013
Generation of an ELISA to detect human and murine ED-A+-fibronectin