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Klinik für Psychiatrie und Psychotherapie / Forschung / Arbeitsgruppen / Identification of Biotypes

Identification of Biotypes

PD Dr. Bianca Besteher

About

Our team investigates neurobiological features of psychopathology in the spectrum of depression via multimodal neuroimaging. Considering a symptom continuum in addition to traditional case-control settings enables several interesting points of view:

  1. inclusion of symptoms overlapping with other diagnoses (e.g. anxiety and somatoform disorders, post-infectious conditions like Post-COVID or ME/CFS),
  2. differentiation of biologically diverse sub-types of one generic diagnosis , especially with regards to sex-specific features and
  3. use of the subclinical part of the spectrum to investigate early origins of clinical syndromes.   

With regard to these aspects we work towards a more precise and neurobiologically founded way of psychiatric diagnostics specific to an individual patient. Also, we are involved in clinical intervention projects regarding management of psychiatric Post-COVID symptoms.

Team

Tonia Rocktäschel, MD

Dario Helbing, MD

Alexander Weuthen, MD

Johanna Ballez

Dominic Riese

Kathrin Blume

Beatrix Eichert

Lara Krickow

MD-students:

Antonia Toepffer, Marie Troll, Eva-Maria Dommaschk, Maximilian Vollmer, Vita Tay, Ina Temeschinko

Projects

CreAtiN bei Post-COVID – Intervention zur Beobachtung der postviraLen FatiguE (CANDLE) - ongoing

Randomized and placebo-controlled intervention study to observe fatigue symptoms, inflammatory parameters, and imaging markers in post-COVID patients. Supported by AlzChem Group.

Mobile WohnortnAhe Versorgung zur Steuerung der sektorüber-greifenden Therapie bei Post-COVID-19 in THüringen (WATCH), Intervention „SOUL“ - ongoing

Development and application of a cognitive-behavioral short-term intervention for the treatment of psychological post-COVID symptoms and improvement of illness management as part of a multimodal intervention for post-COVID patients from Thuringia.

 

Post-COVID Brain - Characterization and Imaging of the Neuropsychiatric Aftermath - data acquisition finished

This multimodal and longitudinal MR-imaging project investigates long-lasting structural, functional and metabolical brain alterations in patients with neuropsychiatric symptoms due to long-COVID and post-COVID

IBIS (Identification of Biotypes in the Spectrum of Depression) – data acquisition finished

Multimodal data set of MDD patients with biological, clinical and imaging data for cluster analysis to characterize biological sub-types of (pre-)clinical depression. These could perspectively facilitate more precise clinical assessment and prediction of the clinical course for an individual patient.

TiPs (Tinnitus & Psyche) - data acquisition from 2016 to 2017, analyses concluded in 2019

The Tips project aimed to identify brain structural correlates of tinnitus and psychiatric comorbidity and interactions between both conditions.

Publications

2024

  1. Belov, V., Erwin-Grabner, T., Aghajani, M., Aleman, A., Amod, A. R., Basgoze, Z. et al. (2024). Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures. Scientific Reports, 14(1), 1084. https://doi.org/10.1038/s41598-023-47934-8
  2. Besteher, B. [Bianca], Rocktäschel, T., Garza, A. P., Machnik, M., Ballez, J., Helbing, D.‑L. et al. (2024). Cortical thickness alterations and systemic inflammation define long-COVID patients with cognitive impairment. Brain, Behavior, and Immunity, 116, 175–184. https://doi.org/10.1016/j.bbi.2023.11.028
  3. Busch, A., Roy, S., Helbing, D. L., Colic, L., Opel, N., Besteher, B. [Bianca] et al. (2024). Gut microbiome in atypical depression. Journal of Affective Disorders, 349, 277–285. https://doi.org/10.1016/j.jad.2024.01.060
  4. Helbing, D. L., Dommaschk, E.‑M., Danyeli, L. V., Liepinsh, E., Refisch, A., Sen, Z. D. et al. (2024). Conceptual foundations of acetylcarnitine supplementation in neuropsychiatric long COVID syndrome: a narrative review. European Archives of Psychiatry and Clinical Neuroscience. https://doi.org/10.1007/s00406-023-01734-3
  5. Herpertz, J., Goltermann, J., Gruber, M., Blitz, R., Taylor, J., Brosch, K. et al. (2024). The impact of depression and childhood maltreatment experiences on psychological adaptation from lockdown to reopening period during the COVID-19 pandemic. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 83, 59–60. https://doi.org/10.1016/j.euroneuro.2024.04.006
  6. Kikinis, Z., Castañeyra-Perdomo, A., González-Mora, J. L., Rushmore, R. J., Toppa, P. H., Haggerty, K. et al. (2024). Investigating the structural network underlying brain-immune interactions using combined histopathology and neuroimaging: a critical review for its relevance in acute and long COVID-19. Frontiers in Psychiatry, 15, 1337888. https://doi.org/10.3389/fpsyt.2024.1337888
  7. Liu, S., Behrens, S. C., Besteher, B. [Bianca], Bilek, E., Chae, W. R., Clemens, V. et al. (2024). Strukturen, Ziele und Bedürfnisse der Early Career Scientists am Deutschen Zentrum für Psychische Gesundheit. Der Nervenarzt [Structures, aims and needs of early career scientists at the German Center for Mental Health], 95(5), 467–473. https://doi.org/10.1007/s00115-024-01631-7
  8. Mackert, S., Niemeyer, C., Mecdad, Y., Ebert, T., Bajaj, T., Durand, S. et al. (2024). Spermidine alleviates depression via control of the stress response. BioRxiv : the Preprint Server for Biology. https://doi.org/10.1101/2024.12.04.626625
  9. Martin, E. M., Srowig, A., Utech, I., Schrenk, S., Kattlun, F., Radscheidt, M. et al. (2024). Persistent cognitive slowing in post-COVID patients: longitudinal study over 6 months. Journal of Neurology, 271(1), 46–58. https://doi.org/10.1007/s00415-023-12069-3
  10. Reuken, P. A. [P. A.], Besteher, B. [B.], Finke, K. [K.], Fischer, A., Holl, A., Katzer, K. et al. (2023). Longterm course of neuropsychological symptoms and ME/CFS after SARS-CoV-2-infection: a prospective registry study. European Archives of Psychiatry and Clinical Neuroscience. https://doi.org/10.1007/s00406-023-01661-3
  11. Reuken, P. A., Besteher, B. [Bianca], Bleidorn, J., Brockmann, D., Finke, K. [Kathrin], Freytag, A. et al. (2024). Web-based telemedicine approach for treatment of post-COVID-19 in Thuringia (WATCH). Digital Health, 10, 20552076241291748. https://doi.org/10.1177/20552076241291748
  12. Teichgräber, U., Ingwersen, M., Sturm, M.‑J., Giesecke, J., Allwang, M., Herzog, I. et al. (2024). Objective structured clinical examination to teach competency in planetary health care and management - a prospective observational study. BMC Medical Education, 24(1), 308. https://doi.org/10.1186/s12909-024-05274-9

 

Vor 2024

  • Besteher, B., Brambilla, P. & Nenadic, I. (2020). Twin studies of brain structure and cognition in schizophrenia. Neurosci Biobehav Rev 109, 103-113.
  • Besteher, B., Chung, H. Y., Mayer, T. E., Witte, O. W., Kirchhof, K. & Schwab, M. (2019a). Acute Encephalopathy and Cardiac Arrest Induced by Intrathecal Gadolinium Administration. Clin Neuroradiol.
  • Besteher, B., Gaser, C., Ivansic, D., Guntinas-Lichius, O., Dobel, C. & Nenadic, I. (2019b). Chronic tinnitus and the limbic system: Reappraising brain structural effects of distress and affective symptoms. Neuroimage Clin 24, 101976.
  • Besteher, B., Gaser, C., Langbein, K., Dietzek, M., Sauer, H. & Nenadic, I. (2017a). Effects of subclinical depression, anxiety and somatization on brain structure in healthy subjects. J Affect Disord 215, 111-117.
  • Besteher, B., Gaser, C. & Nenadic, I. (2019c). Brain Structure and Subclinical Symptoms: A Dimensional Perspective of Psychopathology in the Depression and Anxiety Spectrum. Neuropsychobiology, 1-14.
  • Besteher, B., Gaser, C. & Nenadic, I. (2019d). Brain structure and trait impulsivity: A comparative VBM study contrasting neural correlates of traditional and alternative concepts in healthy subjects. Neuropsychologia 131, 139-147.
  • Besteher, B., Gaser, C. & Nenadic, I. (2019e). Machine-learning based brain age estimation in major depression showing no evidence of accelerated aging. Psychiatry Res Neuroimaging 290, 1-4.
  • Besteher, B., Gaser, C., Spalthoff, R. & Nenadic, I. (2017b). Associations between urban upbringing and cortical thickness and gyrification. J Psychiatr Res 95, 114-120.
  • Besteher, B., Squarcina, L., Spalthoff, R., Bellani, M., Gaser, C., Brambilla, P. & Nenadic, I. (2017c). Brain structural correlates of irritability: Findings in a large healthy cohort. Hum Brain Mapp 38, 6230-6238.
  • Besteher, B., Squarcina, L., Spalthoff, R., Bellani, M., Gaser, C., Brambilla, P. & Nenadic, I. (2019f). Hippocampal Volume as a Putative Marker of Resilience or Compensation to Minor Depressive Symptoms in a Nonclinical Sample. Front Psychiatry 10, 467.
  • Besteher, B., Squarcina, L., Spalthoff, R., Bellani, M., Gaser, C., Nenadic, I. & Brambilla, P. (2018). Subclinical Agoraphobia Symptoms and Regional Brain Volumes in Non-clinical Subjects: Between Compensation and Resilience? Front Psychiatry 9, 541.
  • Besteher, B., Wagner, G., Koch, K., Schachtzabel, C., Reichenbach, J. R., Schlosser, R., Sauer, H. & Schultz, C. C. (2016). Pronounced prefronto-temporal cortical thinning in schizophrenia: Neuroanatomical correlate of suicidal behavior? Schizophr Res 176, 151-157.
  • Chung, H. Y., Essig, F., Wickel, J., Besteher, B., Neugebauer, H., Haeusler, K. G., Mullges, W. & Schwab, M. (2020). Acute onset and severe manifestation of postural orthostatic tachycardia syndrome - Two cases. Clin Neurophysiol 131, 158-159.
  • Freesmeyer, M., Schwab, M., Besteher, B., Grober, S., Waschke, A. & Drescher, R. (2019). High-Resolution PET Cisternography With 64Cu-DOTA for CSF Leak Detection. Clin Nucl Med 44, 735-737.
  • Ivansic, D., Besteher, B., Gantner, J., Guntinas-Lichius, O., Pantev, C., Nenadic, I. & Dobel, C. (2019). Psychometric assessment of mental health in tinnitus patients, depressive and healthy controls. Psychiatry Res 281, 112582.
  • Nenadic, I., Katzmann, I., Besteher, B., Langbein, K. & Gullmar, D. (2020a). Diffusion tensor imaging in borderline personality disorder showing prefrontal white matter alterations. Compr Psychiatry 101, 152172.
  • Nenadic, I., Voss, A., Besteher, B., Langbein, K. & Gaser, C. (2020b). Brain structure and symptom dimensions in borderline personality disorder. Eur Psychiatry 63, e9.
  • Perlini, C., Bellani, M., Besteher, B., Nenadic, I. & Brambilla, P. (2018). The neural basis of hostility-related dimensions in schizophrenia. Epidemiol Psychiatr Sci 27, 546-551.
  • Spalthoff, R., Degenhardt, F., Awasthi, S., Heilmann-Heimbach, S., Besteher, B., Gaser, C., Ripke, S., Nothen, M. M. & Nenadic, I. (2019). Effects of a neurodevelopmental genes based polygenic risk score for schizophrenia and single gene variants on brain structure in non-clinical subjects: A preliminary report. Schizophr Res 212, 225-228.