Medical Scientist-Programm 2022

Thema: "Impact of altered ER homeostasis on Golgi structure and function"

Zusammenfassung:
Many genes encoding structural components of the endoplasmic reticulum (ER), such as ARL6IP1 or FAM134B mutations, are associated with neurodegenerative disorders. Both FAM134B and ARL6IP1 are ER resident proteins, which play a major role for ER structure and ER turnover. Because the ER and the Golgi apparatus are closely interdependent and because of our preliminary data on FAM134B, we here hypothesize that a compromised ER structure can impact on the structure and function of the Golgi apparatus. So far, little attention has been paid to this connection. Therefore, we propose to study the consequences of disruption of the ER proteins FAM134B and ARL6IP1 on Golgi structure, function and the Golgi stress response. Moreover, we will assess whether ER stress inhibitors have an effect on Golgi structure and function.