SP18

Principal Investigator: Julia von Maltzahn (FLI Jena)

Christian Hayn (PhD): Molecular differences underlying functional impairment of aged muscle stem cells

During ageing and in models of premature ageing the number and functionality of muscle stem cells decreases dramatically. Different signalling pathways have been reported to be altered in aged muscle stem cells. Therefore, we are investigating which intrinsic changes in muscle stem cells occur during ageing and impair their functionality. Furthermore, we are examining the interaction of the muscle stem cell with its niche and how changes in the posttranslational modifications of membrane receptors such as glycosylation are changing in muscle stem cells during ageing. Additionally, we are analysing how these changes are affecting downstream signalling pathways.