The novel effect of Neutrophil Extracellular Traps (NETS) in inducing the anaemia associated with sepsis

Farzaneh Kordbacheh, PhD

Australian National University Canberra, The John Curtin School of Medical Research (JCSMR)

Date: Thursday, 14th of September 2017, 3:00 pm

Location: Seminar room 10; Research and Institute Building, House F2, Jena University Hospital, Am Klinikum 1

Continuing education credits LÄK Thuringia: 2 points category A, requested

Dr. Farzaneh Kordbacheh investigates the role of Neutrophil Extracellular Traps (NETs) and their associate histones in sepsis. She discovered that free and NET-associated histones released into the blood can enhance the fragility of RBC membranes such that when they are subjected to the sheer stress associated with flow through the vascular system and also induce acute and rapid thrombocytopenia. In addition to losing the oxygen-carrying capacity of the RBC and causing sepsis associated anaemia, the cell contents can promote NET formation, cytotoxicity and inflammatory responses in different tissues.