Publications since 2010

2025

Tewari, D., Sattler, C., Benndorf, K. (2025)
Functional control of heteromeric Kv2.1/6.4 channels by the voltage sensor domain of the silent Kv6.4 subunit.
J Physiol., 10.1113/JP288376

Benndorf, K., Enke, U., Tewari, D., Kusch, J., Liu, H., Sun, H., Schmauder, R., & Sattler, C. (2025)
Subunit-specific conductance of single homomeric and heteromeric HCN pacemaker channels at femtosiemens
resolution.
Proc. Natl. Acad. Sci. U.S.A. 122, e2422533122

Wand, P.L., Brünings, X., Tewari, D., Reuter, S., Mrowka, R., Benndorf, K., Zimmer, T., Sattler, C. (2025).
Differential Effects of Hearing Loss Mutations in Homomeric P2X2 and Heteromeric P2X2/3 Receptors.
Cells 14, 510

2024

Korn, T., Hansen, U. P., Gabriel, T. S., Rauh, O., Drexler, N., Schroeder, I. (2024)
Binding kinetics of quaternary ammonium ions in Kcv potassium channels.
Channels (Austin, Tex.), 18, 2402749

Mrowka, R., Schmauder, R. (2024).
How to visualize high-dimensional data.
Acta physiol (Oxf), e14219. Advance online publication.

Brünings, X., Schmauder, R., Mrowka, R., Benndorf, K., Sattler, C. (2024)
Subtype-Specific Ligand Binding and Activation Gating in Homomeric and Heteromeric P2X Receptors.
Biomolecules 14, 942

Kuschke, S., Thon, S., Sattler, C., Schwabe, T., Benndorf, K., Schmauder, R. (2024)
cAMP binding to closed pacemaker ion channels is cooperative.
Proc. Natl. Acad. Sci. U. S. A. 121, e2315132121

Porro, A., Saponaro, A., Castelli, R., Introini, B., Alkotob, AH., Ranjbari, G., Enke, U., Kusch, J., Benndorf, K., Santoro, B., Difrancesco, D., Thiel, G., Moroni, A (2024 )
A high affinity switch for cAMP in the HCN pacemaker channels.
Nat. Commun. 15, 843

2023

Benndorf, K., Schulz, E. (2023)
Identifiability of equilibrium constants for receptors with two to five binding sites.
J. Gen. Physiol. 155, e202313423

Schmauder, R., Eick, T., Schulz, E., Sammler, G., Voigt, E., Mayer, G., Ginter, H., Ditze, G., Benndorf, K. 2023)
Fast functional mapping of ligand-gated ion channels.
Commun. Biol. 6, 1003

Kukaj, T., Sattler, C., Zimmer, T., Schmauder, R., and Benndorf, K. (2023)

Kinetic fingerprinting of metabotropic glutamate receptors

Commun. Biol. 6, 104

2022

Yüksel, S., Bonus, M., Schwabe, T., Pfleger, C., Zimmer, T., Enke, U., Saß, I., Gohlke, H., Benndorf, K., and Kusch, J. (2022)

Uncoupling of Voltage- and Ligand-Induced Activation in HCN2 Channels by Glycine Inserts.

Front.Physiol. 13, 895324

Benndorf, K., Eick, T., Sattler, C., Schmauder, R., and Schulz, E. (2022)

A strategy for determining the equilibrium constants for heteromeric ion channels in a complex model

J. Gen. Physiol. 154, e202113041

Münch, J.L., Paul, F., Schmauder, R., and Benndorf, K. (2022)

Bayesian inference of kinetic schemes for ion channels by Kalman filtering

eLife 11, e62714

Kondapuram, M., Frieg, B., Yüksel, S., Schwabe, T., Sattler, C., Lelle, M., Schweinitz, A., Schmauder, R., Benndorf, K., Gohlke, H., and Kusch, J. (2022)

Functional and structural characterization of interactions between opposite subunits in HCN pacemaker channels

Commun. Biol. 5, 430

Rauh, O., Opper, J., Sturm, M., Drexler, N., Scheub, D.D., Hansen, U.P., Thiel, G., and Schroeder, I. (2022)

Role of Ion Distribution and Energy Barriers for Concerted Motion of Subunits in Selectivity Filter Gating of a K+ Channel

J. Mol. Biol. 434, 167522

Sattler, C., and Benndorf, K. (2022)

Enlightening activation gating in P2X receptors

Purinergic Signal., doi: 10.1007/s11302-022-09850-w

Das, S., Popp, V., Power, M., Groeneveld, K., Yan, J., Melle, C., Rogerson, L., Achury, M., Schwede, F., Strasser, T., Euler, T., Paquet-Durand, F., and Nache, V. (2022)

Redefining the role of Ca2+-permeable channels in photoreceptor degeneration using diltiazem

Cell Death Dis. 13, 47

vom Dahl, C., Müller, C.E., Berisha, X., Nagel, G., Zimmer, T. (2022)

Coupling the cardiac voltage-gated sodium channel to channelrhodopsin-2 generates novel optical switches for action potential studies.

Membranes 12, 907

Wucherpfennig, S., Haq, W., Popp, V., Kesh, S., Das, S., Melle, C., Rentsch, A., Schwede, F., Paquet-Durand, F., and Nache, V. (2022)

cGMP Analogues with Opposing Actions on CNG Channels Selectively Modulate Rod or Cone Photoreceptor Function.

Pharmaceutics 14, 2102

2021

Lehmann, J., Jørgensen, M.E., Fratz, S., Müller, H.M., Kusch, J., Scherzer, S., Navarro-Retamal, C., Mayer, D., Böhm, J., Konrad, K.R., Terpitz, U., Dreyer, I., Mueller, T.D., Sauer, M., Hedrich, R., Geiger, D., and Maierhofer, T. (2021)

Acidosis-induced activation of anion channel SLAH3 in the flooding-related stress response of Arabidopsis

Curr. Biol. 31, 3575-3585.e9

Gabriel, T.S., Hansen, U.P., Urban, M., Drexler, N., Winterstein, T., Rauh, O., Thiel, G., Kast, S.M., and Schroeder, I. (2021)

Asymmetric Interplay Between K+ and Blocker and Atomistic Parameters From Physiological Experiments Quantify K+ Channel Blocker Release

Front. Physiol. 12, 737834

Fuchs, E., Messerer, D.A.C., Karpel-Massler, G., Fauler, M., Zimmer, T., Jungwirth, B., and Föhr, K.J. (2021)

Block of Voltage-Gated Sodium Channels as a Potential Novel Anti-cancer Mechanism of TIC10

Front. Pharmacol. 12, 737637

Gusic, M., Benndorf, K., and Sattler, C. (2021)

Dissecting activation steps in P2X7 receptors

Biochem. Biophys. Res. Commun. 569, 112-117

Schirmeyer, J., Hummert, S., Eick, T., Schulz, E., Schwabe, T., Ehrlich, G., Kukaj, T., Wiegand, M., Sattler, C., Schmauder, R., Zimmer, T., Kosmalla, N., Münch, J., Bonus, M., Gohlke, H., and Benndorf, K. (2021)

Thermodynamic profile of mutual subunit control in a heteromeric receptor

Proc. Natl. Acad. Sci. 118, e2100469118

Föhr, K.J., Nastos, A., Fauler, M., Zimmer, T., Jungwirth, B., and Messerer, D.A.C. (2021)

Block of Voltage-Gated Sodium Channels by Atomoxetine in a State- and Use-dependent Manner

Front. Pharmacol. 12, 622489

Pfleger, C., Kusch, J., Kondapuram, M., Schwabe, T., Sattler, C., Benndorf, K., and Gohlke, H. (2021)

Allosteric signaling in C-linker and cyclic nucleotie-binding domain of HCN2 channels

Biophys. J. 120, 950-963

2020

Sattler, C., Eick, T., Hummert, S., Schulz, E., Schmauder, R., Schweinitz, A., Unzeitig, C., Schwede, F., and Benndorf, K. (2020)

Unravelling the intricate cooperativity of subunit gating in P2X2 ion channels

Sci. Rep. 10, 21751

Walther, F., Feind, D., vom Dahl, C., Müller, C.E., Kukaj, T., Sattler, C., Nagel, G., Gao, S., and Zimmer, T. (2020)

Action potentials in Xenopus oocytes triggered by blue light

J. Gen. Physiol. 152, e201912489

Lelle, M., Otte, M., Bonus, M., Gohlke, H., and Benndorf, K. (2020)

Fluorophore‐Labeled Cyclic Nucleotides as Potent Agonists of Cyclic Nucleotide‐Regulated Ion Channels

ChemBioChem 21, 1-11

Sattler, C., Schmauder, R., Schwabe, T., Schweinitz, A., Unzeitig, C., Schwede, F., Otte, M., and Benndorf, K. (2020)

Relating ligand binding to activation gating in P2X2 receptors using a novel fluorescent ATP derivative

J. Neurochem. DOI: 10.1111/jnc.14948

2019

Richter, J.F., Hildner, M., Schmauder, R., Turner, J.R., Schumann, M., and Reiche, J. (2019)

Occludin knockdown is not sufficient to induce transepithelial macromolecule passage

Tissue Barriers 7, 1612661

Leypold, T., Bonus, M., Spiegelhalter, F., Schwede, f., Schwabe, T., Gohlke, H., and Kusch, J. (2019)

N6-modified cAMP derivatives that activate protein kinase A also act as full agonists of murine HCN2 channels

J. Biol. Chem. 294, 17978-17987

Otte, M., Schweinitz, A., Lelle, M., Thon, S., Enke, U., Yüksel, S., Schmauder, R., Bonus, M., Gohlke, H., and Benndorf, K. (2019)

Novel Fluorescent Cyclic Nucleotide Derivatives to Study CNG and HCN Channel Function

Biophys. J. 116, 2411-2422

Grushevskyi, E. O., Kukaj, T., Schmauder, R., Bock, A., Zabel, U., Schwabe, T., Benndorf, K., and Lohse, M. J. (2019)

Stepwise activation of a class C GPCR begins with millisecond dimer rearrangement

Proc. Natl. Acad. Sci. U S A 116, 10150-10155

Lelle, M., Otte, M., Thon, S., Bertinetti, D., Herberg, F. W., and Benndorf, K. (2019)

Chemical synthesis and biological activity of novel brominated 7-deazaadenosine-3',5'-cyclic monophosphate derivatives

Bioorg. Med. Chem. 27, 1704-1713

2018

Ando, T., Bhamidimarri, S. P., Brending, N., Colin-York, H., Collinson, L., De Jonge, N., de Pablo. P. J., Debroye, E., Eggeling, C., Franck, C., Fritzsche, M., Gerritsen, H., Giepmans, B. N. G., Grunewald, K., Hofkens, J., Hoogenboom, J. P., Janssen, K. P. F., Kaufman, R., Klumpermann, J., Kurniawan, N., Kusch, J., Liv, N., Parekh, V., Peckys, D. B., Rehfeldt, F., Reutens, D. C., Roeffaers, M. B. J., Salditt, T., Schaap, I. A. T., Schwarz, U. S., Verkade, P., Vogel, M. W., Wagner, R., Winterhalter, M., Yuan, H., and Zifarelli, G. (2018)

The 2018 correlative microscopy techniques roadmap

J. Phys. D. Appl. Phys. 51, 443001

Sunkara, M. R., Schwabe, T., Ehrlich, G., Kusch, J., and Benndorf, K. (2018)

All four subunits of HCN2 channels contribute to the activation gating in an additive but intricate manner

J. Gen. Physiol. 150, 1261-1271

Hummert, S., Thon, S., Eick, T., Schmauder, R., Schulz, E., ans Benndorf, K. (2018)

Activation gating in HCN2 channels

PLoS Comput. Biol. 14, e1006045

Otte, M., Schweinitz, A., Bonus, M., Enke, U., Schumann, C., Gohlke, H., and Benndorf, K. (2018)

Hydrophobic alkyl chains substituted to the 8-position of cyclic nucleotides enhance activation of CNG and HCN channels by an intricate enthalpy - entropy compensation

Sci. Rep. 8, 14960

2017

Tarradas, A., Pinsach-Abuin, M. L., Mackintosh, C., Llorà-Batlle, O., Pérez-Serra, A., Batlle, M., Pérez-Villa, F., Zimmer, T., Garcia-Bassets, I., Brugada, R., Beltran-Alvarez, P., and Pagans, S. (2017)

Transcriptional regulation of the sodium channel gene (SCN5A) by GATA4 in human heart

Mol. Cell. Cardiol. 102, 74-82

2016

Nache, V., Wongsamitkul, N., Kusch, J., Zimmer, T., Schwede, F., and Benndorf, K. (2016)

Deciphering the function of the CNGB1b subunit in olfactory CNG channels

Sci. Rep. 6, 29378

Wongsamitkul, N., Nache, V., Eick, T., Hummert, S., Schulz, E., Schmauder, R., Schirmeyer, J., Zimmer, T., and Benndorf, K. (2016)

Quantifying the cooperative subunit action in a multimeric membrane receptor

Sci. Rep. 6, 20974

Richter, J. F., Schmauder, R., Krug, S. M., Gebert, A., and Schumann, M. (2016)

A novel method for imaging sites of paracellular passage of macromolecules in epithelial sheets

Control. Release 229, 70-79

Freyermuth, F., Rau, F., Kokunai, Y., Linke, T., Sellier, C., Nakamori, M., Kino, Y., Arandel, L., Jollet, A., Thibault, C., Philipps, M., Vicaire, S., Jost, B., Udd, B., Day, J. W., Duboc, D., Wahbi, K., Matsumura, T., Fujimura, H., Mochizuki, H., Deryckere, F., Kimura, T., Nukina, N., Ishiura, S., Lacroix, V., Campan-Fournier, A., Navratil, V., Chautard, E., Auboeuf, D., Horie, M., Imoto, K., Lee, K. Y., Swanson, M., Lopez de Munainm, A., Inada, S., Itoh, H., Nakazawa, K., Ashihara, T., Wang, E., Zimmer, T., Furling, D., Takahashi, M. P., and Charlet-Berguerand, N. (2016)

Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy

Nat. Commun. 7, 11067

2015

Thon, S., Schulz, E., Kusch, J., and Benndorf, K. (2015)

Conformational Flip of Nonactivated HCN2 Channel Subunits Evoked by Cyclic Nucleotides

Biophys. J. 109, 2268-2276

Kesters, D., Brams, M., Nys, M., Wijckmans, E., Spurny, R., Voets, T., Tytgat, J., Kusch, J., and Ulens, C. (2015)

Structure of the SthK carboxy-terminal region reveals a gating mechanism for cyclic nucleotide-modulated ion channels

PLoS One 10, e0116369

2014

Brams, M., Kusch, J., Spurny, R., Benndorf, K., and Ulens, C. (2014)

Family of prokaryote cyclic nucleotide-modulated ion channels

Proc. Natl. Acad. Sci. U S A 111, 7855-7860

Thon, S., and Benndorf, K. (2014)

Avoiding the formation of vesicles by patch excision from Xenopus oocytes

J. Neurosci. Methods 225, 29-31

Kusch, J., and Zifarelli, G. (2014)

Patch-clamp fluorometry: electrophysiology meets fluorescence

Biophys. J. 106, 1250-1257

Schmidt, A., Lenzig, P., Oslender-Bujotzek, A., Kusch, J., Lucas, S. D., Gründer, S., and Wiemuth, D. (2014)

The bile acid-sensitive ion channel (BASIC) is activated by alterations of its membrane environment

PLoS One 9, e111549

Zimmer, T., Haufe, V., and Blechschmidt, S. (2014)

Voltage-gated sodium channels in the mammalian heart

Cardiol. Sci. Pract. 58, 449-463

2013

Nache, V., Eick, T., Schulz, E., Schmauder, R., and Benndorf, K. (2013)

Hysteresis of ligand binding in CNGA2 ion channels

Nat. Commun. 4, 2866

Thon, S., Schmauder, R., and Benndorf, K. (2013)

Elementary functional properties of single HCN2 channels

Biophys. J. 105, 1581-1589

Beltran-Alvarez, P., Espejo, A., Schmauder, R., Beltran, C., Mrowka, R., Linke, T., Batlle, M., Pérez-Villa, F., Pérez, G. J., Scornik, F. S., Benndorf, K., Pagans, S., Zimmer, T., and Brugada, R. (2013)

Protein arginine methyl transferases-3 and -5 increase cell surface expression of cardiac sodium channel

FEBS Lett. 587, 3159-3165

Gütter, C., Benndorf, K., and Zimmer, T. (2013)

Characterization of N-terminally mutated cardiac Na(+) channels associated with long QT syndrome 3 and Brugada syndrome

Front. Physiol. 4, 153

2012

Benndorf, K., Kusch, J., and Schulz, E. (2012)

Probability Fluxes and Transition Paths in a Markovian Model Describing Complex Subunit Cooperativity in HCN2 Channels

PLoS Comput. Biol. 8, e1002721

Nache, V., Zimmer, T., Wongsamitkul, N., Schmauder, R., Kusch, J., Reinhardt, L., Bönigk, W., Seifert, R., Biskup, C., Schwede, F., and Benndorf, K. (2012)

Differential Regulation by Cyclic Nucleotides of the CNGA4 and CNGB1b Subunits in Olfactory Cyclic Nucleotide-Gated Channels

Sci. Signal. 5, ra48

Kusch, J., Thon, S., Schulz, E., Biskup, C., Nache, V., Zimmer, T., Seifert, R., Schwede, F., and Benndorf, K. (2012)

How subunits cooperate in cAMP-induced activation of homotetrameric HCN2 channels

Nat. Chem. Biol. 8, 162-9

Benndorf, K., Thon, S., and Schulz, E. (2012)

Unraveling subunit cooperativity in homotetrameric HCN2 channels

Biophys. J. 103, 1860-1869

2011

Walzik, S., Schroeter, A., Benndorf, K., and Zimmer, T. (2011)

Alternative splicing of the cardiac sodium channel creates multiple variants of mutant T1620K channels

PLoS One 6, e19188

Zimmer, T., and Benndorf, K. (2011)

Molecular mechanisms of voltage-gated Na+ channel dysfunction in LQT3 syndrome

In Tripathi et al. (eds.): Heart Rate and Rhythm, Springer-Verlag Berlin Heidelberg.

2010

Kusch, J., Zimmer, T., Holschuh, J., Biskup, C., Schulz, E., Nache, V., and Benndorf, K. (2010)

Role of the S4-S5 linker in CNG channel activation

Biophys. J. 99, 2488-96

Kusch, J., Biskup, C., Thon, S., Schulz, E., Nache, V., Zimmer, T., Schwede, F., and Benndorf, K. (2010)

Interdependence of receptor activation and ligand binding in HCN2 pacemaker channels

Neuron 67, 75-85

Schroeter, A., Walzik, S., Blechschmidt, S., Haufe, V., Benndorf, K., and Zimmer, T. (2010)

Structure and function of splice variants of the cardiac voltage-gated sodium channel Na(v)1.5

J. Mol. Cell. Cardiol. 49, 16-24

Ganitkevich, V., Mattea, V., and Benndorf, K. (2010)

Glycolytic oscillations in single ischemic cardiomyocytes at near anoxia

J. Gen. Physiol. 135, 307-19

Gui, J., Wang, T., Jones, R. P., Trump, D., Zimmer, T., and Lei, M. (2010)

Multiple loss-of-function mechanisms contribute to SCN5A-related familial sick sinus syndrome

PLoS One 5, e10985

Zimmer, T. (2010)

Effects of tetrodotoxin on the mammalian cardiovascular system

Mar. Drugs 8, 741-62

Gui, J., Wang, T., Trump, D., Zimmer, T., and Lei, M. (2010)

Mutation-specific effects of polymorphism H558R in SCN5A-related sick sinus syndrome

J. Cardiovasc. Electrophysiol. 5, 564-73

Stanca, S. E., Csaki, A., Urban, M., Nietzsche, S., Biskup, C., and Fritzsche, W. (2010)

Simultaneous topographic and amperometric membrane mapping using an AFM probe integrated biosensor

Biosens. Bioelectron. 26, 2911-6

Rubio, I., Grund, S., Song, S. P., Biskup, C., Bandemer, S., Fricke, M., Förster, M., Graziani, A., Wittig, U., and Kliche, S. (2010)

TCR-induced activation of Ras proceeds at the plasma membrane and requires palmitoylation of N-Ras

J. Immunol. 185, 3536-43

Stanca, S. E., Nietzsche, S., Fritzsche, W., Cranfield, C. G., and Biskup, C. (2010)

Intracellular ion monitoring using a gold-core polymer-shell nanosensor architecture

Nanotechnology 21, 055501