Publikationen 2023
Borges LGD, Pastuschek J, Heimann Y, Dawczynski K, Schleussner E, Pieper DH, Zollkau J, Peons Study G (2023) Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis. Bmc Medicine 21, 18.
Born S, Matthaus-Kramer C, et al. (2023) Sepsis survivors and caregivers perspectives on post-acute rehabilitation and aftercare in the first year after sepsis in Germany. Frontiers in Medicine 10, 10.
Brito ADE (2023) Some statements on medical care in the "new normal" post-covid-19. Medisur-Revista De Ciencias Medicas De Cienfuegos 21, 292-300.
Foo W, Cseresnyes Z, et al. (2023) Tuning the corona-core ratio of polyplex micelles for selective oligonucleotide delivery to hepatocytes or hepatic immune cells. Biomaterials 294, 18.
Guliev RR, Vogler T, et al. (2023) High-throughput Raman spectroscopy allows ex vivo characterization of murine small intestinal intra-epithelial lymphocytes (IEL). Analyst, 13.
Hoff J, Xiong L, Kammann T, Neugebauer S, Micheel JM, Gassler N, Bauer M, Press AT (2023) RIPK3 promoter hypermethylation in hepatocytes protects from bile acid-induced inflammation and necroptosis. Cell Death & Disease 14, 16.
Kroeller S, Wissuwa B, Dennhardt S, Krieg N, Thiemermann C, Daniel C, Amann K, Gunzer F, Coldewey SM (2023) Bruton's tyrosine kinase inhibition attenuates disease progression by reducing renal immune cell invasion in mice with hemolytic-uremic syndrome. Frontiers in Immunology 14, 12.
Leonhardt S, Jurgensen C, et al. (2023) Hepatobiliary long-term consequences of COVID-19: dramatically increased rate of secondary sclerosing cholangitis in critically ill COVID-19 patients. Hepatology International, 16.
Muller MM, Baldauf C, Hornischer S, Klassert TE, Schneegans A, Behnert A, Pletz MW, Hagel S, Slevogt H (2023) Staphylococcus aureus induces tolerance in human monocytes accompanied with expression changes of cell surface markers. Frontiers in Immunology 14, 16.
Naumann M, Arend N, Guliev RR, Kretzer C, Rubio I, Werz O, Neugebauer U (2023) Label-Free Characterization of Macrophage Polarization Using Raman Spectroscopy. International Journal of Molecular Sciences 24, 12.
Ney LM, Wipplinger M, Grossmann M, Engert N, Wegner VD, Mosig AS (2023) Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections. Open Biology 13, 14.
Pistiki A, Ryabchykov O, Bocklitz TW, Rosch P, Popp J (2023) Use of polymers as wavenumber calibration standards in deep-UVRR. Spectrochimica Acta Part a-Molecular and Biomolecular Spectroscopy 287, 7.
Pletz MW, Steiner A, Kesselmeier M, Loffler B, Maschmann J, Stallmach A, Trommer S (2023) Introduction of mandatory masking in health care and community: experience from Jena, Germany. Infection, 4.
Rahman S, Parveen S, Sofi SA, Zahoor S (2023) POST-COVID REMOTE PATIENT MONITORING USING MEDICAL INTERNET OF THINGS AND MACHINE LEARNING ANALYTICS. Scalable Computing-Practice and Experience 24, 1-16.
Schmoch T, Mohnle P, et al. (2023) The prevalence of sepsis-induced coagulopathy in patients with sepsis - a secondary analysis of two German multicenter randomized controlled trials. Annals of Intensive Care 13, 12.
Schnizer C, Andreas N, et al. (2023) Persistent humoral and CD4(+) T-H cell immunity after mild SARS-COV-2 infection-The CoNAN long-term study. Frontiers in Immunology 13, 14.
Streich K, Hartog CS, Fleischmann-Struzek C, Rose N, Bichmann A, Kesselmeier M, Schiefenhovel F, Schmieding M, Born S (2023) Psychometric properties of the Reintegration to Normal Living Index for sepsis survivors. Quality of Life Research, 9.
Valentine MS, Weigel C, Gninzeko FK, Tho C, Graler MH, Reynolds AM, Spiegel S, Heise RL (2023) S1P lyase inhibition prevents lung injury following high pressure-controlled mechanical ventilation in aging mice. Experimental Gerontology 173, 11.
Winkler D, Rose N, et al. (2023) The Effects of Postacute Rehabilitation on Mortality, Chronic Care Dependency, Health Care Use, and Costs in Sepsis Survivors. Annals of the American Thoracic Society 20, 279-288.
Publikationen 2022
Afolabi R, Chinedu S, Ajamma Y, Adam Y, Koenig R, Adebiyi E (2022) Computational identification of Plasmodium falciparum RNA pseudouridylate synthase as a viable drug target, its physicochemical properties, 3D structure prediction and prediction of potential inhibitors. Infection Genetics and Evolution 97, 11.
Billingham LK, Stoolman JS, et al. Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation. Nature Immunology, 39.
Bloos F, Held J, et al. (2022) (1 -> 3)-beta-D-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial. Intensive Care Medicine, 11.
Diab M, Lehmann T, et al. (2022) Cytokine Hemoadsorption During Cardiac Surgery Versus Standard Surgical Care for Infective Endocarditis (REMOVE): Results From a Multicenter Randomized Controlled Trial. Circulation 145, 959-968.
Fleischmann-Struzek C, Rose N, Reinhart K (2022) Sepsis-associated deaths in Germany: characteristics and regional variation. Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz, 8.
Gawlytta R, Kesselmeier M, Scherag A, Niemeyer H, Bottche M, Knaevelsrud C, Rosendahl J (2022) Internet-based cognitive-behavioural writing therapy for reducing post-traumatic stress after severe sepsis in patients and their spouses (REPAIR): results of a randomised-controlled trial. Bmj Open 12, 10.
Ghait M, Husain RA, Duduskar SN, Haack TB, Rooney M, Gohrig B, Bauer M, Rubio I, Deshmukh SD (2022) The TLR-chaperone CNPY3 is a critical regulator of NLRP3-inflammasome activation. European Journal of Immunology, 17.
Gudziol H, Kirschstein T, Pletz MW, Weis S, Guntinas-Lichius O, Bitter T, Grp CS (2022) High prevalence of long-term olfactory dysfunction confirmed by olfactory testing after a community COVID-19 outbreak. Hno 70, 224-231.
Hagel S, Bach F, et al. (2022) Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial. Intensive Care Medicine 48, 311-321.
Hagel S, Bach F, et al. (2022) Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial (vol 48, pg 311, 2022). Intensive Care Medicine, 2.
Hagel S, Pletz MW, Lehmann T Another trial for the TARGET trial. Author's reply. Intensive Care Medicine, 2.
Hagel S, Pletz MW, Lehmann T (2022) Concerns about study design and suggestion of additional analysis of therapeutic drug monitoring-guided piperacillin/tazobactam therapy for patients with sepsis. Author's reply. Intensive Care Medicine, 2.
Hoang TNM, Cseresnyes Z, Hartung S, Blickensdorf M, Saffer C, Rennert K, Mosig AS, Von Lilienfeld-Toal M, Figge MT (2022) Invasive aspergillosis-on-chip: A quantitative treatment study of human Aspergillus fumigatus infection. Biomaterials 283, 14.
Hoffmann B, Gerst R, Cseresnyes Z, Foo W, Sommerfeld O, Press AT, Bauer M, Figge MT (2022) Spatial quantification of clinical biomarker pharmacokinetics through deep learning-based segmentation and signal-oriented analysis of MSOT data. Photoacoustics 26, 12.
Kesselmeier M, Pletz M, Scherag A, Bauer T, Ewig S, Kolditz M (2022) Validation of the qSOFA(-65) score compared to the CRB-65 score for risk prediction in community-acquired pneumonia. Pneumologie 76, 119-119.
Klaus FL, Kirsch C, Muller JP, Huber O, Reiche J (2022) PI3K gamma is a novel regulator of TNF alpha signaling in a human colon cell line HT29/B6. Annals of the New York Academy of Sciences, 12.
Kretzer C, Shkodra B, et al. (2022) Ethoxy acetalated dextran-based nanocarriers accomplish efficient inhibition of leukotriene formation by a novel FLAP antagonist in human leukocytes and blood. Cellular and Molecular Life Sciences 79, 19.
Liu XY, Guo SX, Bocklitz T, Rosch P, Popp J, Yu HQ (2022) Nondestructive 3D imaging and quantification of hydrated biofilm matrix by confocal Raman microscopy coupled with non-negative matrix factorization. Water Research 210, 10.
Lopez-Cortes A, Guerrero S, et al. (2022) Pulmonary Inflammatory Response in Lethal COVID-19 Reveals Potential Therapeutic Targets and Drugs in Phases III/IV Clinical Trials. Frontiers in Pharmacology 13, 17.
Marquet M, Zollkau J, Pastuschek J, Viehweger A, Schleussner E, Makarewicz O, Pletz MW, Ehricht R, Brandt C (2022) Evaluation of microbiome enrichment and host DNA depletion in human vaginal samples using Oxford Nanopore's adaptive sequencing. Scientific Reports 12, 10.
Metzing UB, von Loeffelholz C, et al. (2022) Endoplasmic reticulum stress and the unfolded protein response in skeletal muscle of subjects suffering from peritoneal sepsis. Scientific Reports 12, 11.
Nakar A, Pistiki A, Ryabchykov O, Bocklitz T, Rosch P, Popp J (2022) Label-free differentiation of clinical E. coli and Klebsiella isolates with Raman spectroscopy. Journal of Biophotonics, 9.
Neu C, Skitek K, Kissler H, Baumbach P, Settmacher U, Treml RE, Coldewey SM (2022) Body composition, mitochondrial oxygen metabolism and metabolome of patients with obesity before and after bariatric surgery (COMMITMENT): protocol for a monocentric prospective cohort study. Bmj Open 12, 5.
Niemiec MJ, Kapitan M, et al. (2022) Augmented Enterocyte Damage During Candida albicans and Proteus mirabilis Coinfection. Frontiers in Cellular and Infection Microbiology 12, 19.
Poos AM, Schroeder C, et al. (2022) PITX1 Is a Regulator of TERT Expression in Prostate Cancer with Prognostic Power. Cancers 14, 23.
Ruddel H, Thomas-Ruddel DO, et al. (2022) Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled trial. Critical Care 26, 14.
Schmidt KFR, Huelle K, et al. (2022) Healthcare Utilization and Costs in Sepsis Survivors in Germany-Secondary Analysis of a Prospective Cohort Study. Journal of Clinical Medicine 11, 17.
Shroff T, Aina K, Maass C, Cipriano M, Lambrecht J, Tacke F, Mosig A, Loskill P (2022) Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics. Open Biology 12, 21.
Spoden M, Hartog CS, et al. (2022) Occurrence and Risk Factors for New Dependency on Chronic Care, Respiratory Support, Dialysis and Mortality in the First Year After Sepsis. Frontiers in Medicine 9, 10.
Stallmach A, Kesselmeier M, et al. (2022) Comparison of fatigue, cognitive dysfunction and psychological disorders in post-COVID patients and patients after sepsis: is there a specific constellation? Infection, 9.
Thomas-Ruddel DO, Schlattmann P, Pletz M, Kurzai O, Bloos F (2022) Risk Factors for Invasive Candida Infection in Critically Ill Patients A Systematic Review and Meta-analysis. Chest 161, 345-355.
Unger N, Eiserloh S, Nowak F, Zuchantke S, Liebler-Tenorio E, Sobotta K, Schnee C, Berens C, Neugebauer U (2022) Looking Inside Non-Destructively: Label-Free, Raman-Based Visualization of Intracellular Coxiella burnetii br. Analytical Chemistry 94, 4988-4996.
Van Bulck M, Brandt N, Claus RA, Graler M, Brauer AU (2022) A beta-Induced Alterations in Membrane Lipids Occur before Synaptic Loss Appears. International Journal of Molecular Sciences 23, 19.
Publikationen 2021
Abusukhun M, Winkler MS, et al. (2021) Activation of Sphingomyelinase-Ceramide-Pathway in COVID-19 Purposes Its Inhibition for Therapeutic Strategies. Frontiers in Immunology 12, 12.
Alonso-Roman R, Valentine M, Mosig AS, Gresnigt MS, Hube B (2021) An intestine-on-chip model to study Candida albicans commensalism and pathogenicity. Mycoses 64, 17-17.
Aromolaran O, Beder T, Adedeji E, Ajamma Y, Oyelade J, Adebiyi E, Koenig R (2021) Predicting host dependency factors of pathogens in Drosophila melanogaster using machine learning. Computational and Structural Biotechnology Journal 19, 4581-4592.
Bauer M, Shankar-Hari M, Thomas-Ruddel DO, Wetzker R (2021) Towards an ecological definition of sepsis: a viewpoint. Intensive Care Medicine Experimental 9, 13.
Beder T, Aromolaran O, Donitz J, Tapanelli S, Adedeji EO, Adebiyi E, Bucher G, Koenig R (2021) Identifying essential genes across eukaryotes by machine learning. Nar Genomics and Bioinformatics 3, 13.
Bluemel P, Wickel J, Grunewald B, Ceanga M, Keiner S, Witte OW, Redecker C, Geis C, Kunze A (2021) Sepsis promotes gliogenesis and depletes the pool of radial glia like stem cells in the hippocampus. Experimental Neurology 338.
Boede M, Gensichen JS, et al. (2021) Trajectories of depression in sepsis survivors: an observational cohort study. Critical Care 25.
Born S, Dame C, et al. (2021) Epidemiology of Sepsis Among Children and Neonates in Germany: Results From an Observational Study Based on Nationwide Diagnosis-Related Groups Data Between 2010 and 2016*. Critical Care Medicine 49, 1049-1057.
Busch K, Kny M, et al. (2021) Inhibition of the NLRP3/IL-1 beta axis protects against sepsis-induced cardiomyopathy. Journal of Cachexia Sarcopenia and Muscle, 16.
Cassini A, Fleischmann-Struzek C, Naghavi M, Reinhart K, Allegranzi B, Exper WHOS (2021) Future directions and priorities in sepsis epidemiology research: a call for action. Bulletin of the World Health Organization 99, 398-401.
Chung HY, Neu C, Wickel J, Kuckertz SL, Coldewey SM (2021) Neurofilament Light Chain in Patients with COVID-19 and Bacterial Pneumonia. Annals of Neurology.
Colaco HG, Barros A, et al. (2021) Tetracycline Antibiotics Induce Host-Dependent Disease Tolerance to Infection. Immunity 54, 53-+.
Deinhardt-Emmer S, Bottcher S, et al. (2021) SARS-CoV-2 Causes Severe Epithelial Inflammation and Barrier Dysfunction. Journal of Virology 95, 17.
Detzel MS, Schmalohr BF, Steinbock F, Hopp MT, Ramoji A, George AAP, Neugebauer U, Imhof D (2021) Revisiting the interaction of heme with hemopexin. Biological Chemistry 402, 675-691.
Diab M, Franz M, et al. (2021) Impact of an In-Hospital Endocarditis Team and a State-Wide Endocarditis Network on Perioperative Outcomes. Journal of Clinical Medicine 10, 11.
Ebert C, Tuchscherr L, Unger N, Pollath C, Gladigau F, Popp J, Loffler B, Neugebauer U (2021) Correlation of crystal violet biofilm test results of Staphylococcus aureus clinical isolates with Raman spectroscopic read-out. Journal of Raman Spectroscopy 52, 2660-2670.
Estcourt LJ, Turgeon AF, et al. Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19 A Randomized Clinical Trial. Jama-Journal of the American Medical Association, 13.
Fleischmann C, Reichert F, et al. (2021) Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis. Archives of Disease in Childhood 106, 745-752.
Fleischmann-Struzek C, Kesselmeier M, et al. (2021) Mid-German Sepsis Cohort (MSC): a prospective observational study of sepsis survivorship. Bmj Open 11.
Fleischmann-Struzek C, Rose N, et al. (2021) Epidemiology and Costs of Postsepsis Morbidity, Nursing Care Dependency, and Mortality in Germany, 2013 to 2017. Jama Network Open 4, 14.
Fleischmann-Struzek C, Rose N, Reinhart K (2021) Sepsis-associated deaths in Germany: characteristics and regional variation. Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz, 8.
Fleischmann-Struzek C, Schwarzkopf D, Reinhart K (2021) Sepsis incidence in Germany and worldwide Current knowledge and limitations of research using health claims data. Medizinische Klinik-Intensivmedizin Und Notfallmedizin, 5.
Friedrichs A, Kramme E, Weis S, Pletz M (2021) Antibiotic stewardship Structure and implementation. Medizinische Klinik-Intensivmedizin Und Notfallmedizin 116, 81-92.
Glockner S, Hornung F, Baier M, Weis S, Pletz MW, Deinhardt-Emmer S, Loffler B, Co NANSG (2021) Robust Neutralizing Antibody Levels Detected after Either SARS-CoV-2 Vaccination or One Year after Infection. Viruses-Basel 13, 12.
Grune C, Zens C, et al. (2021) Sustainable preparation of anti-inflammatory atorvastatin PLGA nanoparticles. International Journal of Pharmaceutics 599.
Grune C, Zens C, et al. (2021) Sustainable preparation of anti-inflammatory atorvastatin PLGA nanoparticles. International Journal of Pharmaceutics 599, 14.
Hagel S, Brinkmann A, et al. (2021) Influence of Therapeutic Drug Monitoring (TDM) of Piperacillin on Sepsis-associated Organ Dysfunction in Patients with Sepsis: a randomized controlled Trial. Medizinische Klinik-Intensivmedizin Und Notfallmedizin 116, 47-47.
Hoff J, Karl B, et al. (2021) Controlled Release of the alpha-Tocopherol-Derived Metabolite alpha-13 '-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing. Nanomaterials 11, 16.
Hornung F, Rogal J, Loskill P, Loffler B, Deinhardt-Emmer S (2021) The Inflammatory Profile of Obesity and the Role on Pulmonary Bacterial and Viral Infections. International Journal of Molecular Sciences 22.
Huang J, Ali N, et al. (2021) Vibrational Spectroscopic Investigation of Blood Plasma and Serum by Drop Coating Deposition for Clinical Application. International Journal of Molecular Sciences 22.
Jentho E, Ruiz-Moreno C, et al. (2021) Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme. Proceedings of the National Academy of Sciences of the United States of America 118, 10.
Kammann T, Hoff J, et al. (2021) Intracellularly Released Cholesterol from Polymer-Based Delivery Systems Alters Cellular Responses to Pneumolysin and Promotes Cell Survival. Metabolites 11, 14.
Karakike E, Giamarellos-Bourboulis EJ, Kyprianou M, Fleischmann-Struzek C, Pletz MW, Netea MG, Reinhart K, Kyriazopoulou E (2021) Coronavirus Disease 2019 as Cause of Viral Sepsis: A Systematic Review and Meta-Analysis*. Critical Care Medicine 49, 2042-2057.
Kesselmeier M, Pletz MW, Blankenstein AL, Scherag A, Bauer T, Ewig S, Kolditz M (2021) Validation of the qSOFA score compared to the CRB-65 score for risk prediction in community-acquired pneumonia. Clinical Microbiology and Infection 27, 6.
Kimmig A, Hagel S, Weis S, Bahrs C, Loffler B, Pletz MW (2021) Management of Staphylococcus aureus Bloodstream Infections. Frontiers in Medicine 7.
Konig A, Muller R, Mogavero S, Hube B (2021) Fungal factors involved in host immune evasion, modulation and exploitation during infection. Cellular Microbiology, e13272.
Last A, Maurer M, Mosig AS, Gresnigt MS, Hube B (2021) In vitro infection models to study fungal-host interactions. Fems Microbiology Reviews 45, 22.
Lehnert T, Leonhardt I, Timme S, Thomas-Ruddel D, Bloos F, Sponholz C, Kurzai O, Figge MT, Hunniger K (2021) Ex vivo immune profiling in patient blood enables quantification of innate immune effector functions. Scientific Reports 11.
Lehnert T, Prausse MTE, Hunniger K, Praetorius JP, Kurzai O, Figge MT (2021) Comparative assessment of immune evasion mechanisms in human whole-blood infection assays by a systems biology approach. Plos One 16, 31.
Leonhardt J, Haider RS, et al. (2021) Circulating Bile Acids in Liver Failure Activate TGR5 and Induce Monocyte Dysfunction. Cellular and Molecular Gastroenterology and Hepatology 12, 25-40.
Ma YX, Nenkov M, Chen Y, Press AT, Kaemmerer E, Gassler N (2021) Fatty acid metabolism and acyl-CoA synthetases in the liver-gut axis. World Journal of Hepatology 13, 1512-1533.
Marfil-Sanchez A, Zhang L, et al. (2021) An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness. Gut Microbes 13, 25.
Michelson K, Loffler B, Horing S (2021) Time to positivity as a prognostic factor in bloodstream infections with Enterococcus spp. Diagnostic Microbiology and Infectious Disease 101, 7.
Niemiec MJ, Hammer M, Auge I, van Leeuwen P, Gorki F, Walker A, Steimle A, Frick JS, Jacobsen ID (2021) The gut commensal Bacteroides vulgatus mpk reduces Candida albicans pathogenicity towards epithelial cells. Mycoses 64, 10-10.
Osuchowski MF, Winkler MS, et al. (2021) The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity. Lancet Respiratory Medicine 9, 622-642.
Pistiki A, Ramoji A, et al. (2021) Biochemical Analysis of Leukocytes after In Vitro and In Vivo Activation with Bacterial and Fungal Pathogens Using Raman Spectroscopy. International Journal of Molecular Sciences 22, 17.
Pletz MW, Trommer S, Kolanos S, Rose N, Kinne V, Spott R, Baier M, Lange I (2021) Group Vaccination Five Days before a COVID-19 Outbreak in a Long-Term Care Facility. Vaccines 9, 5.
Press AT, Babic P, et al. (2021) Targeted delivery of a phosphoinositide 3-kinase gamma inhibitor to restore organ function in sepsis. Embo Molecular Medicine 13, 17.
Renieris G, Droggiti DE, et al. (2021) Host cystathionine-gamma lyase derived hydrogen sulfide protects against Pseudomonas aeruginosa sepsis. Plos Pathogens 17.
Rose N, Matthaus-Kramer C, Schwarzkopf D, Scherag A, Born S, Reinhart K, Fleischmann-Struzek C (2021) Association between sepsis incidence and regional socioeconomic deprivation and health care capacity in Germany - an ecological study. Bmc Public Health 21, 11.
Rose N, Storch J, et al. (2021) Preventive effects of influenza and pneumococcal vaccination in the elderly - results from a population-based retrospective cohort study. Human Vaccines & Immunotherapeutics, 9.
Russo AJ, Vasudevan SO, et al. (2021) Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin. Nature Immunology, 22.
Schoneweck F, Schmitz RPH, Rissner F, Scherag A, Loffler B, Pletz MW, Weis S, Brunkhorst FM, Hagel S (2021) The epidemiology of bloodstream infections and antimicrobial susceptibility patterns in Thuringia, Germany: a five-year prospective, state-wide surveillance study (AlertsNet). Antimicrobial Resistance and Infection Control 10, 9.
Shinkar M, Uwamahoro N, Backman E, Holmberg S, Niemiec MJ, Roth J, Vogl T, Urban CF (2021) Immune Resolution Dilemma: Host Antimicrobial Factor S100A8/A9 Modulates Inflammatory Collateral Tissue Damage During Disseminated Fungal Peritonitis. Frontiers in Immunology 12.
Simpson A, Long D, Fleischmann-Struzek C, Minogue J, Venkatesh B, Hammond NE, Tian DH, Schlapbach LJ (2021) Long-Term Functional Outcomes After Sepsis for Adult and Pediatric Critical Care Patients-Protocol for a Systematic Review. Frontiers in Pediatrics 9, 7.
Siwczak F, Loffet E, Kaminska M, Koceva H, Mahe MM, Mosig AS (2021) Intestinal Stem Cell-on-Chip to Study Human Host-Microbiota Interaction. Frontiers in Immunology 12, 13.
Sobbe IV, Krieg N, Dennhardt S, Coldewey SM (2021) Involvement of NF-kappa B1 and the Non-canonical NF-kappa B Signaling Pathway in the Pathogenesis of Acute Kidney Injury in Shiga-toxin-2-induced Hemolytic-uremic Syndrome in Mice. Shock 56, 573-581.
Sommerfeld O, Dahlke K, Sossdorf M, Claus RA, Scherag A, Bauer M, Bloos F (2021) Complement factor D is linked to platelet activation in human and rodent sepsis. Intensive Care Medicine Experimental 9, 13.
Sommerfeld O, Medyukhina A, et al. (2021) Targeting Complement C5a Receptor 1 for the Treatment of Immunosuppression in Sepsis. Molecular Therapy 29, 338-346.
Tannert A, Lopez JG, Petkov N, Ivanova A, Peneva K, Neugebauer U (2021) Lysosome-targeting pH indicator based on peri-fused naphthalene monoimide with superior stability for long term live cell imaging. Journal of Materials Chemistry B 9, 112-124.
Thomas-Ruddel DO, Hoffmann P, et al. (2021) Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature. Critical Care 25, 10.
Thuy AV, Paul JJ, Weigel C, Ziegler AC, Guntinas-Lichius O, Graler MH (2021) Validation of a monoclonal antibody directed against the human sphingosine 1-phosphate receptor type 1. Journal of Immunological Methods 490, 8.
Valentine M, Alonso-Roman R, Mosig AS, Gresnigt MS, Hube B (2021) Modelling vaginal Candida infections using an organ-on-chip approach. Mycoses 64, 25-25.
Vandewalle J, Timmermans S, et al. (2021) Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis. Cell Metabolism 33, 1763-+.
von Loeffelholz C, Coldewey SM, Birkenfeld AL (2021) A Narrative Review on the Role of AMPK on De Novo Lipogenesis in Non-Alcoholic Fatty Liver Disease: Evidence from Human Studies. Cells 10, 24.
von Loeffelholz C, Roth J, Coldewey SM, Birkenfeld AL (2021) The Role of Physical Activity in Nonalcoholic and Metabolic Dysfunction Associated Fatty Liver Disease. Biomedicines 9, 18.
Weis S, Scherag A, et al. (2021) Antibody response using six different serological assays in a completely PCR-tested community after a coronavirus disease 2019 outbreak-the CoNAN study. Clinical Microbiology and Infection 27.
Westermann I, Gastine S, Muller C, Rudolph W, Peters F, Bloos F, Pletz M, Hagel S (2021) Population pharmacokinetics and probability of target attainment in patients with sepsis under renal replacement therapy receiving continuous infusion of meropenem: Sustained low-efficiency dialysis and continuous veno-venous haemodialysis. British Journal of Clinical Pharmacology.
Ziegler AC, Muller T, Graler MH (2021) Sphingosine 1-phosphate in sepsis and beyond: Its role in disease tolerance and host defense and the impact of carrier molecules. Cellular Signalling 78, 109849.
Zollkau J, Schmidt A, Hoyer D, Schneider U, Schleussner E (2021) Prediction of Early-onset Neonatal Sepsis (EONS) after Preterm Premature Rupture of the Membranes (PPROM) using Heart Rate Analysis. Geburtshilfe Und Frauenheilkunde 81, E54-E55.
Zubkowicz M, Held J, Baier M, Pletz MW, Kesselmeier M, Hagel S, Bahrs C (2021) Clinical evaluation of two different (1,3)-beta-D-glucan assays for diagnosis of invasive fungal diseases: A retrospective cohort study. Mycoses 64, 212-219.
Publikationen 2020
Aromolaran O, Beder T, Oswald M, Oyelade J, Adebiyi E, Koenig R (2020) Essential gene prediction in Drosophila melanogaster using machine learning approaches based on sequence and functional features. Computational and Structural Biotechnology Journal 18: 612-621
Bauer M, Wetzker R (2020) The cellular basis of organ failure in sepsis-signaling during damage and repair processes. Medizinische Klinik-Intensivmedizin Und Notfallmedizin 115: 4-9
Chung HY, Wickel J, Brunkhorst FM, Geis C (2020) Sepsis-Associated Encephalopathy: From Delirium to Dementia? Journal of Clinical Medicine 9: 14
Deinhardt-Emmer S, Rennert K, Schicke E, Cseresnyes Z, Windolph M, Nietzsche S, Heller R, Siwczak F, Haupt KF, Carlstedt S, Schacke M, Figge MT, Ehrhardt C, Loffler B, Mosig AS (2020) Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model. Biofabrication 12: 025012
Diab M, Platzer S, Guenther A, Sponholz C, Scherag A, Lehmann T, Velichkov I, Hagel S, Bauer M, Brunkhorst FM, Doenst T (2020) Assessing efficacy of CytoSorb haemoadsorber for prevention of organ dysfunction in cardiac surgery patients with infective endocarditis: REMOVE-protocol for randomised controlled trial. Bmj Open 10: 8
Diab M, Tasar R, Sponholz C, Lehmann T, Pletz MW, Bauer M, Brunkhorst FM, Doenst T (2020) Changes in inflammatory and vasoactive mediator profiles during valvular surgery with or without infective endocarditis: A case control pilot study. PLoS One 15: 23
Dickmann P, Bauer M (2020) Sepsis 2019 - New Trends and Their Implications for Multiple Trauma Patients. Z Orthop Unfall 158: 81-89
Ehrlich C, Hohenstein C, Winning J, Ruddel H (2020) Effect of positive end-expiratory pressure and positioning on jugular vein expansion in emergency department patients. European Journal of Emergency Medicine 27: 110-113
Engelmann C, Riemann M, Carlstedt S, Grimlowski R, Andreas N, Koliesnik I, Meier E, Austerfield P, Haenold R (2020) Identification of undescribed Relb expression domains in the murine brain by new Relb:cre-katushka reporter mice. Developmental Dynamics 249: 983-997
Forstner C, Kolditz M, Kesselmeier M, Ewig S, Rohde G, Barten-Neiner G, Rupp J, Witzenrath M, Welte T, Pletz MW, Dreher M, Cornelissen C, Knuppel W, Stolz D, Suttorp N, Witzenrath M, Creutz P, Mikolajewska A, Bauer T, Krieger D, Pankow W, Thiemig D, Hauptmeier B, Ewig S, Wehde D, Prediger M, Schmager S, Kolditz M, Schulte-Hubbert B, Langner S, Albrich W, Welte T, Freise J, Barten G, Toro OA, Nawrocki M, Nairn J, Witte M, Kroner W, Illig T, Klopp N, Kreuter M, Herth F, Hummler S, Ravn P, Vestergaard-Jensen A, Baunbaek-Knudsen G, Pletz M, Kroegel C, Forstner C, Winning J, Schleenvoigt B, Dalhoff K, Rupp J, Horster R, Dromann D, Rohde G, Drijkoningen J, Braeken D, Buschmann H, Schaberg T, Hering I, Panning M, Wallner M, Grp CS (2020) Pneumococcal conjugate serotype distribution and predominating role of serotype 3 in German adults with community-acquired pneumonia. Vaccine 38: 1129-1136
Gawlytta R, Brunkhorst F, Niemeyer H, Boettche M, Knaevelsrud C, Rosendahl J (2020) Dyadic post-traumatic stress after intensive care: Case report of a sepsis patient and his wife. Intensive and Critical Care Nursing 58: 5
Glaser A, Hammerl F, Graler MH, Coldewey SM, Volkner C, Frech MJ, Yang F, Luo JK, Tonnies E, Halbach OVU, Brandt N, Heimes D, Nesslauer AM, Korenke GC, Owczarek-Lipska M, Neidhardt J, Rolfs A, Wree A, Witt M, Brauer AU (2020) Identification of Brain-Specific Treatment Effects in NPC1 Disease by Focusing on Cellular and Molecular Changes of Sphingosine-1-Phosphate Metabolism. Int J Mol Sci 21: 31
Graber K, Khan F, Gluck B, Weigel C, Marzo S, Doshi H, Ehrhardt C, Heller R, Graler M, Henke A (2020) The role of sphingosine-1-phosphate signaling in HSV-1-infected human umbilical vein endothelial cells. Virus Research 276: 12
Guillen-Guio B, Lorenzo-Salazar JM, Ma SF, Hou PC, Hernandez-Beeftink T, Corrales A, Garcia-Laorden MI, Jou J, Espinosa E, Muriel A, Dominguez D, Lorente L, Martin MM, Rodriguez-Gallego C, Sole-Violan J, Ambros A, Carriedo D, Blanco J, Anon JM, Reilly JP, Jones TK, Ittner CAG, Feng R, Schoneweck F, Kiehntopf M, Noth I, Scholz M, Brunkhorst FM, Scherag A, Meyer NJ, Villar J, Flores C (2020) Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study. Lancet Respiratory Medicine 8: 258-266
Hoflmayer D, Steinhoff A, Hube-Magg C, Kluth M, Simon R, Burandt E, Tsourlakis MC, Minner S, Sauter G, Buscheck F, Wilczak W, Steurer S, Huland H, Graefen M, Haese A, Heinzer H, Schlomm T, Jacobsen F, Hinsch A, Poos AM, Oswald M, Rippe K, Konig R, Schroeder C (2020) Expression of CCCTC-binding factor (CTCF) is linked to poor prognosis in prostate cancer. Molecular Oncology 14: 129-138
Horhold F, Eisel D, Oswald M, Kolte A, Roll D, Osen W, Eichmuller SB, Konig R (2020) Reprogramming of macrophages employing gene regulatory and metabolic network models. PLoS Comput Biol 16: e1007657
Huang J, Ramoji A, Guo SX, Bocklitz T, Boivin-Jahns V, Moller J, Kiehntopf M, Noutsias M, Popp J, Neugebauer U (2020) Vibrational spectroscopy as a powerful tool for follow-up immunoadsorption therapy treatment of dilated cardiomyopathy - a case report. Analyst 145: 486-496
Ibidapo-obe O, Stengel S, Kose-Vogel N, Quickert S, Reuken PA, Busch M, Bauer M, Stallmach A, Bruns T (2020) Mucosal-Associated Invariant T Cells Redistribute to the Peritoneal Cavity During Spontaneous Bacterial Peritonitis and Contribute to Peritoneal Inflammation. Cellular and Molecular Gastroenterology and Hepatology 9: 661-677
Jagtap P, Prasad P, Pateria A, Deshmukh SD, Gupta S (2020) A Single Step in vitro Bioassay Mimicking TLR4-LPS Pathway and the Role of MD2 and CD14 Coreceptors. Front Immunol 11: 9
Kleiber A, Ramoji A, Mayer G, Neugebauer U, Popp J, Henkel T (2020) 3-Step flow focusing enables multidirectional imaging of bioparticles for imaging flow cytometry. Lab Chip 20: 1676-1686
Kose-Vogel N, Stengel S, Gardey E, Kirchberger-Tolstik T, Reuken PA, Stallmach A, Bruns T (2020) Transcriptional Suppression of the NLRP3 Inflammasome and Cytokine Release in Primary Macrophages by Low-Dose Anthracyclines. Cells 9: 17
Leikeim RSM, Kesselmeier M, Löffler B, Rödel J, Höring S (2020) Diagnostic accuracy and clinical impact of loop-mediated isothermal amplification for rapid detection of Staphylococcus aureus bacteremia: a retrospective observational study. European Journal of Clinical Microbiology & Infectious Diseases 39: 679-688
Liu XY, Guo SX, Ramoji A, Bocklitz T, Rosch P, Popp J, Yu HQ (2020) Spatiotemporal Organization of Biofilm Matrix Revealed by Confocal Raman Mapping Integrated with Non-negative Matrix Factorization Analysis. Anal Chem 92: 707-715
Mayer K, Hahn-Ast C, Schwab K, Schmidt-Wolf IGH, Brossart P, Glasmacher A, von Lilienfeld-Toal M (2020) Long-term follow-up of Cladribine, high-dose Cytarabine, and Idarubicin as salvage treatment for relapsed acute myeloid leukemia and literature review. European Journal of Haematology 104: 538-545
Neu C, Baumbach P, Plooij AK, Skitek K, Gotze J, von Loeffelholz C, Schmidt-Winter C, Coldewey SM (2020) Non-invasive Assessment of Mitochondrial Oxygen Metabolism in the Critically Ill Patient Using the Protoporphyrin IX-Triplet State Lifetime Technique-A Feasibility Study. Front Immunol 11: 9
Paul JJ, Weigel C, Muller T, Heller R, Spiegel S, Graler MH (2020) Inflammatory Conditions Disrupt Constitutive Endothelial Cell Barrier Stabilization by Alleviating Autonomous Secretion of Sphingosine 1-Phosphate. Cells 9: 16
Poos AM, Kordass T, Kolte A, Ast V, Oswald M, Rippe K, Konig R (2019) Modelling TERT regulation across 19 different cancer types based on the MIPRIP 2.0 gene regulatory network approach. BMC Bioinformatics 20: 12
Przybilla J, Ahnert P, Bogatsch H, Bloos F, Brunkhorst FM, Bauer M, Loeffler M, Witzenrath M, Suttorp N, Scholz M, SepNet Critical Care Trials G, SepNet Critical Care Trials G, Grp PS (2020) Markov State Modelling of Disease Courses and Mortality Risks of Patients with Community-Acquired Pneumonia. Journal of Clinical Medicine 9: 14
Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, Colombara DV, Ikuta KS, Kissoon N, Finfer S, Fleischmann-Struzek C, Machado FR, Reinhart KK, Rowan K, Seymour CW, Watson RS, West TE, Marinho F, Hay SI, Lozano R, Lopez AD, Angus DC, Murray CJL, Naghavi M (2020) Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet 395: 200-211
Santos I, Colaco HG, Neves-Costaa A, Seixas E, Velho TR, Pedroso D, Barros A, Martins R, Carvalho N, Payen D, Weis S, Yi HS, Shong M, Moita LF (2020) CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15-deficient mice protects against abdominal sepsis. Proc Natl Acad Sci U S A 117: 12281-12287
Schmidt KF, Schwarzkopf D, Baldwin LM, Brunkhorst FM, Freytag A, Heintze C, Reinhart K, Schneider N, von Korff M, Worrack S, Wensing M, Gensichen J, Baenfer M, Berhold C, Bindara-Klippel A, Corea M, Davydov D, Eckholdt L, Eissler F, Ch E, Fleischmann-Struzek C, Freitag A, Gehrke-Beck S, Geist A, Gerlach H, Goldmann A, Graf J, Hamzei F, Hartmann M, Hartog C, Heintze C, Huelle K, Jakobi U, Kerth S, Keh D, Klefisch F, Kuehnemund R, Kuhnsch H, Lehmann T, Lehmke J, Lehmkuhl P, Meier-Hellmann A, Muehlberg J, Mueller F, Oehmichen F, Ollenschlaeger G, Oppert M, Pohl M, Rademacher S, Reil L, Sablotzki A, Schelle M, Schelling G, Scherag A, Schreiber T, Spies C, Thiel P, Tiedemann G, Toepfer L, Toussaint S, Grp SS (2020) Long-Term Courses of Sepsis Survivors: Effects of a Primary Care Management Intervention. American Journal of Medicine 133: 381
Sieg M, Hartmann M, Settmacher U, Arefian H (2020) Comparative cost-effectiveness of cabozantinib as second-line therapy for patients with advanced hepatocellular carcinoma in Germany and the United States. BMC Gastroenterol 20: 12
Spengler K, Kryeziu N, Grosse S, Mosig AS, Heller R (2020) VEGF Triggers Transient Induction of Autophagy in Endothelial Cells via AMPK alpha 1. Cells 9: 18
Stengel S, Quickert S, Lutz P, Ibidapo-Obe O, Steube A, Kose-Vogel N, Yarbakht M, Reuken PA, Busch M, Brandt A, Bergheim I, Deshmukh SD, Stallmach A, Bruns T (2020) Peritoneal Level of CD206 Associates With Mortality and an In flammatory Macrophage Phenotype in Patients With Decompensated Cirrhosis and Spontaneous Bacterial Peritonitis. Gastroenterology 158: 1745-1761
Stepanovska B, Lange AI, Schwalm S, Pfeilschifter J, Coldewey SM, Huwiler A (2020) Downregulation of S1P Lyase Improves Barrier Function in Human Cerebral Microvascular Endothelial Cells Following an Inflammatory Challenge. Int J Mol Sci 21: 19
Syllwasschy BF, Beck MS, Druzeta I, Hopp MT, Ramoji A, Neugebauer U, Nozinovic S, Menche D, Willbold D, Ohlenschlager O, Kuhl T, Imhof D (2020) High-affinity binding and catalytic activity of His/Tyr-based sequences: Extending heme-regulatory motifs beyond CP. Biochimica Et Biophysica Acta-General Subjects 1864: 10
Thomas-Ruddel D, Winning J, Dickmann P, Ouart D, Kortgen A, Janssens U, Bauer M (2020) Coronavirus disease 2019 (COVID-19): update for anesthesiologists and intensivists March 2020. Anaesthesist 10.1007/s00101-020-00760-3: 10
Thomas-Rüddel D, Winning J, Dickmann P, Ouart D, Kortgen A, Janssens U, Bauer M (2020) [Coronavirus disease 2019 (COVID-19): update for anesthesiologists and intensivists March 2020]. Anaesthesist 69: 225-235 (German)
Tuchscherr L, Loffler B, Proctor RA (2020) Persistence of Staphylococcus aureus: Multiple Metabolic Pathways Impact the Expression of Virulence Factors in Small-Colony Variants (SCVs). Frontiers in Microbiology 11: 1028
Zipprich HM, Arends MC, Schumacher U, Bahr V, Scherag A, Kwetkat A, Wedding U, Brunkhorst FM, Witte OW, Prell T, Redecker C (2020) Outcome of Older Patients with Acute Neuropsychological Symptoms Not Fulfilling Criteria of Delirium. Journal of the American Geriatrics Society 68: 1469-1475
Publikationen 2019
Al-Zaben N, Medyukhina A, Dietrich S, Marolda A, Hunniger K, Kurzai O, Figge MT (2019) Automated tracking of label-free cells with enhanced recognition of whole tracks. Sci Rep 9: 10
Ammer-Herrmenau C, Kulkarni U, Andreas N, Ungelenk M, Ravens S, Hubner C, Kather A, Kurth I, Bauer M, Kamradt T (2019) Sepsis induces long-lasting impairments in CD4(+) T-cell responses despite rapid numerical recovery of T-lymphocyte populations. PLoS One 14: 16
Arefian H, Hagel S, Fischer D, Scherag A, Brunkhorst FM, Maschmann J, Hartmann M (2019) Estimating extra length of stay due to healthcare-associated infections before and after implementation of a hospital-wide infection control program. PLoS One 14: 11
Baumbach P, Neu C, Derlien S, Bauer M, Nisser M, Buder A, Coldewey SM (2019) A pilot study of exercise-induced changes in mitochondrial oxygen metabolism measured by a cellular oxygen metabolism monitor (PICOMET). BBA-Molecular Basis of Disease 1865: 749-758
Blankenhaus B, Braza F, Martins R, Bastos-Amador P, Gonzalez-Garcia I, Carlos AR, Mahu I, Faisca P, Nunes JM, Ventura P, Hoerr V, Weis S, Guerra J, Cardoso S, Domingos A, Lopez M, Soares MP (2019) Ferritin regulates organismal energy balance and thermogenesis. Molecular Metabolism 24: 64-79
Blaurock-Moller N, Groger M, Siwczak F, Dinger J, Schmerler D, Mosig AS, Kiehntopf M (2019) CAAP48, a New Sepsis Biomarker, Induces Hepatic Dysfunction in an in vitro Liver-on-Chip Model. Front Immunol 10: 12
Bramer D, Gunther A, Rupprecht S, Nowack S, Adam J, Meyer F, Schwab M, Surber R, Witte OW, Hoyer H, Hoyer D (2019) Very Low Frequency Heart Rate Variability Predicts the Development of Post-Stroke Infections. Translational Stroke Research 10: 607-619
Burghold CM, Hohenstein C, Rueddel H (2019) Trendelenburg position in the ED: many critically ill patients in the emergency department do not tolerate the Trendelenburg position. European Journal of Emergency Medicine 26: 212-216
Ceanga M, Keiner S, Grunewald B, Haselmann H, Frahm C, Couillard-Despres S, Witte OW, Redecker C, Geis C, Kunze A (2019) Stroke Accelerates and Uncouples Intrinsic and Synaptic Excitability Maturation of Mouse Hippocampal DCX+ Adult-Born Granule Cells. Journal of Neuroscience 39: 1755-1766
Demontis D, Walters RK, Martin J, et al. (2019) Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nat Genet 51: 63-75
Dennhardt S, Finke KR, Huwiler A, Coldewey SM (2019) Sphingosine-1-phosphate promotes barrier-stabilizing effects in human microvascular endothelial cells via AMPK-dependent mechanisms. BBA-Molecular Basis of Disease 1865: 774-781
Eisel D, Das K, Dickes E, Konig R, Osen W, Eichmuller SB (2019) Cognate Interaction With CD4(+) T Cells Instructs Tumor-Associated Macrophages to Acquire M1-Like Phenotype. Front Immunol 10: 12
Englert FA, Seidel RA, Galler K, Gouveia Z, Soares MP, Neugebauer U, Clemens MG, Sponholz C, Heinemann SH, Pohnert G, Bauer M, Weis S (2019) Labile heme impairs hepatic microcirculation and promotes hepatic injury. Arch Biochem Biophys 672: 108075
Findeisen A, Arefian H, Doenst T, Hagel S, Pletz MW, Hartmann M, Maschmann J (2019) Economic burden of surgical site infections in patients undergoing cardiac surgery. European Journal of Cardio-Thoracic Surgery 55: 494-500
Fleischmann-Struzek C, Mikolajetz A, Reinhart K, Curtis JR, Haase U, Thomas-Ruddel D, Dennler U, Hartog CS (2019) Hospitalization and intensive Therapy at the End of Life. Dtsch Arztebl Int 116: 653
Friesecke S, Traeger K, Schittek GA, Molnar Z, Bach F, Kogelmann K, Bogdanski R, Weyland A, Nierhaus A, Nestler F, Olboeter D, Tomescu D, Jacob D, Haake H, Grigoryev E, Nitsch M, Baumann A, Quintel M, Schott M, Kielstein JT, Meier-Hellmann A, Born F, Schumacher U, Singer M, Kellum J, Brunkhorst FM (2019) International registry on the use of the CytoSorb (R) adsorber in ICU patients: Study protocol and preliminary results. Medizinische Klinik-Intensivmedizin und Notfallmedizin 114: 699-707
Fuchs A, Pletz MW, Kaasch AJ (2019) Diagnosis of sepsis and empirical treatment in the emergency department. Notfall & Rettungsmedizin 22: 198-204
Gawlytta R, Wintermann GB, Bottche M, Niemeyer H, Knaevelsrud C, Rosendahl J (2019) [Posttraumatic stress disorder after intensive care : Prevalence, risk factors, and treatment]. Med Klin Intensivmed Notfmed 114: 9-14
Graf K, Last A, Gratz R, Allert S, Linde S, Westermann M, Groger M, Mosig AS, Gresnigt MS, Hube B (2019) Keeping Candida commensal: how lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model. Dis Model Mech 12: 16
Hagel S, Fiedler S, Hohn A, Brinkmann A, Frey OR, Hoyer H, Schlattmann P, Kiehntopf M, Roberts JA, Pletz MW, Bloos F, Angermair S, Bracht H, Barth E, Kluge S, Nierhaus A, Motsch J, Brenner T, Annecke T, Bach F, Weigand M, Schappacher M, von Ameln-Mayerhofer A, Michels G, Roehr A, Fuchs T, Eichner S, Barth E, Kong C, Pinder N, Muller C, Petersen M, Schlattmann P, Steinbach G, Jarczak D, Weisman D, Kurlbaum M, Braune A, Grp TS (2019) Therapeutic drug monitoring-based dose optimisation of piperacillin/tazobactam to improve outcome in patients with sepsis (TARGET): a prospective, multi-centre, randomised controlled trial. Trials 20: 330
Hagel S, Ludewig K, Pletz MW, Frosinski J, Moeser A, Wolkewitz M, Gastmeier P, Harbarth S, Brunkhorst FM, Kesselmeier M, Scherag A (2019) Effectiveness of a hospital-wide infection control programme on the incidence of healthcare-associated infections and associated severe sepsis and septic shock: a prospective interventional study. Clinical Microbiology and Infection 25: 462-468
Hagel S, Schmitt S, Kesselmeier M, Baier M, Welte T, Ewig S, Pletz MW (2019) M. pneumoniae and C. pneumoniae are no relevant pathogens in critically ill patients with hospital-acquired respiratory tract infections. Infection 47: 471-474
Hartung S, Rauh C, Hoang TNM, Jahreis S, Wagner K, Macheleidt J, Brakhage AA, Rummler S, Hochhaus A, von Lilienfeld-Toal M (2019) Fast and Quantitative Evaluation of Human Leukocyte Interaction with Aspergillus fumigatus Conidia by Flow Cytometry. Cytometry Part A 95A: 332-338
Heun Y, Pircher J, Czermak T, Bluem P, Hupel G, Bohmer M, Kraemer BF, Pogoda K, Pfeifer A, Woernle M, Ribeiro A, Hubner M, Kreth S, Claus RA, Weis S, Ungelenk L, Krotz F, Pohl U, Mannell H (2019) Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis. EBioMedicine 42: 120-132
Hirschberger S, Hubner M, Strauss G, Effinger D, Bauer M, Weis S, Giamarellos-Bourboulis EJ, Kreth S (2019) Identification of suitable controls for miRNA quantification in T-cells and whole blood cells in sepsis. Sci Rep 9: 13
Huang CY, Daniels R, Lembo A, Hartog C, O'Brien J, Heymann T, Reinhart K, Nguyen HB, Ssep (2019) Life after sepsis: an international survey of survivors to understand the post-sepsis syndrome. International Journal for Quality in Health Care 31: 191-198
Hufsky F, Ibrahim B, Modha S, Clokie MRJ, Deinhardt-Emmer S, Dutilh BE, Lycett S, Simmonds P, Thiel V, Abroi A, Adriaenssens EM, Escalera-Zamudio M, Kelly JN, Lamkiewicz K, Lu L, Susat J, Sicheritz T, Robertson DL, Marz M (2019) The Third Annual Meeting of the European Virus Bioinformatics Center. Viruses-Basel 11: 19
Joerk A, Ritter M, Langguth N, Seidel RA, Freitag D, Herrmann KH, Schaefgen A, Ritter M, Gunther M, Sommer C, Braemer D, Walter J, Ewald C, Kalff R, Reichenbach JR, Westerhausen M, Pohnert G, Witt OW, Holthoff K (2019) Propentdyopents as Heme Degradation Intermediates Constrict Mouse Cerebral Arterioles and Are Present in the Cerebrospinal Fluid of Patients With Subarachnoid Hemorrhage. Circ Res 124: E101-E114
Kapitan M, Niemiec MJ, Steimle A, Frick JS, Jacobsen ID (2019) Fungi as Part of the Microbiota and Interactions with Intestinal Bacteria. In Fungal Physiology and Immunopathogenesis, Rodrigues ML (ed), Vol. 422, pp 265-301. Cham: Springer International Publishing Ag.
Karakike E, Adami ME, Lada M, Gkavogianni T, Koutelidakis IM, Bauer M, Giamarellos-Bourboulis EJ, Tsangaris I (2019) Late Peaks of HMGB1 and Sepsis Outcome: Evidence For Synergy With Chronic Inflammatory Disorders. Shock 52: 334-339
Karunakaran I, Aiam S, Jayagopi S, Frohberger SJ, Hansen JN, Kuehlwein J, Holbling BV, Schumak B, Hubner MP, Graler MH, HaIie A, van Echten-Deckert G (2019) Neural sphingosine 1-phosphate accumulation activates microglia and links impaired autophagy and inflammation. Glia 67: 1859-1872
Keul P, Polzin A, Kaiser K, Gräler M, Dannenberg L, Daum G, Heusch G, Levkau B (2019) Potent anti-inflammatory properties of HDL in vascular smooth muscle cells mediated by HDL-S1P and their impairment in coronary artery disease due to lower HDL-S1P: a new aspect of HDL dysfunction and its therapy. FASEB Journal 33: 1482-1495
Klaile E, Muller MM, Zubiria-Barrera C, Brehme S, Klassert TE, Stock M, Durotin A, Nguyen TD, Feer S, Singer BB, Zipfel PF, Rudolphi S, Jacobsen ID, Slevogt H (2019) Unaltered Fungal Burden and Lethality in Human CEACAM1-Transgenic Mice During Candida albicans Dissemination and Systemic Infection. Frontiers in Microbiology 10: 23
Koliesnik IO, Andreas N, Thuy A, Sreekantapuram S, Haenold R, Weilh F (2019) Alternative NF-kappa B signaling controls peripheral homeostasis and function of regulatory T cells. Immunobiology 224: 687-696
Kolte A, Konig R (2019) Temporal progression of gene regulation of peripheral white blood cells explains gender dimorphism of critically ill patients after trauma. Mol Med 25: 14
König C, Matt B, Kortgen A, Turnbull AE, Hartog CS (2019) What matters most to sepsis survivors: a qualitative analysis to identify specific health-related quality of life domains. Quality of Life Research 28: 637-647
König R, Cao XQ, Oswald M, Forstner C, Rohde G, Rupp J, Witzenrath M, Welte T, Kolditz M, Pletz M, Dreher M, Cornelissen C, Knuppel W, Stolz D, Suttorp N, Witzenrath M, Creutz P, Mikolajewska A, Bauer T, Krieger D, Pankow W, Thiemig D, Hauptmeier B, Ewig S, Wehde D, Prediger M, Schmager S, Kolditz M, Schulte-Hubbert B, Langner S, Albrich W, Welte T, Freise J, Barten G, Toro OA, Nawrocki M, Naim J, Witte M, Kroner W, Illig T, Klopp N, Kreuter M, Herth F, Hummler S, Ravn P, Vestergaard-Jensen A, Baunbaek-Knudsen G, Pletz M, Kroegel C, Frosinski J, Winning J, Schleenvoigt B, Dalhoff K, Rupp J, Horster R, Dromann D, Rohde G, Drijkoningen J, Braeken D, Buschmann H, Schaberg T, Hering I, Panning M, Wallner M, Grp CS (2019) Macrolide combination therapy for patients hospitalised with community-acquired pneumonia? An individualised approach supported by machine learning. European Respiratory Journal 54: 11
Kosilek RP, Baumeister SE, Ittermann T, Grundling M, Brunkhorst FM, Felix SB, Abel P, Friesecke S, Apfelbacher C, Brandl M, Schmidt K, Hoffmann W, Schmidt CO, Chenot JF, Volzke H, Gensichen JS (2019) The association of intensive care with utilization and costs of outpatient healthcare services and quality of life. PLoS One 14: 15
Kresinsky A, Schnoder TM, Jacobsen ID, Rauner M, Hofbauer LC, Ast V, Konig R, Hoffmann B, Svensson CM, Figge MT, Hilger I, Heidel FH, Bohmer FD, Muller JP (2019) Lack of CD45 in FLT3-ITD mice results in a myeloproliferative phenotype, cortical porosity, and ectopic bone formation. Oncogene 38: 4773-4787
Kruger W, Vielreicher S, Kapitan M, Jacobsen ID, Niemiec MJ (2019) Fungal-Bacterial Interactions in Health and Disease. Pathogens 8: 41
Liu JJ, Hoffmann P, Steinmetzer J, Askes SHC, Kupfer S, Gorls H, Grafe S, Neugebauer U, Gandra UR, Schiller A (2019) Visible light-activated biocompatible photo-CORM for CO-release with colorimetric and fluorometric dual turn-on response. Polyhedron 172: 175-181
Mallm JP, Iskar M, Ishaque N, Klett LC, Kugler SJ, Muino JM, Teif VB, Poos AM, Grossmann S, Erdel F, Tavernari D, Koser SD, Schumacher S, Brors B, Konig R, Remondini D, Vingron M, Stilgenbauer S, Lichter P, Zapatka M, Mertens D, Rippe K (2019) Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks. Molecular Systems Biology 15: 20
Maurer M, Gresnigt MS, Last A, Wollny T, Berlinghof F, Pospich R, Cseresnyes Z, Medyukhina A, Graf K, Groger M, Raasch M, Siwczak F, Nietzsche S, Jacobsen ID, Figge MT, Hube B, Huber O, Mosig AS (2019) A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. Biomaterials 220: 119396
Minner S, Lutz J, Hube-Magg C, Kluth M, Simon R, Hoflmayer D, Burandt E, Tsourlakis MC, Sauter G, Buscheck F, Wilczak W, Steurer S, Schlomm T, Huland H, Graefen M, Haese A, Heinzer H, Jacobsen F, Hinsch A, Poos A, Oswald M, Rippe K, Konig R, Schroeder C (2019) Loss of CCAAT-enhancer-binding protein alpha (CEBPA) is linked to poor prognosis in PTEN deleted and TMPRSS2:ERG fusion type prostate cancers. Prostate 79: 302-311
Mondol AS, Topfer N, Ruger J, Neugebauer U, Popp J, Schie IW (2019) New perspectives for viability studies with high-content analysis Raman spectroscopy (HCA-RS). Sci Rep 9: 12
Ndongson-Dongmo B, Lang GP, Mece O, Hechaichi N, Lajqi T, Hoyer D, Brodhun M, Heller R, Wetzker R, Franz M, Levy FO, Bauer R (2019) Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in mice. Basic Res Cardiol 114: 20
Nesslauer AM, Glaser A, Graler M, Engelmann R, Muller-Hilke B, Frank M, Burstein C, Rolfs A, Neidhardt J, Wree A, Witt M, Brauer AU (2019) A therapy with miglustat, 2-hydroxypropyl-beta-cyclodextrin and allopregnanolone restores splenic cholesterol homeostasis in Niemann-pick disease type C1. Lipids in Health and Disease 18: 18
Neugebauer S, Wichmann C, Bremer-Streck S, Hagel S, Kiehntopf M (2019) Simultaneous Quantification of Nine Antimicrobials by LC-MS/MS for Therapeutic Drug Monitoring in Critically Ill Patients. Therapeutic Drug Monitoring 41: 29-37
Persyn A, Rogiers O, Brock M, Vande Velde G, Lamkanfi M, Jacobsen ID, Himmelreich U, Lagrou K, Van Dijck P, Kuchadkova S (2019) Monitoring of Fluconazole and Caspofungin Activity against In Vivo Candida glabrata Biofilms by Bioluminescence Imaging. Antimicrob Agents Chemother 63: 10
Pletz MW, Bauer M, Brakhage AA (2019) One step closer to precision medicine for infectious diseases. Lancet Infectious Diseases 19: 564-565
Raasch M, Fritsche E, Kurtz A, Bauer M, Mosig AS (2019) Microphysiological systems meet hiPSC technology - New tools for disease modeling of liver infections in basic research and drug development. Adv Drug Deliv Rev 140: 51-67
Ramu V, Reddy GU, Liu JJ, Hoffmann P, Sollapur R, Wyrwa R, Kupfer S, Spielmann C, Bonnet S, Neugebauer U, Schiller A (2019) Two-Photon-Induced CO-Releasing Molecules as Molecular Logic Systems in Solution, Polymers, and Cells. Chemistry-a European Journal 25: 8453-8458
Roell D, Rosler TW, Hessenkemper W, Kraft F, Hauschild M, Bartsch S, Abraham TE, Houtsmuller AB, Matusch R, van Royen ME, Baniahmad A (2019) Halogen-substituted anthranilic acid derivatives provide a novel chemical platform for androgen receptor antagonists. Journal of Steroid Biochemistry and Molecular Biology 188: 59-70
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Rubio I, Osuchowski MF, Shankar-Hari M, Skirecki T, Winkler MS, Lachmann G, La Rosee P, Monneret G, Venet F, Bauer M, Brunkhorst FM, Kox M, Cavaillon JM, Uhle F, Weigand MA, Flohe SB, Wiersinga WJ, Martin-Fernandez M, Almansa R, Martin-Loeches I, Torres A, Giamarellos-Bourboulis EJ, Girardis M, Cossarizza A, Netea MG, van der Poll T, Scherag A, Meisel C, Schefold JC, Bermejo-Martin JF (2019) Current gaps in sepsis immunology: new opportunities for translational research. Lancet Infect Dis 19: e422-e436
Saeed K, Wilson DC, Bloos F, Schuetz P, van der Does Y, Melander O, Hausfater P, Legramante JM, Claessens YE, Amin D, Rosenqvist M, White G, Mueller B, Limper M, Callejo CC, Brandi A, Macchi MA, Cortes N, Kutz A, Patka P, Yanez MC, Bernardini S, Beau N, Dryden M, van Gorp ECM, Minieri M, Chan L, Rood PPM, del Castillo JG (2019) The early identification of disease progression in patients with suspected infection presenting to the emergency department: a multi-centre derivation and validation study. Critical Care 23: 15
Scheer CS, Kuhn SO, Fuchs C, Vollmer M, Modler A, Brunkhorst F, Shankar-Hari M, Hahnenkamp K, Gundling M, Rehberg S (2019) DO SEPSIS-3 CRITERIA FACILITATE EARLIER RECOGNITION OF SEPSIS AND SEPTIC SHOCK? A RETROSPECTIVE COHORT STUDY. Shock 51: 306-311
Schmidl L, Schmidl G, Gawlik A, Dellith J, Hubner U, Tympel V, Schmidl F, Plentz J, Geis C, Haselmann H (2019) Combining super-resolution microscopy with neuronal network recording using magnesium fluoride thin films as cover layer for multi-electrode array technology. Sci Rep 9: 9
Schubert J, Bramer D, Huttner HB, Gerner ST, Fuhrer H, Melzer N, Dik A, Pruss H, Ly LT, Fuchs K, Leypoldt F, Nissen G, Schirotzek I, Dohmen C, Bosel J, Lewerenz J, Thaler F, Kraft A, Juranek A, Ringelstein M, Suhs KW, Urbanek C, Scherag A, Geis C, Witte OW, Gunther A, Network GI (2019) Management and prognostic markers in patients with autoimmune encephalitis requiring ICU treatment. Neurology-Neuroimmunology & Neuroinflammation 6: e514
Schwarz N, Knutti N, Rose M, Neugebauer S, Geiger J, Jahns R, Klopp N, Illig T, Mathay C, Betsou F, Scherag A, Kiehntopf M (2019) Quality Assessment of the Preanalytical Workflow in Liquid Biobanking: Taurine as a Serum-Specific Quality Indicator for Preanalytical Process Variations. Biopreservation and Biobanking 17: 458-467
Schwarzkopf D (2019) Nonbeneficial care-a burden for clinicians and relatives. Medizinische Klinik-Intensivmedizin Und Notfallmedizin 114: 222-228
Tannert A, Grohs R, Popp J, Neugebauer U (2019) Phenotypic antibiotic susceptibility testing of pathogenic bacteria using photonic readout methods: recent achievements and impact. Applied Microbiology and Biotechnology 103: 549-566
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Tuchscherr L, Pollath C, Siegmund A, Deinhardt-Emmer S, Hoerr V, Svensson CM, Figge MT, Monecke S, Loffler B (2019) Clinical S. aureus Isolates Vary in Their Virulence to Promote Adaptation to the Host. Toxins 11: 15
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Weis S, Kesselmeier M, Davis JS, Morris AM, Lee S, Scherag A, Hagel S, Pletz MW (2019) Cefazolin versus anti-staphylococcal penicillins for the treatment of patients with Staphylococcus aureus bacteraemia. Clinical Microbiology and Infection 25: 818-827
Westphal S, Stoppe C, Gruenewald M, et al. (2019) Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study. Bmc Cardiovascular Disorders 19: 12
Winkler MS, Martz KB, Nierhaus A, Daum G, Schwedhelm E, Kluge S, Graler MH (2019) Loss of sphingosine 1-phosphate (S1P) in septic shock is predominantly caused by decreased levels of high-density lipoproteins (HDL). Journal of Intensive Care 7: 9
Wintermann GB, Petrowski K, Weidner K, Strauss B, Rosendahl J (2019) Impact of post-traumatic stress symptoms on the health-related quality of life in a cohort study with chronically critically ill patients and their partners: age matters. Critical Care 23: 10
Wissbrock A, Goradia NB, Kumar A, George AAP, Kuhl T, Bellstedt P, Ramachandran R, Hoffmann P, Galler K, Popp J, Neugebauer U, Hampel K, Zimmermann B, Adam S, Wiendl M, Kronke G, Hamza I, Heinemann SH, Frey S, Hueber AJ, Ohlenschlaeger O, Imhof D (2019) Structural insights into heme binding to IL-36 alpha proinflammatory cytokine. Sci Rep 9: 14
Yarbakht M, Pradhan P, Kose-Vogel N, Bae H, Stengel S, Meyer T, Schmitt M, Stallmach A, Popp J, Bocklitz TW, Bruns T (2019) Nonlinear Multimodal Imaging Characteristics of Early Septic Liver Injury in a Mouse Model of Peritonitis. Anal Chem 91: 11116-11121
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Publikationen 2018
Ali N, Girnus S, Rosch P, Popp J, Bocklitz T (2018) Sample-Size Planning for Multivariate Data: A Raman-Spectroscopy-Based Example. Anal Chem 90: 12485-12492
Ansari SS, Sharma AK, Soni H, Ali DM, Tews B, Koenig R, Eibl H, Berger MR (2018) Induction of ER and mitochondrial stress by the alkylphosphocholine erufosine in oral squamous cell carcinoma cells. Cell Death Dis 9: 296
Bauer M, Coldewey SM, Leitner M, Loffler B, Weis S, Wetzker R (2018) Deterioration of Organ Function As a Hallmark in Sepsis: The Cellular Perspective. Front Immunol 9: 1460
Bauer M, Weis S, Netea MG, Wetzker R (2018) Remembering Pathogen Dose: Long-Term Adaptation in Innate Immunity. Trends Immunol 39: 438-445
Baumbach P, Gotz T, Gunther A, Weiss T, Meissner W (2018) Chronic intensive care-related pain: Exploratory analysis on predictors and influence on health-related quality of life. Eur J Pain 10.1002/ejp.1129
Beder T, Saluz HP (2018) Virulence-related comparative transcriptomics of infectious and non-infectious chlamydial particles. BMC Genomics 19: 575
Betsch C, Rossmann C, Pletz MW, Vollmar HC, Freytag A, Wichmann O, Hanke R, Hanke W, Heinemeier D, Schmid P, Eitze S, Weber W, Reinhardt A, Kupke NK, Forstner C, Fleischmann-Struzek C, Mikolajetz A, Romhild J, Neufeind J, Rieck T, Suchecka K, Reinhart K (2018) Increasing influenza and pneumococcal vaccine uptake in the elderly: study protocol for the multi-methods prospective intervention study Vaccination60. BMC Public Health 18: 885
Blaess M, Bibak N, Claus RA, Kohl M, Bonaterra GA, Kinscherf R, Laufer S, Deigner HP (2018) NB 06: From a simple lysosomotropic aSMase inhibitor to tools for elucidating the role of lysosomes in signaling apoptosis and LPS-induced inflammation. Eur J Med Chem 153: 73-104
Bloos F, Held J, Schlattmann P, Brillinger N, Kurzai O, Cornely OA, Thomas-Ruddel D (2018) (1,3)-beta-D-glucan-based diagnosis of invasive Candida infection versus culture-based diagnosis in patients with sepsis and with an increased risk of invasive Candida infection (CandiSep): study protocol for a randomized controlled trial. Trials 19: 472
Bondeva T, Schindler C, Schindler K, Wolf G (2018) MORG1(+/-) mice are protected from histological renal damage and inflammation in a murine model of endotoxemia. BMC Nephrol 19: 29
Brunzel M, Majdanski TC, Vitz J, Nischang I, Schubert US (2018) Fast Screening of Diol Impurities in Methoxy Poly(Ethylene Glycol)s (mPEG)s by Liquid Chromatography on Monolithic Silica Rods. Polymers 10: 1395
Carlos AR, Weis S, Moita MR, Singh S, Blankenhaus B, Cardoso S, Larsen R, Rebelo S, Schaeuble S, Del Barrio L, Mithieux G, Rajas F, Lindig S, Bauer M, Soares MP (2018) Iron-mediated control of glucose metabolism is central to promote disease tolerance to polymicrobial infections. Free Radical Bio Med 120: S112-S112
Carlos AR, Weis S, Soares MP (2018) Cross-Talk Between Iron and Glucose Metabolism in the Establishment of Disease Tolerance. Front Immunol 9: 2498
Chung HY, Witt CJ, Hurtado-Oliveros J, Wickel J, Graler MH, Lupp A, Claus RA (2018) Acid Sphingomyelinase Inhibition Stabilizes Hepatic Ceramide Content and Improves Hepatic Biotransformation Capacity in a Murine Model of Polymicrobial Sepsis. Int J Mol Sci 19
Dennhardt S, Pirschel W, Wissuwa B, Daniel C, Gunzer F, Lindig S, Medyukhina A, Kiehntopf M, Rudolph WW, Zipfel PF, Gunzer M, Figge MT, Amann K, Coldewey SM (2018) Modeling Hemolytic-Uremic Syndrome: In-Depth Characterization of Distinct Murine Models Reflecting Different Features of Human Disease. Front Immunol 9: 1459
Doulias T, Quickert S, Weis S, Claus RA, Kontopoulou K, Giamarellos-Bourboulis EJ, Bauer M, Koutelidakis IM (2018) Low-dose hydrocortisone prolongs survival in a lethal sepsis model in adrenalectomized rats. J Surg Res 227: 72-80
Eitze S, Fleischmann-Struzek C, Betsch C, Reinhart K, vaccination60+ study g (2018) Determinants of sepsis knowledge: a representative survey of the elderly population in Germany. Crit Care 22: 273
Elke G, Bloos F, Wilson DC, Brunkhorst FM, Briegel J, Reinhart K, Loeffler M, Kluge S, Nierhaus A, Jaschinski U, Moerer O, Weyland A, Meybohm P, SepNet Critical Care Trials G (2018) The use of mid-regional proadrenomedullin to identify disease severity and treatment response to sepsis - a secondary analysis of a large randomised controlled trial. Crit Care 22
Elke G, Bloos F, Wilson DC, Meybohm P, SepNet Critical Care Trials G (2018) Identification of developing multiple organ failure in sepsis patients with low or moderate SOFA scores. Crit Care 22: 147
Fahrner R, Groeger M, Settmacher U, Mosig AS (2018) Influence of extracellular nucleotides on hepatic inflammation in a microfluidically perfused liver-on-chip model. Brit J Surg 105: 22-23
Fang H, Hua C, Weiss S, Liu A, Cheng W, Claus R, Rödel J, Dirsch O, Dahmen U (2018) Modulation of Innate Immunity by G-CSF and Inflammatory Response by LBPK95A Improves the Outcome of Sepsis in a Rat Model. J Immunol Res 2018: 12
Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N (2018) The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med 6: 223-230
Fleischmann-Struzek C, Mikolajetz A, Schwarzkopf D, Cohen J, Hartog CS, Pletz M, Gastmeier P, Reinhart K (2018) Challenges in assessing the burden of sepsis and understanding the inequalities of sepsis outcomes between National Health Systems: secular trends in sepsis and infection incidence and mortality in Germany. Intensive Care Med 44: 1826-1835
Fleischmann-Struzek C, Thomas-Ruddel DO, Schettler A, Schwarzkopf D, Stacke A, Seymour CW, Haas C, Dennler U, Reinhart K (2018) Comparing the validity of different ICD coding abstraction strategies for sepsis case identification in German claims data. PLoS One 13: e0198847
Geraci J, Neubauer S, Poellath C, Hansen U, Rizzo F, Krafft C, Westermann M, Hussain M, Peters G, Pletz MW, Loeffler B, Makarewicz O, Tuchscherr L (2018) The Staphylococcus aureus extracellular matrix protein (Emp) has a fibrous structure and binds to different extracellular matrices (vol 7, 13665, 2017). Sci Rep 8
Groeger M, Dinger J, Kiehntopf M, Peters FT, Rauen U, Mosig AS (2018) Preservation of Cell Structure, Metabolism, and Biotransformation Activity of Liver-On-Chip Organ Models by Hypothermic Storage. Adv Healthc Mater 7
Hartog CS, Reinhart K (2018) Staff and family response to end-of-life care in the ICU. Curr Opin Anesthesiol 31: 195-200
Haselmann H, Mannara F, Werner C, Planaguma J, Miguez-Cabello F, Schmidl L, Grunewald B, Petit-Pedrol M, Kirmse K, Classen J, Demir F, Klocker N, Soto D, Doose S, Dalmau J, Hallermann S, Geis C (2018) Human Autoantibodies against the AMPA Receptor Subunit GluA2 Induce Receptor Reorganization and Memory Dysfunction. Neuron 100: 91-105 e109
Helbing DL, Bohm L, Witte OW (2018) Sepsis-associated encephalopathy. CMAJ 190: E1083
Hilbert-Carius P, Schwarzkopf D, Reinhart K, Hartog CS, Lefering R, Bernhard M, Struck MF (2018) Synthetic colloid resuscitation in severely injured patients: analysis of a nationwide trauma registry (TraumaRegister DGU). Sci Rep 8: 11567
Horing S, Loffler B, Pletz MW, Rossler S, Weis S, Schleenvoigt BT (2018) Dual antiretroviral therapy with tenofovir (TDF) and darunavir/ritonavir (DRV/RTV) in an HIV-1 positive patient: a case report, review, and meta-analysis of the literature on dual treatment strategies using protease inhibitors in combination with an NRTI. Infection 46: 599-605
Horn P, von Loeffelholz C, Forkert F, Stengel S, Reuken P, Aschenbach R, Stallmach A, Bruns T (2018) Low circulating chemerin levels correlate with hepatic dysfunction and increased mortality in decompensated liver cirrhosis. Sci Rep 8: 9242
Irizar PA, Schaeuble S, Esser D, Groth M, Frahm C, Priebe S, Baumgart M, Hartmann N, Marthandan S, Menzel U, Mueller J, Schmidt S, Ast V, Caliebe A, Koenig R, Krawczak M, Ristow M, Schuster S, Cellerino A, Diekmann S, Englert C, Hemmerich P, Suehnel J, Guthke R, Witte OW, Platzer M, Ruppin E, Kaleta C (2018) Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly. Nat Commun 9
Karrasch M, Geraci J, Sachse S, Rodel J, Loffler B, Bauer M, Thomas-Ruddel D, Hagel S, Aschenbach R, Bloos F (2018) Early adjustment of antimicrobial therapy after PCR/electrospray ionization mass spectrometry-based pathogen detection in critically ill patients with suspected sepsis. Clin Chem Lab Med 56: e207-e209
Kesselmeier M, Putter C, Volckmar AL, Baurecht H, Grallert H, Illig T, Ismail K, Ollikainen M, Silen Y, Keski-Rahkonen A, Bulik CM, Collier DA, Zeggini E, Hebebrand J, Scherag A, Hinney A, Gcan, Wtccc (2018) High-throughput DNA methylation analysis in anorexia nervosa confirms TNXB hypermethylation. World J Biol Psychiatry 19: 187-199
Kesselmeier M, Scherag A (2018) Commentary: Arguing for Adaptive Clinical Trials in Sepsis. Front Immunol 9
Kirchhoff J, Glaser U, Bohnert JA, Pletz MW, Popp J, Neugebauer U (2018) Simple Ciprofloxacin Resistance Test and Determination of Minimal Inhibitory Concentration within 2 h Using Raman Spectroscopy. Anal Chem 90: 1811-1818
Kulkarni U, Herrmenau C, Win SJ, Bauer M, Kamradt T (2018) IL-7 treatment augments and prolongs sepsis-induced expansion of IL-10-producing B lymphocytes and myeloid-derived suppressor cells. PLoS One 13
Lehmann R, Muller MM, Klassert TE, Driesch D, Stock M, Heinrich A, Conrad T, Moore C, Schier UK, Guthke R, Slevogt H (2018) Differential regulation of the transcriptomic and secretomic landscape of sensor and effector functions of human airway epithelial cells. Mucosal Immunol 11: 627-642
Leonhardt J, Grosse S, Marx C, Siwczak F, Stengel S, Bruns T, Bauer R, Kiehntopf M, Williams DL, Wang ZQ, Mosig AS, Weis S, Bauer M, Heller R (2018) Candida albicans beta-Glucan Differentiates Human Monocytes Into a Specific Subset of Macrophages. Front Immunol 9: 13
Luo S, Dasari P, Reiher N, Hartmann A, Jacksch S, Wende E, Barz D, Niemiec MJ, Jacobsen I, Beyersdorf N, Huenig T, Klos A, Skerka C, Zipfel PF (2018) The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments. Mol Immunol 93: 266-277
Majdanski TC, Vitz J, Meier A, Brunzel M, Schubert S, Nischang I, Schubert US (2018) “Green” ethers as solvent alternatives for anionic ring-opening polymerizations of ethylene oxide (EO): In-situ kinetic and advanced characterization studies. Polymer 159: 86-94
Mede R, Hoffmann P, Neumann C, Goerls H, Schmitt M, Popp J, Neugebauer U, Westerhausen M (2018) Acetoxymethyl Concept for Intracellular Administration of Carbon Monoxide with Mn(CO)(3)-Based PhotoCORMs. Chem-Eur J 24: 3321-3329
Meinel C, Sparta G, Dahse H-M, Hoerhold F, Koenig R, Westermann M, Coldewey SM, Cseresnyes Z, Figge MT, Hammerschmidt S, Skerka C, Zipfel PF (2018) Streptococcus pneumoniae From Patients With Hemolytic Uremic Syndrome Binds Human Plasminogen via the Surface Protein PspC and Uses Plasmin to Damage Human Endothelial Cells. J Infect Dis 217: 358-370
Mohnle P, Hirschberger S, Hinske LC, Briegel J, Hubner M, Weis S, Dimopoulos G, Bauer M, Giamarellos-Bourboulis EJ, Kreth S (2018) MicroRNAs 143 and 150 in whole blood enable detection of T-cell immunoparalysis in sepsis. Mol Med 24: 54
Neubert F, Beliu G, Terpitz U, Werner C, Geis C, Sauer M, Doose S (2018) Bioorthogonal Click Chemistry Enables Site-specific Fluorescence Labeling of Functional NMDA Receptors for Super-Resolution Imaging. Angewandte Chemie-International Edition 57: 16364-16369
Nierhaus A, Bloos F, Wilson DC, Elke G, Meybohm P, SepNet Critical Care Trials G (2018) Predicting the requirement for renal replacement therapy in intensive care patients with sepsis. Crit Care 22: 201
Pein H, Ville A, Pace S, Temml V, Garscha U, Raasch M, Alsabil K, Viault G, Dinh CP, Guilet D, Troisi F, Neukirch K, Konig S, Bilancia R, Waltenberger B, Stuppner H, Wallert M, Lorkowski S, Weinigel C, Rummler S, Birringer M, Roviezzo F, Sautebin L, Helesbeux JJ, Seraphin D, Mosig AS, Schuster D, Rossi A, Richomme P, Werz O, Koeberle A (2018) Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase. Nat Commun 9: 3834
Petit-Pedrol M, Sell J, Planaguma J, Mannara F, Radosevic M, Haselmann H, Ceanga M, Sabater L, Spatola M, Soto D, Gasull X, Dalmau J, Geis C (2018) LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory. Brain 141: 3144-3159
Pilat Z, Bernatova S, Jezek J, Kirchhoff J, Tannert A, Neugebauer U, Samek O, Zemanek P (2018) Microfluidic Cultivation and Laser Tweezers Raman Spectroscopy of E. coli under Antibiotic Stress. Sensors (Basel) 18
Pletz MW, Weis S, Forstner C, Wagenlehner F (2018) Urosepsis. Urologe 57: 79-92
Pletz MW, Weis S, Forstner C, Wagenlehner F (2018) Urosepsis. Med Klin Intensivmed Notfmed 113: 143-156
Polke M, Leonhardt I, Kurzai O, Jacobsen ID (2018) Farnesol signalling in Candida albicans - more than just communication. Crit Rev Microbiol 44: 230-243
Prausse MTE, Lehnert T, Timme S, Hunniger K, Leonhardt I, Kurzai O, Figge MT (2018) Predictive Virtual Infection Modeling of Fungal Immune Evasion in Human Whole Blood. Front Immunol 9: 560
Retsas T, Huse K, Lazaridis LD, Karampela N, Bauer M, Platzer M, Kolonia V, Papageorgiou E, Giamarellos-Bourboulis EJ, Dimopoulos G (2018) Haplotypes composed of minor frequency single nucleotide polymorphisms of the TNF gene protect from progression into sepsis: A study using the new sepsis classification. Int J Infect Dis 67: 102-106
Reuken PA, Albig H, Roedel J, Hocke M, Will U, Stallmach A, Bruns T (2018) Fungal Infections in Patients With Infected Pancreatic Necrosis and Pseudocysts: Risk Factors and Outcome. Pancreas 47: 92-98
Ritter M, Neupane S, Seidel RA, Steinbeck C, Pohnert G (2018) In vivo and in vitro identification of Z-BOX C - a new bilirubin oxidation end product. Org Biomol Chem 16: 3553-3555
Ryabchykov O, Brautigam K, Galler K, Neugebauer U, Mosig A, Bocklitz T, Popp J (2018) Raman spectroscopic investigation of the human liver stem cell line HepaRG J Raman Spectrosc 49: 935-942
Salm F, Schwab F, Behnke M, Brunkhorst FM, Scherag A, Geffers C, Gastmeier P (2018) Nudge to better care - blood cultures and catheter-related bloodstream infections in Germany at two points in time (2006, 2015). Antimicrob Resist Infect Control 7: 141
Schaarschmidt B, Vlaic S, Medyukhina A, Neugebauer S, Nietzsche S, Gonnert FA, Rodel J, Singer M, Kiehntopf M, Figge MT, Jacobsen ID, Bauer M, Press AT (2018) Molecular signatures of liver dysfunction are distinct in fungal and bacterial infections in mice. Theranostics 8: 3766-3780
Schie IW, Rueger J, Mondol AS, Ramoji A, Neugebauer U, Krafft C, Popp J (2018) High-Throughput Screening Raman Spectroscopy Platform for Label-Free Cellomics. Anal Chem 90: 2023-2030
Schmidt JJ, Lueck C, Ziesing S, Stoll M, Haller H, Gottlieb J, Eder M, Welte T, Hoeper MM, Scherag A, David S (2018) Clinical course, treatment and outcome of Pneumocystis pneumonia in immunocompromised adults: a retrospective analysis over 17 years. Crit Care 22: 307
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Tannert A, Ramoji A, Neugebauer U, Popp J (2018) Photonic monitoring of treatment during infection and sepsis: development of new detection strategies and potential clinical applications. Anal Bioanal Chem 410: 773-790
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Thunstrom Salzer A, Niemiec MJ, Hosseinzadeh A, Stylianou M, Astrom F, Rohm M, Ahlm C, Wahlin A, Ermert D, Urban CF (2018) Assessment of Neutrophil Chemotaxis Upon G-CSF Treatment of Healthy Stem Cell Donors and in Allogeneic Transplant Recipients. Front Immunol 9: 1968
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Waschke A, Arefian H, Walter J, Hartmann M, Maschmann J, Kalff R (2018) Cost-effectiveness of the long-term use of temozolomide for treating newly diagnosed glioblastoma in Germany. J Neuro-Oncol 138: 359-367
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Publikationen 2017
Alonso-Pernas P, Arias-Cordero E, Novoselov A, Ebert C, Rybak J, Kaltenpoth M, Westermann M, Neugebauer U, Boland W (2017) Bacterial Community and PHB-Accumulating Bacteria Associated with the Wall and Specialized Niches of the Hindgut of the Forest Cockchafer (Melolontha hippocastani). Front Microbiol 8: 291
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Arefian H, Heublein S, Scherag A, Brunkhorst FM, Younis MZ, Moerer O, Fischer D, Hartmann M (2017) Hospital-related cost of sepsis: A systematic review. J Infection 10.1016/j.jinf.2016.11.006
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Bloos F, Ruddel H, Thomas-Ruddel D, Schwarzkopf D, Pausch C, Harbarth S, Schreiber T, Grundling M, Marshall J, Simon P, Levy MM, Weiss M, Weyland A, Gerlach H, Schurholz T, Engel C, Matthaus-Kramer C, Scheer C, Bach F, Riessen R, Poidinger B, Dey K, Weiler N, Meier-Hellmann A, Haberle HH, Wobker G, Kaisers UX, Reinhart K, group Ms (2017) Effect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomized trial. Intensive Care Med 10.1007/s00134-017-4782-4
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Borisow N, Kleiter I, Gahlen A, Fischer K, Wernecke K-D, Pache F, Ruprecht K, Havla J, Krumbholz M, Kuempfel T, Aktas O, Ringelstein M, Geis C, Kleinschnitz C, Berthele A, Hemmer B, Angstwurm K, Weissert R, Stellmann J-P, Schuster S, Stangel M, Lauda F, Tumani H, Mayer C, Zeltner L, Ziemann U, Linker RA, Schwab M, Marziniak M, Bergh FT, Hofstadt-van Oy U, Neuhaus O, Winkelmann A, Marouf W, Rueckriem L, Faiss J, Wildemann B, Paul F, Jarius S, Trebst C, Hellwig K, Study NNO (2017) Influence of female sex and fertile age on neuromyelitis optica spectrum disorders. Multiple Sclerosis J 23: 1092-1103
Borken F, Markwart R, Requardt RP, Schubert K, Spacek M, Verner M, Ruckriem S, Scherag A, Oehmichen F, Brunkhorst FM, Rubio I (2017) Chronic Critical Illness from Sepsis Is Associated with an Enhanced TCR Response. J Immunol 10.4049/jimmunol.1700142
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Chung H-Y, Kollmey AS, Schrepper A, Kohl M, Blaess MF, Stehr SN, Lupp A, Graeler MH, Claus RA (2017) Adjustment of Dysregulated Ceramide Metabolism in a Murine Model of Sepsis-Induced Cardiac Dysfunction. Int J Mol Sci 18
Chung H-Y, Witt CJ, Jbeily N, Hurtado-Oliveros J, Giszas B, Lupp A, Graeler MH, Bruns T, Stallmach A, Gonnert FA, Claus RA (2017) Acid Sphingomyelinase Inhibition Prevents Development of Sepsis Sequelae in the Murine Liver. Sci Rep 7
Davidson JE, Aslakson RA, Long AC, Puntillo KA, Kross EK, Hart J, Cox CE, Wunsch H, Wickline MA, Nunnally ME, Netzer G, Kentish-Barnes N, Sprung CL, Hartog C, Coombs M, Gerritsen RT, Hopkins RO, Franck LS, Skrobik Y, Kon AA, Scruth EA, Harvey MA, Lewis-Newby M, White DB, Swoboda SM, Cooke CR, Levy MM, Azoulay E, Curtis JR (2017) Guidelines for Family-Centered Care in the Neonatal, Pediatric, and Adult ICU. Crit Care Med 45: 103-128
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Fahrner R, Moller A, Press AT, Kortgen A, Kiehntopf M, Rauchfuss F, Settmacher U, Mosig AS (2017) Short-term treatment with taurolidine is associated with liver injury. BMC Pharmacol Toxicol 18: 61
Gawlytta R, Niemeyer H, Boettche M, Scherag A, Knaevelsrud C, Rosendahl J (2017) Internet-based cognitive-behavioural writing therapy for reducing post-traumatic stress after intensive care for sepsis in patients and their spouses (REPAIR): study protocol for a randomised-controlled trial. Bmj Open 7
Gawlytta R, Wintermann G, Jaenichen D, Knaevelsrud C, Niemeyer H, Böttche C, Rosendahl J (2017) Posttraumatische Belastungsstörung nach intensivmedizinischer Behandlung einer Sepsis: Patienten und Partner als Betroffene. Trauma und Gewalt 11: 308-318
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Geisel MH, Bauer M, Hennig F, Hoffmann B, Lehmann N, Mohlenkamp S, Kroger K, Kara K, Muller T, Moebus S, Erbel R, Scherag A, Jockel KH, Mahabadi AA, investigative group of the Heinz Nixdorf Recall s (2017) Comparison of coronary artery calcification, carotid intima-media thickness and ankle-brachial index for predicting 10-year incident cardiovascular events in the general population. Eur Heart J 10.1093/eurheartj/ehx120
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Grunewald B, Lange MD, Werner C, O'Leary A, Weishaupt A, Popp S, Pearce DA, Wiendl H, Reif A, Pape HC, Toyka KV, Sommer C, Geis C (2017) Defective synaptic transmission causes disease signs in a mouse model of juvenile neuronal ceroid lipofuscinosis. Elife 6
Guo S, Bocklitz T, Neugebauer U, Popp J (2017) Common mistakes in cross-validating classification models. Anal Method 9: 4410-4417
Heidenreich S, Witte N, Weber P, Goehring I, Tolkachov A, von Loeffelholz C, Doecke S, Bauer M, Stockmann M, Pfeiffer AFH, Birkenfeld AL, Pietzke M, Kempa S, Muenzner M, Schupp M (2017) Retinol saturase coordinates liver metabolism by regulating ChREBP activity. Nat Commun 8
Hinney A, Kesselmeier M, Jall S, Volckmar AL, Foecker M, Antel J, Heid IM, Winkler TW, Grant SFA, Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H, Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM, Adan R, Brandys M, van Elburg A, Perica VB, Franklin CS, Tschoep MH, Zeggini E, Bulik CM, Collier D, Scherag A, Mueller TD, Hebebrand J, Gcan, Wtccc, Giant, Egg, Price Fdn Collaborative G, Children's Hosp P (2017) Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Mol Psychiatry 22: 192-201
Jacobsen ID, Hube B (2017) Candida albicans morphology: still in focus. Expert Rev Anti Infect Ther 15: 327-330
Kesselmeier M, Lorenzo Bermejo J (2017) Robust logistic regression to narrow down the winner's curse for rare and recessive susceptibility variants. Brief Bioinform 10.1093/bib/bbw074
Kirov H, Schwarzer M, Neugebauer S, Faerber G, Diab M, Doenst T (2017) Metabolomic profiling in patients undergoing Off-Pump or On-Pump coronary artery bypass surgery. Bmc Cardiovascular Disorders 17: 1-8
Kissoon N, Reinhart K, Daniels R, Machado MFR, Schachter RD, Finfer S (2017) Sepsis in Children: Global Implications of the World Health Assembly Resolution on Sepsis. Pediatric Crit Care Med 18: E625-E627
Klaile E, Mueller MM, Schaefer MR, Clauder A-K, Feer S, Heyl KA, Stock M, Klassert TE, Zipfel PF, Singer BB, Slevogt H (2017) Binding of Candida albicans to Human CEACAM1 and CEACAM6 Modulates the Inflammatory Response of Intestinal Epithelial Cells. MBio 8
Klassert TE, Braeuer J, Hoelzer M, Stock M, Riege K, Zubiria-Barrera C, Muller MM, Rummler S, Skerka C, Marz M, Slevogt H (2017) Differential Effects of Vitamins A and D on the Transcriptional Landscape of Human Monocytes during Infection. Sci Rep 7
Koese N, Stengel S, Stallmach A, Bruns T (2017) Regulation of the NLRP3 inflammasome in monocytes and macrophages from patients with decompensated cirrhosis by low-dose genotoxic stress. J Hepatol 66: S585-S585
Lehnert T, Figge MT (2017) Dimensionality of Motion and Binding Valency Govern Receptor-Ligand Kinetics As Revealed by Agent-Based Modeling. Front Immunol 8
Leiske MN, Truetzschler A-K, Armoneit S, Sungur P, Hoeppener S, Lehmann M, Traeger A, Schubert US (2017) Mission ImPOxable - or the unknown utilization of non-toxic poly(2-oxazoline)s as cryoprotectants and surfactants at the same time. Journal of Materials Chemistry B 5: 9102-9113
Leonhardt J, Villela DC, Teichmann A, Munter L-M, Mayer MC, Mardahl M, Kirsch S, Namsolleck P, Lucht K, Benz V, Alenina N, Daniell N, Horiuchi M, Iwai M, Multhaup G, Schuelein R, Bader M, Santos RA, Unger T, Steckelings UM (2017) Evidence for Heterodimerization and Functional Interaction of the Angiotensin Type 2 Receptor and the Receptor MAS. Hypertension 69: 1128-+
Mai M, Stengel S, Al-Herwi E, Peter J, Schmidt C, Rubio I, Stallmach A, Bruns T (2017) Genetic variants of TRAF6 modulate peritoneal immunity and the risk of spontaneous bacterial peritonitis in cirrhosis: A combined prospective-retrospective study. Sci Rep 7
Mailaender-Sanchez D, Braunsdorf C, Grumaz C, Mueller C, Lorenz S, Stevens P, Wagener J, Hebecker B, Hube B, Bracher F, Sohn K, Schaller M (2017) Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. PLoS One 12
Malavia D, Lehtovirta-Morley LE, Alamir O, Weiss E, Gow NAR, Hube B, Wilson D (2017) Zinc Limitation Induces a Hyper-Adherent Goliath Phenotype in Candida albicans. Front Microbiol 8
Martin R, Pohlers S, Muhlschlegel FA, Kurzai O (2017) CO2 sensing in fungi: at the heart of metabolic signaling. Curr Genetics 63: 965-972
Matt B, Schwarzkopf D, Reinhart K, Konig C, Hartog CS (2017) Relatives' perception of stressors and psychological outcomes - Results from a survey study. J Crit Care 39: 172-177
Mede R, Hoffmann P, Klein M, Goerls H, Schmitt M, Neugebauer U, Gessner G, Heinemann SH, Popp J, Westerhausen M (2017) A Water-Soluble Mn(CO)(3)-Based and Non-Toxic PhotoCORM for Administration of Carbon Monoxide Inside of Cells. Z Anorg Allg Chem 643: 2057-2062
Mede R, Traber J, Klein M, Goerls H, Gessner G, Hoffmann P, Schmitt M, Popp J, Heinemann SH, Neugebauer U, Westerhausen M (2017) Synthesis and solution stability of water-soluble kappa N-2,kappa O-bis(3,5-dimethylpyrazolyl)ethanol manganese(I) tricarbonyl bromide (CORM-ONN1). Dalton Transactions 46: 1684-1693
Mehta S, Burns KEA, Machado FR, Fox-Robichaud AE, Cook DJ, Calfee CS, Ware LB, Burnham EL, Kissoon i, Marshall JC, Mancebo J, Finfer S, Hartog C, Reinhart K, Maitland K, Stapleton RD, Kwizera A, Amin P, Abroug F, Smith O, Laake JH, Shrestha GS, Herridge MS (2017) Gender Parity in Critical Care Medicine. Am J Respir Crit Care Med 196: 425-429
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Mitroi DN, Karunakaran I, Graeler M, Saba JD, Ehninger D, Dolores Ledesma M, van Echten-Deckert G (2017) SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. Autophagy 13: 885-899
Morel J, Hargreaves I, Brealey D, Neergheen V, Backman JT, Lindig S, Blass M, Bauer M, McAuley DF, Singer M (2017) Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis. Clin Sci (Lond) 131: 747-758
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Rademann P, Weidinger A, Drechsler S, Meszaros A, Zipperle J, Jafarmadar M, Dumitrescu S, Hacobian A, Ungelenk L, Roestel F, Kaszaki J, Szabo A, Skulachev VP, Bauer M, Bahrami S, Weis S, Kozlov AV, Osuchowski MF (2017) Mitochondria-Targeted Antioxidants SkQ1 and MitoTEMPO Failed to Exert a Long-Term Beneficial Effect in Murine Polymicrobial Sepsis. Oxidat Med Cell Longevity6412682 10.1155/2017/6412682
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Thomas-Rueddel DO, Bauer M (2017) Limited evidence to recommend lactate kinetics-guided therapy. Crit Care 21
Trauer J, Muhi S, McBryde ES, Al Harbi SA, Arabi YM, Boyle AJ, Cartin-Ceba R, Chen W, Chen Y-T, Falcone M, Gajic O, Godsell J, Gong MN, Kor D, Loesche W, McAuley DF, O'Neal HR, Jr., Osthoff M, Otto GP, Sossdorf M, Tsai M-J, Valerio-Rojas JC, van der Poll T, Violi F, Ware L, Widmer AF, Wiewel MA, Winning J, Eisen DP (2017) Quantifying the Effects of Prior Acetyl-Salicylic Acid on Sepsis-Related Deaths: An Individual Patient Data Meta-Analysis Using Propensity Matching. Crit Care Med 45: 1871-1879
Turnbull AE, Hartog CS (2017) Goal-concordant care in the ICU: a conceptual framework for future research. Intensive Care Med 43: 1847-1849
Van de Vyver H, Bovenkamp PR, Hoerr V, Schwegmann K, Tuchscherr L, Niemann S, Kursawe L, Grosse C, Moter A, Hansen U, Neugebauer U, Kuhlmann MT, Peters G, Hermann S, Loeffler B (2017) A Novel Mouse Model of Staphylococcus aureus Vascular Graft Infection Noninvasive Imaging of Biofilm Development in Vivo. Am J Pathol 187: 268-279
Verma AH, Richardson JP, Zhou C, Coleman BM, Moyes DL, Ho J, Huppler AR, Ramani K, McGeachy MJ, Mufazalov IA, Waisman A, Kane LP, Biswas PS, Hube B, Naglik JR, Gaffen SL (2017) Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin. Sci Immunol 2
von Loeffelholz C, Docke S, Lock JF, Lieske S, Horn P, Kriebel J, Wahl S, Singmann P, de Las Heras Gala T, Grallert H, Raschzok N, Sauer IM, Heller R, Jahreis G, Claus RA, Bauer M, Stockmann M, Birkenfeld AL, Pfeiffer AF (2017) Increased lipogenesis in spite of upregulated hepatic 5'AMP-activated protein kinase in human non-alcoholic fatty liver. Hepatol Res 10.1111/hepr.12825
von Loeffelholz C, Lieske S, Neuschafer-Rube F, Willmes DM, Raschzok N, Sauer IM, Konig J, Fromm M, Horn P, Chatzigeorgiou A, Pathe-Neuschafer-Rube A, Jordan J, Pfeiffer AFH, Mingrone G, Bornstein SR, Stroehle P, Harms C, Wunderlich FT, Helfand SL, Bernier M, de Cabo R, Shulman GI, Chavakis T, Puschel GP, Birkenfeld AL (2017) The Human Longevity Gene Homolog INDY and Interleukin-6 Interact in Hepatic Lipid Metabolism. Hepatology 10.1002/hep.29089
von Loeffelholz C, Pfeiffer AFH, Lock JF, Lieske S, Doecke S, Murahovschi V, Kriebel J, Gala TdlH, Grallert H, Rudovich N, Stockmann M, Spranger J, Jahreis G, Bornstein SR, Lau G, Xu A, Schulz-Menger J, Exner L, Haufe S, Jordan J, Engeli S, Birkenfeld AL (2017) ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives. Hormone Metab Res 49: 343-349
von Wnuck Lipinski K, Weske S, Keul P, Peters S, Baba HA, Heusch G, Graler MH, Levkau B (2017) Hepatocyte nuclear factor 1A deficiency causes hemolytic anemia in mice by altering erythrocyte sphingolipid homeostasis. Blood 130: 2786-2798
Weis S, Carlos AR, Moita MR, Singh S, Blankenhaus B, Cardoso S, Larsen R, Rebelo S, Schaeuble S, Del Barrio L, Mithieux G, Rajas F, Lindig S, Bauer M, Soares MP (2017) Metabolic Adaptation Establishes Disease Tolerance to Sepsis. Cell 169: 1263-+
Weis S, Hagel S, Schmitz RP, Scherag A, Brunkhorst FM, Forstner C, Loffler B, Pletz MW (2017) Study on the utility of a statewide counselling programme for improving mortality outcomes of patients with Staphylococcus aureus bacteraemia in Thuringia (SUPPORT): a study protocol of a cluster-randomised crossover trial. Bmj Open 7: e013976
Weis S, Kimmig A, Hagel S, Pletz MW (2017) Antibiotic stewardship and Staphylococcus aureus Bacteremia. Med Klin Intensivmed Notfmed 112: 192-198
Weis S, Rubio I, Ludwig K, Weigel C, Jentho E (2017) Hormesis and Defense of Infectious Disease. Int J Mol Sci 18
Winkler MS, Nierhaus A, Poppe A, Greiwe G, Graeler MH, Daum G (2017) Sphingosine-1-Phosphate: A Potential Biomarker and Therapeutic Target for Endothelial Dysfunction and Sepsis? Shock 47: 666-672
Wintermann G-B, Rosendahl J, Weidner K, Strauss B, Petrowski K (2017) Risk Factors of Delayed Onset Posttraumatic Stress Disorder in Chronically Critically Ill Patients. J Nerv Mental Dis 205: 780-787
Wollina U, Wetzker R, Abdel-Naser MB, Kruglikov IL (2017) Role of adipose tissue in facial aging. Clin Interv Aging 12: 2069-2076
Zimmermann S, Tuchscherr L, Roedel J, Loeffler B, Bohnert JA (2017) Optimized efflux assay for the NorA multidrug efflux pump in Staphylococcus aureus. J Microbiol Method 142: 39-40
Publikationen 2016
Ali S, Akhter S, Neubauer H, Scherag A, Kesselmeier M, Melzer F, Khan I, El-Adawy H, Azam A, Qadeer S, Ali Q (2016) Brucellosis in pregnant women from Pakistan: an observational study. BMC infectious diseases 16: 468
Allert S, Brunke S, Hube B (2016) In Vivo Transcriptional Profiling of Human Pathogenic Fungi during Infection: Reflecting the Real Life? PLoS Pathog 12
Arefian H, Hagel S, Heublein S, Rissner F, Scherag A, Brunkhorst FM, Baldessarini RJ, Hartmann M (2016a) Extra length of stay and costs because of health care-associated infections at a German university hospital. American journal of infection control 44: 160-166
Arefian H, Vogel M, Kwetkat A, Hartmann M (2016b) Economic Evaluation of Interventions for Prevention of Hospital Acquired Infections: A Systematic Review. PloS one 11: e0146381
Axer H, Grimm A, Pausch C, Teschner U, Zinke J, Eisenach S, Beck S, Guntinas-Lichius O, Brunkhorst FM, Witte OW (2016) The impairment of small nerve fibers in severe sepsis and septic shock. Crit Care 20
Bauer M, Giamarellos-Bourboulis EJ, Kortgen A, Moeller E, Felsmann K, Cavaillon JM, Guntinas-Lichius O, Rutschmann O, Ruryk A, Kohl M, Wlotzka B, Russwurm S, Marshall JC, Reinhart K (2016) A Transcriptomic Biomarker to Quantify Systemic Inflammation in Sepsis - A Prospective Multicenter Phase II Diagnostic Study. E Biomedicine 6: 114-125
Baumbach P, Goetz T, Guenther A, Weiss T, Meissner W (2016a) Prevalence and Characteristics of Chronic Intensive Care-Related Pain: The Role of Severe Sepsis and Septic Shock. Crit Care Med 44: 1129-1137
Baumbach P, Meissner W, Guenther A, Witte OW, Goetz T (2016b) Perceived cognitive impairments after critical illness: a longitudinal study in survivors and family member controls. Acta Anaesth Scand 60: 1121-1130
Baumbach P, Weiss T, Giermann C, Cubillos S, Meissner W, Norgauer J (2016c) Standardized quantitative sensory testing in patients with psoriasis vulgaris: evidence for altered large and small fibre functioning. Journal of the European Academy of Dermatology and Venereology : JEADV 30: E137-E140
Bergmann L, Martini S, Kesselmeier M, Armbruster W, Notheisen T, Adamzik M, Eichholz R (2016) Phrenic nerve block caused by interscalene brachial plexus block: breathing effects of different sites of injection. BMC anesthesiology 16: 45
Blaurock N, Schmerler D, Huenniger K, Kurzai O, Ludewig K, Baier M, Brunkhorst FM, Imhof D, Kiehntopf M (2016) C-Terminal Alpha-1 Antitrypsin Peptide: A New Sepsis Biomarker with Immunomodulatory Function. Mediators of Inflammation
Bloos F, Trips E, Nierhaus A, Briegel J, Heyland DK, Jaschinski U, Moerer O, Weyland A, Marx G, Grundling M, Kluge S, Kaufmann I, Ott K, Quintel M, Jelschen F, Meybohm P, Rademacher S, Meier-Hellmann A, Utzolino S, Kaisers UX, Putensen C, Elke G, Ragaller M, Gerlach H, Ludewig K, Kiehntopf M, Bogatsch H, Engel C, Brunkhorst FM, Loeffler M, Reinhart K, for SepNet Critical Care Trials G (2016a) Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock: A Randomized Clinical Trial. JAMA internal medicine
Bloos F, Zhang Z, Boulain T (2016b) Lactate-guided resuscitation saves lives: yes. Intens Care Med 42: 466-469
Bottcher B, Pollath C, Staib P, Hube B, Brunke S (2016) Candida species Rewired Hyphae Developmental Programs for Chlamydospore Formation. Front Microbiol 7
Brewitz HH, Goradia N, Schubert E, Galler K, Kuehl T, Syllwasschy B, Popp J, Neugebauer U, Hagelueken G, Schiemann O, Ohlenschlaeger O, Imhof D (2016) Heme interacts with histidine- and tyrosine-based protein motifs and inhibits enzymatic activity of chloramphenicol acetyltransferase from Escherichia coli. Biochim Biophys Acta-General Subjects 1860: 1343-1353
Brunkhorst FM, Olgemoeller U (2016) Projects and Activities of the Department of Infectiology/Immunology. Medizinische Klinik, Intensivmedizin und Notfallmedizin 111: 360-361
Bruns T, Reuken PA, Stengel S, Gerber L, Appenrodt B, Schade JH, Lammert F, Zeuzem S, Stallmach A (2016a) NOD2 Risk Variants and Pathological Bacterial Translocation in Decompensated Cirrhosis. Digestive diseases and sciences 61: 2142-2144
Bruns T, Reuken PA, Stengel S, Gerber L, Appenrodt B, Schade JH, Lammert F, Zeuzem S, Stallmach A (2016b) The prognostic significance of bacterial DNA in patients with decompensated cirrhosis and suspected infection. Liver Int 36: 1133-1142
Chung H-Y, Hupe DC, Otto GP, Sprenger M, Bunck AC, Dorer MJ, Bockmeyer CL, Deigner H-P, Graeler MH, Claus RA (2016) Acid Sphingomyelinase Promotes Endothelial Stress Response in Systemic Inflammation and Sepsis. Molecular medicine 22: 412-423
Coldewey SM, Benetti E, Collino M, Pfeilschifter J, Sponholz C, Bauer M, Huwiler A, Thiemermann C (2016) Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis. Scientific reports 6
Cortes-Poch I, Hartog CS (2016) Change Is Not Necessarily Progress: Revision of the Sepsis Definition Should Be Based on New Scientific Insights. American journal of respiratory and critical care medicine 194: 16-18
Doppler K, Schleyer B, Geis C, Gruenewald B, Putz E, Villmann C, Sommer C (2016) LOCKJAW IN STIFF-PERSON SYNDROME WITH AUTOANTIBODIES AGAINST GLYCINE RECEPTORS. Neurology - Neuroimmunol Neuroinflamm 3
Dreiling M, Bischoff S, Schiffner R, Rupprecht S, Kiehntopf M, Schubert H, Witte OW, Nathanielsz PW, Schwab M, Rakers F (2016) Stress-induced decrease of uterine blood flow in sheep is mediated by alpha 1-adrenergic receptors. Stress 19: 547-551
Englert C, Truetzschler A-K, Raasch M, Bus T, Borchers P, Mosig AS, Traeger A, Schubert US (2016) Crossing the blood-brain barrier: Glutathione-conjugated poly(ethylene imine) for gene delivery. Journal of controlled release : official journal of the Controlled Release Society 241: 1-14
Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, Angus DC, Reinhart K, International Forum of Acute Care T (2016a) Assessment of Global Incidence and Mortality of Hospital-treated Sepsis - Current Estimates and Limitations. American journal of respiratory and critical care medicine
Fleischmann C, Thomas-Rueddel DO, Hartmann M, Hartog CS, Welte T, Heublein S, Dennler U, Reinhart K (2016b) Hospital Incidence and Mortality Rates of Sepsis An Analysis of Hospital Episode (DRG) Statistics in Germany From 2007 to 2013. Deutsches Arzteblatt international 113: 159-+
Galler K, Froehlich E, Kortgen A, Bauer M, Popp J, Neugebauer U (2016a) Hepatic cirrhosis and recovery as reflected by Raman spectroscopy: information revealed by statistical analysis might lead to a prognostic biomarker. Analytical and bioanalytical chemistry 408: 8053-8063
Galler K, Requardt RP, Glaser U, Markwart R, Bocklitz T, Bauer M, Popp J, Neugebauer U (2016b) Single cell analysis in native tissue: Quantification of the retinoid content of hepatic stellate cells. Scientific reports 6
Geisel MH, Coassin S, Hessler N, Bauer M, Eisele L, Erbel R, Haun M, Hennig F, Moskau-Hartmann S, Hoffmann B, Joeckel K-H, Kedenko L, Kiechl S, Kollerits B, Mahabadi A-A, Moebus S, Nuernberg G, Nuernberg P, Paulweber B, Vens M, Willeit J, Willeit K, Klockgether T, Ziegler A, Scherag A, Kronenberg F (2016) Update of the effect estimates for common variants associated with carotid intima media thickness within four independent samples: The Bonn IMT Family Study, the Heinz Nixdorf Recall Study, the SAPHIR Study and the Bruneck Study. Atherosclerosis 249: 83-87
Gerwien F, Safyan A, Wisgott S, Hille F, Kaemmer P, Linde J, Brunke S, Kasper L, Hube B (2016) A Novel Hybrid Iron Regulation Network Combines Features from Pathogenic and Nonpathogenic Yeasts. mBio 7
Giamarellos-Bourboulis EJ, Platzer M, Karagiannidis I, Kanni T, Nikolakis G, Ulrich J, Bellutti M, Gollnick H, Bauer M, Zouboulis CC, Huse K (2016) High Copy Numbers of beta-Defensin Cluster on 8p23.1, Confer Genetic Susceptibility, and Modulate the Physical Course of Hidradenitis Suppurativa/Acne Inversa. The Journal of investigative dermatology
Gietzelt M, Hofer T, Knaup-Gregori P, Konig R, Lopprich M, Poos A, Ganzinger M (2016) The Use of Tools, Modelling Methods, Data Types, and Endpoints in Systems Medicine: A Survey on Projects of the German e:Med-Programme. Studies Health Technol Informatics 228: 670-674
Goetz T, Baumbach P, Huonker R, Kranczioch C, Witte OW, Debener S, Klingner C, Brunkhorst FM, Guenther A (2016a) Slowed peak resting frequency and MEG overactivation in survivors of severe sepsis and septic shock. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 127: 1247-1253
Goetz T, Baumbach P, Reuken P, Huonker R, Kranczioch C, Debener S, Brunkhorst FM, Witte OW, Klingner C, Guenther A (2016b) The loss of neural synchrony in the post septic brain. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 127: 2200-2207
Groger M, Rennert K, Giszas B, Weiss E, Dinger J, Funke H, Kiehntopf M, Peters FT, Lupp A, Bauer M, Claus RA, Huber O, Mosig AS (2016) Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model. Scientific reports 6: 21868
Grunewald B, Bennett JL, Toyka KV, Sommer C, Geis C (2016) Efficacy of Polyvalent Human Immunoglobulins in an Animal Model of Neuromyelitis Optica Evoked by Intrathecal Anti-Aquaporin 4 Antibodies. International journal of molecular sciences 17
Hagel S, Ludewig K, Moeser A, Baier M, Loffler B, Schleenvoigt B, Forstner C, Pletz MW (2016) Characteristics and management of patients with influenza in a German hospital during the 2014/2015 influenza season. Infection 44: 667-672
Hahn-Ast C, Felder L, Mayer K, Mueckter S, Ruhnke M, Hein R, Hellmich M, Schwab K, Rachow T, Brossart P, von Lilienfeld-Toal M (2016) Outcome of empirical or targeted antifungal therapy after antifungal prophylaxis in febrile neutropenia. Annals of hematology 95: 1001-1009
Hamzei F, Vry M-S, Saur D, Glauche V, Hoeren M, Mader I, Weiller C, Rijntjes M (2016) The Dual-Loop Model and the Human Mirror Neuron System: an Exploratory Combined fMRI and DTI Study of the Inferior Frontal Gyrus. Cerebral Cortex 26: 2215-2224
Hanke D, Huonker R, Weiss T, Witte OW, Gotz T (2016) Modality-independent reduction mechanisms of primary sensory evoked fields in a one-back task. NeuroImage 124: 918-922
Hebecker B, Vlaic S, Conrad T, Bauer M, Brunke S, Kapitan M, Linde J, Hube B, Jacobsen ID (2016) Dual-species transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions. Scientific reports 6
Heinrich A, Heyl KA, Klaile E, Muller MM, Klassert TE, Wiessner A, Fischer K, Schumann RR, Seifert U, Riesbeck K, Moter A, Singer BB, Bachmann S, Slevogt H (2016) Moraxella catarrhalis induces CEACAM3-Syk-Card9-dependent activation of human granulocytes. Cellular microbiology
Hemdan NYA, Weigel C, Reimann C-M, Graler MH (2016) Modulating sphingosine 1-phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis. European journal of immunology 46: 2767-2777
Hennig A, Markwart R, Wolff K, Schubert K, Cui Y, Prior IA, Esparza-Franco MA, Ladds G, Rubio I (2016) Feedback activation of neurofibromin terminates growth factor-induced Ras activation. Cell communication and signaling : CCS 14
Herrtwich L, Nanda I, Evangelou K, Nikolova T, Horn V, Sagar, Erny D, Stefanowski J, Rogell L, Klein C, Gharun K, Follo M, Seidl M, Kremer B, Muenke N, Senges J, Fliegauf M, Aschman T, Pfeifer D, Sarrazin S, Sieweke MH, Wagner D, Dierks C, Haaf T, Ness T, Zaiss MM, Voll RE, Deshmukh SD, Prinz M, Goldmann T, Hoelscher C, Hauser AE, Lopez-Contreras AJ, Gruen D, Gorgoulis V, Diefenbach A, Henneke P, Triantafyllopoulou A (2016) DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas. Cell 167: 1264-+
Hessler N, Geisel MH, Coassin S, Erbel R, Heilmann S, Hennig F, Hoffmann B, Joeckel K-H, Moebus S, Moskau-Hartmann S, Nuernberg G, Nuernberg P, Vens M, Klockgether T, Kronenberg F, Scherag A, Ziegler A (2016) Linkage and Association Analysis Identifies TRAF1 Influencing Common Carotid Intima-Media Thickness. Stroke; a journal of cerebral circulation 47: 2904-2909
Hilgenstock R, Weiss T, Huonker R, Witte OW (2016) Behavioural and neurofunctional impact of transcranial direct current stimulation on somatosensory learning. Human Brain Mapping 37: 1277-1295
Hoefs S, Mogavero S, Hube B (2016) Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota. J Microbiol 54: 149-169
Hoerr V, Duggan GE, Zbytnuik L, Poon KK, Grosse C, Neugebauer U, Methling K, Loffler B, Vogel HJ (2016) Characterization and prediction of the mechanism of action of antibiotics through NMR metabolomics. BMC Microbiol 16: 82
Horn P, Metzing UB, Steidl R, Romeike B, Rauchfuss F, Sponholz C, Thomas-Ruddel D, Ludewig K, Birkenfeld AL, Settmacher U, Bauer M, Claus RA, von Loeffelholz C (2016) Chemerin in peritoneal sepsis and its associations with glucose metabolism and prognosis: a translational cross-sectional study. Crit Care 20: 39
Jakab A, Mogavero S, Foerster TM, Pekmezovic M, Jablonowski N, Dombradi V, Pocsi I, Hube B (2016) Effects of the glucocorticoid betamethasone on the interaction of Candida albicans with human epithelial cells. Microbiol Sgm 162: 2116-2125
Keh D, Trips E, Marx G, Wirtz SP, Abduljawwad E, Bercker S, Bogatsch H, Briegel J, Engel C, Gerlach H, Goldmann A, Kuhn S-O, Huter L, Meier-Hellmann A, Nierhaus A, Kluge S, Lehmke J, Loeffler M, Oppert M, Resener K, Schadler D, Schuerholz T, Simon P, Weiler N, Weyland A, Reinhart K, Brunkhorst FM, SepNet-Critical Care Trials G (2016) Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis The HYPRESS Randomized Clinical Trial. JAMA internal medicine 316: 1775-1785
Kesselmeier M, Lorenzo Bermejo J (2016) Robust logistic regression to narrow down the winner's curse for rare and recessive susceptibility variants. Briefings in bioinformatics
Kesselmeier M, Putter C, Volckmar AL, Baurecht H, Grallert H, Illig T, Ismail K, Ollikainen M, Silen Y, Keski-Rahkonen A, Bulik CM, Collier DA, Zeggini E, Hebebrand J, Scherag A, Hinney A, Gcan, Wtccc (2016) High-throughput DNA methylation analysis in anorexia nervosa confirms TNXB hypermethylation. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry: 1-13
Klein M, Neugebauer U, Schmitt M, Popp J (2016) Elucidation of the CO-Release Kinetics of CORM-A1 by Means of Vibrational Spectroscopy. Chem Phys Chem 17: 985-993
Kleiter I, Gahlen A, Borisow N, Fischer K, Wernecke KD, Wegner B, Hellwig K, Pache F, Ruprecht K, Havla J, Krumbholz M, Kumpfel T, Aktas O, Hartung HP, Ringelstein M, Geis C, Kleinschnitz C, Berthele A, Hemmer B, Angstwurm K, Stellmann JP, Schuster S, Stangel M, Lauda F, Tumani H, Mayer C, Zeltner L, Ziemann U, Linker R, Schwab M, Marziniak M, Then Bergh F, Hofstadt-van Oy U, Neuhaus O, Winkelmann A, Marouf W, Faiss J, Wildemann B, Paul F, Jarius S, Trebst C, Neuromyelitis Optica Study G (2016) Neuromyelitis optica: Evaluation of 871 attacks and 1,153 treatment courses. Ann Neurol 79: 206-216
Klinger-Strobel M, Ernst J, Lautenschlager C, Pletz MW, Fischer D, Makarewicz O (2016a) A blue fluorescent labeling technique utilizing micro- and nanoparticles for tracking in LIVE/DEAD((R)) stained pathogenic biofilms of Staphylococcus aureus and Burkholderia cepacia. International journal of nanomedicine 11: 575-583
Klinger-Strobel M, Glaeser S, Makarewicz O, Wyrwa R, Weisser J, Pletz MW, Schiller A (2016b) Bactericidal Effect of a Photoresponsive Carbon Monoxide-Releasing Nonwoven against Staphylococcus aureus Biofilms. Antimicrobial agents and chemotherapy 60: 4037-4046
Klinger-Strobel M, Makarewicz O, Pletz MW, Stallmach A, Lautenschlaeger C (2016c) TiO2-containing and ZnO-containing borosilicate glass-a novel thin glass with exceptional antibiofilm performances to prevent microfouling. J Mater Sci-Mater M 27
Kolditz M, Scherag A, Rohde G, Ewig S, Welte T, Pletz M, Group CS (2016) Comparison of the qSOFA and CRB-65 for risk prediction in patients with community-acquired pneumonia. Intens Care Med
Kolter J, Feuerstein R, Spoeri E, Gharun K, Elling R, Trieu-Cuot P, Goldmann T, Waskow C, Chen ZJ, Kirschning CJ, Deshmukh SD, Henneke P (2016) Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion. J Immunol 196: 2733-2741
Kordass T, Weber CE, Oswald M, Ast V, Bernhardt M, Novak D, Utikal J, Eichmuller SB, Konig R (2016) SOX5 is involved in balanced MITF regulation in human melanoma cells. BMC medical genomics 9: 10
Ksionda O, Melton AA, Bache J, Tenhagen M, Bakker J, Harvey R, Winter SS, Rubio I, Roose JP (2016) RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines. Oncogene
Kusic D, Ramoji A, Neugebauer U, Rosch P, Popp J (2016) Raman Spectroscopic Characterization of Packaged L. pneumophila Strains Expelled by T. thermophila. Analytical chemistry 88: 2533-2537
Lange K, Buerger M, Stallmach A, Bruns T (2016) Effects of Antibiotics on Gut Microbiota. Digestive Diseases 34: 260-268
Luo T, Krueger T, Knuepfer U, Kasper L, Wielsch N, Hube B, Kortgen A, Bauer M, Giamarellos-Bourboulis EJ, Dimopoulos G, Brakhage AA, Kniemeyer O (2016) Immunoproteomic Analysis of Antibody Responses to Extracellular Proteins of Candida albicans Revealing the Importance of Glycosylation for Antigen Recognition. Journal of proteome research 15: 2394-2406
Manchanda H, Seidel N, Blaess MF, Claus RA, Linde J, Slevogt H, Sauerbrei A, Guthke R, Schmidtke M (2016) Differential Biphasic Transcriptional Host Response Associated with Coevolution of Hemagglutinin Quasispecies of Influenza A Virus. Front Microbiol 7
Matthaeus-Kraemer CT, Thomas-Rueddel DO, Schwarzkopf D, Rueddel H, Poidinger B, Reinhart K, Bloos F (2016) Crossing the handover chasm: Clinicians' perceptions of barriers to the early detection and timely management of severe sepsis and septic shock. J Crit Care 36: 85-91
Mitroi DN, Deutschmann AU, Raucamp M, Karunakaran I, Glebov K, Hans M, Walter J, Saba J, Graeler M, Ehninger D, Sopova E, Shupliakov O, Swandulla D, van Echten-Deckert G (2016) Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin-proteasome mediated mechanism. Scientific reports 6
Moeller C, Fleischmann C, Thomas-Rueddel D, Vlasakov V, Rochwerg B, Theurer P, Gattinoni L, Reinhart K, Hartog CS (2016) How safe is gelatin? A systematic review and meta-analysis of gelatin-containing plasma expanders vs crystalloids and albumin. J Crit Care 35: 75-83
Mothes H, Koeppen J, Bayer O, Richter M, Kabisch B, Schwarzkopf D, Hein HA, Zanow J, Doenst T, Settmacher U (2016) Acute mesenteric ischemia following cardiovascular surgery - A nested case-control study. International journal of surgery 26: 79-85
Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Hofs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Forster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Hader A, Kurzai O, Luo T, Kruger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR (2016) Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature 532: 64-68
Naranjo-Ortiz MA, Brock M, Brunke S, Hube B, Marcet-Houben M, Gabaldon T (2016) Widespread Inter- and Intra-Domain Horizontal Gene Transfer of D-Amino Acid Metabolism Enzymes in Eukaryotes. Front Microbiol 7
Neugebauer S, Giamarellos-Bourboulis EJ, Pelekanou A, Marioli A, Baziaka F, Tsangaris I, Bauer M, Kiehntopf M (2016) Metabolite Profiles in Sepsis: Developing Prognostic Tools Based on the Type of Infection. Crit Care Med 44: 1649-1662
Noack K, Mahendrarajah N, Hennig D, Schmidt L, Grebien F, Hildebrand D, Christmann M, Kaina B, Sellmer A, Mahboobi S, Kubatzky K, Heinzel T, Kramer OH (2016) Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells. Arch Toxicol
Otto GP, Rathkolb B, Oestereicher MA, Lengger CJ, Moerth C, Micklich K, Fuchs H, Gailus-Durner V, Wolf E, Hrabe de Angelis M (2016) Clinical Chemistry Reference Intervals for C57BL/6J, C57BL/6N, and C3HeB/FeJ Mice (Mus musculus). Journal of the American Association for Laboratory Animal Science : JAALAS 55: 375-386
Planaguma J, Haselmann H, Mannara F, Petit-Pedrol M, Grunewald B, Aguilar E, Ropke L, Martin-Garcia E, Titulaer MJ, Jercog P, Graus F, Maldonado R, Geis C, Dalmau J (2016) Ephrin-B2 prevents N-methyl-D-aspartate receptor antibody effects on memory and neuroplasticity. Ann Neurol 80: 388-400
Poos AM, Maicher A, Dieckmann AK, Oswald M, Eils R, Kupiec M, Luke B, Konig R (2016) Mixed Integer Linear Programming based machine learning approach identifies regulators of telomerase in yeast. Nucl Acid Res 44: e93-e93
Press AT, Ungelenk L, Rinkenauer AC, Groeger M, Lehmann F, Mosig A, Schubert US, Clemens MG, Bauer M (2016) A new fluorescent dye for cell tracing and mitochondrial imaging in vitro and in vivo. J Biophotonics 9: 888-900
Raasch M, Rennert K, Jahn T, Gaertner C, Schoenfelder G, Huber O, Seiler AEM, Mosig AS (2016) An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex development. Biomicrofluidics 10
Rachow T, Dornaus S, Sayer HG, Hermann B, Hochhaus A, von Lilienfeld-Toal M (2016) Case report: false positive elevated serum-galactomannan levels after autologous hematopoietic stem cell transplantation caused by oral nutritional supplements. Clin Case Rep 4: 505-508
Ramoji A, Galler K, Glaser U, Henkel T, Mayer G, Dellith J, Bauer M, Popp J, Neugebauer U (2016) Characterization of different substrates for Raman spectroscopic imaging of eukaryotic cells. J Raman Spectrosc 47: 773-786
Rennert K, Heisig K, Groeger M, Wallert M, Funke H, Lorkowski S, Huber O, Mosig AS (2016a) Recruitment of CD16(+) monocytes to endothelial cells in response to LPS-treatment and concomitant TNF release is regulated by CX3CR1 and interfered by soluble fractalkine. Cytokine 83: 41-52
Rennert K, Otto P, Funke H, Huber O, Tomaso H, Mosig AS (2016b) A human macrophage - hepatocyte co-culture model for comparative studies of infection and replication of Francisella tularensis LVS strain and subspecies holarctica and mediasiatica. BMC Microbiol 16
Richter ME, Neugebauer S, Engelmann F, Hagel S, Ludewig K, La Rosee P, Sayer HG, Hochhaus A, von Lilienfeld-Toal M, Bretschneider T, Pausch C, Engel C, Brunkhorst FM, Kiehntopf M (2016) Biomarker candidates for the detection of an infectious etiology of febrile neutropenia. Infection
Ritter M, Seidel RA, Bellstedt P, Schneider B, Bauer M, Goerls H, Pohnert G (2016) Isolation and Identification of Intermediates of the Oxidative Bilirubin Degradation. Organic letters 18: 4432-4435
Rittirsch D, Schoenborn V, Lindig S, Wanner E, Sprengel K, Gunkel S, Blaess M, Schaarschmidt B, Sailer P, Marsmann S, Simmen H-P, Cinelli P, Bauer M, Claus RA, Wanner GA (2016) An Integrated Clinico-transcriptomic Approach Identifies a Central Role of the Heme Degradation Pathway for Septic Complications After Trauma. Ann Surg 264: 1125-1134
Rueddel J, Schleenvoigt BT, Schueler E, Schmidt C, Pletz MW, Stallmach A (2016) Yellow fever vaccination during treatment with infliximab in a patient with ulcerative colitis: A case report. Zeitschrift fur Gastroenterologie 54: 1081-1084
Ruffo E, Malacarne V, Larsen SE, Das R, Patrussi L, Wulfing C, Biskup C, Kapnick SM, Verbist K, Tedrick P, Schwartzberg PL, Baldari CT, Rubio I, Nichols KE, Snow AL, Baldanzi G, Graziani A (2016) Inhibition of diacylglycerol kinase alpha restores restimulation-induced cell death and reduces immunopathology in XLP-1. Science translational medicine 8: 321ra327
Rump K, Unterberg M, Bergmann L, Bankfalvi A, Menon A, Schaefer S, Scherag A, Bazzi Z, Siffert W, Peters J, Adamzik M (2016) AQP5-1364A/C polymorphism and the AQP5 expression influence sepsis survival and immune cell migration: a prospective laboratory and patient study. J Transl Med 14
Ryabchykov O, Bocklitz T, Ramoji A, Neugebauer U, Foerster M, Kroegel C, Bauer M, Kiehntopf M, Popp J (2016) Automatization of spike correction in Raman spectra of biological samples. Chemometrics and Intelligent Laboratory Systems 155: 1-6
Salah FS, Ebbinghaus M, Muley VY, Zhou Z, Al-Saadi KRD, Pacyna-Gengelbach M, O'Sullivan GA, Betz H, Koenig R, Wang ZQ, Braeuer R, Petersen I (2016) Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death. Cell Death Disease 7
Schafer ST, Franken L, Adamzik M, Schumak B, Scherag A, Engler A, Schonborn N, Walden J, Koch S, Baba HA, Steinmann J, Westendorf AM, Fandrey J, Bieber T, Kurts C, Frede S, Peters J, Limmer A (2016) Mitochondrial DNA: An Endogenous Trigger for Immune Paralysis. Anesthesiology
Scherag A, Schoneweck F, Kesselmeier M, Taudien S, Platzer M, Felder M, Sponholz C, Rautanen A, Hill AV, Hinds CJ, Hossain H, Suttorp N, Kurzai O, Slevogt H, Giamarellos-Bourboulis EJ, Armaganidis A, Trips E, Scholz M, Brunkhorst FM (2016) Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality. E BioMedicine
Schindler K, Bondeva T, Schindler C, Claus RA, Franke S, Wolf G (2016) Preconditioned suppression of prolyl-hydroxylases attenuates renal injury but increases mortality in septic murine models. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Schmidt K, Worrack S, Von Korff M, Davydow D, Brunkhorst F, Ehlert U, Pausch C, Mehlhorn J, Schneider N, Scherag A, Freytag A, Reinhart K, Wensing M, Gensichen J, Group SS (2016) Effect of a Primary Care Management Intervention on Mental Health-Related Quality of Life Among Survivors of Sepsis: A Randomized Clinical Trial. JAMA : the journal of the American Medical Association 315: 2703-2711
Schulz A, Buettner R, Toledo A, Baader SL, von Maltzahn J, Irintchev A, Bauer R, Morrison H (2016) Neuron-Specific Deletion of the Nf2 Tumor Suppressor Impairs Functional Nerve Regeneration. PloS one 11
Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A, Rubenfeld G, Kahn JM, Shankar-Hari M, Singer M, Deutschman CS, Escobar GJ, Angus DC (2016) Assessment of clinical criteria for sepsis: For the third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA : the journal of the American Medical Association 315: 762-774
Sharma AK, Eils R, Koenig R (2016) Copy Number Alterations in Enzyme-Coding and Cancer-Causing Genes Reprogram Tumor Metabolism. Cancer research 76: 4058-4067
Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Djillali A, Bauer M, Bellomo R, Bernard GR, Chiche J-D, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld G, van der Poll T, Vincent J-L, Angus DC (2016) The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA : the journal of the American Medical Association 315: 801-810
Sponholz C, Kramer M, Schoneweck F, Menzel U, Inanloo Rahatloo K, Giamarellos-Bourboulis EJ, Papavassileiou V, Lymberopoulou K, Pavlaki M, Koutelidakis I, Perdios I, Scherag A, Bauer M, Platzer M, Huse K (2016a) Polymorphisms of cystathionine beta-synthase gene are associated with susceptibility to sepsis. European journal of human genetics : EJHG
Sponholz C, Matthes K, Rupp D, Backaus W, Klammt S, Karailieva D, Bauschke A, Settmacher U, Kohl M, Clemens MG, Mitzner S, Bauer M, Kortgen A (2016b) Molecular adsorbent recirculating system and single-pass albumin dialysis in liver failure - a prospective, randomised crossover study. Crit Care 20: 2
Stoeckel S, Kirchhoff J, Neugebauer U, Roesch P, Popp J (2016) The application of Raman spectroscopy for the detection and identification of microorganisms. J Raman Spectrosc 47: 89-109
Taudien S, Lausser L, Giamarellos-Bourboulis EJ, Sponholz C, Schoneweck F, Felder M, Schirra LR, Schmid F, Gogos C, Groth S, Petersen BS, Franke A, Lieb W, Huse K, Zipfel PF, Kurzai O, Moepps B, Gierschik P, Bauer M, Scherag A, Kestler HA, Platzer M (2016) Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive. E BioMedicine
Teutschbein J, Simon S, Lother J, Springer J, Hortschansky P, Morton CO, Loeffler J, Einsele H, Conneally E, Rogers TR, Guthke R, Brakhage AA, Kniemeyer O (2016) Proteomic Profiling of Serological Responses to Aspergillus fumigatus Antigens in Patients with Invasive Aspergillosis. Journal of proteome research 15: 1580-1591
Theilacker C, Ludewig K, Serr A, Schimpf J, Held J, Boegelein M, Bahr V, Rusch S, Pohl A, Kogelmann K, Frieseke S, Bogdanski R, Brunkhorst FM, Kern WV, Splenectomy Pneumococcus F (2016) Overwhelming Postsplenectomy Infection: A Prospective Multicenter Cohort Study. Clin Infect Diseases 62: 871-878
Trivedi PJ, Bruns T, Ward S, Mai M, Schmidt C, Hirschfield GM, Weston CJ, Adams DH (2016) Intestinal CCL25 expression is increased in colitis and correlates with inflammatory activity. J Autoimmun 68: 98-104
Tuchscherr L, Kreis CA, Hoerr V, Flint L, Hachmeister M, Geraci J, Bremer-Streck S, Kiehntopf M, Medina E, Kribus M, Raschke M, Pletz M, Peters G, Loeffler B (2016) Staphylococcus aureus develops increased resistance to antibiotics by forming dynamic small colony variants during chronic osteomyelitis. The Journal of antimicrobial chemotherapy 71: 438-448
Vanaja SK, Russo AJ, Behl B, Banerjee I, Yankova M, Deshmukh SD, Rathinam VA (2016) Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation. Cell 165: 1106-1119
Vogel M, Schmitz RP, Hagel S, Pletz MW, Gagelmann N, Scherag A, Schlattmann P, Brunkhorst FM (2016) Infectious disease consultation for Staphylococcus aureus bacteremia - A systematic review and meta-analysis. The Journal of infection 72: 19-28
Vogt A, Reuken PA, Stengel S, Stallmach A, Bruns T (2016) Dual-sugar tests of small intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: a prospective study. World journal of gastroenterology : WJG 22: 3275-3284
von Lilienfeld-Toal M, Berger A, Christopeit M, Hentrich M, Heussel CP, Kalkreuth J, Klein M, Kochanek M, Penack O, Hauf E, Rieger C, Silling G, Vehreschild M, Weber T, Wolf H-H, Lehners N, Schalk E, Mayer K (2016) Community acquired respiratory virus infections in cancer patients-Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology. Eur J Cancer 67: 200-212
von Loeffelholz C, Horn P, Birkenfeld AL, Claus RA, Metzing BU, Doecke S, Jahreis G, Heller R, Hoppe S, Stockmann M, Lock JF, Rieger A, Weickert MO, Settmacher U, Rauchfuss F, Pfeiffer AFH, Bauer M, Sponholz C (2016) Fetuin A is a Predictor of Liver Fat in Preoperative Patients with Nonalcoholic Fatty Liver Disease. Journal of investigative surgery : the official journal of the Academy of Surgical Research 29: 266-274
Wang HJ, Hinney A, Song JY, Scherag A, Meng XR, Grallert H, Illig T, Hebebrand J, Wang Y, Ma J (2016) Association of common variants identified by recent genome-wide association studies with obesity in Chinese children: a case-control study. BMC medical genetics 17: 7
Weis S, Kaasch AJ, Rieg S, Loeffler B, Hagel S, Forstner C, Brunkhorst FM, Pletz MW (2016) Which antibiotic to choose? - In Reply. Dtsch Med Wochenschr 141: 675-676
Werner C, Pauli M, Doose S, Weishaupt A, Haselmann H, Grunewald B, Sauer M, Heckmann M, Toyka KV, Asan E, Sommer C, Geis C (2016) Human autoantibodies to amphiphysin induce defective presynaptic vesicle dynamics and composition. Brain : a journal of neurology 139: 365-379
Wintermann G-B, Weidner K, Strauss B, Rosendahl J, Petrowski K (2016) Predictors of posttraumatic stress and quality of life in family members of chronically critically ill patients after intensive care. Ann Intensive Care 6
Zimmermann HW, Bruns T, Weston CJ, Curbishley SM, Liaskou E, Li K-K, Resheq YJ, Badenhorst PW, Adams DH (2016) Bidirectional transendothelial migration of monocytes across hepatic sinusoidal endothelium shapes monocyte differentiation and regulates the balance between immunity and tolerance in liver. Hepatology 63: 233-246
Publikationen 2015
Boettcher B, Palige K, Jacobsen ID, Hube B, Brunke S (2015) Csr1/Zap1 Maintains Zinc Homeostasis and Influences Virulence in Candida dubliniensis but Is Not Coupled to Morphogenesis. Eukaryot Cell 14: 661-670
Brandes S, Mokhtari Z, Essig F, Hunniger K, Kurzai O, Figge MT (2015) Automated segmentation and tracking of non-rigid objects in time-lapse microscopy videos of polymorphonuclear neutrophils. Med Image Anal 10.1016/j.media.2014.10.002
Brunke S, Quintin J, Kasper L, Jacobsen ID, Richter ME, Hiller E, Schwarzmuller T, d'Enfert C, Kuchler K, Rupp S, Hube B, Ferrandon D (2015) Of mice, flies - and men? Comparing fungal infection models for large-scale screening efforts. Disease Models & Mechanisms 10.1242/dmm.019901
Bruns T, Lutz P, Stallmach A, Nischalke HD (2015) Low ascitic fluid protein does not indicate an increased risk for spontaneous bacterial peritonitis in current cohorts. J Hepatol 10.1016/j.jhep.2015.03.040
Bruns T, Zimmermann HW, Pachnio A, Li KK, Trivedi PJ, Reynolds G, Hubscher S, Stamataki Z, Badenhors PW, Weston CJ, Moss PA, Adams DH (2015) CMV Infection of Human Sinusoidal Endothelium Regulates Hepatic T Cell Recruitment and Activation. J Hepatol 10.1016/j.jhep.2015.02.046
Cambau E, Bauer M (2015) Multi-pathogen real-time PCR system adds benefit for my patients: yes. Intensive Care Med 41: 528-530
Duggan S, Leonhardt I, Huenniger K, Kurzai O (2015) Host response to Candida albicans bloodstream infection and sepsis. Virulence 6: 316-326
Ekaney ML, Bockmeyer CL, Sossdorf M, Reuken PA, Conradi F, Schuerholz T, Blaess MF, Friedman SL, Losche W, Bauer M, Claus RA (2015) Preserved expression of mRNA coding von Willebrand factor-cleaving protease, ADAMTS13 by selenite and activated protein C. Molecular medicine 10.2119/molmed.2014.00202
Gabrielli E, Pericolini E, Luciano E, Sabbatini S, Roselletti E, Perito S, Kasper L, Hube B, Vecchiarelli A (2015) Induction of Caspase-11 by Aspartyl Proteinases of Candida albicans and Implication in Promoting Inflammatory Response. Infection and immunity 83: 1940-1948
Geis C, Ritter C, Ruschil C, Weishaupt A, Grunewald B, Stoll G, Holmoy T, Misu T, Fujihara K, Hemmer B, Stadelmann C, Bennett JL, Sommer C, Toyka KV (2015) The intrinsic pathogenic role of autoantibodies to aquaporin 4 mediating spinal cord disease in a rat passive-transfer model. Exp Neurol 265: 8-21
Goeb E, Reymann S, Langhauser F, Schuhmann MK, Kraft P, Thielmann I, Goebel K, Brede M, Homola G, Solymosi L, Stoll G, Geis C, Meuth SG, Nieswandt B, Kleinschnitz C (2015) Blocking of Plasma Kallikrein Ameliorates Stroke by Reducing Thromboinflammation. Ann Neurol 77: 784-803
Götz T, Milde T, Curio G, Debener S, Lehmann T, Leistritz L, Witte OW, Witte H, Haueisen J (2015) Primary somatosensory contextual modulation is encoded by oscillation frequency change. Clinical Neurophysiology 10.1016/j.clinph.2014.12.028
Grosse C, Bergner N, Dellith J, Heller R, Bauer M, Mellmann A, Popp J, Neugebauer U (2015) Label-free imaging and spectroscopic analysis of intracellular bacterial infections. Analytical Chemistry 87: 2137-2142
Hagel S, Reischke J, Kesselmeier M, Winning J, Gastmeier P, Brunkhorst FM, Scherag A, Pletz MW (2015) Quantifying the Hawthorne Effect in Hand Hygiene Compliance Through Comparing Direct Observation With Automated Hand Hygiene Monitoring. Infection Control and Hospital Epidemiology 10.1017/ice.2015.93: 1-6
Hartog CS, Benbenishty J (2015) Understanding nurse-physician conflicts in the ICU. Intensive Care Med 10.1007/s00134-014-3517-z
Hartog CS, Schwarzkopf D, Riedemann NC, Pfeifer R, Guenther A, Egerland K, Sprung CL, Hoyer H, Gensichen J, Reinhart K (2015) End-of-life care in the intensive care unit: A patient-based questionnaire of intensive care unit staff perception and relatives' psychological response. Palliat Med 29: 336-345
Haselmann H, Ropke L, Werner C, Kunze A, Geis C (2015) Interactions of Human Autoantibodies with Hippocampal GABAergic Synaptic Transmission - Analyzing Antibody-Induced Effects ex vivo. Front Neurol 6: 136-136
Heinekamp T, Schmidt H, Lapp K, Pahtz V, Shopova I, Koster-Eiserfunke N, Kruger T, Kniemeyer O, Brakhage AA (2015) Interference of Aspergillus fumigatus with the immune response. Seminars in Immunopathology 37: 141-152
Hube B, Hay R, Brasch J, Veraldi S, Schaller M (2015) Dermatomycoses and inflammation: The adaptive balance between growth, damage, and survival. J Myc Med 25: E44-E58
Huenniger K, Bieber K, Martin R, Lehnert T, Figge MT, Loeffler J, Guo R-F, Riedemann NC, Kurzai O (2015) A Second Stimulus Required for Enhanced Antifungal Activity of Human Neutrophils in Blood Is Provided by Anaphylatoxin C5a. J Immunol 194: 1199-1210
Joynt GM, Lipman J, Hartog C, Guidet B, Paruk F, Feldman C, Kissoon N, Sprung CL (2015) The Durban World Congress Ethics Round Table IV: health care professional end-of-life decision making. J Crit Care 30: 224-230
Karch A, Castell S, Schwab F, Geffers C, Bongartz H, Brunkhorst FM, Gastmeier P, Mikolajczyk RT (2015) Proposing an empirically justified reference threshold for blood culture sampling rates in intensive care units. Journal of Clinical Microbiology 53: 648-652
Klinger-Strobel M, Lautenschlager C, Fischer D, Mainz JG, Bruns T, Tuchscherr L, Pletz MW, Makarewicz O (2015) Aspects of pulmonary drug delivery strategies for infections in cystic fibrosis - where do we stand? Expert Opinion on Drug Delivery 10.1517/17425247.2015.1007949: 1-24
Knippenberg S, Ueberberg B, Maus R, Bohling J, Ding N, Tarres MT, Hoymann H-G, Jonigk D, Izykowski N, Paton JC, Ogunniyi AD, Lindig S, Bauer M, Welte T, Seeger W, Guenther A, Sisson TH, Gauldie J, Kolb M, Maus UA (2015) Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin. Thorax 70: 636-646
Kramer M, Quickert S, Sponholz C, Menzel U, Huse K, Platzer M, Bauer M, Claus RA (2015) Alternative Splicing of SMPD1 in Human Sepsis. PloS one 10
Kunze A, Achilles A, Keiner S, Witte OW, Redecker C (2015) Two distinct populations of doublecortin-positive cells in the perilesional zone of cortical infarcts. BMC Neuroscience 16
Lappchen CH, Ringer T, Blessin J, Schulz K, Seidel G, Lange R, Hamzei F (2015) Daily iTBS worsens hand motor training - A combined TMS, fMRI and mirror training study. NeuroImage 107: 257-265
Leonhardt I, Spielberg S, Weber M, Albrecht-Eckardt D, Blaess M, Claus R, Barz D, Scherlach K, Hertweck C, Loeffler J, Huenniger K, Kurzai O (2015) The Fungal Quorum-Sensing Molecule Farnesol Activates Innate Immune Cells but Suppresses Cellular Adaptive Immunity. mBio 6
Liu A, Weiss S, Fang H, Claus RA, Roedel J, Dirsch O, Dahmen U (2015) Lipopolysaccharide-binding protein (LBP) blockade augments the protective effect of granulocyte colony-stimulating factor (G-CSF) in a rat sepsis model. Shock 43: 497-503
Liu X, Hinney A, Scholz M, Scherag A, Tonjes A, Stumvoll M, Stadler PF, Hebebrand J, Bottcher Y (2015) Indications for Potential Parent-of-Origin Effects within the FTO Gene. PloS one 10: e0119206
Locke AE, Kahali B, Berndt SI, et al. (2015) Genetic studies of body mass index yield new insights for obesity biology. Nature 518: 197-206 (contributing CSCC member: Scherag A)
Matthaeus-Kraemer CT, Thomas-Rueddel DO, Schwarzkopf D, Rueddel H, Poidinger B, Reinhart K, Bloos F (2015) Barriers and supportive conditions to improve quality of care for critically ill patients: A team approach to quality improvement. J Crit Care 10.1016/j.jcrc.2015.03.022
Mayer K, Hahn-Ast C, Muckter S, Schmitz A, Krause S, Felder L, Bekeredjian-Ding I, Molitor E, Brossart P, von Lilienfeld-Toal M (2015) Comparison of antibiotic prophylaxis with cotrimoxazole/colistin (COT/COL) versus ciprofloxacin (CIP) in patients with acute myeloid leukemia. Supportive Care in Cancer 23: 1321-1329
Murahovschi V, Pivovarova O, Ilkavets I, Dmitrieva RM, Docke S, Keyhani-Nejad F, Gogebakan O, Osterhoff M, Kemper M, Hornemann S, Markova M, Kloting N, Stockmann M, Weickert MO, Lamounier-Zepter V, Neuhaus P, Konradi A, Dooley S, von Loeffelholz C, Bluher M, Pfeiffer AF, Rudovich N (2015) WISP1 is a novel adipokine linked to inflammation in obesity. Diabetes 10.2337/db14-0444
Nead KT, Li A, Wehner MR, Neupane B, Gustafsson S, Butterworth A, Engert JC, Davis AD, Hegele RA, Miller R, den Hoed M, Khaw KT, Kilpelainen TO, Wareham N, Edwards TL, Hallmans G, Varga TV, Kardia SL, Smith JA, Zhao W, Faul JD, Weir D, Mi J, Xi B, Quinteros SC, Cooper C, Sayer AA, Jameson K, Grontved A, Fornage M, Sidney S, Hanis CL, Highland HM, Haring HU, Heni M, Lasky-Su J, Weiss ST, Gerhard GS, Still C, Melka MM, Pausova Z, Paus T, Grant SF, Hakonarson H, Price RA, Wang K, Scherag A, Hebebrand J, Hinney A, BioBank Japan A-BMIGC, Franks PW, Frayling TM, McCarthy MI, Hirschhorn JN, Loos RJ, Ingelsson E, Gerstein HC, Yusuf S, Beyene J, Anand SS, Meyre D (2015) Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals. Human molecular genetics 10.1093/hmg/ddv097
Nussbaum C, Bannenberg S, Keul P, Graler MH, Goncalves-de-Albuquerque CF, Korhonen H, von Wnuck Lipinski K, Heusch G, de Castro Faria Neto HC, Rohwedder I, Gothert JR, Prasad VP, Haufe G, Lange-Sperandio B, Offermanns S, Sperandio M, Levkau B (2015) Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. Nature Communications 6: 6416
Otto GP, Grunwald B, Geis C, Kothe S, Hurtado-Oliveros J, Chung HY, Ekaney M, Bockmeyer CL, Sossdorf M, Busch M, Claus RA (2015) Impact of antibiotic treatment intensity on long-term sepsis-associated kidney injury in a polymicrobial peritoneal contamination and infection model. Nephron 129: 137-142
Otto GP, Hurtado-Oliveros J, Chung H-Y, Knoll K, Neumann T, Mueller HJ, Herbsleb M, Kohl M, Busch M, Sossdorf M, Claus RA (2015) Plasma Neutrophil Gelatinase-Associated Lipocalin Is Primarily Related to Inflammation during Sepsis: A Translational Approach. PloS one 10
Pers TH, Karjalainen JM, Chan Y, Westra HJ, Wood AR, Yang J, Lui JC, Vedantam S, Gustafsson S, Esko T, Frayling T, Speliotes EK, Genetic Investigation of ATC, Boehnke M, Raychaudhuri S, Fehrmann RS, Hirschhorn JN, Franke L (2015) Biological interpretation of genome-wide association studies using predicted gene functions. Nature Communications 6: 5890
Pivovarova O, von Loeffelholz C, Ilkavets I, Sticht C, Zhuk S, Murahovschi V, Lukowski S, Docke S, Kriebel J, de Las Heras Gala T, Malashicheva A, Kostareva A, Lock JF, Stockmann M, Grallert H, Gretz N, Dooley S, Pfeiffer AF, Rudovich N (2015) Modulation of insulin degrading enzyme activity and liver cell proliferation. Cell Cycle 10.1080/15384101.2015.1046647: 1-8
Raasch M, Rennert K, Jahn T, Peters S, Henkel T, Huber O, Schulz I, Becker H, Lorkowski S, Funke H, Mosig A (2015) Microfluidically supported biochip design for culture of endothelial cell layers with improved perfusion conditions. Biofabrication 7
Rautanen A, Mills TC, Gordon AC, Hutton P, Steffens M, Nuamah R, Chiche JD, Parks T, Chapman SJ, Davenport EE, Elliott KS, Bion J, Lichtner P, Meitinger T, Wienker TF, Caulfield MJ, Mein C, Bloos F, Bobek I, Cotogni P, Sramek V, Sarapuu S, Kobilay M, Ranieri VM, Rello J, Sirgo G, Weiss YG, Russwurm S, Schneider EM, Reinhart K, Holloway PA, Knight JC, Garrard CS, Russell JA, Walley KR, Stuber F, Hill AV, Hinds CJ, Investigators EEG (2015) Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. The Lancet Respiratory Medicine 3: 53-60
Reis H, Putter C, Megger DA, Bracht T, Weber F, Hoffmann AC, Bertram S, Wohlschlager J, Hagemann S, Eisenacher M, Scherag A, Schlaak JF, Canbay A, Meyer HE, Sitek B, Baba HA (2015) A structured proteomic approach identifies 14-3-3Sigma as a novel and reliable protein biomarker in panel based differential diagnostics of liver tumors. Biochimica et Biophysica Acta 10.1016/j.bbapap.2014.10.024
Schoeneweck F, Kuhnt E, Scholz M, Brunkhorst FM, Scherag A (2015) Common genomic variation in the FER gene: useful to stratify patients with sepsis due to pneumonia? Intensive Care Med 41: 1379-1381
Schroder UC, Beleites C, Assmann C, Glaser U, Hubner U, Pfister W, Fritzsche W, Popp J, Neugebauer U (2015) Detection of vancomycin resistances in enterococci within 3 (1/2) hours. Scientific Reports 5: 8217
Schwarzkopf D, Westermann I, Skupin H, Riedemann NC, Reinhart K, Pfeifer R, Fritzenwanger M, Guenther A, Witte OW, Hartog CS (2015) A novel questionnaire to measure staff perception of end-of-life decision making in the intensive care unit-Development and psychometric testing. J Crit Care 30: 187-195
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Publikationen 2014
Augsten M, Bottcher A, Spanbroek R, Rubio I, Friedrich K (2014) Graded inhibition of oncogenic Ras-signaling by multivalent Ras-binding domains. Cell Communication and Signaling 12: 1
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Dorner L, Schwarzkopf D, Skupin H, Philipp S, Gugel K, Meissner W, Schuler S, Hartog CS (2014) Teaching medical students to talk about death and dying in the ICU: feasibility of a peer-tutored workshop. Intensive Care Med 10.1007/s00134-014-3541-z
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Ene IV, Brunke S, Brown AJ, Hube B (2014) Metabolism in Fungal Pathogenesis. Cold Spring Harbor perspectives in medicine 10.1101/cshperspect.a019695
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Geis C (2014) Effects of pooled human immunoglobulins in an animal model of neuromyelitis optica with chronic application of autoantibodies to aquaporin 4. Clinical and experimental immunology 178 Suppl 1: 130-131
Geissler K, Bohne S, Siggel R, Sachse S, Kiehntopf M, Bauer M, Straube E, Guntinas-Lichius O (2014) Preoperative serum pattern analysis to predict the outcome of tonsillectomy in adults with chronic tonsillitis. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies 10.1007/s00405-014-3084-5
Giamarellos-Bourboulis EJ (2014) Should we be moving from suppression to stimulation to deal with immunoparalysis in sepsis patients? Immunotherapy 6: 113-115
Gondan M, Blurton SP, Kesselmeier M (2014) Even faster and even more accurate first-passage time densities and distributions for the Wiener diffusion model. J Math Psychol 60: 20-22
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Götz T, Huonker R, Witte OW, Haueisen J (2014) Thalamocortical Impulse Propagation and Information Transfer in EEG and MEG. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 31: 253-260
Griewank KG, Murali R, Puig-Butille JA, Schilling B, Livingstone E, Potrony M, Carrera C, Schimming T, Moller I, Schwamborn M, Sucker A, Hillen U, Badenas C, Malvehy J, Zimmer L, Scherag A, Puig S, Schadendorf D (2014) TERT promoter mutation status as an independent prognostic factor in cutaneous melanoma. Journal of the National Cancer Institute 106
Grimm A, Axer H (2014) Hochauflösender Ultraschall in der Darstellung des Plexus brachialis und der zervikalen Nervenwurzeln. Neurophysiol Lab 36: 135-146
Grimm A, Decard BF, Bischof A, Axer H (2014) Ultrasound of the peripheral nerves in systemic vasculitic neuropathies. Journal of the neurological sciences 347: 44-49
Grimm A, Heiling B, Schumacher U, Witte OW, Axer H (2014) Ultrasound differentiation of axonal and demyelinating neuropathies. Muscle & nerve 50: 976-983
Grimm A, Heiling B, Witte OW, Axer H (2014) Nervenultraschall bei Polyneuropathie - sinnvoll oder nicht? Neurophysiol Lab
Grunewald B, Geis C (2014) Measuring spinal presynaptic inhibition in mice by dorsal root potential recording in vivo. Journal of visualized experiments : JoVE 10.3791/51473
Hagel S, Bruns T, Pletz MW, Engel C, Kalff R, Ewald C (2014) External ventricular drain infections: risk factors and outcome. Interdisciplinary perspectives on infectious diseases 2014: 708531
Hartog C, Bloos F (2014) Venous oxygen saturation. Best practice & research Clinical anaesthesiology 28: 419-428
Hartog CS, Natanson C, Sun J, Klein HG, Reinhart K (2014) Concerns over use of hydroxyethyl starch solutions. Brit Med J 349
Hartog CS, Peschel I, Schwarzkopf D, Curtis JR, Westermann I, Kabisch B, Pfeifer R, Guenther A, Michalsen A, Reinhart K (2014) Are written advance directives helpful to guide end-of-life therapy in the intensive care unit? A retrospective matched-cohort study. J Crit Care 29: 128-133
Hattersley JG, Pfeiffer AF, Roden M, Petzke KJ, Hoffmann D, Rudovich NN, Randeva HS, Vatish M, Osterhoff M, Goegebakan O, Hornemann S, Nowotny P, Machann J, Hierholzer J, von Loeffelholz C, Mohlig M, Arafat AM, Weickert MO (2014) Modulation of amino acid metabolic signatures by supplemented isoenergetic diets differing in protein and cereal fiber content. The Journal of clinical endocrinology and metabolism 10.1210/jc.2014-2302: jc20142302
Hebecker B, Naglik JR, Hube B, Jacobsen ID (2014) Pathogenicity mechanisms and host response during oral Candida albicans infections. Expert Rev Anti Infect Ther 10.1586/14787210.2014.916210
Henry BD, Neill DR, Becker KA, Gore S, Bricio-Moreno L, Ziobro R, Edwards MJ, Muhlemann K, Steinmann J, Kleuser B, Japtok L, Luginbuhl M, Wolfmeier H, Scherag A, Gulbins E, Kadioglu A, Draeger A, Babiychuk EB (2014) Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice. Nature biotechnology 10.1038/nbt.3037
Heyl KA, Klassert TE, Heinrich A, Muller MM, Klaile E, Dienemann H, Grunewald C, Bals R, Singer BB, Slevogt H (2014) Dectin-1 is expressed in human lung and mediates the proinflammatory immune response to nontypeable Haemophilus influenzae. mBio 5: e01492-01414
Hillmann F, Linde J, Beckmann N, Cyrulies M, Strassburger M, Heinekamp T, Haas H, Guthke R, Kniemeyer O, Brakhage AA (2014) The novel globin protein fungoglobin is involved in low oxygen adaptation of Aspergillus fumigatus. Molecular microbiology 93: 539-553
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Hoppe S, von Loeffelholz C, Lock JF, Doecke S, Sinn BV, Rieger A, Malinowski M, Pfeiffer AFH, Neuhaus P, Stockmann M (2014) Nonalcoholic Steatohepatits and Liver Steatosis Modify Partial Hepatectomy Recovery. Journal of investigative surgery : the official journal of the Academy of Surgical Research
InanlooRahatloo K, Parsa AF, Huse K, Rasooli P, Davaran S, Platzer M, Kramer M, Fan JB, Turk C, Amini S, Steemers F, Gunderson K, Ronaghi M, Elahi E (2014) Mutation in ST6GALNAC5 identified in family with coronary artery disease. Scientific reports 4: 3595
Jacobsen ID, Luttich A, Kurzai O, Hube B, Brock M (2014) In vivo imaging of disseminated murine Candida albicans infection reveals unexpected host sites of fungal persistence during antifungal therapy. The Journal of antimicrobial chemotherapy 69: 2785-2796
Jbeily N, Claus RA, Dahlke K, Neugebauer U, Bauer M, Gonnert FA (2014) Comparative suitability of CFDA-SE and rhodamine 6G for in vivo assessment of leukocyte-endothelium interactions. J Biophotonics 7: 369-375
Joerk A, Seidel RA, Walter SG, Wiegand A, Kahnes M, Klopfleisch M, Kirmse K, Pohnert G, Westerhausen M, Witte OW, Holthoff K (2014) Impact of heme and heme degradation products on vascular diameter in mouse visual cortex. Journal of the American Heart Association 3
Karaca I, Tamboli IY, Glebov K, Richter J, Fell LH, Grimm MO, Haupenthal VJ, Hartmann T, Graler MH, van Echten-Deckert G, Walter J (2014) Deficiency of Sphingosine-1-phosphate Lyase Impairs Lysosomal Metabolism of the Amyloid Precursor Protein. The Journal of biological chemistry 289: 16761-16772
Karner M, Kocjan A, Stein J, Schreiber S, von Boyen G, Uebel P, Schmidt C, Kupcinskas L, Dina I, Zuelch F, Keilhauer G, Stremmel W (2014) First Multicenter Study of Modified Release Phosphatidylcholine "LT-02" in Ulcerative Colitis: A Randomized, Placebo-Controlled Trial in Mesalazine-Refractory Courses. The American journal of gastroenterology 10.1038/ajg.2014.104
Kasper L, Seider K, Gerwien F, Allert S, Brunke S, Schwarzmuller T, Ames L, Zubiria-Barrera C, Mansour MK, Becken U, Barz D, Vyas JM, Reiling N, Haas A, Haynes K, Kuchler K, Hube B (2014) Identification of Candida glabrata Genes Involved in pH Modulation and Modification of the Phagosomal Environment in Macrophages. PloS one 9: e96015
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Klein M, Neugebauer U, Gheisari A, Malassa A, Jazzazi TM, Froehlich F, Westerhausen M, Schmitt M, Popp J (2014) IR spectroscopic methods for the investigation of the CO release from CORMs. The journal of physical chemistry A 118: 5381-5390
Kool M, Jones DT, Jager N, Northcott PA, Pugh TJ, Hovestadt V, Piro RM, Esparza LA, Markant SL, Remke M, Milde T, Bourdeaut F, Ryzhova M, Sturm D, Pfaff E, Stark S, Hutter S, Seker-Cin H, Johann P, Bender S, Schmidt C, Rausch T, Shih D, Reimand J, Sieber L, Wittmann A, Linke L, Witt H, Weber UD, Zapatka M, Konig R, Beroukhim R, Bergthold G, van Sluis P, Volckmann R, Koster J, Versteeg R, Schmidt S, Wolf S, Lawerenz C, Bartholomae CC, von Kalle C, Unterberg A, Herold-Mende C, Hofer S, Kulozik AE, von Deimling A, Scheurlen W, Felsberg J, Reifenberger G, Hasselblatt M, Crawford JR, Grant GA, Jabado N, Perry A, Cowdrey C, Croul S, Zadeh G, Korbel JO, Doz F, Delattre O, Bader GD, McCabe MG, Collins VP, Kieran MW, Cho YJ, Pomeroy SL, Witt O, Brors B, Taylor MD, Schuller U, Korshunov A, Eils R, Wechsler-Reya RJ, Lichter P, Pfister SM, Project IPT (2014) Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. Cancer cell 25: 393-405
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Seidel RA, Schowtka B, Klopfleisch M, Küh T, Weiland A, Koch A, Görls H, Imhof D, Pohnert G, Westerhausen M (2014) Total synthesis and characterization of the bilirubin oxidation product (Z)-2-(4-ethenyl-3-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)ethanamide (Z-BOX B). Tetrahedron Letters 55: 6526-6529
Seider K, Gerwien F, Kasper L, Allert S, Brunke S, Jablonowski N, Schwarzmuller T, Barz D, Rupp S, Kuchler K, Hube B (2014) Immune evasion, stress resistance, and efficient nutrient acquisition are crucial for intracellular survival of Candida glabrata within macrophages. Eukaryot Cell 13: 170-183
Sponholz C, Bayer O, Kabisch B, Wurm K, Ebert K, Bauer M, Kortgen A (2014) Anticoagulation strategies in venovenous hemodialysis in critically ill patients: a five-year evaluation in a surgical intensive care unit. TheScientificWorldJournal 2014: 808320
Sponholz C, Gonnert FA, Kortgen A, Bauer M (2014) [Monitoring of liver function in the critically ill]. Anaesthesist 63: 603-612; quiz 613-604
Sponholz C, Schelenz C, Reinhart K, Schirmer U, Stehr SN (2014) Catecholamine and volume therapy for cardiac surgery in Germany--results from a postal survey. PloS one 9: e103996
Sponholz C, Settmacher U, Bauer M, Kortgen A (2014) Regional Citrate Anticoagulation for Continuous Renal Replacement Therapy in the Perioperative Care of Liver Transplant Recipients: A Single Center Experience. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 10.1111/1744-9987.12196
Sprung CL, Paruk F, Kissoon N, Hartog CS, Lipman J, Du B, Argent A, Hodgson RE, Guidet B, Groeneveld AB, Feldman C (2014) The Durban World Congress Ethics Round Table Conference Report: I. Differences between withholding and withdrawing life-sustaining treatments. J Crit Care 29: 890-895
Sprung CL, Truog RD, Curtis JR, Joynt GM, Baras M, Michalsen A, Briegel J, Kesecioglu J, Efferen L, De Robertis E, Bulpa P, Metnitz P, Patil N, Hawryluck L, Manthous C, Moreno R, Leonard S, Hill NS, Wennberg E, McDermid RC, Mikstacki A, Mularski RA, Hartog CS, Avidan A (2014) Seeking Worldwide Professional Consensus on the Principles of End-of-Life Care for the Critically Ill. The Consensus for Worldwide End-of-Life Practice for Patients in Intensive Care Units (WELPICUS) Study. American journal of respiratory and critical care medicine 190: 855-866
Stewardson AJ, Harbarth S, Graves N, Group TS (2014) Valuation of hospital bed-days released by infection control programs: a comparison of methods. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America 35: 1294-1297
Stubendorff B, Finke S, Walter M, Kniemeyer O, von Eggeling F, Gruschwitz T, Steiner T, Ott U, Wolf G, Wunderlich H, Junker K (2014) Urine protein profiling identified alpha-1-microglobulin and haptoglobin as biomarkers for early diagnosis of acute allograft rejection following kidney transplantation. World journal of urology 32: 1619-1624
Suratanee A, Schaefer MH, Betts MJ, Soons Z, Mannsperger H, Harder N, Oswald M, Gipp M, Ramminger E, Marcus G, Manner R, Rohr K, Wanker E, Russell RB, Andrade-Navarro MA, Eils R, Konig R (2014) Characterizing protein interactions employing a genome-wide siRNA cellular phenotyping screen. PLoS computational biology 10: e1003814
Thuy AV, Reimann CM, Hemdan NY, Graler MH (2014) Sphingosine 1-phosphate in blood: function, metabolism, and fate. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 34: 158-171
Trivedi PJ, Bruns T, Cheung A, Li KK, Kittler C, Kumagi T, Shah H, Corbett C, Al-Harthy N, Acarsu U, Coltescu C, Tripathi D, Stallmach A, Neuberger J, Janssen HL, Hirschfield GM (2014) Optimising risk stratification in primary biliary cirrhosis: AST/platelet ratio index predicts outcome independent of ursodeoxycholic acid response. J Hepatol 10.1016/j.jhep.2014.01.029
Ummanni R, Mannsperger HA, Sonntag J, Oswald M, Sharma AK, Konig R, Korf U (2014) Evaluation of reverse phase protein array (RPPA)-based pathway-activation profiling in 84 non-small cell lung cancer (NSCLC) cell lines as platform for cancer proteomics and biomarker discovery. Biochimica et biophysica acta 1844: 950-959
Voigt J, Hunniger K, Bouzani M, Jacobsen ID, Barz D, Hube B, Loffler J, Kurzai O (2014) Human natural killer cells acting as phagocytes against Candida albicans and mounting an inflammatory response that modulates neutrophil antifungal activity. The Journal of infectious diseases 209: 616-626
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Wartenberg A, Linde J, Martin R, Schreiner M, Horn F, Jacobsen ID, Jenull S, Wolf T, Kuchler K, Guthke R, Kurzai O, Forche A, d'Enfert C, Brunke S, Hube B (2014) Microevolution of Candida albicans in Macrophages Restores Filamentation in a Nonfilamentous Mutant. PLoS genetics 10: e1004824
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Wilson D, Mayer FL, Miramon P, Slesiona S, Jacobsen ID, Hube B (2014) Candida albicans specific genes: distinct roles in host-pathogen interactions. Eukaryot Cell 13: 977-989
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Publikationen 2013
Aschoff M, Hotz-Wagenblatt A, Glatting KH, Fischer M, Eils R, Konig R (2013) SplicingCompass: differential splicing detection using RNA-Seq data. Bioinformatics 10.1093/bioinformatics/btt101
Axer H, Grimm A, Porzelius C, Teschner U, Schumacher U, Witte OW, Brunkhorst FM (2013) Impairment of small somatic and autonomic nerve fibres in intensive care unit patients with severe sepsis and critical illness polyneuropathy -- a single center controlled observational study. BMC neurology 13: 159
Axer H, Zinke J, Axer M, Grimm A (2013) Elektrophysiologische Diagnostik der Critical Illness Polyneuropathie und Critical Illness Myopathie. Neurophysiol Lab 35: 18-33
Bacher P, Kniemeyer O, Schonbrunn A, Sawitzki B, Assenmacher M, Rietschel E, Steinbach A, Cornely OA, Brakhage AA, Thiel A, Scheffold A (2013) Antigen-specific expansion of human regulatory T cells as a major tolerance mechanism against mucosal fungi. Mucosal immunology 10.1038/mi.2013.107
Bacher P, Schink C, Teutschbein J, Kniemeyer O, Assenmacher M, Brakhage AA, Scheffold A (2013) Antigen-Reactive T Cell Enrichment for Direct, High-Resolution Analysis of the Human Naive and Memory Th Cell Repertoire. J Immunol 10.4049/jimmunol.1202221
Bayer O, Schwarzkopf D, Doenst T, Cook D, Kabisch B, Schelenz C, Bauer M, Riedemann NC, Sakr Y, Kohl M, Reinhart K, Hartog CS (2013) Perioperative fluid therapy with tetrastarch and gelatin in cardiac surgery-a prospective sequential analysis*. Crit Care Med 41: 2532-2542
Beauvais A, Bozza S, Kniemeyer O, Formosa C, Balloy V, Henry C, Roberson RW, Dague E, Chignard M, Brakhage AA, Romani L, Latge JP (2013) Deletion of the alpha-(1,3)-Glucan Synthase Genes Induces a Restructuring of the Conidial Cell Wall Responsible for the Avirulence of Aspergillus fumigatus. PLoS Pathog 9: e1003716
Beleites C, Neugebauer U, Bocklitz T, Krafft C, Popp J (2013) Sample size planning for classification models. Analytica chimica acta 760: 25-33
Bielecki P, Komor U, Bielecka A, Musken M, Puchalka J, Pletz MW, Ballmann M, Martins Dos Santos VA, Weiss S, Haussler S (2013) Ex vivo transcriptional profiling reveals a common set of genes important for the adaptation of Pseudomonas aeruginosa to chronically infected host sites. Environmental microbiology 15: 570-587
Bloos F, Bayer O, Sachse S, Straube E, Reinhart K, Kortgen A (2013) Attributable costs of patients with candidemia and potential implications of polymerase chain reaction-based pathogen detection on antifungal therapy in patients with sepsis. J Crit Care 28: 2-8
Bohne S, Siggel R, Sachse S, Kiehntopf M, Bauer M, Straube E, Guntinas-Lichius O (2013) Clinical significance and diagnostic usefulness of serologic markers for improvement of outcome of tonsillectomy in adults with chronic tonsillitis. Journal of negative results in biomedicine 12: 11
Brunke S, Hube B (2013) Two unlike cousins: Candida albicans and C. glabrata infection strategies. Cellular microbiology 10.1111/cmi.12091
Caldarelli A, Muller JP, Paskowski-Rogacz M, Herrmann K, Bauer R, Koch S, Heninger AK, Krastev D, Ding L, Kasper S, Fischer T, Brodhun M, Bohmer FD, Buchholz F (2013) A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling. Leukemia 10.1038/leu.2013.83
Christaki E, Giamarellos-Bourboulis EJ (2013) The complex pathogenesis of bacteremia: From antimicrobial clearance mechanisms to the genetic background of the host. Virulence 5
Docke S, Lock JF, Birkenfeld AL, Hoppe S, Lieske S, Rieger A, Raschzok N, Sauer IM, Florian S, Osterhoff MA, Heller R, Herrmann K, Lindenmuller S, Horn P, Bauer M, Weickert MO, Neuhaus P, Stockmann M, Mohlig M, Pfeiffer AF, von Loeffelholz C (2013) Elevated hepatic chemerin mRNA expression in human non-alcoholic fatty liver disease. European journal of endocrinology / European Federation of Endocrine Societies 169: 547-557
Dorr JR, Yu Y, Milanovic M, Beuster G, Zasada C, Dabritz JH, Lisec J, Lenze D, Gerhardt A, Schleicher K, Kratzat S, Purfurst B, Walenta S, Mueller-Klieser W, Graler M, Hummel M, Keller U, Buck AK, Dorken B, Willmitzer L, Reimann M, Kempa S, Lee S, Schmitt CA (2013) Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. Nature 10.1038/nature12437
Fang H, Liu A, Sun J, Kitz A, Dirsch O, Dahmen U (2013) Granulocyte Colony Stimulating Factor Induces Lipopolysaccharide (LPS) Sensitization via Upregulation of LPS Binding Protein in Rat. PloS one 8: e56654
Finkensieper A, Bekhite MM, Fischer H, Nitza S, al. e (2013) Antibacterial Capacity of Differentiated Murine Embryonic Stem Cells During Defined in vitro Inflammatory Conditions. StemCellDev
Geissler KJ, Jung MJ, Riecken LB, Sperka T, Cui Y, Schacke S, Merkel U, Markwart R, Rubio I, Than ME, Breithaupt C, Peuker S, Seifert R, Kaupp UB, Herrlich P, Morrison H (2013) Regulation of Son of sevenless by the membrane-actin linker protein ezrin. Proceedings of the National Academy of Sciences of the United States of America 110: 20587-20592
Ghanem H, Hagel S, Keller P, Prochnau D, Stallmach A, Pletz MW (2013) [A 22-year-old patient from Ghana with fever and reduced CD4 T-cell count]. Internist (Berl) 54: 100-104
Giamarellos-Bourboulis EJ (2013) The failure of biologics in sepsis: where do we stand? International journal of antimicrobial agents 42 Suppl: S45-47
Giannitsioti E, Damoraki G, Rokkas C, Tsaganos T, Fragou A, Kannelaki S, Athanasia S, Giamarellos-Bourboulis EJ (2013) Impact of haplotypes of TNF in the natural course of infective endocarditis. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20: 459-464
Giatrakos S, Huse K, Kanni T, Tzanetakou V, Kramer M, Grech I, Papadavid E, Katoulis A, Stavrianeas N, Nothnagel M, Platzer M, Bauer M, Giamarellos-Bourboulis EJ (2013) Haplotypes of IL-12Rbeta1 impact on the clinical phenotype of hidradenitis suppurativa. Cytokine 10.1016/j.cyto.2013.03.008
Gonnert FA, Recknagel P, Hilger I, Claus RA, Bauer M, Kortgen A (2013) Hepatic excretory function in sepsis: implications from biophotonic analysis of transcellular xenobiotic transport in a rodent model. Crit Care 17: R67
Götz T, Huonker R, Kranczioch C, Reuken P, Witte OW, Günther A, Debener S (2013) Impaired evoked and resting-state brain oscillations in patients with liver cirrhosis as revealed by magnetoencephalography. NeuroImage: Clinical 2: 873-882
Grimm A, Brunkhorst FM, Axer H (2013) Neuromuskuläre Schwäche-Sepsis-induzierte CIP und CIM. NeuroTransmitter 24: 36-43
Grimm A, Teschner U, Porzelius C, Ludewig K, Zielske J, Witte OW, Brunkhorst FM, Axer H (2013) Muscle ultrasound for early assessment of critical illness neuromyopathy in severe sepsis. Crit Care 17: R227
Grimm A, Witte OW, Axer H (2013) Muskelultraschall in der neurologischen Diagnostik – ein Überblick. Neurophysiol Lab 35: 47-60
Hagel S, Ludewig K, Frosinski J, Hutagalung R, Porzelius C, Gastmeier P, Harbarth S, Pletz MW, Brunkhorst FM (2013) [Effectiveness of a hospital-wide educational programme for infection control to reduce the rate of health-care associated infections and related sepsis (ALERTS) - methods and interim results]. Dtsch Med Wochenschr 138: 1717-1722
Hagel S, Pletz MW, Brunkhorst FM, Seifert H, Kern WV (2013) [Bacteremia and sepsis]. Internist (Berl) 54: 399-407
Hagel S, Stallmach A, Keller P, Pletz M (2013) [Multiresistant Organisms.]. Zentralbl Chir 10.1055/s-0032-1328343
Hartog CS, Jensen HI (2013) Family-centered ICU care may be good for everyone. Intensive Care Med 10.1007/s00134-013-2996-7
Hartog CS, Welte T, Schlattmann P, Reinhart K (2013) Fluid replacement with hydroxyethyl starch in critical care--a reassessment. Deutsches Arzteblatt international 110: 443-450
Hennicke F, Grumbt M, Lermann U, Ueberschaar N, Palige K, Bottcher B, Jacobsen ID, Staib C, Morschhauser J, Monod M, Hube B, Hertweck C, Staib P (2013) Factors supporting cysteine tolerance and sulfite production in Candida albicans. Eukaryot Cell EC.00336-12 [pii] 10.1128/EC.00336-12
Heublein S, Wehner F, Hochsmann B, Hochhaus A, Hartmann M, La Rosee P (2013) Modelling cost effectiveness of horse antithymocyte globulin for treating severe aplastic anaemia in Germany. Annals of hematology 10.1007/s00277-013-1688-2
Holters S, Anacker J, Jansen L, Beer-Grondke K, Durst M, Rubio I (2013) Tetraspanin 1 promotes invasiveness of cervical cancer cells. International journal of oncology 43: 503-512
Hoshi T, Wissuwa B, Tian Y, Tajima N, Xu R, Bauer M, Heinemann SH, Hou S (2013) Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca2+-dependent K+ channels. Proceedings of the National Academy of Sciences of the United States of America 110: 4816-4821
Hoyer D, Tetschke F, Jaekel S, Nowack S, Witte OW, Schleussner E, Schneider U (2013) Fetal functional brain age assessed from universal developmental indices obtained from neuro-vegetative activity patterns. PloS one 8: e74431
Jbeily N, Suckert I, Gonnert FA, Acht B, Bockmeyer CL, Grossmann SD, Blaess MF, Lueth A, Deigner HP, Bauer M, Claus RA (2013) Hyperresponsiveness of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host response. Journal of lipid research 54: 410-424
Jun JE, Rubio I, Roose JP (2013) Regulation of Ras Exchange Factors and Cellular Localization of Ras Activation by Lipid Messengers in T Cells. Frontiers in immunology 4: 239
Klaile E, Klassert TE, Scheffrahn I, Muller MM, Heinrich A, Heyl KA, Dienemann H, Grunewald C, Bals R, Singer BB, Slevogt H (2013) Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons. Respiratory research 14: 85
Klopfleisch M, Seidel RA, Gorls H, Richter H, Beckert R, Imhof W, Reiher M, Pohnert G, Westerhausen M (2013) Total Synthesis and Detection of the Bilirubin Oxidation Product (Z)-2-(3-Ethenyl-4-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)ethanamide (Z-BOX A). Organic letters 15: 4608-4611
Kothe S, Muller JP, Bohmer SA, Tschongov T, Fricke M, Koch S, Thiede C, Requardt RP, Rubio I, Bohmer FD (2013) Features of Ras activation by a mislocalized oncogenic tyrosine kinase: FLT3 ITD signals through K-Ras at the plasma membrane of acute myeloid leukemia cells. Journal of cell science 126: 4746-4755
Kramer M, Sponholz C, Slaba M, Wissuwa B, Claus RA, Menzel U, Huse K, Platzer M, Bauer M (2013) Alternative 5' untranslated regions are involved in expression regulation of human heme oxygenase-1. PloS one 8: e77224
Kretz A, Herrmann KH, Fischer S, Engelmann C, Witte OW, Reichenbach JR, Weih F, Haenold R (2013) Dysfunctional NF-kappaB and brain myelin formation. European journal of human genetics : EJHG 10.1038/ejhg.2013.240
Kroll K, Pahtz V, Kniemeyer O (2013) Elucidating the fungal stress response by proteomics. Journal of proteomics 10.1016/j.jprot.2013.06.001
Kuhl T, Wissbrock A, Goradia N, Sahoo N, Galler K, Neugebauer U, Popp J, Heinemann SH, Ohlenschlager O, Imhof D (2013) Analysis of Fe(III) Heme Binding to Cysteine-Containing Heme-Regulatory Motifs in Proteins. ACS chemical biology 10.1021/cb400317x
Lindig S, Quickert S, Vodovotz Y, Wanner GA, Bauer M (2013) Age-independent co-expression of antimicrobial gene clusters in the blood of septic patients. International journal of antimicrobial agents 42 Suppl: S2-7
Louis K, Netea MG, Carrer DP, Kotsaki A, Mylona V, Pistiki A, Savva A, Roditis K, Alexis A, Van der Meer JW, Giamarellos-Bourboulis EJ (2013) Bacterial translocation in an experimental model of multiple organ dysfunctions. The Journal of surgical research 10.1016/j.jss.2013.01.064
Lubkemeier I, Requardt RP, Lin X, Sasse P, Andrie R, Schrickel JW, Chkourko H, Bukauskas FF, Kim JS, Frank M, Malan D, Zhang J, Wirth A, Dobrowolski R, Mohler PJ, Offermanns S, Fleischmann BK, Delmar M, Willecke K (2013) Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels. Basic research in cardiology 108: 348
Luttich A, Brunke S, Hube B, Jacobsen ID (2013) Serial passaging of Candida albicans in systemic murine infection suggests that the wild type strain SC5314 is well adapted to the murine kidney. PloS one 8: e64482
Martin R, Albrecht-Eckardt D, Brunke S, Hube B, Hunniger K, Kurzai O (2013) A Core Filamentation Response Network in Candida albicans Is Restricted to Eight Genes. PloS one 8: e58613
Mayer FL, Wilson D, Hube B (2013) Candida albicans pathogenicity mechanisms. Virulence 4: 119-128
Mayer FL, Wilson D, Hube B (2013) Hsp21 potentiates antifungal drug tolerance in Candida albicans. PloS one 8: e60417
Mihailidou I, Pelekanou A, Pistiki A, Spyridaki A, Tzepi IM, Damoraki G, Giamarellos-Bourboulis EJ (2013) Dexamethasone Down-Regulates Expression of Triggering Receptor Expressed on Myeloid Cells-1: Evidence for a TNFalpha-Related Effect. Frontiers in public health 1: 50
Miramon P, Kasper L, Hube B (2013) Thriving within the host: Candida spp. interactions with phagocytic cells. Med Microbiol Immunol 10.1007/s00430-013-0288-z
Muszkieta L, Beauvais A, Pahtz V, Gibbons JG, Anton Leberre V, Beau R, Shibuya K, Rokas A, Francois JM, Kniemeyer O, Brakhage AA, Latge JP (2013) Investigation of Aspergillus fumigatus biofilm formation by various "omics" approaches. Front Microbiol 4: 13
Neuschafer-Rube F, Lieske S, Kuna M, Henkel J, Perry RJ, Erion DM, Pesta D, Willmes DM, Brachs S, von Loeffelholz C, Tolkachov A, Schupp M, Pathe-Neuschafer-Rube A, Pfeiffer AF, Shulman GI, Puschel GP, Birkenfeld AL (2013) The Mammalian INDY Homolog is Induced by CREB in a Rat Model of Type 2 Diabetes. Diabetes 10.2337/db13-0749
Offen N, Flemming J, Kamawal H, Ahmad R, Wolber W, Geis C, Zaehres H, Scholer HR, Ehrenreich H, Muller AM, Siren AL (2013) Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells. Molecular medicine 19: 399-408
Otto GP, Busch M, Sossdorf M, Claus RA (2013) Impact of sepsis-associated cytokine storm on plasma NGAL during acute kidney injury in a model of polymicrobial sepsis. Crit Care 17: 419
Otto GP, Kropf M, Rodel J, Losche W, Ruster C, Claus RA, Sossdorf M, Busch M (2013) Novel approach for bacteremia detection in patients with end-stage renal failure undergoing hemodialysis. The International journal of artificial organs 10.5301/ijao.5000243: 0
Otto GP, Ludewig K, Jacobsen ID, Schaarschmidt B, Hube B, Bauer M (2013) Limitation of (1-->3)-beta-D-glucan monitoring in major elective surgery involving cardiopulmonary bypass. Crit Care 17: 437
Palige K, Linde J, Martin R, Bottcher B, Citiulo F, Sullivan DJ, Weber J, Staib C, Rupp S, Hube B, Morschhauser J, Staib P (2013) Global transcriptome sequencing identifies chlamydospore specific markers in Candida albicans and Candida dubliniensis. PloS one 8: e61940
Papaioannou M, Soderholm AA, Hong W, Dai Y, Roediger J, Roell D, Thiele M, Nyronen TH, Baniahmad A (2013) Computational and functional analysis of the androgen receptor antagonist atraric acid and its derivatives. Anti-cancer agents in medicinal chemistry
Peter J, Frey O, Stallmach A, Bruns T (2013) Attenuated antigen-specific T cell responses in cirrhosis are accompanied by elevated serum interleukin-10 levels and down-regulation of HLA-DR on monocytes. BMC gastroenterology 13: 37
Pietrella D, Pandey N, Gabrielli E, Pericolini E, Perito S, Kasper L, Bistoni F, Cassone A, Hube B, Vecchiarelli A (2013) Secreted aspartic proteases of Candida albicans activate the NLRP3 inflammasome. European journal of immunology 43: 679-692
Plaimas K, Wang Y, Rotimi SO, Olasehinde G, Fatumo S, Lanzer M, Adebiyi E, Konig R (2013) Computational and experimental analysis identified 6-diazo-5-oxonorleucine as a potential agent for treating infection by Plasmodium falciparum. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 10.1016/j.meegid.2013.09.019
Pletz MW (2013) [Pneumococcal vaccine]. Dtsch Med Wochenschr 138: 1734-1737
Pletz MW, Michaylov N, Schumacher U, van der Linden M, Duesberg CB, Fuehner T, Klugman KP, Welte T, Makarewicz O (2013) Antihypertensives suppress the emergence of fluoroquinolone-resistant mutants in pneumococci: An in vitro study. International journal of medical microbiology : IJMM 10.1016/j.ijmm.2013.02.014
Prell T, Peschel T, Kohler B, Bokemeyer MH, Dengler R, Gunther A, Grosskreutz J (2013) Structural brain abnormalities in cervical dystonia. BMC neuroscience 14: 123
Prkno A, Wacker C, Brunkhorst FM, Schlattmann P (2013) Procalcitonin-guided therapy in intensive care unit patients with severe sepsis and septic shock - a systematic review and meta-analysis. Crit Care 17: R291
Pye DS, Rubio I, Pusch R, Lin K, Pettitt AR, Till KJ (2013) Chemokine unresponsiveness of chronic lymphocytic leukemia cells results from impaired endosomal recycling of rap1 and is associated with a distinctive type of immunological anergy. J Immunol 191: 1496-1504
Recknagel P, Gonnert FA, Halilbasic E, Gajda M, Jbeily N, Lupp A, Rubio I, Claus RA, Kortgen A, Trauner M, Singer M, Bauer M (2013) Mechanisms and functional consequences of liver failure substantially differ between endotoxaemia and faecal peritonitis in rats. Liver Int 33: 283-293
Reuken PA, Stallmach A, Bruns T (2013) Mortality after urinary tract infections in patients with advanced cirrhosis - Relevance of acute kidney injury and comorbidities. Liver Int 33: 220-230
Rosendahl J, Brunkhorst FM, Jaenichen D, Strauss B (2013) Physical and mental health in patients and spouses after intensive care of severe sepsis: a dyadic perspective on long-term sequelae testing the Actor-Partner Interdependence Model. Crit Care Med 41: 69-75
Rudiger A, Dyson A, Felsmann K, Carre JE, Taylor V, Hughes S, Clatworthy I, Protti A, Pellerin D, Lemm J, Claus RA, Bauer M, Singer M (2013) Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis. Clin Sci (Lond) 124: 391-401
Rupprecht S, Walther B, Gudziol H, Steenbeck J, Freesmeyer M, Witte OW, Gunther A, Schwab M (2013) Clinical markers of early nigrostriatal neurodegeneration in idiopathic rapid eye movement sleep behavior disorder. Sleep medicine 14: 1064-1070
Schack M, Sachse S, Rodel J, Frangoulidis D, Pletz MW, Rohde GU, Straube E, Boden K (2013) Coxiella burnetii (Q fever) as a cause of community-acquired pneumonia during the warm season in Germany. Epidemiology and infection 10.1017/S0950268813002914: 1-6
Schleenvoigt BT, Keller PM, Lehmann M, Gras F, Hagel S, Stallmach A, Pletz MW (2013) [Cutaneous manifestation of tuberculosis causing impaired healing after minor injury]. Dtsch Med Wochenschr 138: 2297-2302
Schmidt C, Lautenschlager C, Petzold B, Sakr Y, Marx G, Stallmach A (2013) Confocal laser endomicroscopy reliably detects sepsis-related and treatment-associated changes in intestinal mucosal microcirculation. British journal of anaesthesia 10.1093/bja/aet219
Schmidt C, Schneble N, Muller JP, Bauer R, Perino A, Marone R, Rybalkin SD, Wymann MP, Hirsch E, Wetzker R (2013) Phosphoinositide 3-kinase gamma mediates microglial phagocytosis via lipid kinase-independent control of cAMP. Neuroscience 233: 44-53
Schmitz RP, Keller PM, Baier M, Hagel S, Pletz MW, Brunkhorst FM (2013) Quality of blood culture testing - a survey in intensive care units and microbiological laboratories across four European countries. Crit Care 17: R248
Schroder UC, Ramoji A, Glaser U, Sachse S, Leiterer C, Csaki A, Hubner U, Fritzsche W, Pfister W, Bauer M, Popp J, Neugebauer U (2013) Combined Dielectrophoresis-Raman Setup for the Classification of Pathogens Recovered from the Urinary Tract. Analytical chemistry 10.1021/ac4021616
Schulz A, Baader SL, Niwa-Kawakita M, Jung MJ, Bauer R, Garcia C, Zoch A, Schacke S, Hagel C, Mautner VF, Hanemann CO, Dun XP, Parkinson DB, Weis J, Schroder JM, Gutmann DH, Giovannini M, Morrison H (2013) Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy. Nature neuroscience 10.1038/nn.3348
Schwarzkopf D, Behrend S, Skupin H, Westermann I, Riedemann NC, Pfeifer R, Gunther A, Witte OW, Reinhart K, Hartog CS (2013) Family satisfaction in the intensive care unit: a quantitative and qualitative analysis. Intensive Care Med 39: 1071-1079
Sens E, Knorr C, Preul C, Meissner W, Witte OW, Miltner WH, Weiss T (2013) Differences in somatosensory and motor improvement during temporary functional deafferentation in stroke patients and healthy subjects. Behavioural brain research 252: 110-116
Shopova I, Bruns S, Thywissen A, Kniemeyer O, Brakhage AA, Hillmann F (2013) Extrinsic extracellular DNA leads to biofilm formation and colocalizes with matrix polysaccharides in the human pathogenic fungus Aspergillus fumigatus. Front Microbiol 4: 141
Song SP, Hennig A, Schubert K, Markwart R, Schmidt P, Prior IA, Bohmer FD, Rubio I (2013) Ras palmitoylation is necessary for N-Ras activation and signal propagation in growth factor signalling. The Biochemical journal 10.1042/BJ20121799
Sossdorf M, Fischer J, Meyer S, Dahlke K, Wissuwa B, Seidel C, Schrepper A, Bockmeyer CL, Lupp A, Neugebauer S, Schmerler D, Rodel J, Claus RA, Otto GP (2013) Physical Exercise Induces Specific Adaptations Resulting in Reduced Organ Injury and Mortality During Severe Polymicrobial Sepsis. Crit Care Med 41: 246-255
Sossdorf M, Otto GP, Boettel J, Winning J, Losche W (2013) Benefit of low-dose aspirin and non-steroidal anti-inflammatory drugs in septic patients. Crit Care 17: 402
Sossdorf M, Otto GP, Menge K, Claus RA, Losche W, Kabisch B, Kohl M, Smolenski UC, Schlattmann P, Reinhart K, Winning J (2013) Potential effect of physiotherapeutic treatment on mortality rate in patients with severe sepsis and septic shock: A retrospective cohort analysis. J Crit Care 10.1016/j.jcrc.2013.06.023
Stallmach A, Hagel S, Bruns T, Pletz M, Eckmann C (2013) [Empirical antibiotic therapy in intra-abdomial infections: cases and evidence-based therapeutic recommendations]. Zeitschrift fur Gastroenterologie 51: 1069-1081
Stehr SN, Woest I, Hartog CS, Reinhart K (2013) [Sepsis : Putting knowledge into practice]. Internist (Berl) 54: 63-74
Stein C, Makarewicz O, Pfeifer Y, Brandt C, Ramos JC, Klinger M, Pletz MW (2013) Direct RNA-based detection and differentiation of CTX-M-type extended-spectrum beta-lactamases (ESBL). PloS one 8: e80079
Toufekoula C, Papadakis V, Tsaganos T, Routsi C, Orfanos SE, Kotanidou A, Carrer DP, Raftogiannis M, Baziaka F, Giamarellos-Bourboulis EJ (2013) Compartmentalization of lipid peroxidation in sepsis by multidrug-resistant gram-negative bacteria: experimental and clinical evidence. Crit Care 17: R6
Wacker C, Prkno A, Brunkhorst FM, Schlattmann P (2013) Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. The Lancet infectious diseases 13: 426-435
Wagener J, Schneider JJ, Baxmann S, Kalbacher H, Borelli C, Nuding S, Kuchler R, Wehkamp J, Kaeser MD, Mailander-Sanchez D, Braunsdorf C, Hube B, Schild L, Forssmann WG, Korting HC, Liepke C, Schaller M (2013) A peptide derived from the highly conserved protein GAPDH is involved in tissue protection by different antifungal strategies and epithelial immunomodulation. The Journal of investigative dermatology 133: 144-153
Walter B, Eiselt M, Cumming P, Xiong G, Hinz R, Uthe S, Brust P, Bauer R (2013) Resistance of brain glucose metabolism to thiopental-induced CNS depression in newborn piglets. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 31: 157-164
Wilson D, Hebecker B, Moyes DL, Miramon P, Jablonowski N, Wisgott S, Allert S, Naglik JR, Hube B (2013) Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection. Antimicrobial agents and chemotherapy 57: 5178-5180
Zimmermann HW, Reuken PA, Koch A, Bartneck M, Adams DH, Trautwein C, Stallmach A, Tacke F, Bruns T (2013) Soluble urokinase plasminogen activator receptor is compartmentally regulated in decompensated cirrhosis and indicates immune activation and short-term mortality. Journal of internal medicine 274: 86-100
Publikationen 2012
Bauer R, Schubert H (2012) Therapeutische Hypothermie – pathophysiologische und molekularbiologische Implikationen der Hirnprotektion. Intensiv- und Notfallbehandlung 37: 1-9
Bayer O, Reinhart K, Kohl M, Kabisch B, Marshall J, Sakr Y, Bauer M, Hartog C, Schwarzkopf D, Riedemann N (2012) Effects of fluid resuscitation with synthetic colloids or crystalloids alone on shock reversal, fluid balance, and patient outcomes in patients with severe sepsis: a prospective sequential analysis. Crit Care Med 40: 2543-2551
Bloos F, Sachse S, Kortgen A, Pletz MW, Lehmann M, Straube E, Riedemann NC, Reinhart K, Bauer M (2012) Evaluation of a polymerase chain reaction assay for pathogen detection in septic patients under routine condition: an observational study. PloS one 7: e46003
Bohne S, Schelhorn-Neise P, Brunkhorst FM, Guntinas-Lichius O (2012) [Severe organic dysphagia after long-term ventilation in a patient with sepsis and multiorgan failure]. Medizinische Klinik, Intensivmedizin und Notfallmedizin 107: 564-566
Brunkhorst FM, Oppert M, Marx G, Bloos F, Ludewig K, Putensen C, Nierhaus A, Jaschinski U, Meier-Hellmann A, Weyland A, Grundling M, Moerer O, Riessen R, Seibel A, Ragaller M, Buchler MW, John S, Bach F, Spies C, Reill L, Fritz H, Kiehntopf M, Kuhnt E, Bogatsch H, Engel C, Loeffler M, Kollef MH, Reinhart K, Welte T (2012) Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial. JAMA : the journal of the American Medical Association 307: 2390-2399
Bruns T, Peter J, Reuken PA, Grabe DH, Schuldes SR, Brenmoehl J, Scholmerich J, Wiest R, Stallmach A (2012) NOD2 gene variants are a risk factor for culture-positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis. Liver Int 32: 223-230
Bruns T, Reuken PA, Fischer J, Berg T, Stallmach A (2012) Further evidence for the relevance of TLR2 gene variants in spontaneous bacterial peritonitis. J Hepatol 56: 1207-1208; author reply 1208-1209
Citiulo F, Jacobsen ID, Miramon P, Schild L, Brunke S, Zipfel P, Brock M, Hube B, Wilson D (2012) Candida albicans scavenges host zinc via Pra1 during endothelial invasion. PLoS Pathog 8: e1002777
Godfrey R, Arora D, Bauer R, Stopp S, Muller JP, Heinrich T, Bohmer SA, Dagnell M, Schnetzke U, Scholl S, Ostman A, Bohmer FD (2012) Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ. Blood 119: 4499-4511
Gonnert FA, Kunisch E, Gajda M, Lambeck S, Weber M, Claus RA, Bauer M, Kinne RW (2012) Hepatic Fibrosis in a Long-term Murine Model of Sepsis. Shock 37: 399-407
Gow NA, Hube B (2012) Importance of the Candida albicans cell wall during commensalism and infection. Current opinion in microbiology 15: 406-412
Grimm A, Günther A, Witte OW, Axer H (2012) Critical-Illness-Polyneuropathie und Critical-Illness-Myopathie. Medizinische Klinik, Intensivmedizin und Notfallmedizin 107: 649-659
Hartog CS, Winning J, Bauer M (2012) Volume replacement after trauma: an update. Swiss medical weekly 142: w13685
Jacobsen ID, Wilson D, Wachtler B, Brunke S, Naglik JR, Hube B (2012) Candida albicans dimorphism as a therapeutic target. Expert Rev Anti Infect Ther 10: 85-93
Jaenichen D, Brunkhorst FM, Strauss B, Rosendahl J (2012) [Physical and mental long-term sequelae following intensive care of severe sepsis in patients and relatives]. Psychotherapie, Psychosomatik, medizinische Psychologie 62: 335-343
Kleiman A, Hubner S, Rodriguez Parkitna JM, Neumann A, Hofer S, Weigand MA, Bauer M, Schmid W, Schutz G, Libert C, Reichardt HM, Tuckermann JP (2012) Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages. Faseb J 26: 722-729
Kotsaki A, Giamarellos-Bourboulis EJ (2012) Emerging drugs for the treatment of sepsis. Expert opinion on emerging drugs 17: 379-391
Kotzampassi K, Giamarellos-Bourboulis EJ (2012) Probiotics for infectious diseases: more drugs, less dietary supplementation. International journal of antimicrobial agents 40: 288-296
Lambeck S, Weber M, Gonnert FA, Mrowka R, Bauer M (2012) Comparison of sepsis-induced transcriptomic changes in a murine model to clinical blood samples identifies common response patterns. Front Microbiol 3: 284
Loesche W, Boettel J, Kabisch B, Winning J, Claus RA, Bauer M (2012) Do aspirin and other antiplatelet drugs reduce the mortality in critically ill patients? Thrombosis 2012: 720254
Mariappan A, Makarewicz O, Chen XH, Borriss R (2012) Two-component response regulator DegU controls the expression of bacilysin in plant-growth-promoting bacterium Bacillus amyloliquefaciens FZB42. Journal of molecular microbiology and biotechnology 22: 114-125
Mayer FL, Wilson D, Jacobsen ID, Miramon P, Slesiona S, Bohovych IM, Brown AJ, Hube B (2012) Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans. PloS one 7: e38584
Miramon P, Dunker C, Windecker H, Bohovych IM, Brown AJ, Kurzai O, Hube B (2012) Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress. PloS one 7: e52850
Muller S, Baldin C, Groth M, Guthke R, Kniemeyer O, Brakhage AA, Valiante V (2012) Comparison of transcriptome technologies in the pathogenic fungus Aspergillus fumigatus reveals novel insights into the genome and MpkA dependent gene expression. BMC genomics 13: 519
Neugebauer U, Grosse C, Bauer M, Kemper B, Barroso-Pena A, Bauwens A, Glueder M, Woerdemann M, Dewenter L, Denz C, Kloss S, Rosch P, Sabat A, Schutze K, Friedrich A, Bally GV, Popp J, Mellmann A (2012) From Infection to Detection: Imaging S. aureus - host interactions. Biomedizinische Technik Biomedical engineering 10.1515/bmt-2012-4284
Neugebauer U, Marz A, Henkel T, Schmitt M, Popp J (2012) Spectroscopic detection and quantification of heme and heme degradation products. Analytical and bioanalytical chemistry 404: 2819-2829
Otto GP, Kropf M, Sossdorf M, Recknagel P, Losche W, Rodel J, Claus RA, Busch M (2012) Screening for bacteremia in sepsis and renal failure using hemofilters for renal replacement therapy. Infection 10.1007/s15010-012-0372-0
Otto GP, Neugebauer S, Claus RA, Sossdorf M (2012) Arginine metabolism is markedly impaired in polymicrobial infected mice. Crit Care 16: 412
Otto GP, Sossdorf M, Boettel J, Kabisch B, Breuel H, Winning J, Losche W (2012) Effects of low-dose acetylsalicylic acid and atherosclerotic vascular diseases on the outcome in patients with severe sepsis or septic shock. Platelets 10.3109/09537104.2012.724482
Otto GP, Wissuwa B, Mehnert A, Marx S, Raessler M, Losche W, Claus RA, Sossdorf M (2012) A method for detection and quantification of hydroxyethyl starch in plasma. Crit Care 16: 426
Pletz MW, Ewig S, Lange C, Welte T, Hoffken G (2012) [Update pneumonia 2012]. Dtsch Med Wochenschr 137: 2265-2280; quiz 2281-2264
Quintin J, Saeed S, Martens JH, Giamarellos-Bourboulis EJ, Ifrim DC, Logie C, Jacobs L, Jansen T, Kullberg BJ, Wijmenga C, Joosten LA, Xavier RJ, van der Meer JW, Stunnenberg HG, Netea MG (2012) Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes. Cell host & microbe 12: 223-232
Ramoji A, Neugebauer U, Bocklitz T, Foerster M, Kiehntopf M, Bauer M, Popp J (2012) Toward a spectroscopic hemogram: Raman spectroscopic differentiation of the two most abundant leukocytes from peripheral blood. Analytical chemistry 84: 5335-5342
Rauchfuss F, Lambeck S, Claus RA, Ullmann J, Schulz T, Weber M, Katenkamp K, Guthke R, Bauer M, Settmacher U (2012) Sustained liver regeneration after portal vein embolization --a human molecular pilot study. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 44: 681-688
Recknagel P, Claus RA, Neugebauer U, Bauer M, Gonnert FA (2012) In vivo imaging of hepatic excretory function in the rat by fluorescence microscopy. J Biophotonics 7: 571-581
Recknagel P, Gonnert FA, Westermann M, Lambeck S, Lupp A, Rudiger A, Dyson A, Carre JE, Kortgen A, Krafft C, Popp J, Sponholz C, Fuhrmann V, Hilger I, Claus RA, Riedemann NC, Wetzker R, Singer M, Trauner M, Bauer M (2012) Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis. PLoS medicine 9: e1001338
Reinhart K, Bauer M, Riedemann NC, Hartog CS (2012) New approaches to sepsis: molecular diagnostics and biomarkers. Clinical microbiology reviews 25: 609-634
Requardt RP, Hirrlinger PG, Wilhelm F, Winkler U, Besser S, Hirrlinger J (2012) Ca(2)(+) signals of astrocytes are modulated by the NAD(+)/NADH redox state. Journal of neurochemistry 120: 1014-1025
Reuken PA, Bruns T, Zimmer B, Michael A, Brunkhorst FM, Pletz MW, Stallmach A (2012) Recurrent fever and bacteraemia after endoscopic variceal haemostasis with cyanoacrylate: a case report. Infection 40: 351-353
Reuken PA, Pletz MW, Baier M, Pfister W, Stallmach A, Bruns T (2012) Emergence of spontaneous bacterial peritonitis due to enterococci - risk factors and outcome in a 12-year retrospective study. Aliment Pharmacol Ther 35: 1199-1208
Richter F, Bauer R, Ebersberger A, Lehmenkuhler A, Schaible HG (2012) Enhanced neuronal excitability in adult rat brainstem causes widespread repetitive brainstem depolarizations with cardiovascular consequences. J Cereb Blood Flow Metab
Schmerler D, Neugebauer S, Ludewig K, Bremer-Streck S, Brunkhorst FM, Kiehntopf M (2012) Targeted metabolomics for discrimination of systemic inflammatory disorders in critically ill patients. Journal of lipid research 53: 1369-1375
Schmidt K, Mehlhorn J, Kausche S, Schmücker K, Thiel P, Heintze C, Brunkhorst FM, Gensichen J (2012) Postintensive Nachsorge in der Hausarztpraxis. Medical special 6: 10-11
Schmidt K, Thiel P, Mehlhorn J, Mueller F, Gensichen J (2012) Residuen kritischer Erkrankungen in der Hausarztpraxis. Intensiv- und Notfallbehandlung 37: 139-145
Schmitt M, Dietzek B, Neugebauer U, Krafft C, Rösch P, Popp J (2012) Raman-Spektroskopie - der Weg zu einer labelfreien biomedizinischen Diagnostik. Endo heute 25: 262-267
Schubert H, Eiselt M, Walter B, Fritz H, Brodhun M, Bauer R (2012) Isoflurane/nitrous oxide anesthesia and stress-induced procedures enhance neuroapoptosis in intrauterine growth-restricted piglets. Intensive Care Med 38: 1205-1214
Schwarzkopf D, Meissner W, Wedding U, Riedemann NC, Pfeifer R, Fritzenwanger M, Günther A, Egerland K, Henkel M, Skupin H, Muecke M, Hartog CS (2012) Kommunikation im Team und Burnout: Eine Befragung von intensiv- und palliativmedizinischen Pflegekräften und Ärzten zu Therapiebeschränkungen am Lebensende. Z Palliativmed 13: 293-300
Sobke A, Klinger M, Hermann B, Sachse S, Nietzsche S, Makarewicz O, Keller PM, Pfister W, Straube E (2012) The urinary antibiotic 5-nitro-8-hydroxyquinoline (Nitroxoline) reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Antimicrobial agents and chemotherapy 56: 6021-6025
Sponholz C, Huse K, Kramer M, Giamarellos-Bourboulis EJ, Claus RA, Kern A, Engel C, Kuhnt E, Kiehntopf M, Routsi C, Mylona V, Tsangaris I, Heinemann SH, Reinhart K, Platzer M, Bauer M (2012) Gene polymorphisms in the heme degradation pathway and outcome of severe human sepsis. Shock 38: 459-465
Stallmach A, Hagel S, Bruns T, Bauer M (2012) Zu kurz gedacht: Aufgaben fur die Nachwuchsforderung in der klinischen Forschung. [Cut a long story too short: Challenges in clinical research]. Dtsch Med Wochenschr 137: 496-500
Tierney L, Linde J, Muller S, Brunke S, Molina JC, Hube B, Schock U, Guthke R, Kuchler K (2012) An Interspecies Regulatory Network Inferred from Simultaneous RNA-seq of Candida albicans Invading Innate Immune Cells. Front Microbiol 3: 85
Tzepi IM, Giamarellos-Bourboulis EJ, Carrer DP, Tsaganos T, Claus RA, Vaki I, Pelekanou A, Kotsaki A, Tziortzioti V, Topouzis S, Bauer M, Papapetropoulos A (2012) Angiopoietin-2 enhances survival in experimental sepsis induced by multidrug-resistant Pseudomonas aeruginosa. The Journal of pharmacology and experimental therapeutics 343: 278-287
Vassilev T, Bauer M (2012) Passive immunotherapy of sepsis with intravenous immune globulin: not all IVIg preparations are created equal. Crit Care 16: 407
Wachtler B, Citiulo F, Jablonowski N, Forster S, Dalle F, Schaller M, Wilson D, Hube B (2012) Candida albicans-epithelial interactions: dissecting the roles of active penetration, induced endocytosis and host factors on the infection process. PloS one 7: e36952
Weber M, Lambeck S, Ding N, Henken S, Kohl M, Deigner HP, Enot DP, Igwe EI, Frappart L, Kiehntopf M, Claus RA, Kamradt T, Weih D, Vodovotz Y, Briles DE, Ogunniyi AD, Paton JC, Maus UA, Bauer M (2012) Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia. Faseb J 26: 2424-2436
Weimann A, Kern BR, Loffler M, Sablotzki A, Thiele F, Brunkhorst FM (2012) [Enrolment of intensive care patients in clinical studies : Ethical, legal and organizational problems from an interdisciplinary point of view.]. Medizinische Klinik, Intensivmedizin und Notfallmedizin 10.1007/s00063-012-0153-7
Wilson D, Citiulo F, Hube B (2012) Zinc exploitation by pathogenic fungi. PLoS Pathog 8: e1003034
Publikationen 2011
Axer H, Romeike BFM, Brunkhorst F, Zinke J, Ringer TM, Günther A (2011) Neurological sequelae of sepsis: II) Neuromuscular weakness. The Open Critical Care Medicine Journal 4: 8-14
Bruns T, Peter J, Hagel S, Herrmann A, Stallmach A (2011) The augmented neutrophil respiratory burst in response to Escherichia coli is reduced in liver cirrhosis during infection. Clinical and experimental immunology 164: 346-356
Bruns T, Peter J, Hagel S, Pfeifer R, Prinz P, Stallmach A (2011) Homozygous carrier of the NOD2 1007fs frame-shift mutation presenting with refractory community-acquired spontaneous bacterial peritonitis and developing fatal pulmonary mucormycosis: A case report. Hepatology research : the official journal of the Japan Society of Hepatology 41: 1009-1014
Gonnert FA, Recknagel P, Seidel M, Jbeily N, Dahlke K, Bockmeyer CL, Winning J, Losche W, Claus RA, Bauer M (2011) Characteristics of clinical sepsis reflected in a reliable and reproducible rodent sepsis model. The Journal of surgical research 170: e123-134
Hagel S, Brunkhorst F (2011) Sepsis. Intensivmed Notfmed 1: 57-73
Hagel S, Bruns T, Herrmann A, Stallmach A, Schmidt C (2011) Abnormal Glucose Tolerance: A Predictor Of 30-Day Mortality In Patients With Decompensated Liver Cirrhosis. Zeitschrift fur Gastroenterologie 49: 331-334
Kiehntopf M, Schmerler D, Brunkhorst FM, Winkler R, Ludewig K, Osterloh D, Bloos F, Reinhart K, Deufel T (2011) Mass spectometry-based protein patterns in the diagnosis of sepsis/systemic inflammatory response syndrome. Shock 36: 560-569
Ringer TM, Axer H, Romeike BFM, Zinke J, Brunkhorst F, Witte OW, Günther A (2011) Neurological sequelae of sepsis: I) Septic encephalopathy. The Open Critical Care Medicine Journal 4: 2-7
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