Long-term Cognitive and Functional Outcome of Survivors of Severe Sepsis following a computerized Cognitive Training
Acronym: Loss-Cog-Train
Principal Investigator: Prof. Dr. Farsin Hamzei
Research Area: E Long-term Sequelae
Project Number: E5.2
Duration: 01.07.2012 - 30.06.2015
Module: In-house Professorship Group
The Problem
Cognitive deficits have been described several years after an event of sepsis. The aim of this multicenter randomized controlled trial is to investigate the long-term effect of a computer-based cognitive training in severe sepsis survivors.
Preparative work for the funding period and working plan
Different aspects of cognition, like alertness, memory, visual constructive function, executive cognitive function and speech will be evaluated. The scores of each test are normalized by using gender, education and age specific values and expressed in percent of the normal status. A “Global Index Score” will be calculated as mean of the individual test scores. These tests will be evaluated at time point t0 (= at time point of admission to the post-acute rehabilitation centers) and six weeks after admission to the rehabilitation centers (t1). At this time point, patients will be screened for eligibility, and randomized to intervention group (IG) and control group (CG). We expect that three months of cognitive training in IG will improve cognitive function in comparison to CG. Cognitive function and functional disability will be evaluated in IG and CG a three months after randomization (t2 = immediately after the end of intervention) in order to demonstrate short-term effects of therapy and 12 months after randomization to assess long term effects of therapy (= t3).
Contact
Tel. +49 (0)36601 - 49 471
Moritz Klinik GmbH & Co. KG
Hermann-Sachse-Straße 46
07639 Bad Klosterlausnitz