Learning and adaptation are fundamental properties of the brain that are based on the continuous remodelling of neuronal networks. Our research group at the Department of Neurology investigates cellular and molecular mechanisms underlying dynamic structural and functional changes in the young, aging and diseased brain, focusing on adult neural stem cells and neurogenesis, as well as neuronal and glial plasticity. Therefore, we employ modern neuroimaging methods (e.g. magnetic resonance imaging, confocal laser microscopy), state-of-the art molecular techniques (e.g. single-cell sequencing, RiboTag), bioinformatics and behavioural testing.  

In the upcoming summer course, we will introduce our research topics as well as (i) interventions to induce plasticity, (ii) behavioral tests to assess functional outcomes, (iii) imaging techniques to visualize plasticity in the brain and (iv) molecular biological and histological methods to investigate cellular changes in plastic brain areas. In addition, you will gain practical experience with cell type-specific RNA extraction, quantitative PCR, immunohistochemical methods and confocal laser microscopy.

A) Electrophysiological recordings of stimulus-dependent responses in 2 different areas of the hippocampus. B) Mouse passing the Barnes maze test. C) Newborn neurons (purple) and D) newborn neuronal precorsor cells (purple) in the adult dentate granule layer. E) Tracing of a neuron residing layer II-III of the mouse motor cortex. F) MRI image of volumetric changes in rat model of cortical malformations.