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Klinik für Psychiatrie und Psychotherapie
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Klinik für Psychiatrie und Psychotherapie / Forschung / Arbeitsgruppen / Structural Brain Mapping

Structural Brain Mapping

Prof. Dr. Christian Gaser

About

Our research program is directed toward the development of advanced computation tools for the analysis of structural brain data that are applied among others to investigate training-induced brain plasticity and identifying influencing factors on brain ageing. We are developing algorithms and tools for processing voxel- and surface-based imaging data which encompasses segmentation, surface reconstruction, and disease prediction. Our Computational Anatomy Toolbox for voxel- and surface-based morphometry is widely used in the scientific community (>40000 downloads).

Team 

  • Dr. Katja Franke
  • Dr. Robert Dahnke
  • Tannaz Saraei
  • Polona Kalc

Projects

Personalized aging pattern for early risk detection and prevention of cognitive impairment and dementia in cognitively healthy individuals (Pattern-Cog)Pattern-cog – Personalised ageing pattern for early risk detection and prevention of cognitive impairment and dementia in cognitively healthy individuals

Age-dependent impact of physical activity on gut-brain axis in humans (SMARTAGE)
https://www.uniklinikum-jena.de/etnsmartage/en

Identification and manipulation of the psychosomatic clocks of the lifespan (IMPULS)
https://www.uni-jena.de/201008_Alternsforschung_IMPULS

Computational Anatomy Toolbox (CAT12)
http://neuro.uni-jena.de/cat

Publications

  • Besteher B, Machnik M, Troll M, Toepffer A, Zerekidze A, Rocktäschel T, Heller C, Kikinis Z, Brodoehl S, Finke K, Reuken PA, Opel N, Stallmach A, Gaser C, Walter M. Larger gray matter volumes in neuropsychiatric long-COVID syndrome Psychiatry Res. 2022 Nov;317:114836. doi: 10.1016/j.psychres.2022.114836. Epub 2022 Sep 6.
  • Bittner N, Jockwitz C, Franke K, Gaser C, Moebus S, Bayen UJ, Amunts K, Caspers S. When your brain looks older than expected: combined lifestyle risk and BrainAGE Brain Struct Funct. 2021 Apr;226(3):621-645. doi: 10.1007/s00429-020-02184-6. Epub 2021 Jan 10.
  • Broessner G, Ellerbrock I, Menz MM, Frank F, Verius M, Gaser C, May A. Repetitive T1 Imaging Influences Gray Matter Volume Estimations in Structural Brain Imaging Front Neurol. 2021 Oct 28;12:755749. doi: 10.3389/fneur.2021.755749. eCollection 2021.
  • Bussas M, Grahl S, Pongratz V, Berthele A, Gasperi C, Andlauer T, Gaser C, Kirschke JS, Wiestler B, Zimmer C, Hemmer B, Mühlau M. Gray matter atrophy in relapsing-remitting multiple sclerosis is associated with white matter lesions in connecting fibers Mult Scler. 2022 May;28(6):900-909. doi: 10.1177/13524585211044957. Epub 2021 Sep 30.
  • Cherbuin N, Walsh EI, Shaw M, Luders E, Anstey KJ, Sachdev PS, Abhayaratna WP, Gaser C. Optimal Blood Pressure Keeps Our Brains Younger Front Aging Neurosci. 2021 Oct 5;13:694982. doi: 10.3389/fnagi.2021.694982. eCollection 2021.
  • Delvecchio G, Maggioni E, Pigoni A, Crespo-Facorro B, Nenadić I, Benedetti F, Gaser C, Sauer H, Roiz-Santiañez R, Poletti S, Rossetti MG, Bellani M, Perlini C, Ruggeri M, Diwadkar VA, Brambilla P. Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study Front Aging Neurosci. 2021 Feb 5;13:622054. doi: 10.3389/fnagi.2021.622054. eCollection 2021.
  • Draganski B, Gaser C, Busch V, Schuierer G, Bogdahn U, May A (2004) Neuroplasticity: changes in grey matter induced by training. Nature 427(6972):311-2.
  • Draganski B, Gaser C, Kempermann G, Kuhn HG, Winkler J, Büchel C, May A (2006) Temporal and spatial dynamics of brain structure changes during extensive learning. J Neurosci. 26(23):6314-7.
  • Evermann U, Gaser C, Meller T, Pfarr JK, Grezellschak S, Nenadić I. Nonclinical psychotic-like experiences and schizotypy dimensions: Associations with hippocampal subfield and amygdala volumes Hum Brain Mapp. 2021 Oct 15;42(15):5075-5088. doi: 10.1002/hbm.25601. Epub 2021 Jul 24.
  • Fisch L, Leenings R, Winter NR, Dannlowski U, Gaser C, Cole JH, Hahn T. Editorial: Predicting Chronological Age From Structural Neuroimaging: The Predictive Analytics Competition 2019 Front Psychiatry. 2021 Aug 5;12:710932. doi: 10.3389/fpsyt.2021.710932. eCollection 2021.
  • Franke K, Ziegler G, Klöppel S, Gaser C; Alzheimer's Disease Neuroimaging Initiative (2010) Estimating the age of healthy subjects from T1-weighted MRI scans using kernel methods: exploring the influence of various parameters. Neuroimage 50(3):883-92.
  • Franke K., Gaser C. Ten Years of BrainAGE as a Neuroimaging Biomarker of Brain Aging: What Insights Have We Gained? (2019) Front Neurol 10:789.
  • Garo-Pascual M, Gaser C, Zhang L, Tohka J, Medina M, Strange BA. Brain structure and phenotypic profile of superagers compared with age-matched older adults: a longitudinal analysis from the Vallecas Project Lancet Healthy Longev. 2023 Aug;4(8):e374-e385. doi: 10.1016/S2666-7568(23)00079-X. Epub 2023 Jul 13.
  • Gaser C, Franke K, Klöppel S, Koutsouleris N, Sauer H; Alzheimer's Disease Neuroimaging Initiative (2013) BrainAGE in Mild Cognitive Impaired Patients: Predicting the Conversion to Alzheimer's Disease. PLoS One 8(6):e67346.
  • Gaser C, Schlaug G (2003) Brain structures differ between musicians and non-musicians. J Neurosci. 23(27):9240-5.
  • Gaser C, Volz HP, Kiebel S, Riehemann S, Sauer H (1999) Detecting structural changes in whole brain based on nonlinear deformations-application to schizophrenia research. Neuroimage 10(2):107-13.
  • Giannakopoulos P, Montandon ML, Herrmann FR, Hedderich D, Gaser C, Kellner E, Rodriguez C, Haller S. Alzheimer resemblance atrophy index, BrainAGE, and normal pressure hydrocephalus score in the prediction of subtle cognitive decline: added value compared to existing MR imaging markers Eur Radiol. 2022 Nov;32(11):7833-7842. doi: 10.1007/s00330-022-08798-0. Epub 2022 Apr 29.
  • Glutig K, Lange L, Krüger PC, Gräger S, de Vries H, Brandl U, Gaser C, Mentzel HJ. Differences in Cerebellar Volume as a Diagnostic and Prognostic Biomarker in Children and Adolescents With Epilepsy of Unknown Etiology J Child Neurol. 2022 Dec;37(12-14):939-948. doi: 10.1177/08830738221114241. Epub 2022 Sep 15.
  • Grahl S, Bussas M, Wiestler B, Eichinger P, Gaser C, Kirschke J, Zimmer C, Berthele A, Hemmer B, Mühlau M. Differential Effects of Fingolimod and Natalizumab on Magnetic Resonance Imaging Measures in Relapsing-Remitting Multiple Sclerosis Neurotherapeutics. 2021 Oct;18(4):2589-2597. doi: 10.1007/s13311-021-01118-2. Epub 2021 Sep 24.
  • Gull S, Gaser C, Herrmann KH, Urbach A, Boehme M, Afzal S, Reichenbach JR, Witte OW, Schmidt S. Brain Macro-Structural Alterations in Aging Rats: A Longitudinal Lifetime Approach Cells. 2023 Jan 28;12(3):432. doi: 10.3390/cells12030432.
  • Hahn T, Ernsting J, Winter NR, Holstein V, Leenings R, Beisemann M, Fisch L, Sarink K, Emden D, Opel N, Redlich R, Repple J, Grotegerd D, Meinert S, Hirsch JG, Niendorf T, Endemann B, Bamberg F, Kröncke T, Bülow R, Völzke H, von Stackelberg O, Sowade RF, Umutlu L, Schmidt B, Caspers S, Kugel H, Kircher T, Risse B, Gaser C, Cole JH, Dannlowski U, Berger K. An uncertainty-aware, shareable, and transparent neural network architecture for brain-age modeling Sci Adv. 2022 Jan 7;8(1):eabg9471. doi: 10.1126/sciadv.abg9471. Epub 2022 Jan 5.
  • Hedderich DM, Menegaux A, Schmitz-Koep B, Nuttall R, Zimmermann J, Schneider SC, Bäuml JG, Daamen M, Boecker H, Wilke M, Zimmer C, Wolke D, Bartmann P, Sorg C, Gaser C. Increased Brain Age Gap Estimate (BrainAGE) in Young Adults After Premature Birth Front Aging Neurosci. 2021 Apr 1;13:653365. doi: 10.3389/fnagi.2021.653365. eCollection 2021.
  • Jamalabadi H, Zuberer A, Kumar VJ, Li M, Alizadeh S, Amani AM, Gaser C, Esterman M, Walter M. The missing role of gray matter in studying brain controllability Netw Neurosci. 2021 Mar 1;5(1):198-210. doi: 10.1162/netn_a_00174. eCollection 2021.
  • Jawinski P, Markett S, Drewelies J, Düzel S, Demuth I, Steinhagen-Thiessen E, Wagner GG, Gerstorf D, Lindenberger U, Gaser C, Kühn S. Linking Brain Age Gap to Mental and Physical Health in the Berlin Aging Study II Front Aging Neurosci. 2022 Jul 22;14:791222. doi: 10.3389/fnagi.2022.791222. eCollection 2022.
  • Kirschner M, Hodzic-Santor B, Antoniades M, Nenadic I, Kircher T, Krug A, Meller T, Grotegerd D, Fornito A, Arnatkeviciute A, Bellgrove MA, Tiego J, Dannlowski U, Koch K, Hülsmann C, Kugel H, Enneking V, Klug M, Leehr EJ, Böhnlein J, Gruber M, Mehler D, DeRosse P, Moyett A, Baune BT, Green M, Quidé Y, Pantelis C, Chan R, Wang Y, Ettinger U, Debbané M, Derome M, Gaser C, Besteher B, Diederen K, Spencer TJ, Fletcher P, Rössler W, Smigielski L, Kumari V, Premkumar P, Park HRP, Wiebels K, Lemmers-Jansen I, Gilleen J, Allen P, Kozhuharova P, Marsman JB, Lebedeva I, Tomyshev A, Mukhorina A, Kaiser S, Fett AK, Sommer I, Schuite-Koops S, Paquola C, Larivière S, Bernhardt B, Dagher A, Grant P, van Erp TGM, Turner JA, Thompson PM, Aleman A, Modinos G. Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study Mol Psychiatry. 2022 Feb;27(2):1167-1176. doi: 10.1038/s41380-021-01359-9. Epub 2021 Oct 27.
  • Koutsouleris N, Meisenzahl EM, Davatzikos C, Bottlender R, Frodl T, Scheuerecker J, Schmitt G, Zetzsche T, Decker P, Reiser M, Möller HJ, Gaser C (2009) Use of neuroanatomical pattern classification to identify subjects in at-risk mental states of psychosis and predict disease transition. Arch Gen Psychiatry 66(7):700-12.
  • Kurth F, Gaser C, Luders E (2015) A 12-step user guide for analyzing voxel-wise gray matter asymmetries in statistical parametric mapping (SPM). Nat Protoc. 10(2):293-304.
  • Kurth F, Gaser C, Luders E. Development of sex differences in the human brain Cogn Neurosci. 2021 Jul-Oct;12(3-4):155-162. doi: 10.1080/17588928.2020.1800617. Epub 2020 Sep 9.
  • Kurth F, Gaser C, Sánchez FJ, Luders E. Brain Sex in Transgender Women Is Shifted towards Gender Identity J Clin Med. 2022 Mar 13;11(6):1582. doi: 10.3390/jcm11061582.
  • Kurth F, Levitt JG, Gaser C, Alger J, Loo SK, Narr KL, O'Neill J, Luders E. Preliminary evidence for a lower brain age in children with attention-deficit/hyperactivity disorder Front Psychiatry. 2022 Dec 2;13:1019546. doi: 10.3389/fpsyt.2022.1019546. eCollection 2022.
  • Ligges C, Ligges M, Gaser C. Cross-Sectional Investigation of Brain Volume in Dyslexia Front Neurol. 2022 Mar 8;13:847919. doi: 10.3389/fneur.2022.847919. eCollection 2022.
  • Luders E, Gaser C, Gingnell M, Engman J, Sundström Poromaa I, Kurth F. Postpartum Gray Matter Changes in the Auditory Cortex J Clin Med. 2021 Nov 29;10(23):5616. doi: 10.3390/jcm10235616.
  • Luders E, Gaser C, Gingnell M, Engman J, Sundström Poromaa I, Kurth F. Significant increases of the amygdala between immediate and late postpartum: Pronounced effects within the superficial subregion J Neurosci Res. 2021 Sep;99(9):2261-2270. doi: 10.1002/jnr.24855. Epub 2021 Jun 8.
  • Luders E, Gaser C, Gingnell M, Engman J, Sundström Poromaa I, Kurth F. Gray matter increases within subregions of the hippocampal complex after pregnancy Brain Imaging Behav. 2021 Dec;15(6):2790-2794. doi: 10.1007/s11682-021-00463-2. Epub 2021 Apr 21.
  • Maitra R, Horne CM, O'Daly O, Papanastasiou E, Gaser C; IMAGEN list of authors; IMAGEN Consortium. Psychotic Like Experiences in Healthy Adolescents are Underpinned by Lower Fronto-Temporal Cortical Gyrification: a Study from the IMAGEN Consortium Schizophr Bull. 2023 Mar 15;49(2):309-318. doi: 10.1093/schbul/sbac132.
  • Martins M, Reis AM, Castro SL, Gaser C. Gray matter correlates of reading fluency deficits: SES matters, IQ does not Brain Struct Funct. 2021 Nov;226(8):2585-2601. doi: 10.1007/s00429-021-02353-1. Epub 2021 Aug 6.
  • Matziorinis AM, Gaser C, Koelsch S. Is musical engagement enough to keep the brain young? Brain Struct Funct. 2023 Mar;228(2):577-588. doi: 10.1007/s00429-022-02602-x. Epub 2022 Dec 27.
  • Nenadić I, Lorenz C, Gaser C. Narcissistic personality traits and prefrontal brain structure Sci Rep. 2021 Aug 3;11(1):15707. doi: 10.1038/s41598-021-94920-z.
  • Pfarr JK, Meller T, Brosch K, Stein F, Thomas-Odenthal F, Evermann U, Wroblewski A, Ringwald KG, Hahn T, Meinert S, Winter A, Thiel K, Flinkenflügel K, Jansen A, Krug A, Dannlowski U, Kircher T, Gaser C, Nenadić I. Data-driven multivariate identification of gyrification patterns in a transdiagnostic patient cohort: A cluster analysis approach Neuroimage. 2023 Sep 6;281:120349. doi: 10.1016/j.neuroimage.2023.120349. Online ahead of print.
  • Rogenmoser L, Kernbach J, Schlaug G, Gaser C. Keeping brains young with making music (2018) Brain Struct Funct. 223(1):297-305.
  • Rubbert C, Wolf L, Turowski B, Hedderich DM, Gaser C, Dahnke R, Caspers J; Alzheimer’s Disease Neuroimaging Initiative. Impact of defacing on automated brain atrophy estimation Insights Imaging. 2022 Mar 26;13(1):54. doi: 10.1186/s13244-022-01195-7.
  • Ruiz-Rizzo AL, Bublak P, Kluckow S, Finke K, Gaser C, Schwab M, Güllmar D, Müller HJ, Witte OW, Rupprecht S. Neural distinctiveness of fatigue and low sleep quality in multiple sclerosis Eur J Neurol. 2022 Oct;29(10):3017-3027. doi: 10.1111/ene.15445. Epub 2022 Jun 25.
  • Sakreida K, Chiu WH, Dukart J, Eickhoff SB, Frodl T, Gaser C, Landgrebe M, Langguth B, Mirlach D, Rautu IS, Wittmann M, Poeppl TB. Disentangling dyskinesia from parkinsonism in motor structures of patients with schizophrenia Brain Commun. 2022 Jul 23;4(4):fcac190. doi: 10.1093/braincomms/fcac190. eCollection 2022.
  • Schmidt S, Gull S, Herrmann KH, Boehme M, Irintchev A, Urbach A, Reichenbach JR, Klingner CM, Gaser C, Witte OW. Experience-dependent structural plasticity in the adult brain: How the learning brain grows Neuroimage. 2021 Jan 15;225:117502. doi: 10.1016/j.neuroimage.2020.117502. Epub 2020 Oct 24.
  • Schmitt S, Besteher B, Gaser C, Nenadić I. Human time perspective and its structural associations with voxel-based morphometry and gyrification Brain Imaging Behav. 2021 Oct;15(5):2237-2245. doi: 10.1007/s11682-020-00416-1. Epub 2020 Dec 3.
  • Schmitz-Koep B, Haller B, Coupé P, Menegaux A, Gaser C, Zimmer C, Wolke D, Bartmann P, Sorg C, Hedderich DM. Grey and White Matter Volume Changes after Preterm Birth: A Meta-Analytic Approach J Pers Med. 2021 Aug 30;11(9):868. doi: 10.3390/jpm11090868.
  • Schmitz-Koep B, Menegaux A, Gaser C, Brandes E, Schinz D, Thalhammer M, Daamen M, Boecker H, Zimmer C, Priller J, Wolke D, Bartmann P, Sorg C, Hedderich DM. Altered Gray Matter Cortical and Subcortical T1-Weighted/T2-Weighted Ratio in Premature-Born Adults Biol Psychiatry Cogn Neurosci Neuroimaging. 2023 May;8(5):495-504. doi: 10.1016/j.bpsc.2022.02.013. Epub 2022 Mar 8.
  • Schumann A, Gaser C, Sabeghi R, Schulze PC, Festag S, Spreckelsen C, Bär KJ. Using machine learning to estimate the calendar age based on autonomic cardiovascular function Front Aging Neurosci. 2023 Jan 23;14:899249. doi: 10.3389/fnagi.2022.899249. eCollection 2022.
  • Sevinc G, Rusche J, Wong B, Datta T, Kaufman R, Gutz SE, Schneider M, Todorova N, Gaser C, Thomalla G, Rentz D, Dickerson BD, Lazar SW. Mindfulness Training Improves Cognition and Strengthens Intrinsic Connectivity Between the Hippocampus and Posteromedial Cortex in Healthy Older Adults Front Aging Neurosci. 2021 Aug 27;13:702796. doi: 10.3389/fnagi.2021.702796. eCollection 2021.
  • Simonsson O, Bouso JC, Kurth F, Araújo DB, Gaser C, Riba J, Luders E. Preliminary evidence of links between ayahuasca use and the corpus callosum Front Psychiatry. 2022 Oct 26;13:1002455. doi: 10.3389/fpsyt.2022.1002455. eCollection 2022.
  • Steinbach R, Prell T, Gaur N, Roediger A, Gaser C, Mayer TE, Witte OW, Grosskreutz J. Patterns of grey and white matter changes differ between bulbar and limb onset amyotrophic lateral sclerosis Neuroimage Clin. 2021;30:102674. doi: 10.1016/j.nicl.2021.102674. Epub 2021 Apr 15.