Allgemeines
Akronym: ROSISEP
Projektleiter: Dr. med. Andreas Finkensieper
Forschungsfeld: D Sepsisbedingtes Organversagen
Projektnummer: D1.8
Projektlaufzeit: 01.04.2011 bis 31.03.2013
Modul: Rotationsstelle
Projektbeschreibung
Sepsis has been defined as a systemic inflammatory response to infection. Patients with myocardial dysfunction have significantly higher mortality compared with septic patients without cardiovascular impairment. Myocardial dysfunction is a complication in patients with sepsis, and early recognition and aggressive supportive therapy are mandatory as mortality in patients with septic shock is still high The objective of this project is that septic plasma components (e.g. cytokines) potentially induce an imbalance of reactive oxygen species (ROS) and nitric oxide (NO) in isolated cardiomyocytes from mice as well as in differentiated beating clusters derived from embryonic stem cells (ES cells). We postulate that an inhibition of critical members of the NADPH oxidase family may protect cardiomyocytes during sepsis and attenuate the inflammatory process and circumvent septic myocardial dysfunction as well.
Aims in conclusion:
- Determine whether ROS are generated in cardiomyocytes as a result of circulating cytokines
- Identify the expression pattern of NADPH oxidase isoforms and NO-generating enzymes in cardiomyocytes derived from septic mice
- Identify factors and predictors that increase the prognosis of survival during septic organ failure
Kontakt
Tel. +49 (0)3641 - 9 32 41 39
Universitätsklinikum Jena
Universitäts-Herzzentrum
Klinik für Innere Medizin I
Erlanger Allee 101
07747 Jena