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Gross M, Mkrtchyan H, Glaser M, Fricke HJ, Höffken K, Heller A, Weise A, Liehr T. Delineation of yet unknown cryptic subtelomere aberrations in 50% of acute myeloid leukemia with normal GTG-banding karyotype. Int J Oncol 2009, 34:417-423.
Manvelyan M, Kempf P, Weise A, Mrasek K, Heller A, Lier A, Höffken K, Fricke H-J, Sayer HG, Liehr T, Mkrtchyan H. Preferred co-localization of chromosome 8 and 21 in myeloid bone marrow cells detected by three dimensional molecular cytogenetics. Int J Mol Med 2009, 24:335-341.
2008
Scholl S, Theuer C, Scheble V, Kunert C, Heller A, Mügge LO, Fricke HJ, Höffken K, Wedding U. Clinical impact of nucleophosmin mutations and Flt3 internal tandem duplications in patients older than 60 yr with acute myeloid leukaemia. Eur J Haematol. 2008 Mar;80(3):208-15.
2006
Liehr T, Starke H, Heller A, Kosyakova N, Mrasek K, Gross M, Karst C, Steinhaeuser U, Hunstig F, Fickelscher I, Kuechler A, Trifonov V, Romanenko SA, Weise A. Multicolor fluorescence in situ hybridization (FISH) applied to FISH-banding. Cytogenet Genome Res. 2006;114(3-4):240-4.
2005
Schreyer I, Neumann A, Beensen V, Eichhorn KH, Heller A, Claussen U, Liehr T. Dup(13)(q14.2-q14.3): yet another new differential diagnostic aspect for short stature-like phenotype. J Histochem Cytochem. 2005, Vol 53, pp 365-366.
Karst C, Heller A, Claussen U, Gebhart E, Liehr T. Detection of cryptic chromosomal aberrations in the in vitro non-proliferating cells of acute myeloid leukemia. Int J Oncol. 2005, Vol 27, pp 355-359.
Macedo Silva ML, Land M, Heller A, Abdelhay E, do Socorro Pombo-de-Oliveira M, Ribeiro R, Alves G, Lerner D, Liehr T. New rearrangement t(3;17)(q26.3;q12) in an AML patient with a poor outcome. Oncol Rep. 2005, Vol. 14, pp 663-666.
Rodriguez L, Starke H, Guardia NM, Tonnies H, Neitzel H, Kozlowski P, Mazauric ML, Heller A, Grondona FL, Mansilla E, Santos Munoz MJ, Liehr T, Martinez-Frias ML.Three new cases with a supernumerary ring chromosome 1. Clin Dysmorphol. 2005 Oct;14(4):169-75.
2004
Heller A, Fricke HJ, Starke H, Loncarevic IF, Claussen U, Liehr T. Characterization of a highly aberrant plasma cell leukemia karyotype: a case report. Oncolocy reports. 2004, Vol 11, pp 89-92.
Heller A, Loncarevic IF, Glaser M, Gebhart E, Trautmann U, Claussen U, Liehr T. Breakpoint differentiation in chromosomal aberrations of hematological malignancies - Identification of 33 previously unrecorded breakpoints. Int J Onc. 2004, Vol 24, pp 127-136.
Lehrer H, Weise A, Michel S, Starke H, Mrasek K, Heller A, Kuechler A, Claussen U, Liehr T.The hierarchically organized splitting of chromosome bands into sub-bands analyzed by multicolor banding (MCB). Cytogenet Genome Res. 2004;105(1):25-8.
Zumkeller W, Volleth M, Muschke P, Tönnies H, Heller A, Liehr T, Wieacker P, Stumm M. Genotype / phenotype analysis in a patient with pure and complete trisomy 12p. J Med Genet. 2004, Vol 129A, pp 261-264.
Liehr T, Heller A, Eichhorn KH, Beensen V, Schulze E, Starke H, Claussen U, Schreyer I. Inherited cryptic chromosomal aberrations may be more easily detected in their balanced forms: a case report with hidden der(1)t(1;17)(q44;p13.2). Prenat Diagn. 2004 Dec 15;24(12):1022-4.
2003
Starke H, Mitulla B, Nietzel A, Heller A, Beensen V, Grosswendt G, Claussen U, von Eggeling F, Liehr T.First patient with trisomy 21 accompanied by an additional der(4)(:p11 --> q11:) plus partial uniparental disomy 4p15-16. Am J Med Genet A. 2003 Jan 1;116(1):26-30
Nietzel A, Albrecht B, Starke H, Heller A, Gillessen-Kaesbach G, Claussen U, Liehr T.Partial hexasomy 15pter-->15q13 including SNRPN and D15S10: first molecular cytogenetically proven case report. J Med Genet. 2003 Mar;40(3):e28. No abstract available
Liehr T, Starke H, Heller A, Weise A, Beensen V, Senger G, Kittner G, Prechtel M, Claussen U, Seidel J. Evidence for a new microdeletion syndrome in 15q21. Int J Mol Med 2003, Vol. 11, pp 575-577.
Trifonov V, Seidel J, Starke H, Martina P, Beensen V, Ziegler M, Hartmann I, Heller A, Nietzel A, Claussen U, Liehr T.Enlarged chromosome 13 p-arm hiding a cryptic partial trisomy 6p22.2-pter. Prenat Diagn. 2003 May;23(5):427-30.
Heller A, Rubtsov N, Kytola S, Karamysheva TV, Sablina OV, Degtyareva MM, Starke H, Metzke H, Claussen U, Liehr T. Highly complex karyotypic changes in acute myelogenous leukemia: a case report. Int J Oncol 2003, Vol. 23, pp 139-143.
Seidel J, Heller A, Senger G, Starke H, Chudoba I, Kelbova C , Tönnies H, Neitzel H, Haase C, Beensen V, Zintl F, Claussen U, Liehr T. A multiple translocation event in a patient with hexadactyly, facial dysmorphism, mental retardation and behavior disorder characterized comprehensively by molecular cytogenetics - Case report and review of the literature. Eur J Pediatr. 2003, Vol 162, pp 582-588.
Mrasek K, Heller A, Rubtsov N, Trifonov V, Starke H, Claussen U, Liehr T. Detailed Hylobates lar karyotype definied by 25-color FISH and multicolor banding (MCB). Int J Mol Med. 2003, Vol 12, pp 139-46.
Liehr T, Ziegler M, Starke H, Heller A, Kuechler A, Kittner G, Beensen V, Seidel J, Hassler H, Musebeck J, Claussen U.Conspicuous GTG-banding results of the centromere-near region can be caused by alphoid DNA heteromorphism. Clin Genet. 2003 Aug;64(2):166-7.
Starke H, Mitulla B, Beensen V, Trifonov V, Rubtsov N, Heller A, Ziegler M, Neumann A, Claussen U, Liehr T.First postnatal case of mosaic del(22)/r(22). Prenat Diagn. 2003 Sep;23(9):765-7
Starke H, Nietzel A, Weise A, Heller A, Mrasek K, Belitz B, Kelbova C, Volleth M, Albrecht B, Mitulla B, Trappe R, Bartels I, Adolph S, Dufke A, Singer S, Stumm M, Wegner RD, Seidel J, Schmidt A, Küchler A, Schreyer I, Claussen U, von Eggeling F, Liehr T. Small supernumerary marker chromosomes (SMC): genotype - phenotype correlation and classification. Hum Genet. 2003, Vol 114, pp 51-67.
Heller A, Brecevic L, Glaser M, Loncarevic IF, Gebhart E, Claussen U, Liehr T. Trisomy 8 as the sole chromosomal aberration in myelocytic mailgnancies: a comprehensive molecular cytogenetic analysis reveals no cryptic aberrations. Cancer Genet Cytogenet. 2003, Vol 146, pp 81-83.
Heller A, Trifonov V, Rubtsov N, Sauerbrey A, Starke H, Loncarevic IF, Claussen U, Liehr T. Complex chromosomal rearrangements in a secondary acute myeloblastic leukemia after chemotherapy in TRAPS. Int J Onc. 2003, Vol 19, pp 1789-1792.
Oliver-Bonet M, Liehr T, Nietzel A, Heller A, Starke H, Claussen U, Codina-Pascual M, Pujol A, Abad C, Egozcue J, Navarro J, Benet J.Karyotyping of human synaptonemal complexes by cenM-FISH. Eur J Hum Genet. 2003 Nov;11(11):879-83
Weise A, Heller A, Starke H, Mrasek K, Kuechler A, Pool-Zobel BL, Claussen U, Liehr T.Multitude multicolor chromosome banding (mMCB) - a comprehensive one-step multicolor FISH banding method. Cytogenet Genome Res. 2003;103(1-2):34-9
Liehr T, Nietzel A, Starke H, Heller A, Weise A, Kuechler A, Senger G, Ebner S, Martin T, Stumm M, Wegner R, Tonnies H, Hoppe C, Claussen U, Von Eggeling F.Characterization of Small Marker Chromosomes (SMC) by Recently Developed Molecular Cytogenetic Approaches. J Assoc Genet Technol. 2003;29(1):5-10
2002
Liehr T, Heller A, Starke H, Rubtsov N, Trifonov V, Mrasek K, Weise A, Kuechler A, Claussen U. Microdissection based high resolution multicolor banding (MCB) for all 24 human chromosomes. Int J Mol Med 2002, Vol 9, pp 335-339.
Weise A, Starke H, Heller A, Uwe C, Liehr T.Evidence for interphase DNA decondensation transverse to the chromosome axis: a multicolor banding analysis. Int J Mol Med. 2002 Apr;9(4):359-61
Liehr T, Schmidt M, Starke H, Ziegler M, Kittner G, Heller A, Rubtsov N, Trifonov V, Claussen U. First case of trisomy 13 plus mosaic trisomy 1q. Fet Diag Ther 2002, Vol. 17, pp133-136.
Loncarevic IF, Römer J, Starke H, Heller A, Bleck C, Ziegler M, Fiedler W, Liehr T, Clement JH, Claussen U. Heterogenic molecular basis for loss of ABL1-BCR transcription: Deletions in der(9)t(9;22) and variants of standard t(9;22) in BCR-ABL1-positive chronic myeloid leukemia. Genes Chr Cancer 2002, Vol. 34, pp 193-200.
Heller A, Starke H, Trifonov V, Rubtsov N, Wedding U, Loncarevic IF, Bleck C, Claussen U, Liehr T. A complex translocation event between the two homologues of chromosomes 5 leading to a del(5)(q21q33) as a sole aberration in a case clinically diagnosed as CML - characterization of the aberration by multicolor banding (MCB). Int J Oncol 2002, Vol. 20, pp 1179-1181.
Weise A, Starke H, Heller A, Tonnies H, Volleth M, Stumm M, Gabriele S, Nietzel A, Claussen U, Liehr T. Chromosome 2 aberrations in clinical cases characterised by high resolution multicolour banding and region specific FISH probes. J Med Genet. 2002 Jun;39(6):434-9
Liehr T, Schreyer I, Neumann A, Beensen V, Ziegler M, Hartmann I, Starke H, Heller A, Nietzel A, Claussen U.Two more possible pitfalls of rapid prenatal diagnostics using interphase nuclei. Prenat Diagn. 2002 Jun;22(6):497-9
Bandyopadhyay R, Heller A, Knox-DuBois C, McCaskill C, Berend SA, Page SL, Shaffer LG. Parental origin and timing of de novo Robertsonian translocation formation. Am J Hum Genet 2002; Vol. 71, pp 1456-1462.
Liehr T, Weise A, Heller A, Starke H, Mrasek K, Kuechler A, Weier HU, Claussen U. Multicolor chromosome banding (MCB) with YAC/BAC-based probes and region-specific microdissection DNA libraries. Cytogenet Genome Res 2002, Vol. 97, pp 43-50.
Starke H, Seidel J, Henn W, Reichardt S, Volleth M, Stumm M, Behrend C, Sandig KR, Kelbova C, Senger G, Albrecht B, Hansmann I, Heller A, Claussen U, Liehr T.Homologous sequences at human chromosome 9 bands p12 and q13-21.1 are involved in different patterns of pericentric rearrangements. Eur J Hum Genet. 2002 Dec;10(12):790-800.
Publikationen ehem. Mitarbeiter
Characteristic chromosomal imbalances in pediatric pheochromocytoma. Hering A., Guratowska M., Bucsky P., Claussen U., Decker J., Ernst G., Hoeppner W., Michel S., Neumann HP., Parlowsky T., Loncarevic IF., Genes Chromosomes and Cancer 2006
ATRA can enhance apoptosis that is induced by Flt3 tyrosine kinase inhibition in Flt3-ITD positive cells. Scholl S, Muller R, Clement JH, Loncarevic IF, Bohmer FD, Hoffken K. Leuk Res. 2006 Feb 10
Minimal residual disease based on patient specific Flt3-ITD and -ITT mutations in acute myeloid leukemia. Scholl S, Loncarevic IF, Krause C, Kunert C, Clement JH, Hoffken K. Leuk Res. 2005 Jul;29(7):849-53.
Specific detection of Flt3 point mutations by highly sensitive real-time polymerase chain reaction in acute myeloid leukemia. Scholl S, Krause C, Loncarevic IF, Muller R, Kunert C, Wedding U, Sayer HG, Clement JH, Hoffken K. J Lab Clin Med. 2005 Jun;145(6):295-304.
Analyses of minimal residual disease based on Flt3 mutations in allogeneic peripheral blood stem cell transplantation. Scholl S, Loncarevic IF, Krause C, Clement JH, Hoffken K, Sayer HG. J Cancer Res Clin Oncol. 2005 May; 131(5):279-83
Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence. Taudien S, Galgoczy P, Huse K, Reichwald K, Schilhabel M, Szafranski K, Shimizu A, Asakawa S, Frankish A, Loncarevic IF, Shimizu N, Siddiqui R, Platzer M. BMC Genomics. 2004 Dec 10;5(1):92.
Characterization of a highly aberrant plasma cell leukemia karyotype: a case report. Heller A, Fricke HJ, Starke H, Loncarevic IF, Claussen U, Liehr T. Oncol Rep. (2004) Jan;11(1):89-92.
Breakpoint differentiation in chromosomal aberrations of hematological malignancies: Identification of 33 previously unrecorded breakpoints. Heller A, Loncarevic IF, Glaser M, Gebhart E, Trautmann U, Claussen U, Liehr T,Int J Oncol. 2004 Jan;24(1):127-36
Interphase FISH assay for the detection of rearrangements of the EVI-1 locus in chromosome band 3q26 in myeloid leukemia. Wieser R, Schreiner U, Rieder H, Pirc-Danoewinata H, Grüner H, Knopp A, Loncarevic IF, Fonatsch C, Hematologica (2003) 88: 01 27-31
A complex translocation event between the two homologues of chromosomes 5 leading to a del(5)(q21q33) as a sole aberration in a case clinically diagnosed as CML: Characterization of the aberration by multicolor banding. Heller A, Starke H, Trifonov V, Rubtsov N, Wedding U, Loncarevic IF, Bleck C, Claussen U, Liehr T, Int J Oncol (2002) 20:1179-1181
Heterogenic molecular basis for loss of ABL1-BCR transcription: deletions in der(9)t(9;22) and variants of standard t(9;22) in BCR-ABL1 positive Chronic Myeloid Leukemia. Loncarevic IF, Römer J, Starke H, Heller A, Bleck C, Ziegler M, Fiedler W, Liehr T, Clement HJ, Claussen U, Genes Chromosome and Cancer (2002) 34: 193-200
Improved definition of chromosomal breakpoints using high- resolution multicolour banding. Lemke J, Chudoba I, Senger G, Stumm M, Loncarevic IF, Henry C, Zabel B, Claussen U, Human Genetics (2002) 108:478-483
Molecular cytogenetic characterization of an acquired minute supernumerary marker chromosome as the sole abnormality in a case clinically diagnosed as atypical Philadelphia-negative chronic myelogenous leukaemia. Starke H, Raida M, Trifonov V, Clement JH, Loncarevic IF, Heller A, Bleck C, Nietzel A, Rubtsov N, Claussen U, Liehr T, British Journal Of Haematology (2001) 113:435-438
A long distance-PCR derived FISH probe detects a deletion between p15 and p16 in CML and T-ALL patients. Bleichert A, Fiedler W, Claussen U, Ernst G, Loncarevic IF, Heller A, Liehr T, Kunert C, Von Eggeling F, International Journal Of Molecular Medicine (2001) 7:591-595
A new multicolor-FISH approach for the characterization of marker chromosomes: centromere-specific multicolor-FISH (cenM-FISH). Nietzel A, Rocchi M, Starke H, Heller A, Fiedler W, Wlodarska I, Loncarevic IF, Beensen V, Claussen U, Liehr T, Humen Genetics (2001) 108:199-204
Two-photon multicolor FISH: A verstile techniqe to detect specific sequences within singe DNA molecules in cells and tissues. König K, Göhlert A, Liehr T, Loncarevic IF, Riemann I, Single Molecules (2000) 1:41-51
The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q. Borkhardt A, Bojesen S, Haas OA, Fuchs U, Bartelheimer D, Loncarevic IF, Bohle RM, Harbott J, Repp R, Jaeger U, Viehmann S, Henn T, Korth P, Scharr D, Lampert F, PNAS (2000) 97:9168-9173
Trisomy 21 is a recurrent secondary aberration in childhood acute lymphoblastic leukemia with TEL/AMLI gene fusion. Loncarevic IF, Roitzheim B, Ritterbach J, Viehmann S, Borkhardt A, Lampert F, Harbott L, Genes Chromosomes & Cancer (1999) 24:272-277
Mutations on free and integrated Hepatitis-B virus-DNA in a hepatocellular carcinoma - footprints of homologous recombination. Georgi-Geisberger P, Berns H, Loncarevic IF, Yu ZY, Tang ZY, Zentgraf H, Schroeder CH, Oncology (1992) 49:386-395
A new cAMP responsive element in the transcribed region of the human c-fos gene. Haertig E, Loncarevic IF, Buescher M, Herrlich P, Rahmsdorf HJ, Nucleic Acids Research (1991) 19:4153-4159
Resection of hepatocellular carcinoma - oligocentric origin of recurrent and multinodular tumors. Liang XH, Loncarevic IF, Tang ZY, Yu YQ, Zentgraf H, Schroeder CH, Journal Of Gastroenterology And Hepatology (1991) 6:77-80
Mous monoclonal-antibody directed against Hepatitis-B virus X-protein synthesized in escherichia coli - detection of reactive antigen in liver cell carcinoma and chronic hepatitis. Zentgraf H, Herrmann G, Klein R, Schranz P, Loncarevic IF, Herrmann D, Huebner K, Schroeder CH, Oncology (1990) 47:143-&
Sequence of a replication competent Hetatitis-B virus genome with a preX open reading frame. Loncarevic IF, Zentgraf H, Schröder CH, Nucleic Acids Research (1990) 18:4940-4940
Replication of Hepatitis-B virus in a hepatocellular carcinoma. Loncarevic IF, Schranz P, Zentgraf H, Liang XH, Herrmann G, Tang ZY, Schröder CH, Virology (1990) 174:158-168
Defective replication untis of Hepatitis-B virus. Schranz P, Zentgraf H, Loncarevic IF, Niepmann M, Schroeder CH, Journal Of Virology (1990) 64:1851-1854
Herstellung von Nukleinsäureproben und ihr Einsatz in der in situ-Hybridisierung. Herrmann G, Herrmann D, Loncarevic IF, mta (1989) 11, 1013-1019.
ATRA can enhance apoptosis that is induced by Flt3 tyrosine kinase inhibition in Flt3-ITD positive cells. Scholl S, Muller R, Clement JH, Loncarevic IF, Bohmer FD, Hoffken K. Leuk Res. (2006) May;30(5):633-42.
Molecular heterogeneity of t(11;17) translocations in leukemia. Sabine Strehl, Margit König, Claus Meyer, Jochen Harbott, Ulrich Jäger, Anne von Bergh, Ivan F. Loncarevic, Marie Jarosova, Helmut Schmidt, Steven D.P. Moore, Rolf Marschalek, Oskar A. Haas Genes Chromosomes Cancer (2006) Nov;45(11):1041-9
Immune escape for renal cell carcinoma: CD70 mediates apoptosis in lymphocytes. Diegmann J, Junker K, Loncarevic IF, Michel S, Schimmel B, von Eggeling F. Neoplasia. (2006) Nov;8(11):933-8.
Molecular heterogeneity of t(11;17) translocations in leukemia. Sabine Strehl, Margit König, Claus Meyer, Jochen Harbott, Ulrich Jäger, Anne von Bergh, Ivan F. Loncarevic, Marie Jarosova, Helmut Schmidt, Steven D.P. Moore, Rolf Marschalek, Oskar A. Haas Genes Chromosomes Cancer (2006) Nov;45(11):1041-9.
Buchbeiträge
A Nietzel, A Heller, H Starke, T Liehr. Centromere-specific multicolor-FISH (cenM-FISH). In: FISH-Technology, Springer-labmanual, Springer, Berlin, 2002, pp 425-431, ISBN: 3-540-67276-1.
T Liehr, A Nietzel, M Rocchi, A Heller, H Starke, U Claussen, F v Eggeling. Centromere-specific multicolor-FISH (cenM-FISH) followed by analysis for uniparental disomy - a useful tool in prenatal diagnosis. In: Early prenatal diagnosis, fetal cells and DNA in the mother - present state and perpectives. The Karolinum Press, Prag, 2002, pp 293-300, ISBN: 80-246-0397-7.
reviews
T Liehr, A Heller, H Starke, U Claussen. Fluorescence in situ hybridization (FISH) banding methods - applications in research and diagnostic. Expert Review of Molecular Diagnostics 2002, Vol 2, pp 217-225.
Liehr T, Starke H, Heller A, Kosyakova N, Mrasek K, Gross M, Karst C, Steinhaeuser U, Hunstig F, Fickelscher I, Kuechler A, Trifonov V, Romanenko SA, Weise A. Multicolor fluorescence in situ hybridization (FISH) applied to FISH-banding. Cytogenet Genome Res. 2006;114(3-4):240-4. Review